Fever

8
Pipeline Programs
6
Companies
6
Clinical Trials
3
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
3
4
Early DiscoveryClinical DevelopmentMarket

On Market (3)

Approved therapies currently available

U
CAMBIAApproved
diclofenac potassium
Unknown Company
oral2009
Novartis
CATAFLAMApproved
diclofenac potassium
Novartis
oral1993
U
ZIPSORApproved
diclofenac potassium
Unknown Company
oral2009

Competitive Landscape

6 companies ranked by most advanced pipeline stage

Novartis
NovartisBASEL, Switzerland
1 program
1
Diclofenac potassiumPhase 41 trial
Active Trials
NCT01019980Terminated2
BP
Basilea PharmaceuticaSwitzerland - Allschwil
1 program
1
Ceftobiprole MedocarilPhase 31 trial
Active Trials
NCT00529282TerminatedEst. Jan 2008
Pfizer
PfizerNEW YORK, NY
1 program
1
Ibuprofen 250 mg / Acetaminophen 500 mgPhase 31 trial
Active Trials
NCT02761980Completed290Est. Dec 2017
Sanofi
SanofiPARIS, France
1 program
1
paracetamol 4.8% paediatric oral suspensionPhase 31 trial
Active Trials
NCT00434681Completed48Est. Apr 2007
Knight Therapeutics
Knight TherapeuticsQC - Montréal
1 program
1
DaptomycinPhase 21 trial
Active Trials
NCT00335478Completed54Est. Oct 2008
C
CENTOGENEGermany - Rostock
1 program
COVID-19 Epidemic Response StudyN/A1 trial
Active Trials
NCT04357496Withdrawn0Est. May 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
NovartisDiclofenac potassium
PfizerIbuprofen 250 mg / Acetaminophen 500 mg
Basilea PharmaceuticaCeftobiprole Medocaril
Sanofiparacetamol 4.8% paediatric oral suspension
Knight TherapeuticsDaptomycin
CENTOGENECOVID-19 Epidemic Response Study

Clinical Trials (6)

Total enrollment: 394 patients across 6 trials

NCT01019980NovartisDiclofenac potassium

Efficacy of Diclofenac Potassium Versus Acetaminophen in Febrile Children With Acute Upper Respiratory Tract Infections

Start: Mar 20102 patients
Phase 4Terminated
NCT02761980PfizerIbuprofen 250 mg / Acetaminophen 500 mg

A Study of Ibuprofen 250 mg / Acetaminophen 500 mg Comparing The Antipyretic Effects in Healthy Male Volunteers

Start: Dec 2016Est. completion: Dec 2017290 patients
Phase 3Completed
NCT00529282Basilea PharmaceuticaCeftobiprole Medocaril

A Study of Ceftobiprole in Patients With Fever and Neutropenia.

Start: Oct 2007Est. completion: Jan 2008
Phase 3Terminated
NCT00434681Sanofiparacetamol 4.8% paediatric oral suspension

Paracetamol Oral Paediatric Suspension at 4.8% : Study of Acceptability and Safety.

Start: Oct 2006Est. completion: Apr 200748 patients
Phase 3Completed
NCT00335478Knight TherapeuticsDaptomycin

Daptomycin in Treating Neutropenia and Fever in Patients With Cancer

Start: Dec 2006Est. completion: Oct 200854 patients
Phase 2Completed
NCT04357496CENTOGENECOVID-19 Epidemic Response Study

COVID-19 Epidemic Response Study

Start: May 2021Est. completion: May 20210
N/AWithdrawn

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs — potential near-term approvals
6 companies competing in this space