Fever

Pipeline Programs

Companies

Clinical Trials

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule

3100%

+ 19 programs with unclassified modality

On Market (2)

Approved therapies currently available

ACHES-N-PAINApproved

ibuprofen

Pfizer

oral1987

CALDOLORApproved

ibuprofen

Cumberland Pharmaceuticals

Nonsteroidal Anti-inflammatory Drug [EPC]intravenous2009

Competitive Landscape

16 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Cumberland PharmaceuticalsTN - Nashville

4 programs

Intravenous IbuprofenPhase 4Small Molecule1 trial

CaldolorPhase 31 trial

IbuprofenPhase 3Small Molecule1 trial

ibuprofenPhase 3Small Molecule1 trial

Active Trials

NCT00225706CompletedEst. Aug 2007

NCT01131000Completed123Est. Aug 2005

NCT01002573Completed118Est. Jun 2013

+1 more trials

PfizerNEW YORK, NY

1 program

Ibuprofen 250 mg / Acetaminophen 500 mgPhase 31 trial

Active Trials

NCT02761980Completed290Est. Dec 2017

SandozAustria - Kundl

1 program

Diclofenac potassiumPhase 41 trial

Active Trials

NCT01019980Terminated2

ViiV HealthcareNC - Durham

2 programs

ciprofloxacin and amoxicillinPhase 3

ParacetamolPhase 1

Colorado TherapeuticsCO - Louisville

1 program

Low Risk: Oupatient ManagementPhase 31 trial

Active Trials

NCT03768869Withdrawn0Est. Apr 2009

BayerLEVERKUSEN, Germany

1 program

ciprofloxacin and amoxicillinPhase 3

Allergy TherapeuticsUK - West Sussex

2 programs

Free Malaria Rapid Diagnostic TestN/A1 trial

Malaria RDT & conditional voucher for ACT from retail sectorN/A1 trial

Active Trials

NCT02199977Completed444Est. Jul 2015

NCT02461628Completed40,340Est. Jul 2017

MasimoIRVINE, CA

2 programs

Masimo INVSENSOR00063N/A1 trial

Masimo Temperature deviceN/A1 trial

Active Trials

NCT05787782Completed60Est. Mar 2023

NCT05674344Completed170Est. Mar 2023

Relief TherapeuticsSwitzerland - Geneva

1 program

Artesunate + Amodiaquine Fixed Dose CombinationN/A1 trial

Active Trials

NCT00612547Completed1,200Est. Feb 2009

CENTOGENEGermany - Rostock

1 program

COVID-19 Epidemic Response StudyN/A1 trial

Active Trials

NCT04357496Withdrawn0Est. May 2021

Quanta TherapeuticsCA - South SF

1 program

Q-temp-w1N/A1 trial

Active Trials

NCT05014152Completed100Est. Sep 2022

Doron TherapeuticsNC - Chapel Hill

1 program

Thermal camera by Flir -HM series.N/A1 trial

Active Trials

NCT01782183Unknown100Est. Dec 2018

GSKLONDON, United Kingdom

1 program

ParacetamolPHASE_11 trial

Active Trials

NCT01767428Completed30Est. Apr 2010

Knight TherapeuticsQC - Montréal

1 program

DaptomycinPHASE_21 trial

Active Trials

NCT00335478Completed54Est. Oct 2008

SanofiPARIS, France

1 program

paracetamol 4.8% paediatric oral suspensionPHASE_31 trial

Active Trials

NCT00434681Completed48Est. Apr 2007

NovartisBASEL, Switzerland

1 program

Diclofenac potassiumPHASE_4

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

Cumberland PharmaceuticalsIntravenous Ibuprofen

SandozDiclofenac potassium

PfizerIbuprofen 250 mg / Acetaminophen 500 mg

Cumberland Pharmaceuticalsibuprofen

Sanofiparacetamol 4.8% paediatric oral suspension

Colorado TherapeuticsLow Risk: Oupatient Management

Cumberland PharmaceuticalsCaldolor

Cumberland PharmaceuticalsIbuprofen

Knight TherapeuticsDaptomycin

GSKParacetamol

MasimoMasimo INVSENSOR00063

MasimoMasimo Temperature device

CENTOGENECOVID-19 Epidemic Response Study

Quanta TherapeuticsQ-temp-w1

Doron TherapeuticsThermal camera by Flir -HM series.

