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Fatigue

6
Pipeline Programs
14
Companies
15
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
2
0
3
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

11 companies ranked by most advanced pipeline stage

Alliance Pharmaceuticals
4 programs
3
Valeriana officinalis extractPhase 31 trial
armodafinil 150 mgPhase 31 trial
methylphenidate hydrochloridePhase 31 trial
American ginsengN/A1 trial
Active Trials
NCT00182780Completed290Est. Apr 2010
NCT00075842Completed227Est. Jan 2010
NCT01781468Completed328Est. Dec 2019
+1 more trials
Apollo Therapeutics
Apollo TherapeuticsUK - Cambridge
1 program
1
Apollo DevicePhase 22 trials
Active Trials
NCT04983342Completed27Est. Aug 2022
NCT04854850Completed25Est. Mar 2023
Dompé
DompéItaly - L'Aquila
1 program
1
ReparixinPhase 21 trial
Active Trials
NCT05212701Withdrawn0Est. Jul 2024
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
2 programs
1
transcranial direct current stimulationPhase 11 trial
Unbundling of cordsN/A1 trial
Active Trials
NCT01707095Completed84Est. Jan 2014
NCT02840214Withdrawn0
Arctic Therapeutics
Arctic TherapeuticsIceland - Reykjavik
1 program
A 12-week interdisciplinary complex interventionN/A1 trial
Active Trials
NCT04931407Completed15Est. Jan 2022
Autonomous Therapeutics
1 program
Coca-ColaN/A1 trial
Active Trials
NCT06557746Not Yet Recruiting22Est. Apr 2025
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
Coca-ColaN/A
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
Kinesio taping with tensionN/A1 trial
Active Trials
NCT02104570Completed24Est. May 2014
Providence Therapeutics
1 program
Protected time and Dedicated timeN/A1 trial
Active Trials
NCT00983008Terminated11Est. Sep 2010
Bristol Myers Squibb
1 program
dexmethylphenidatePHASE_21 trial
Active Trials
NCT00047476Completed160Est. Mar 2004
Pierre Fabre
Pierre FabreFrance - Aignan
1 program
Ferrous sulphatePHASE_41 trial
Active Trials
NCT00689793Completed154Est. Apr 2011

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Pierre FabreFerrous sulphate
Alliance Pharmaceuticalsarmodafinil 150 mg
Alliance Pharmaceuticalsmethylphenidate hydrochloride
Alliance PharmaceuticalsValeriana officinalis extract
DompéReparixin
Bristol Myers Squibbdexmethylphenidate
Autonomous TherapeuticsCoca-Cola
Arctic TherapeuticsA 12-week interdisciplinary complex intervention
Apollo TherapeuticsApollo Device
Apollo TherapeuticsApollo Device
Oregon TherapeuticsKinesio taping with tension
Colorado TherapeuticsUnbundling of cords
Providence TherapeuticsProtected time and Dedicated time
Alliance PharmaceuticalsAmerican ginseng

Clinical Trials (15)

Total enrollment: 1,515 patients across 15 trials

NCT00689793Pierre FabreFerrous sulphate

Clinical Evaluation of Iron Treatment Efficiency Among Non-anemic But Iron-deficient Female Blood Donors

Start: Nov 2008Est. completion: Apr 2011154 patients
Phase 4Completed
NCT01781468Alliance Pharmaceuticalsarmodafinil 150 mg

Armodafinil in Reducing Cancer-Related Fatigue in Patients With High Grade Glioma

Start: Jun 2013Est. completion: Dec 2019328 patients
Phase 3Completed
NCT00376675Alliance Pharmaceuticalsmethylphenidate hydrochloride

Methylphenidate in Treating Patients With Fatigue Caused by Cancer

Start: Feb 2008Est. completion: Jun 2010148 patients
Phase 3Completed
NCT00075842Alliance PharmaceuticalsValeriana officinalis extract

(Valerian) for Improving Sleep in Patients With Cancer Receiving Adjuvant Therapy

Start: Aug 2003Est. completion: Jan 2010227 patients
Phase 3Completed
NCT05212701DompéReparixin

To Assess Efficacy and Safety of Oral Reparixin in Patients With Fatigue and Locally Advanced / Metastatic Breast Cancer

Start: Apr 2022Est. completion: Jul 20240
Phase 2Withdrawn
NCT00047476Bristol Myers Squibbdexmethylphenidate

D-MPH in the Treatment of Fatigue and Neurobehavioral Function Related to Chemotherapy in Adult Cancer Patients

Start: Jun 2002Est. completion: Mar 2004160 patients
Phase 2Completed
NCT02840214Colorado Therapeuticstranscranial direct current stimulation

Impact of Transcranial Direct Current Stimulation on Fatigability and Fatigue Induced by a Selective Attention Task

0
Phase 1Withdrawn
NCT06557746Autonomous TherapeuticsCoca-Cola

Coca-Cola vs. Oxygen for Fatigue Management in Tibet Surgeons

Start: Sep 2024Est. completion: Apr 202522 patients
N/ANot Yet Recruiting
NCT04931407Arctic TherapeuticsA 12-week interdisciplinary complex intervention

A Feasibility Study in Chronically Fatigued Cancer Survivors

Start: Apr 2021Est. completion: Jan 202215 patients
N/ACompleted
NCT04983342Apollo TherapeuticsApollo Device

Apollo Device for Metastatic Breast Cancer (MBC)

Start: Feb 2021Est. completion: Aug 202227 patients
N/ACompleted
NCT04854850Apollo TherapeuticsApollo Device

Apollo Device for Fatigue in Systemic Sclerosis

Start: Jul 2020Est. completion: Mar 202325 patients
N/ACompleted
NCT02104570Oregon TherapeuticsKinesio taping with tension

Effects of Muscle Fatigue and Kinesio Taping on Shoulder Position Sense

Start: Feb 2014Est. completion: May 201424 patients
N/ACompleted
NCT01707095Colorado TherapeuticsUnbundling of cords

Bundling and Unbundling the Laparoscopic Electrosurgery Cord With the Camera Cord

Start: Sep 2012Est. completion: Jan 201484 patients
N/ACompleted
NCT00983008Providence TherapeuticsProtected time and Dedicated time

Effect and Utilization of Protected Time Among Interns on Extended Duty-Hour Call Shifts

Start: Oct 2009Est. completion: Sep 201011 patients
N/ATerminated
NCT00182780Alliance PharmaceuticalsAmerican ginseng

American Ginseng in Treating Patients With Cancer-Related Fatigue

Start: Oct 2005Est. completion: Apr 2010290 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
14 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.