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Epilepsies, Partial

10
Pipeline Programs
8
Companies
18
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
1
2
0
5
1
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Pfizer
NEURONTINApproved
gabapentin
Pfizer
oral2002
20M Part D

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
7 programs
5
1
PregabalinPhase 31 trial
PregabalinPhase 31 trial
gabapentinPhase 31 trial
gabapentinPhase 31 trial
pregabalin 600 mg/dayPhase 31 trial
+2 more programs
Active Trials
NCT00567268Completed1,273Est. May 2014
NCT01441401Completed82Est. Sep 2014
NCT00448916Completed54Est. Oct 2013
+4 more trials
Ono Pharmaceutical
Ono PharmaceuticalJapan - Osaka
1 program
1
CenobamatePhase 21 trial
Active Trials
NCT06590896Recruiting100Est. Jan 2027
Marinus Pharmaceuticals
1 program
1
ganaxolonePhase 21 trial
Active Trials
NCT00512317Completed123Est. Sep 2013
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
1
Andrews/Reiter behavioral treatment for epilepsyPhase 1/21 trial
Active Trials
NCT00212745Completed8Est. Mar 2009
Supernus Pharmaceuticals
1 program
1
SPN-804OPhase 11 trial
Active Trials
NCT00918047Completed18Est. Nov 2010
UCB Pharma
UCB PharmaBelgium - Brussels
6 programs
LacosamideN/A1 trial
LacosamideN/A1 trial
Vimpat® Added as Adjunctive Therapy to One Baseline Antiepileptic DrugN/A1 trial
SPM 927PHASE_2_31 trial
SeletracetamPHASE_2_31 trial
+1 more programs
Active Trials
NCT03559673No Longer Available
NCT00771927Completed1,005Est. Mar 2012
NCT01098162Completed576Est. Jul 2013
+3 more trials
LivaNova
LivaNovaUK - London
1 program
Microburst StimulationN/A1 trial
Active Trials
NCT03446664Completed33Est. Oct 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Pfizergabapentin
Pfizergabapentin
Pfizerpregabalin 600 mg/day
PfizerPregabalin
UCB PharmaLevetiracetam 250 mg
PfizerPregabalin
UCB PharmaSeletracetam
UCB PharmaSPM 927
Ono PharmaceuticalCenobamate
Marinus Pharmaceuticalsganaxolone
Oregon TherapeuticsAndrews/Reiter behavioral treatment for epilepsy
Supernus PharmaceuticalsSPN-804O
LivaNovaMicroburst Stimulation
Pfizergabapentin
UCB PharmaVimpat® Added as Adjunctive Therapy to One Baseline Antiepileptic Drug

Showing 15 of 17 trials with date data

Clinical Trials (18)

Total enrollment: 4,402 patients across 18 trials

A Phase III Open-Label Extension Study Of Gabapentin As Adjunctive Therapy In Japanese Pediatric Patients With Partial Seizures

Start: May 2008Est. completion: Dec 201065 patients
Phase 3Completed

A Phase III Open-Label Study Of Gabapentin As Adjunctive Therapy In Japanese Pediatric Patients With Partial Seizures

Start: Jan 2008Est. completion: Dec 200992 patients
Phase 3Completed
NCT00524030Pfizerpregabalin 600 mg/day

Efficacy And Safety Study Of Pregabalin (Lyrica) As Monotherapy In Patients With Partial Seizures

Start: Sep 2007Est. completion: Jun 2011161 patients
Phase 3Terminated

Open-Label Extension Study Of Safety And Tolerability Of Pregabalin In Pediatric Patients With Partial-Onset Seizures

Start: May 2007Est. completion: Oct 201354 patients
Phase 3Completed
NCT00280696UCB PharmaLevetiracetam 250 mg

A Double-blind Confirmatory Trial of Levetiracetam in Epilepsy Patients With Partial Onset Seizures

Start: Nov 2005Est. completion: Nov 2007352 patients
Phase 3Completed

Pregabalin Open-Label Extension Trial in Patients With Partial Seizures

Start: Sep 2001Est. completion: Feb 2006300 patients
Phase 3Completed

A Study to Evaluate the Efficacy and Safety of Seletracetam in Adult Patients With Refractory Partial Onset Seizures

Start: May 20080
Phase 2/3Withdrawn

Safety and Tolerability of Intravenous SPM 927 as Replacement for Oral SPM 927 in Subjects With Partial Seizures

Start: Feb 2005Est. completion: May 2006160 patients
Phase 2/3Completed

Safety of Cenobamate in Japanese Subjects With Partial Onset Seizures

Start: Nov 2022Est. completion: Jan 2027100 patients
Phase 2Recruiting

Open-label Extension to Protocol 1042-0600

Start: Jun 2007Est. completion: Sep 2013123 patients
Phase 2Completed
NCT00212745Oregon TherapeuticsAndrews/Reiter behavioral treatment for epilepsy

Pilot Trial of a Behavioral Treatment for Epilepsy

Start: Feb 2004Est. completion: Mar 20098 patients
Phase 1/2Completed

Study of PK and Safety of OXC (Oxcarbazepine) XR (Extended Release) as Adjunctive Therapy in Pediatric Epilepsy Patients

Start: Jun 2009Est. completion: Nov 201018 patients
Phase 1Completed

Compassionate Use Program With Lacosamide in Patients With Partial-onset or Generalized Tonic-clonic Seizures

N/ANo Longer Available
NCT03446664LivaNovaMicroburst Stimulation

Microburst Vagus Nerve Stimulator (VNS) Therapy Feasibility Study

Start: Feb 2018Est. completion: Oct 202133 patients
N/ACompleted

Safety and Efficacy of Gabapen for Pediatric (Regulatory Post Marketing Commitment Plan)

Start: Dec 2011Est. completion: Sep 201482 patients
N/ACompleted
NCT01098162UCB PharmaVimpat® Added as Adjunctive Therapy to One Baseline Antiepileptic Drug

Vimpat® Added as Adjunctive Therapy to One Baseline Antiepileptic Drug

Start: Mar 2010Est. completion: Jul 2013576 patients
N/ACompleted

Post-Authorization Safety Study to Assess the Safety of Vimpat as add-on Therapy in Patients With Partial-onset Seizures

Start: Oct 2008Est. completion: Mar 20121,005 patients
N/ACompleted

Drug Use Investigation Of Gabapentin

Start: Aug 2007Est. completion: May 20141,273 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 4,402 patients
8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.