Showing 15 of 18 trials with date data

Clinical Trials (18)

Total enrollment: 43,114 patients across 18 trials

NCT01530880 Cumberland PharmaceuticalsIntravenous Ibuprofen

Aggressive Fever Control With Intravenous Ibuprofen After Non-traumatic Brain Hemorrhage

Start: Oct 2012Est. completion: Mar 201635 patients

Phase 4Terminated

NCT01019980 SandozDiclofenac potassium

Efficacy of Diclofenac Potassium Versus Acetaminophen in Febrile Children With Acute Upper Respiratory Tract Infections

Start: Mar 20102 patients

Phase 4Terminated

NCT02761980 PfizerIbuprofen 250 mg / Acetaminophen 500 mg

A Study of Ibuprofen 250 mg / Acetaminophen 500 mg Comparing The Antipyretic Effects in Healthy Male Volunteers

Start: Dec 2016Est. completion: Dec 2017290 patients

Phase 3Completed

NCT01002573 Cumberland Pharmaceuticalsibuprofen

Safety, Efficacy, and Pharmacokinetic Study of Intravenous Ibuprofen in Pediatric Patients

Start: Jul 2010Est. completion: Jun 2013118 patients

Phase 3Completed

NCT00434681 Sanofiparacetamol 4.8% paediatric oral suspension

Paracetamol Oral Paediatric Suspension at 4.8% : Study of Acceptability and Safety.

Start: Oct 2006Est. completion: Apr 200748 patients

Phase 3Completed

NCT03768869 Colorado TherapeuticsLow Risk: Oupatient Management

Fever and Neutropenia in Pediatric Oncology Patients

Start: Feb 2006Est. completion: Apr 20090

Phase 3Withdrawn

NCT00225706 Cumberland PharmaceuticalsCaldolor

A Study of Caldolor in Hospitalized Febrile Pediatric Patients

Start: Oct 2005Est. completion: Aug 2007

Phase 3Completed

NCT01131000 Cumberland PharmaceuticalsIbuprofen

Efficacy, Safety, and Pharmacokinetics of Intravenous Ibuprofen in Adult Febrile Patients

Start: Jun 2002Est. completion: Aug 2005123 patients

Phase 3Completed

NCT00335478 Knight TherapeuticsDaptomycin

Daptomycin in Treating Neutropenia and Fever in Patients With Cancer

Start: Dec 2006Est. completion: Oct 200854 patients

Phase 2Completed

NCT01767428 GSKParacetamol

Pharmacokinetic Study to Compare Two Formulations of Paracetamol

Start: Apr 2010Est. completion: Apr 201030 patients

Phase 1Completed

NCT05787782 MasimoMasimo INVSENSOR00063

Validation of the Masimo INVSENSOR00063 in Febrile and Afebrile Subejcts

Start: Feb 2023Est. completion: Mar 202360 patients

N/ACompleted

NCT05674344 MasimoMasimo Temperature device

Calibration and Validation of the Masimo Temperature Device in Febrile Patients

Start: Dec 2022Est. completion: Mar 2023170 patients

N/ACompleted

NCT04357496 CENTOGENECOVID-19 Epidemic Response Study

COVID-19 Epidemic Response Study

Start: May 2021Est. completion: May 20210

N/AWithdrawn

NCT05014152 Quanta TherapeuticsQ-temp-w1

Prospective Trial for Clinical Validation of "QOCA Disposable BLE Thermometer "

Start: Mar 2021Est. completion: Sep 2022100 patients

N/ACompleted

NCT01782183 Doron TherapeuticsThermal camera by Flir -HM series.

Thermographic Characteristics of Sore Throat by Thermographic Camera

Start: Sep 2016Est. completion: Dec 2018100 patients

N/AUnknown

NCT02461628 Allergy TherapeuticsMalaria RDT & conditional voucher for ACT from retail sector

Innovative Public-private Partnership to Target Subsidized Antimalarials in the Retail Sector (Aim 2)

Start: Jul 2015Est. completion: Jul 201740,340 patients

N/ACompleted

NCT02199977 Allergy TherapeuticsFree Malaria Rapid Diagnostic Test

Innovative Public-private Partnership to Target Subsidized Antimalarials in the Retail Sector

Start: Jun 2014Est. completion: Jul 2015444 patients

N/ACompleted

NCT00612547 Relief TherapeuticsArtesunate + Amodiaquine Fixed Dose Combination

ACT for the Home Management in Malagasy Children

Start: Feb 2008Est. completion: Feb 20091,200 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

7 late-stage (Phase 3) programs, potential near-term approvals

16 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.