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Emphysema

10
Pipeline Programs
16
Companies
40
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
1
3
2
1
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 41 programs with unclassified modality

Competitive Landscape

16 companies ranked by most advanced pipeline stage

CSL Seqirus
CSL SeqirusUK - Maidenhead
1 program
1
Alpha1- proteinase inhibitor [human]Phase 4
Temple Therapeutics
Temple TherapeuticsNetherlands - Geleen
2 programs
1
1
Budesonide/formoterolPhase 31 trial
600 mg ibuprofen three times daily for 48 weeksPhase 2
Active Trials
NCT01602523Unknown40Est. Aug 2014
Boston Scientific
Boston ScientificCA - Valencia
9 programs
1
1
1
Lung Volume Reduction CoilPhase 2/31 trial
Lung Volume Reduction CoilPhase 1/21 trial
Lung Volume Reduction CoilPhase 11 trial
Endobronchial CoilsN/A1 trial
LVRC SystemN/A1 trial
+4 more programs
Active Trials
NCT03360396Completed120Est. Nov 2022
NCT02059057Terminated102Est. Jul 2019
NCT01220908Completed36Est. Mar 2012
+6 more trials
Kamada
KamadaIsrael - Negev
1 program
1
Kamada AAT for inhalationPhase 2/31 trial
Active Trials
NCT01217671Completed168Est. Jun 2015
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
2 programs
2
600 mg ibuprofen three times daily for 48 weeksPhase 21 trial
DoxycyclinePhase 2Small Molecule1 trial
Active Trials
NCT02006576Completed118Est. Mar 2018
NCT05382208Active Not Recruiting133Est. Feb 2027
Uptake Medical
Uptake MedicalCA - San Jose
4 programs
1
BTVA SystemPhase 11 trial
BTVA SystemN/A1 trial
InterVapor® treatment plus Optimal Medical TherapyN/A1 trial
Treatment plus Optimal Medical TherapyN/A1 trial
Active Trials
NCT01102712Completed34Est. Aug 2011
NCT01719263Completed69Est. Oct 2015
NCT05118269Terminated3Est. Jun 2024
+1 more trials
Pulmonx
PulmonxCA - Redwood City
7 programs
AeriSealN/A1 trial
AeriSeal SystemN/A1 trial
Bronchoscopic transparenchymal interlobar fissure closure using AerisealN/A1 trial
Chartis SystemN/A1 trial
EBVN/A1 trial
+2 more programs
Active Trials
NCT04559464Completed102Est. Oct 2024
NCT02877459Completed14Est. Aug 2018
NCT04256408Completed3Est. Aug 2022
+4 more trials
Olympus
OlympusPA - Center Valley
6 programs
IBV® Valve SystemN/A1 trial
OL-BF-001N/A1 trial
Spiration Valve SystemN/A1 trial
Spiration Valve SystemN/A1 trial
Spiration Valve SystemN/A1 trial
+1 more programs
Active Trials
NCT00475007Completed277Est. Aug 2017
NCT02470052Terminated38Est. Aug 2018
NCT02914340Completed9Est. Sep 2018
+3 more trials
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
2 programs
Implementation of 9 mm intrabronchial valvesN/A1 trial
Zephyr endobronchial valvePHASE_31 trial
Active Trials
NCT03008226Unknown120Est. Aug 2017
NCT00613860Withdrawn0Est. Apr 2012
XVIVO
XVIVOSweden - Mölndal
2 programs
Steen Solution™N/A1 trial
Transplantation of lungs obtained from Non-Heart-Beating DonorsN/A1 trial
Active Trials
NCT01241942Terminated11Est. Mar 2013
NCT01615484Completed24Est. Jan 2017
Eppendorf
EppendorfGermany - Hamburg
1 program
Endoscopic lung volume reduction coil treatmentN/A1 trial
Active Trials
NCT02996149Terminated1Est. Dec 2019
Foresee Pharmaceuticals
1 program
Hyperpolarized 129XeN/A1 trial
Active Trials
NCT04761393Recruiting45Est. Jan 2025
Siemens Healthineers
Siemens HealthineersGermany - Forchheim
1 program
Stereotactic Ablative RadiotherapyN/A1 trial
Active Trials
NCT03673176Completed9Est. Aug 2021
Arda Therapeutics
Arda TherapeuticsCA - San Carlos
1 program
Autologous MSCs transplantationPHASE_11 trial
Active Trials
NCT01758055UnknownEst. Jan 2014
Grifols
GrifolsNEW YORK, NY
1 program
Prolastin-C, 60 mg/kgPHASE_21 trial
Active Trials
NCT01213043Completed30Est. Jan 2012
CSL Behring
CSL BehringIL - Bradley
1 program
Alpha1- proteinase inhibitor [human]PHASE_41 trial
Active Trials
NCT00670007Completed140Est. Sep 2014

