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Functional Mitral Regurgitation

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Pipeline Programs
6
Companies
13
Clinical Trials
3 recruiting
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Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
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Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

6 companies ranked by most advanced pipeline stage

Cardiac Dimensions
Cardiac DimensionsAustralia - Sydney
3 programs
Carillon Mitral Contour SystemN/A1 trial
Carillon Mitral Contour SystemN/A1 trial
Carillon Mitral Contour SystemN/A1 trial
Active Trials
NCT03142152Recruiting300Est. Dec 2030
NCT05677568Enrolling By Invitation250Est. Jun 2030
NCT04529928Terminated4Est. Dec 2022
Polares Medical
Polares MedicalCA - Palo Alto
2 programs
Transcatheter mitral valve repairN/A5 trials
Transcatheter mitral valve repairN/A1 trial
Active Trials
NCT07757607Not Yet Recruiting20Est. Dec 2032
NCT07757776Not Yet Recruiting20Est. Dec 2032
NCT07757698Not Yet Recruiting15Est. Dec 2032
+3 more trials
Ancora Heart
Ancora HeartCA - Santa Clara
1 program
AccuCinch® Ventriculoplasty SystemN/A1 trial
Active Trials
NCT01899573Completed8Est. Mar 2016
Biocorp
BiocorpFrance - Issoire
1 program
Coriofix SystemN/A1 trial
Active Trials
NCT06583876Recruiting15Est. Apr 2028
Edwards Lifesciences
1 program
Edwards Cardioband SystemN/A1 trial
Active Trials
NCT03016975Terminated12Est. Sep 2022
Abbott
AbbottABBOTT PARK, IL
1 program
MitraClip ProcedureN/A1 trial
Active Trials
NCT04350372Completed16Est. Oct 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Polares MedicalTranscatheter mitral valve repair
Polares MedicalTranscatheter mitral valve repair
Polares MedicalTranscatheter mitral valve repair
BiocorpCoriofix System
Polares MedicalTranscatheter mitral valve repair
Polares MedicalTranscatheter mitral valve repair
Polares MedicalTranscatheter mitral valve repair
Cardiac DimensionsCarillon Mitral Contour System
AbbottMitraClip Procedure
Cardiac DimensionsCarillon Mitral Contour System
Cardiac DimensionsCarillon Mitral Contour System
Edwards LifesciencesEdwards Cardioband System
Ancora HeartAccuCinch® Ventriculoplasty System

Clinical Trials (13)

Total enrollment: 760 patients across 13 trials

NCT07757776Polares MedicalTranscatheter mitral valve repair

A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (DE)

Start: Nov 2026Est. completion: Dec 203220 patients
N/ANot Yet Recruiting
NCT07757607Polares MedicalTranscatheter mitral valve repair

A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (FR)

Start: Nov 2026Est. completion: Dec 203220 patients
N/ANot Yet Recruiting
NCT07757698Polares MedicalTranscatheter mitral valve repair

A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (AU)

Start: Nov 2026Est. completion: Dec 203215 patients
N/ANot Yet Recruiting
NCT06583876BiocorpCoriofix System

Bio Refine for Functional Mitral Regurgitation - a Safety & Feasibility Study

Start: Jun 2024Est. completion: Apr 202815 patients
N/ARecruiting
NCT07796659Polares MedicalTranscatheter mitral valve repair

EXPLORE MRace (GE): Early Feasibility Experience of Posterior Leaflet Restoration to Reduce Mitral Regurgitation Using the MRace Implant

Start: May 2022Est. completion: Dec 2032100 patients
N/ARecruiting
NCT04679714Polares MedicalTranscatheter mitral valve repair

EXPLORE FMR: Early Feasibility Study of the PLAR Implant and Delivery System to Treat Functional Mitral Regurgitation

Start: Apr 2021Est. completion: Dec 20260
N/AWithdrawn
NCT04666467Polares MedicalTranscatheter mitral valve repair

Early Feasibility Study of the PLAR Implant and Delivery System to Treat Functional Mitral Regurgitation ( EXPLORE FMR )

Start: Apr 2021Est. completion: Dec 20220
N/AWithdrawn
NCT04529928Cardiac DimensionsCarillon Mitral Contour System

An Initial Evaluation of the Carillon Mitral Contour System for Treatment of Atrial Function Mitral Regurgitation

Start: Oct 2020Est. completion: Dec 20224 patients
N/ATerminated
NCT04350372AbbottMitraClip Procedure

MitraClip Russia Trial

Start: Feb 2020Est. completion: Oct 202016 patients
N/ACompleted
NCT03142152Cardiac DimensionsCarillon Mitral Contour System

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

Start: Jan 2018Est. completion: Dec 2030300 patients
N/ARecruiting
NCT05677568Cardiac DimensionsCarillon Mitral Contour System

The CINCH-FMR Post-Market Registry: Percutaneous Repair in Functional Mitral Regurgitation

Start: Jun 2017Est. completion: Jun 2030250 patients
N/AEnrolling By Invitation
NCT03016975Edwards LifesciencesEdwards Cardioband System

Edwards Cardioband System ACTIVE Pivotal Clinical Trial (ACTIVE)

Start: Jun 2017Est. completion: Sep 202212 patients
N/ATerminated
NCT01899573Ancora HeartAccuCinch® Ventriculoplasty System

Percutaneous Left Ventricular Reshaping to Reduce Functional Mitral Regurgitation and Improve LV Function

Start: Oct 2013Est. completion: Mar 20168 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 actively recruiting trials targeting 760 patients
6 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.