Giant Cell Arteritis

6
Pipeline Programs
5
Companies
3
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
3
0
2
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
2100%
+ 3 programs with unclassified modality

On Market (1)

Approved therapies currently available

Roche
ACTEMRAApproved
tocilizumab
Roche
Interleukin-6 Receptor Antagonist [EPC]injection2010

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Roche
RocheSTAVANGER NORWAY, Norway
1 program
1
1
tocilizumab and IV steroids combinationPhase 2
CP
Chugai PharmaJapan - Tokyo
2 programs
1
1
TocilizumabPhase 3Monoclonal Antibody1 trial
tocilizumab and IV steroids combinationPhase 21 trial
Active Trials
NCT04239196Unknown58Est. Dec 2022
NCT04888221Active Not Recruiting66Est. Aug 2025
Regeneron
RegeneronTARRYTOWN, NY
1 program
1
Sarilumab SAR153191Phase 3
Kiniksa Pharmaceuticals
1 program
1
mavrilimumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT03827018Completed70Est. Nov 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Chugai PharmaTocilizumab
Chugai Pharmatocilizumab and IV steroids combination
Kiniksa Pharmaceuticalsmavrilimumab

Clinical Trials (3)

Total enrollment: 194 patients across 3 trials

Efficacy of Tocilizumab in Association to Steroids in Giant Cell Arteritis With Cerebro-vascular Involvement

Start: Sep 2021Est. completion: Aug 202566 patients
Phase 3Active Not Recruiting
NCT04239196Chugai Pharmatocilizumab and IV steroids combination

Efficacy of Tocilizumab for the Treatment of Acute AION Related to GCA

Start: Sep 2020Est. completion: Dec 202258 patients
Phase 2Unknown

KPL-301 for Subjects With Giant Cell Arteritis

Start: Sep 2018Est. completion: Nov 202070 patients
Phase 2Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
5 companies competing in this space