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
CSL BehringAlpha1- proteinase inhibitor [human]
Temple TherapeuticsBudesonide/formoterol
Heidelberg PharmaZephyr endobronchial valve
Boston ScientificLung Volume Reduction Coil
KamadaKamada AAT for inhalation
Angeles TherapeuticsDoxycycline
Angeles Therapeutics600 mg ibuprofen three times daily for 48 weeks
GrifolsProlastin-C, 60 mg/kg
OlympusIntra Bronchial Valve
Boston ScientificLung Volume Reduction Coil
Arda TherapeuticsAutologous MSCs transplantation
Boston ScientificLung Volume Reduction Coil
Uptake MedicalBTVA System
PulmonxZephyr Endobronchial Valve
Uptake MedicalTreatment plus Optimal Medical Therapy

Showing 15 of 40 trials with date data

Clinical Trials (40)

Total enrollment: 4,372 patients across 40 trials

NCT00670007CSL BehringAlpha1- proteinase inhibitor [human]

Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency.

Start: Apr 2008Est. completion: Sep 2014140 patients
Phase 4Completed
NCT01602523Temple TherapeuticsBudesonide/formoterol

Effect of Symbicort on Sleep Quality in Patients With Emphysema

Start: Mar 2011Est. completion: Aug 201440 patients
Phase 3Unknown
NCT00613860Heidelberg PharmaZephyr endobronchial valve

Sequential Endoscopic Lung Volume Reduction

Start: Jan 2008Est. completion: Apr 20120
Phase 3Withdrawn
NCT01421082Boston ScientificLung Volume Reduction Coil

Evaluation of Physiologic Parameters to Study the Mechanism of Action of the Lung Volume Reduction Coil in Subjects With Homogeneous Emphysema

Start: Feb 2012Est. completion: Mar 201310 patients
Phase 2/3Completed
NCT01217671KamadaKamada AAT for inhalation

International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 Antitrypsin Deficient Patients With Emphysema

Start: Dec 2009Est. completion: Jun 2015168 patients
Phase 2/3Completed

Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)

Start: Aug 2022Est. completion: Feb 2027133 patients
Phase 2Active Not Recruiting
NCT02006576Angeles Therapeutics600 mg ibuprofen three times daily for 48 weeks

Prostaglandin Inhibition for Emphysema

Start: Jan 2014Est. completion: Mar 2018118 patients
Phase 2Completed
NCT01213043GrifolsProlastin-C, 60 mg/kg

Safety and Pharmacokinetics of Alpha-1 Proteinase Inhibitor in Subjects With Alpha1-Antitrypsin Deficiency

Start: Nov 2010Est. completion: Jan 201230 patients
Phase 2Completed
NCT00145548OlympusIntra Bronchial Valve

Pilot Study of the Spiration IBV™ System

Start: Dec 2003Est. completion: Aug 200791 patients
Phase 2Completed
NCT01328899Boston ScientificLung Volume Reduction Coil

Feasibility Study of PneumRx's Lung Volume Reduction Coil (LVRC)

Start: Dec 2009Est. completion: Jan 201360 patients
Phase 1/2Completed
NCT01758055Arda TherapeuticsAutologous MSCs transplantation

