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Endothelial Dysfunction

5
Pipeline Programs
9
Companies
11
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
2
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 11 programs with unclassified modality

On Market (1)

Approved therapies currently available

AstraZeneca
BRILINTAApproved
ticagrelor
AstraZeneca
P2Y12 Platelet Inhibitor [EPC]oral2011
692M Part D

Competitive Landscape

8 companies ranked by most advanced pipeline stage

AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
TicagrelorPhase 41 trial
Active Trials
NCT02379676Unknown38Est. Mar 2017
Sandoz
SandozAustria - Kundl
1 program
1
AliskirenPhase 31 trial
Active Trials
NCT01067326Terminated22Est. Dec 2011
ViiV Healthcare
ViiV HealthcareNC - Durham
1 program
1
darapladibPhase 3
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
2 programs
1
TelmisartanPhase 2Small Molecule1 trial
Traditional hookah smokingN/A1 trial
Active Trials
NCT03690427Completed19Est. Sep 2021
NCT01578772Completed17Est. Mar 2013
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
3 programs
Aronia full spectrum - half doseN/A1 trial
ClimaraN/A1 trial
Optimizing Pulsatility During Cardiopulmonary BypassN/A1 trial
Active Trials
NCT03824041Completed24Est. Jul 2021
NCT02256540Completed25Est. Mar 2016
NCT05344573Recruiting66Est. Jul 2025
Verona Pharma
Verona PharmaUK - London
2 programs
Passive mobilization - PMN/A1 trial
tomato sauceN/A1 trial
Active Trials
NCT03087643Completed51Est. Oct 2017
NCT01968369Completed19Est. Dec 2015
CardiaTec
CardiaTecUK - Cambridge
1 program
Evaluation of a New Non-Invasive Device for Detection of Endothelial DysfunctionN/A1 trial
Active Trials
NCT00650741Unknown30
BioMarin Pharmaceutical
1 program
Sapropterin DihydrochloridePHASE_21 trial
Active Trials
NCT00532844Completed52Est. Mar 2009

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
AstraZenecaTicagrelor
SandozAliskiren
Angeles TherapeuticsTelmisartan
BioMarin PharmaceuticalSapropterin Dihydrochloride
Colorado TherapeuticsOptimizing Pulsatility During Cardiopulmonary Bypass
Colorado TherapeuticsAronia full spectrum - half dose
Angeles TherapeuticsTraditional hookah smoking
Verona PharmaPassive mobilization - PM
Colorado TherapeuticsClimara
Verona Pharmatomato sauce
CardiaTecEvaluation of a New Non-Invasive Device for Detection of Endothelial Dysfunction

Clinical Trials (11)

Total enrollment: 363 patients across 11 trials

Effect of Ticagrelor Versus Clopidogrel on Endothelial Dysfunction and Vascular Inflammation

Start: Jan 2015Est. completion: Mar 201738 patients
Phase 4Unknown

The Effect of Tekturna on Endothelial Function and Endothelial Progenitor Cells in Patients With Early Atherosclerosis

Start: Feb 2010Est. completion: Dec 201122 patients
Phase 3Terminated

A Clinical Trial for People HIV+ Age > 50 at Risk for Heart Disease

Start: Aug 2012Est. completion: Mar 201317 patients
Phase 2Completed
NCT00532844BioMarin PharmaceuticalSapropterin Dihydrochloride

A Phase 2, Pharmacokinetic (PK) Study of 6R-BH4 Alone or 6R-BH4 With Vitamin C in Subjects With Endothelial Dysfunction

Start: Sep 2007Est. completion: Mar 200952 patients
Phase 2Completed
NCT05344573Colorado TherapeuticsOptimizing Pulsatility During Cardiopulmonary Bypass

Optimizing Pulsatility During Cardiopulmonary Bypass

Start: Jul 2022Est. completion: Jul 202566 patients
N/ARecruiting
NCT03824041Colorado TherapeuticsAronia full spectrum - half dose

Effects of Aronia Berries on Vascular Endothelial Function and the Gut Microbiota in Middle-Aged/Older Adults

Start: Feb 2019Est. completion: Jul 202124 patients
N/ACompleted
NCT03690427Angeles TherapeuticsTraditional hookah smoking

The Cardiovascular Effects of Electronic Hookah Vaping

Start: Dec 2018Est. completion: Sep 202119 patients
N/ACompleted
NCT03087643Verona PharmaPassive mobilization - PM

Passive Mobilization and Vascular Function

Start: Oct 2016Est. completion: Oct 201751 patients
N/ACompleted

The Effects of Resveratrol and Acute Exercise on Endothelial Function in Postmenopausal Women

Start: Aug 2014Est. completion: Mar 201625 patients
N/ACompleted

Effects of Tomato Sauce on Endothelial Dysfunction Induced by a High Fat Meal in Healthy Subjects

Start: Oct 2013Est. completion: Dec 201519 patients
N/ACompleted
NCT00650741CardiaTecEvaluation of a New Non-Invasive Device for Detection of Endothelial Dysfunction

Evaluation of a New Non-Invasive Device for Detection of Endothelial Dysfunction

Start: Feb 200830 patients
N/AUnknown

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 363 patients
9 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.