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Erosive Esophagitis

9
Pipeline Programs
10
Companies
27
Clinical Trials
1 recruiting
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
3
6
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
3100%
+ 13 programs with unclassified modality

On Market (2)

Approved therapies currently available

AstraZeneca
NEXIUMApproved
esomeprazole magnesium
AstraZeneca
oral2008
74M Part D
AstraZeneca
NEXIUM 24HRApproved
esomeprazole magnesium
AstraZeneca
oral2014

Competitive Landscape

10 companies ranked by most advanced pipeline stage

AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
4 programs
1
3
EsomeprazolePhase 4Small Molecule1 trial
EsomeprazolePhase 4Small Molecule1 trial
esomeprazole magnesiumPhase 41 trial
Nexium 20mgPhase 3
Active Trials
NCT00641602Completed1,000Est. Aug 2003
NCT00644735Completed750Est. Jan 2004
NCT00206180Completed120Est. Aug 2005
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
1 program
1
Omeprazole/sodium bicarbonatePhase 41 trial
Active Trials
NCT00693225Completed91Est. Dec 2010
Onconic Therapeutics
1 program
1
JP-1366 20mgPhase 31 trial
Active Trials
NCT05443984Completed300Est. Jan 2023
Yooyoung Pharmaceutical
Yooyoung PharmaceuticalKorea - Jincheon
1 program
1
YYD601 40mgPhase 31 trial
Active Trials
NCT03943992Completed170Est. Jul 2020
Phathom Pharmaceuticals
Phathom PharmaceuticalsFLORHAM PARK, NJ
3 programs
VonoprazanN/A1 trial
VonoprazanPHASE_11 trial
VonoprazanPHASE_31 trial
Active Trials
NCT06660342Recruiting728Est. Sep 2034
NCT06391177Completed15Est. Sep 2024
NCT04124926Completed1,027Est. Aug 2021
Takeda
TakedaTOKYO, Japan
2 programs
DexlansoprazolePHASE_3Small Molecule5 trials
VonoprazanPHASE_41 trial
Active Trials
NCT02615184Terminated24Est. Apr 2026
NCT02616302Completed71Est. Jul 2026
NCT04311541Withdrawn0Est. Jan 2022
+3 more trials
Parexel
ParexelMA - Boston
1 program
X842PHASE_2
Cinclus Pharma
Cinclus PharmaSweden - Stockholm
1 program
X842PHASE_21 trial
Active Trials
NCT05055128Completed248Est. Sep 2022
IQVIA
IQVIADURHAM, NC
1 program
Nexium 20mgPHASE_3
Thermo Fisher Scientific
1 program
Nexium 20mgPHASE_31 trial
Active Trials
NCT05267613Active Not Recruiting53Est. Aug 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
TakedaDexlansoprazole
TakedaVonoprazan
TakedaDexlansoprazole
TakedaDexlansoprazole
Bausch HealthOmeprazole/sodium bicarbonate
AstraZenecaesomeprazole magnesium
AstraZenecaEsomeprazole
AstraZenecaEsomeprazole
Thermo Fisher ScientificNexium 20mg
Onconic TherapeuticsJP-1366 20mg
Phathom PharmaceuticalsVonoprazan
Yooyoung PharmaceuticalYYD601 40mg
TakedaDexlansoprazole
TakedaDexlansoprazole
TakedaDexlansoprazole

Showing 15 of 27 trials with date data

Clinical Trials (27)

Total enrollment: 5,837 patients across 27 trials

NCT03079050TakedaDexlansoprazole

An Open-Label Trial of Dexlansoprazole 60mg for the Relief of Heartburn During the Fasting Month of Ramadan

Start: Feb 2017Est. completion: Jul 201733 patients
Phase 4Completed

Vonoprazan Study in Patients With Erosive Esophagitis to Evaluate Long-term Safety

Start: Mar 2016Est. completion: Mar 2022208 patients
Phase 4Completed
NCT02351960TakedaDexlansoprazole

Dexlansoprazole in Asian Participants With Gastroesophageal Reflux Disease

Start: Mar 2015Est. completion: Jul 2016296 patients
Phase 4Completed
NCT01328652TakedaDexlansoprazole

Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy

Start: Jun 2011Est. completion: Jan 201380 patients
Phase 4Unknown
NCT00693225Bausch HealthOmeprazole/sodium bicarbonate

Impact of Timing on the Efficacy of Zegerid 40 mg in Healing Reflux Esophagitis: A Pilot Study

Start: Jan 2008Est. completion: Dec 201091 patients
Phase 4Completed
NCT00206180AstraZenecaesomeprazole magnesium

NEXIUM® in the Treatment of Moderate and Severe Erosive Esophagitis

Start: Jun 2004Est. completion: Aug 2005120 patients
Phase 4Completed

A Multicenter, Randomized, Double Blind, Double Dummy, Parallel-Group Efficacy Study Comparing 8 Weeks of Treatment With Esomeprazole Magnesium (40mg qd) to Lansoprazole (30mg qd) for the Healing of Erosive Esophagitis in Patients With Moderate or Severe Erosive Esophagitis

Start: Dec 2002Est. completion: Aug 20031,000 patients
Phase 4Completed

Multicenter, Randomized, Double-Blind, Double-Dummy, Parallel-Group Comparison of the Remission Rates of Once Daily Treatment With Esomeprazole 20mg and Lansoprazole 15mg for 6 Months in Patients Whose EE Has Been Healed

Start: Dec 2002Est. completion: Jan 2004750 patients
Phase 4Completed

Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis.

