Endothelial Dysfunction

4
Pipeline Programs
4
Companies
5
Clinical Trials
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
0
3
Early DiscoveryClinical DevelopmentMarket

On Market (2)

Approved therapies currently available

AstraZeneca
BRILINTAApproved
ticagrelor
AstraZeneca
P2Y12 Platelet Inhibitor [EPC]oral2011
U
TICAGRELORApproved
ticagrelor
Unknown Company
P2Y12 Platelet Inhibitor [EPC]oral2025

Competitive Landscape

4 companies ranked by most advanced pipeline stage

AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
TicagrelorPhase 41 trial
Active Trials
NCT02379676Unknown38Est. Mar 2017
BioMarin Pharmaceutical
1 program
1
Sapropterin DihydrochloridePhase 21 trial
Active Trials
NCT00532844Completed52Est. Mar 2009
Verona Pharma
Verona PharmaUK - London
2 programs
Passive mobilization - PMN/A1 trial
tomato sauceN/A1 trial
Active Trials
NCT03087643Completed51Est. Oct 2017
NCT01968369Completed19Est. Dec 2015
CardiaTec
CardiaTecUK - Cambridge
1 program
Evaluation of a New Non-Invasive Device for Detection of Endothelial DysfunctionN/A1 trial
Active Trials
NCT00650741Unknown30

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
AstraZenecaTicagrelor
BioMarin PharmaceuticalSapropterin Dihydrochloride
Verona PharmaPassive mobilization - PM
Verona Pharmatomato sauce
CardiaTecEvaluation of a New Non-Invasive Device for Detection of Endothelial Dysfunction

Clinical Trials (5)

Total enrollment: 190 patients across 5 trials

NCT02379676AstraZenecaTicagrelor

Effect of Ticagrelor Versus Clopidogrel on Endothelial Dysfunction and Vascular Inflammation

Start: Jan 2015Est. completion: Mar 201738 patients
Phase 4Unknown
NCT00532844BioMarin PharmaceuticalSapropterin Dihydrochloride

A Phase 2, Pharmacokinetic (PK) Study of 6R-BH4 Alone or 6R-BH4 With Vitamin C in Subjects With Endothelial Dysfunction

Start: Sep 2007Est. completion: Mar 200952 patients
Phase 2Completed
NCT03087643Verona PharmaPassive mobilization - PM

Passive Mobilization and Vascular Function

Start: Oct 2016Est. completion: Oct 201751 patients
N/ACompleted
NCT01968369Verona Pharmatomato sauce

Effects of Tomato Sauce on Endothelial Dysfunction Induced by a High Fat Meal in Healthy Subjects

Start: Oct 2013Est. completion: Dec 201519 patients
N/ACompleted
NCT00650741CardiaTecEvaluation of a New Non-Invasive Device for Detection of Endothelial Dysfunction

Evaluation of a New Non-Invasive Device for Detection of Endothelial Dysfunction

Start: Feb 200830 patients
N/AUnknown

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 companies competing in this space