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GERD

26
Pipeline Programs
14
Companies
39
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
9
0
3
0
4
10
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
11100%
+ 28 programs with unclassified modality

On Market (1)

Approved therapies currently available

AstraZeneca
PRILOSECApproved
omeprazole
AstraZeneca
oral1989
3M Part D

Competitive Landscape

13 companies ranked by most advanced pipeline stage

AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
20 programs
1
4
7
AntacidsPhase 41 trial
EsomeprazolePhase 4Small Molecule1 trial
EsomeprazolePhase 4Small Molecule1 trial
EsomeprazolePhase 4Small Molecule1 trial
EsomeprazolePhase 4Small Molecule1 trial
+15 more programs
Active Trials
NCT01134367Completed1,000Est. Dec 2010
NCT00634023Completed500Est. May 2008
NCT00524355Completed2,717Est. Nov 2007
+17 more trials
Dr. Reddy's Laboratories
2 programs
2
OMEZ 40Phase 41 trial
omeprazole+domperidone SRPhase 41 trial
Active Trials
NCT02922699Completed120Est. Jun 2013
NCT02140073Unknown60Est. Jun 2014
Onconic Therapeutics
1 program
1
JP-1366Phase 21 trial
Active Trials
NCT04282954Completed188Est. Dec 2020
Indivior
IndiviorUK - Slough
1 program
1
XP19986 CRPhase 21 trial
Active Trials
NCT00838396Completed58Est. Aug 2006
Chong Kun Dang Pharmaceutical
6 programs
6
CKD-381Phase 11 trial
CKD-381Phase 11 trial
CKD-381Phase 11 trial
CKD-381Phase 11 trial
CKD-382Phase 11 trial
+1 more programs
Active Trials
NCT03211143Completed41Est. Aug 2017
NCT04830930Completed28Est. Jul 2021
NCT03558425Completed41Est. Sep 2018
+3 more trials
Yooyoung Pharmaceutical
Yooyoung PharmaceuticalKorea - Jincheon
2 programs
2
YYD601 1Phase 11 trial
YYD601 20mgPhase 11 trial
Active Trials
NCT03558477Completed30Est. Feb 2018
NCT03985319Completed28Est. Mar 2020
Ono Pharmaceutical
Ono PharmaceuticalJapan - Osaka
1 program
1
ONO-8539Phase 11 trial
Active Trials
NCT01707901Completed14
Medtronic
MedtronicNJ - Phillipsburg
1 program
EndoFLIPN/A1 trial
Active Trials
NCT06159972Unknown50Est. Dec 2024
Aplos Medical
Aplos MedicalMN - Eden Prairie
1 program
Omega-CuffN/A1 trial
Active Trials
NCT04793035Active Not Recruiting8Est. Mar 2026
Takeda
TakedaTOKYO, Japan
1 program
Prevacid SolutabsN/A1 trial
Active Trials
NCT00624546Terminated24Est. Jan 2014
Eisai
EisaiChina - Liaoning
1 program
Rabeprazole sodiumPHASE_11 trial
Active Trials
NCT00747695Completed31Est. Sep 2009
Cinclus Pharma
Cinclus PharmaSweden - Stockholm
1 program
linaprazan glurate 25 mg QDPHASE_11 trial
Active Trials
NCT05742984Completed75Est. Apr 2023
Genomics
GenomicsUK - Oxford
1 program
Neobianacid®PHASE_41 trial
Active Trials
NCT03238534Completed275Est. Sep 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GenomicsNeobianacid®
Dr. Reddy's Laboratoriesomeprazole+domperidone SR
Dr. Reddy's LaboratoriesOMEZ 40
AstraZenecaesomeprazole
AstraZenecaEsomeprazole
AstraZenecaAntacids
AstraZenecaEsomeprazole
AstraZenecaEsomeprazole
AstraZenecaEsomeprazole
AstraZenecaEsomeprazole
AstraZenecaEsomeprazole
AstraZenecaEsomeprazole
AstraZenecaEsomeprazole
AstraZenecaOmeprazole
Onconic TherapeuticsJP-1366

Showing 15 of 39 trials with date data

Clinical Trials (39)

