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Graves' Disease

2
Pipeline Programs
4
Companies
7
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Sandoz
SandozAustria - Kundl
1 program
1
CFZ533Phase 2
Yarrow Bioscience
Yarrow BioscienceNY - New York
1 program
1
Experimental: YB-101Phase 21 trial
Active Trials
NCT07682896Recruiting232Est. Sep 2029
Immunovant
ImmunovantDURHAM, NC
3 programs
IMVT-1402PHASE_21 trial
IMVT-1402PHASE_21 trial
IMVT-1402PHASE_21 trial
Active Trials
NCT07286006Enrolling By Invitation372Est. Mar 2030
NCT07018323Recruiting210Est. May 2027
NCT06727604Recruiting240Est. Jun 2028
Novartis
NovartisBASEL, Switzerland
1 program
CFZ533PHASE_23 trials
Active Trials
NCT03781414Terminated129Est. Apr 2023
NCT02713256Completed15Est. Apr 2017
NCT02217410Completed59Est. Nov 2017

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Yarrow BioscienceExperimental: YB-101
ImmunovantIMVT-1402
ImmunovantIMVT-1402
ImmunovantIMVT-1402
NovartisCFZ533
NovartisCFZ533
NovartisCFZ533

Clinical Trials (7)

Total enrollment: 1,257 patients across 7 trials

NCT07682896Yarrow BioscienceExperimental: YB-101

Evaluation of YB-101 for Safety, Tolerability, Pharmacokinetics, and Efficacy in Graves' Disease

Start: Jun 2026Est. completion: Sep 2029232 patients
Phase 2Recruiting

A Long-Term Extension Study of IMVT-1402 in Adult Participants With Graves' Disease (GD)

Start: Jan 2026Est. completion: Mar 2030372 patients
Phase 2Enrolling By Invitation

A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

Start: Jun 2025Est. completion: May 2027210 patients
Phase 2Recruiting

A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

Start: Dec 2024Est. completion: Jun 2028240 patients
Phase 2Recruiting

Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Liver Transplant Recipients With Additional 12-month Follow-up and Long-term Extension

Start: Oct 2019Est. completion: Apr 2023129 patients
Phase 2Terminated

A Study to Evaluate the Safety and Effect of CFZ533 on Patients With Graves' Disease

Start: Apr 2016Est. completion: Apr 201715 patients
Phase 2Completed

CCFZ533X2201 - PoC Study in de Novo Renal Transplantation

Start: Feb 2015Est. completion: Nov 201759 patients
Phase 1/2Completed

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 actively recruiting trials targeting 1,257 patients
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.