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Gastric Ulcers

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Pipeline Programs
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Approved Products

Pipeline by Development Stage

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Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

1 companies ranked by most advanced pipeline stage

Takeda
TakedaTOKYO, Japan
1 program
TAK-438PHASE_35 trials
Active Trials
NCT01452698Completed409Est. Aug 2012
NCT03808493Completed48Est. Mar 2019
NCT03085836Completed33Est. Aug 2017
+2 more trials

Trial Timeline

Clinical trial activity over time

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Showing 15 of 21 trials with date data

Clinical Trials (21)

Total enrollment: 5,604 patients across 21 trials

Efficacy of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Erosive Esophagitis

Est. completion: Aug 2012409 patients
Phase 3Completed

Phase 3 Study of TAK-438 10 mg in the Treatment of Non-Erosive Gastroesophageal Reflux Disease (NERD)

Start: Nov 2016Est. completion: Feb 2018484 patients
Phase 3Completed

A Randomized, Double-Blind, Multicenter Study to Evaluate the Acid-inhibitory and Dose-response Efficacy of TAK-438 (20 mg, 40 mg) in Patients With Proton Pump Inhibitor (PPI) - Resistant Erosive Esophagitis

Start: Jul 2012Est. completion: Sep 201319 patients
Phase 3Completed

A Unblinded Study of TAK-438 (20 mg) for Prevention of Recurrence of Gastric or Duodenal Ulcer During Long-Term Low-Dose Aspirin Therapy

Start: May 2012Est. completion: Aug 201327 patients
Phase 3Completed

A Unblinded Study of TAK-438 (20 mg) for Prevention of Recurrence of Gastric or Duodenal Ulcer During Long-Term Non-Steroid Anti-Inflammatory Drug (NSAID) Therapy

Start: Apr 2012Est. completion: Sep 201330 patients
Phase 3Completed

Long-term Extension Study of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Low-dose Aspirin

Start: Mar 2012Est. completion: Oct 2013439 patients
Phase 3Completed

Efficacy of TAK-438 Compared to Placebo in the Treatment of Non-Erosive Gastroesophageal Reflux Disease

Start: Dec 2011Est. completion: Feb 2013827 patients
Phase 3Completed

Efficacy of TAK-438 Compared to AG-1749 (Lansoprazole) in the Maintenance Treatment of Healed Erosive Esophagitis

Start: Oct 2011Est. completion: Mar 2013607 patients
Phase 3Completed

Efficacy and Safety of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Low-dose Aspirin

Start: Oct 2011Est. completion: Apr 2013621 patients
Phase 3Completed

Efficacy and Safety of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti-inflammatory Drug (NSAID)

Start: Oct 2011Est. completion: Jun 2013642 patients
Phase 3Completed

Efficacy and Safety of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Duodenal Ulcer

Start: Oct 2011Est. completion: Feb 2013372 patients
Phase 3Completed

Long-Term Safety Study of TAK-438 in the Maintenance Treatment of Healed Erosive Esophagitis

Start: Sep 2011Est. completion: Jul 2013305 patients
Phase 3Completed

Long-term Extension Study of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti-inflammatory Drug (NSAID)

Start: Sep 2011Est. completion: Dec 2013406 patients
Phase 3Completed

A Bioequivalence (BE) Study of TAK-438 Orally Disintegrating (OD) Tablet

Start: Jan 2019Est. completion: Mar 201948 patients
Phase 1Completed

A Pharmacokinetic Study of TAK-438 in Healthy Adult Chinese Participants

Start: Apr 2017Est. completion: Aug 201733 patients
Phase 1Completed

TAK-438 Bismuth Drug Interaction Study

Start: Sep 2016Est. completion: May 201730 patients
Phase 1Completed

TAK-438_110 Drug Interaction With Cytochrome P450 3A4 (CYP3A4) Inhibitor Clarithromycin

Start: Aug 2010Est. completion: Sep 201016 patients
Phase 1Completed

TAK-438 - Safety, Blood Levels & Effects of Repeated Doses

Start: Oct 2008Est. completion: Feb 200948 patients
Phase 1Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TAK-438 in Healthy Male Participants

Start: Oct 2008Est. completion: Mar 200960 patients
Phase 1Completed

Safety, Tolerability, and Pharmacokinetics of TAK-438 in Healthy Western Male Subjects, Preliminary Food Effect Analysis, and an Ethnic Comparison With Japanese Subjects

Start: Oct 2007Est. completion: Feb 200873 patients
Phase 1Completed

Safety, Tolerability and Pharmacokinetics of TAK-438 in Healthy Male Participants

Start: Sep 2007Est. completion: Dec 2007108 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

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The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.