Total enrollment: 18,737 patients across 39 trials

NCT03238534GenomicsNeobianacid®

Efficacy and Safety Evaluation of Neobianacid® in GERD and EPS

Start: Sep 2017Est. completion: Sep 2021275 patients
Phase 4Completed
NCT02140073Dr. Reddy's Laboratoriesomeprazole+domperidone SR

Research of Efficient Use of Omeprazole in Combination With Domperidone in Gastroesophageal Reflux Disease of Mild to Moderate Severity

Start: Dec 2013Est. completion: Jun 201460 patients
Phase 4Unknown

Efficacy and Saafety of Omez Iin Patients With H.Pylori Associated Diseases

Start: Jan 2013Est. completion: Jun 2013120 patients
Phase 4Completed

Nexium (Esomeprazole) in Symptom Adapted Therapy in GERD Patients

Start: Mar 2007Est. completion: Oct 20083,029 patients
Phase 4Completed

Nexium RESPONSE Trial

Start: May 2006Est. completion: Nov 20071,000 patients
Phase 4Completed

Nexium 40mg Once Daily vs Prevacid 30mg Twice a Day for Control of Severe GERD

Start: Oct 2005Est. completion: Dec 200750 patients
Phase 4Completed

An Open-Label Study of Once-Daily Oral Administration of Esomeprazole 40 mg in Patients With Symptoms of Gastroesophageal Reflux Disease (GERD)

Start: Oct 2005Est. completion: Jan 2006350 patients
Phase 4Completed

PPI Test in GP Patients

Start: Jan 2003100 patients
Phase 4Completed

An Open, Randomized, Two Way Crossover Study Comparing the Effect of 20mg Esomeprazole Administered Orally and Intravenously as a 15 Minute Infusion on Basal and Pentagastrin-Stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Disease (GERD)

Start: Sep 2002Est. completion: Oct 200260 patients
Phase 4Completed

Open, Randomized, Two Way Crossover 40mg, Orally and Intravenously

Start: Aug 2002Est. completion: Oct 200260 patients
Phase 4Completed

Efficacy and Safety of Esomeprazole Once Daily for the Treatment of GERD in Neonatal Patients

Start: Oct 2006Est. completion: Apr 200932 patients
Phase 3Completed

Esomeprazole for Prevention of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs

Start: Feb 2001Est. completion: Feb 2003334 patients
Phase 3Completed

Esomeprazole for Relief of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs

Start: Jan 2001Est. completion: Aug 2002808 patients
Phase 3Completed

Sopran - Omeprazole Treatment Versus Surgery

Start: Jan 1998Est. completion: Oct 2005219 patients
Phase 3Completed

Clinical Trial to Evaluate the Safety and Efficacy of JP-1366 in Patients With Erosive Gastroesophageal Reflux Disease

Start: Nov 2019Est. completion: Dec 2020188 patients
Phase 2Completed

Validation of Patient-reported Outcomes Measures for the Assessment of Gastroesophageal Reflux Disease (GERD) Symptoms

Start: May 2008Est. completion: Jan 2009478 patients
Phase 2Completed

A Study to Evaluate the Efficacy and Safety of Controlled Release Arbaclofen Placarbil (XP19986) in Patients With Gastroesophageal Reflux Disease

Start: Oct 2005Est. completion: Aug 200658 patients
Phase 2Completed
NCT05742984Cinclus Pharmalinaprazan glurate 25 mg QD

Investigate Linaprazan Glurate/Linaprazan in Healthy Subjects

Start: Jan 2023Est. completion: Apr 202375 patients
Phase 1Completed

A Study to Evaluate the PK, PD and Safety of CKD-382 in Healthy Subjects

Start: Oct 2021Est. completion: Feb 202242 patients
Phase 1Unknown

A Study to Investigate the Effect of Food on the PK, PD of CKD-381 in Healthy Volunteers

Start: Apr 2021Est. completion: Jul 202128 patients
Phase 1Completed

A Study to Compare PK, PD and Safety of CKD-382 in Healthy Subjects

Start: Sep 2020Est. completion: Sep 202148 patients
Phase 1Unknown

Clinical Trial to Assess the PK/PD of YYD601 20mg After Oral Administration if Healthy Adult Subjects (Phase1)

