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Granulomatosis With Polyangiitis

2
Pipeline Programs
5
Companies
5
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
1
0
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
3100%
+ 4 programs with unclassified modality

On Market (1)

Approved therapies currently available

TAVNEOSApproved
avacopan
Unknown Company
Complement 5a Receptor Antagonist [EPC]oral2021
34M Part D

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
avacopanPhase 2/32 trials
Active Trials
NCT06468826Completed13Est. Oct 2024
NCT06207682Completed32Est. Aug 2022
Airway Therapeutics
Airway TherapeuticsGA - Marietta
2 programs
Airway assessmentN/A1 trial
Granulomatosis With Polyangiitis Natural History StudyN/A
Active Trials
NCT03182049Withdrawn0Est. May 2023
Genentech
GenentechCA - Oceanside
2 programs
RituximabN/AMonoclonal Antibody
ObinutuzumabPHASE_2Monoclonal Antibody
Chia Tai TianQing Pharmaceutical Group
1 program
Meperizumab injectionPHASE_11 trial
Active Trials
NCT05353179Unknown88Est. Oct 2022
Roche
RocheSTAVANGER NORWAY, Norway
1 program
RituximabPHASE_2Monoclonal Antibody1 trial
Active Trials
NCT01750697Completed25Est. May 2018

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
RocheRituximab
Amgenavacopan
Amgenavacopan
Chia Tai TianQing Pharmaceutical GroupMeperizumab injection
Airway TherapeuticsAirway assessment

Clinical Trials (5)

Total enrollment: 158 patients across 5 trials

A Phase IIa Study of Intravenous Rituximab in Pediatric Participants With Severe Granulomatosis With Polyangiitis (Wegener's) or Microscopic Polyangiitis

Start: May 2013Est. completion: May 201825 patients
Phase 2Completed

A Study of Avacopan in Participants With Normal Renal Function and Participants With End-Stage Renal Disease (ESRD)

Start: Jun 2024Est. completion: Oct 202413 patients
Phase 1Completed

Effect of Repeated Oral Doses of Avacopan on the Pharmacokinetics (PK) of a Single Dose of Simvastatin

Start: Jun 2022Est. completion: Aug 202232 patients
Phase 1Completed

Study on Pharmacokinetics of Meperizumab Injection and NUCALA® in Healthy Male Volunteers

Start: Jun 2022Est. completion: Oct 202288 patients
Phase 1Unknown

Natural History of Granulomatosis With Polyangiitis: Clinical and Genetic Biomarkers of Airway Disease NoAAC PR-03 Study

Start: Dec 2020Est. completion: May 20230
N/AWithdrawn

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.