Start: Jul 2022Est. completion: Aug 202653 patients
Phase 3Active Not Recruiting

JP-1366 20mg Versus Esomeprazole 40mg in Patients With Erosive Esophagitis

Start: Jan 2022Est. completion: Jan 2023300 patients
Phase 3Completed

Efficacy and Safety of Vonoprazan Compared to Lansoprazole in Participants With Erosive Esophagitis

Start: Oct 2019Est. completion: Aug 20211,027 patients
Phase 3Completed

Clinical Trial to Assess the Efficacy and Safety of YYD601 in the Treatment of Esophageal Reflux Disease (ERD)

Start: Jan 2019Est. completion: Jul 2020170 patients
Phase 3Completed
NCT02873702TakedaDexlansoprazole

Efficacy and Safety of Dexlansoprazole in Healing and Maintaining Healing of Erosive Esophagitis

Start: Dec 2016Est. completion: Nov 201737 patients
Phase 3Terminated
NCT02615184TakedaDexlansoprazole

A Study to Check the Safety of Dexlansoprazole and Learn If it Can Heal Erosive Esophagitis (EE) and Keep it Healed in Children 2 to 11 Years Old

Start: May 2023Est. completion: Apr 202624 patients
Phase 2Terminated
NCT02616302TakedaDexlansoprazole

A Study to Check the Safety of Dexlansoprazole and Learn if it Can Treat Symptomatic Nonerosive Gastroesophageal Reflux Disease in Children 2 to 11 Years Old

Start: Feb 2023Est. completion: Jul 202671 patients
Phase 2Completed

A Study in Patients With Erosive Esophagitis to Investigate Safety, Tolerability, and Healing Rates After 4 Weeks Treatment of X842 or Lansoprazole and Symptom Pattern During Subsequent 4 Weeks Treatment With Lansoprazole

Start: Aug 2021Est. completion: Sep 2022248 patients
Phase 2Completed
NCT01642602TakedaDexlansoprazole

Safety and Efficacy of Dexlansoprazole Delayed-Release Capsules in Treating Symptomatic Non-Erosive Gastroesophageal Reflux Disease in Adolescents

Start: Jul 2012Est. completion: Jan 2014104 patients
Phase 2Completed

A Study to Evaluate Vonoprazan Concentrations in Breast Milk of Healthy Lactating Women Receiving Vonoprazan 20 mg Once Daily or Vonoprazan 20 mg Twice Daily

Start: May 2024Est. completion: Sep 202415 patients
Phase 1Completed
NCT03801148TakedaDexlansoprazole

A Study to Compare the Bioavailability (BA) of Dexlansoprazole Delayed-release Capsules

Start: Jan 2019Est. completion: Apr 2019122 patients
Phase 1Completed
NCT03316976TakedaDexlansoprazole

A Study to Evaluate the Pharmacokinetics of Dexlansoprazole 30 Milligram (mg) and 60 mg Delayed-release Capsules in Healthy Chinese Participants

Start: Nov 2017Est. completion: Feb 201840 patients
Phase 1Completed
NCT03131895TakedaDexlansoprazole

Bioequivalence Study of Dexlansoprazole Capsules From Two Manufacturing Plants

Start: Apr 2017Est. completion: Jul 2017116 patients
Phase 1Completed
NCT02096458TakedaDexlansoprazole

Sensory Evaluation of Dexlansoprazole Delayed-Release Orally Disintegrating Tablets

Start: Feb 2014Est. completion: Feb 20148 patients
Phase 1Completed
NCT01045096TakedaDexlansoprazole

Study to Evaluate the Pharmacokinetics and Safety of Dexlansoprazole in Pediatric Subjects With Symptomatic Gastroesophageal Reflux Disease

Start: Mar 2010Est. completion: Feb 201136 patients
Phase 1Completed
NCT00942175TakedaDexlansoprazole

A Study of the Effects of Multiple Doses of Dexlansoprazole, Lansoprazole, Omeprazole or Esomeprazole on the Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Participants.

Start: Dec 2009Est. completion: Jul 2010160 patients
Phase 1Completed

A Study of the Safety of Vonoprazan Exposure in Pregnant Women and Their Offspring

Start: May 2025Est. completion: Sep 2034728 patients
N/ARecruiting
NCT04311541TakedaDexlansoprazole

A Study of Dexlansoprazole Modified Release (MR) in Gastroesophageal Reflux Disease (GERD) Participants in the Russian Federation

Start: Mar 2020Est. completion: Jan 20220
N/AWithdrawn
NCT01328392TakedaDexlansoprazole

Evaluating Treatment Response in Laryngo-Pharyngeal Reflux

Start: May 2011Est. completion: Apr 20120
N/AWithdrawn

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 5,837 patients
10 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.