Start: Jul 2019Est. completion: Mar 202028 patients
Phase 1Completed

A Study to Compare PK, PD and Safety of CKD-381 and D026 in Healthy Subjects

Start: Jun 2018Est. completion: Sep 201841 patients
Phase 1Completed

A Study to Compare PK and Safety of CKD-381 and D026 in Healthy Male Subjects

Start: Mar 2018Est. completion: May 201818 patients
Phase 1Completed

PK/PD Clinical Trial of YYD601 in Healthy Adult Male

Start: Sep 2017Est. completion: Feb 201830 patients
Phase 1Completed

A Study to Compare PK, PD and Safety of CKD-381 in Healthy Subjects

Start: Jun 2017Est. completion: Aug 201741 patients
Phase 1Completed

A Study of the Effect of ONO-8539 on Oesophageal Pain Hypersensitivity in Patients With Non-erosive Reflux Disease

Start: Dec 201214 patients
Phase 1Completed
NCT00747695EisaiRabeprazole sodium

A Pharmacokinetic and Safety Study of Single and Multiple Doses of Rabreprazole in Pediatric Patients With Gastroesophageal Reflux Disease (GERD) 1 to 11 Years Old, Inclusive

Start: Mar 2008Est. completion: Sep 200931 patients
Phase 1Completed

Omega Cuff for GERD Feasibility Study

Start: Aug 2023Est. completion: Mar 20268 patients
N/AActive Not Recruiting

Can EndoFLIP Improve Quality of Life Before and After Fundoplication?

Start: Jan 2023Est. completion: Dec 202450 patients
N/AUnknown
NCT01134367AstraZenecaAn Epidemiological Study to Describe Symptom Control and Impact of Gastroesophageal Reflux Disease

An Epidemiological Study to Describe Symptom Control and Impact of Gastroesophageal Reflux Disease

Start: May 2010Est. completion: Dec 20101,000 patients
N/ACompleted
NCT00624546TakedaPrevacid Solutabs

Effect of Antireflux Therapy on the Expression of Genes in Patients With GERD

Start: Jan 2009Est. completion: Jan 201424 patients
N/ATerminated
NCT01079884AstraZenecaesomeprazole 40 mg

Gastroesophageal Reflux Disease (GERD)/Nighttime Heartburn and Driving Performance

Start: Jul 2008Est. completion: Mar 201118 patients
N/ACompleted
NCT00688675AstraZenecaGastroesophageal Reflux Disease (GERD) Segmentation: Document How Swiss General Practitioners (GPs)

Gastroesophageal Reflux Disease (GERD) Segmentation: Document How Swiss General Practitioners (GPs) Allocate Their GERD Patients to the Three GERD Patient Segments

Start: Feb 2008Est. completion: Aug 20082,912 patients
N/ACompleted
NCT00634023AstraZenecaCanadian, Multi-Centre Study of Symptom Burden and Clinical Management in Subjects With GERD

Canadian, Multi-Centre Study of Symptom Burden and Clinical Management in Subjects With GERD

Start: Jan 2008Est. completion: May 2008500 patients
N/ACompleted
NCT00567619AstraZenecaLIFE NIS, GERD-Patients - Evaluation of Burden of Disease Determined by GERD Impact Scale (GIS)

LIFE NIS, GERD-Patients - Evaluation of Burden of Disease Determined by GERD Impact Scale (GIS)

Start: Jul 2007900 patients
N/ACompleted
NCT00524355AstraZenecaEpidemiological Study to Assess the Symptoms and Patterns of Diagnosis and Treatment of GERD

Epidemiological Study to Assess the Symptoms and Patterns of Diagnosis and Treatment of GERD

Start: Mar 2007Est. completion: Nov 20072,717 patients
N/ACompleted
NCT00545883AstraZenecaImpact of GERD on Daily Life (NIS)

Impact of GERD on Daily Life (NIS)

Start: Jun 2006Est. completion: Mar 20082,001 patients
N/ACompleted

The Effect of Lifestyle-Adjustments Prior to Medical Treatment on the Effect of Medical Treatment in Reflux Patients

Start: Jun 2004Est. completion: Mar 2008990 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs, potential near-term approvals
14 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.