Geographic Atrophy

21
Pipeline Programs
11
Companies
24
Clinical Trials
4 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
2
8
1
6
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
2100%
+ 22 programs with unclassified modality

Competitive Landscape

11 companies ranked by most advanced pipeline stage

Apellis Pharmaceuticals
Apellis PharmaceuticalsAustralia - Hawthorn East
6 programs
1
1
2
APL-2Phase 31 trial
APL-2Phase 31 trial
PegcetacoplanPhase 21 trial
PEGCETACOPLANPhase 11 trial
Geographic Atrophy Long-Terms Outcomes StudyN/A1 trial
+1 more programs
Active Trials
NCT06499571Completed255Est. Jul 2023
NCT06161584Active Not Recruiting300Est. Jun 2027
NCT03777332Completed19Est. Apr 2021
+3 more trials
Roche
RocheSTAVANGER NORWAY, Norway
4 programs
2
2
LampalizumabPhase 3Monoclonal Antibody1 trial
LampalizumabPhase 3Monoclonal Antibody2 trials
RO7303359Phase 11 trial
RO7669330Phase 11 trial
Active Trials
NCT04615325Completed37Est. Jan 2023
NCT06961370Recruiting132Est. Jan 2027
NCT02247531Terminated975Est. Jan 2018
+2 more trials
Alcon
AlconFORT WORTH, TX
3 programs
2
1
AL-8309B Ophthalmic SolutionPhase 31 trial
Al-78898APhase 21 trial
CLG561Phase 2
Active Trials
NCT01603043TerminatedEst. Nov 2012
NCT00890097Terminated772Est. May 2012
Annexon Biosciences
Annexon BiosciencesCA - Brisbane
2 programs
1
1
VonaprumentPhase 31 trial
ANX007Phase 21 trial
Active Trials
NCT04656561CompletedEst. Sep 2023
NCT06510816Active Not RecruitingEst. Oct 2027
Alkeus Pharmaceuticals
1 program
1
ALK-001 oral capsulePhase 2/31 trial
Active Trials
NCT03845582CompletedEst. Jun 2024
Genentech
GenentechCA - Oceanside
2 programs
2
OpRegenPhase 21 trial
ShamPhase 21 trial
Active Trials
NCT05626114Recruiting60Est. Mar 2031
NCT02288559Completed96Est. Jun 2017
Ionis Pharmaceuticals
1 program
1
IONIS-FB-LrxPhase 21 trial
Active Trials
NCT03446144Withdrawn0Est. Oct 2018
S
SantenCA - Emeryville
1 program
1
SirolimusPhase 21 trial
Active Trials
NCT01675947TerminatedEst. Feb 2016
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
ABBV-6628Phase 1/21 trial
Active Trials
NCT07160179Recruiting66Est. Oct 2029
Sanofi
SanofiPARIS, France
1 program
1
SAR446597Phase 1/21 trial
Active Trials
NCT07215234Recruiting104Est. Jul 2032
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
2 programs
1
BI 771716Phase 11 trial
Patients With Geographic Atrophy and Their Patient Journey in the United States (US)N/A1 trial
Active Trials
NCT05891275Completed68,563Est. Dec 2023
NCT06006585Completed20Est. May 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Annexon BiosciencesVonaprument
Apellis PharmaceuticalsAPL-2
Apellis PharmaceuticalsAPL-2
RocheLampalizumab
RocheLampalizumab
RocheLampalizumab
AlconAL-8309B Ophthalmic Solution
Alkeus PharmaceuticalsALK-001 oral capsule
GenentechOpRegen
Annexon BiosciencesANX007
Ionis PharmaceuticalsIONIS-FB-Lrx
Apellis PharmaceuticalsPegcetacoplan
GenentechSham
AlconAl-78898A
SantenSirolimus

Showing 15 of 24 trials with date data

Clinical Trials (24)

Total enrollment: 74,803 patients across 24 trials

A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Geographic Atrophy (GA)

Start: Jul 2024Est. completion: Oct 2027
Phase 3Active Not Recruiting

Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration

Start: Aug 2018Est. completion: Jun 2022621 patients
Phase 3Completed

A Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration

Start: Aug 2018Est. completion: Jun 2022637 patients
Phase 3Completed
NCT02745119RocheLampalizumab

Long-Term Safety of Lampalizumab Intravitreal (ITV) Injections in Participants With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (OMASPECT)

Start: Jul 2016Est. completion: Jan 2018994 patients
Phase 3Terminated
NCT02247531RocheLampalizumab

A Study Investigating the Safety and Efficacy of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Start: Oct 2014Est. completion: Jan 2018975 patients
Phase 3Terminated
NCT02247479RocheLampalizumab

A Study Investigating the Efficacy and Safety of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Start: Sep 2014Est. completion: Jan 2018906 patients
Phase 3Terminated
NCT00890097AlconAL-8309B Ophthalmic Solution

Geographic Atrophy Treatment Evaluation

Start: Apr 2009Est. completion: May 2012772 patients
Phase 3Terminated

Phase 2/3 Study of ALK-001 in Geographic Atrophy

Start: May 2019Est. completion: Jun 2024
Phase 2/3Completed

A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251

Start: Mar 2023Est. completion: Mar 203160 patients
Phase 2Recruiting

A Study Investigating the Efficacy and Safety of Intravitreal Injections of ANX007 in Patients With Geographic Atrophy

Start: Feb 2021Est. completion: Sep 2023
Phase 2Completed

Safety and Efficacy of IONIS-FB-Lrx in up to 120 Patients 55 and Older With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)

Start: Mar 2018Est. completion: Oct 20180
Phase 2Withdrawn

Study of Pegcetacoplan (APL-2) Therapy in Patients With Geographic Atrophy

Start: Sep 2015Est. completion: Jan 2018246 patients
Phase 2Completed

A Study of Lampalizumab Intravitreal Injections Administered Every Two Weeks or Every Four Weeks to Participants With Geographic Atrophy

Start: Mar 2015Est. completion: Jun 201796 patients
Phase 2Completed

A Multicenter, Proof-Of-Concept Study Of Intravitreal AL-78898A In Patients With Geographic Atrophy (GA) Associated With Age-Related Macular Degeneration (AMD)

Start: Jun 2012Est. completion: Nov 2012
Phase 2Terminated

Intravitreal Injections of Sirolimus in the Treatment of Geographic Atrophy

Start: Feb 2012Est. completion: Feb 2016
Phase 2Terminated

A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration

Start: Oct 2025Est. completion: Jul 2032104 patients
Phase 1/2Recruiting

Study to Assess the Adverse Events and How Intravitreal ABBV-6628 Moves Through the Body of Adult Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Start: Aug 2025Est. completion: Oct 202966 patients
Phase 1/2Recruiting

A Study to Investigate Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Immunogenicity of RO7669330 in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Start: Jul 2025Est. completion: Jan 2027132 patients
Phase 1Recruiting

A Study to Test How Well Different Doses of BI 771716 Are Tolerated by People With an Advanced Form of Age-related Macular Degeneration (AMD) Called Geographic Atrophy

Start: Oct 2023Est. completion: May 202420 patients
Phase 1Completed

A Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Intravitreal Injections of RO7303359 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration

Start: Dec 2020Est. completion: Jan 202337 patients
Phase 1Completed

Study to Evaluate the Safety of Intravitreal APL-2 in Patients Diagnosed With Geographic Atrophy

Start: Nov 2018Est. completion: Apr 202119 patients
Phase 1Completed

A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Start: Sep 2023Est. completion: Jun 2027300 patients
N/AActive Not Recruiting
NCT05891275Boehringer IngelheimPatients With Geographic Atrophy and Their Patient Journey in the United States (US)

Patients With Geographic Atrophy and Their Patient Journey in the United States (US)

Start: May 2023Est. completion: Dec 202368,563 patients
N/ACompleted
NCT06499571Apellis PharmaceuticalsGeographic Atrophy Long-Terms Outcomes Study

Geographic Atrophy Long-Terms Outcomes Study

Start: Sep 2022Est. completion: Jul 2023255 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

6 late-stage (Phase 3) programs — potential near-term approvals
4 actively recruiting trials targeting 74,803 patients
11 companies competing in this space