Safety Study of Endobronchial Transplantation of Autologous Mesenchymal Stem Cells (MSCs) in Emphysema Patients

Start: Dec 2012Est. completion: Jan 2014
Phase 1Unknown
NCT01334307Boston ScientificLung Volume Reduction Coil

Randomized Comparison of the RePneu Lung Volume Reduction Coil (LVRC) to Standard of Care for the Treatment of Emphysema (RESET Study)

Start: Feb 2010Est. completion: Sep 201347 patients
Phase 1Completed

Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction

Start: Dec 2009Est. completion: Aug 201110 patients
Phase 1Completed
NCT06332885PulmonxZephyr Endobronchial Valve

Zephyr Valve Japan Post-Marketing Surveillance

Start: Mar 2024Est. completion: Mar 2028140 patients
N/ARecruiting
NCT05118269Uptake MedicalTreatment plus Optimal Medical Therapy

A Randomized Controlled Trial of InterVapor® in France - The TARGET Trial

Start: Jul 2023Est. completion: Jun 20243 patients
N/ATerminated

Characterizing Matrix Metalloproteinase-12 (MMP12) in Sputum

Start: Nov 2022Est. completion: Jan 202545 patients
N/ARecruiting
NCT04302272OlympusSpiration Valve System

STRIVE Post-Market Registry Study

Start: Oct 2021Est. completion: Oct 2029150 patients
N/ARecruiting
NCT04256408PulmonxBronchoscopic transparenchymal interlobar fissure closure using Aeriseal

Mind The Gap - Crossing Borders Study

Start: Jun 2021Est. completion: Aug 20223 patients
N/ACompleted

Fissure Closure With the AeriSeal System for CONVERTing Collateral Ventilation Status (CONVERT)

Start: Dec 2020Est. completion: Oct 2024102 patients
N/ACompleted
NCT04186546PulmonxZephyr Valve Procedure

Zephyr Valve Registry (ZEVR)

Start: Nov 2019Est. completion: Dec 2026150 patients
N/AActive Not Recruiting
NCT03360396Boston ScientificEndobronchial Coils

Study of PneumRx Endobronchial Coil System in Treatment of Subjects With Severe Emphysema

Start: May 2018Est. completion: Nov 2022120 patients
N/ACompleted
NCT02996149EppendorfEndoscopic lung volume reduction coil treatment

Endoscopic Lung Volume Reduction Coil Treatment in Patients With Chronic Hypercapnic Respiratory Failure

Start: Nov 2016Est. completion: Dec 20191 patients
N/ATerminated
NCT02877459PulmonxAeriSeal System

Clinical Investigation of a Modified Staged Treatment Algorithm Using the AeriSeal System

Start: Nov 2016Est. completion: Aug 201814 patients
N/ACompleted
NCT02914340OlympusSpiration Valve System

REACH SVS Control Patient Cross-Over Study

Start: Sep 2016Est. completion: Sep 20189 patients
N/ACompleted

A Prospective Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the OL-BF-001 for Severe Emphysema

Start: Aug 2015Est. completion: Aug 201838 patients
N/ATerminated
NCT02499380Boston ScientificPneumRx Coil System

Changes in Lung Physiology and Cardiac Performance in Patients With Emphysema Post Bilateral RePneu Coil Treatment

Start: Jun 2015Est. completion: Oct 201820 patients
N/ATerminated
NCT03008226Heidelberg PharmaImplementation of 9 mm intrabronchial valves

Spiration Valve System 9 mm European Post Market Evaluation Study

Start: Jun 2015Est. completion: Aug 2017120 patients
N/AUnknown

LVRC IDE Crossover Study (Crossover From IDE Trial CLN0009)

Start: Dec 2013Est. completion: Jul 2019102 patients
N/ATerminated
NCT01615484XVIVOTransplantation of lungs obtained from Non-Heart-Beating Donors

Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability

Start: Sep 2013Est. completion: Jan 201724 patients
N/ACompleted

Pulmonx Endobronchial Valves Used in Treatment of Emphysema (LIBERATE Study)

Start: Jul 2013Est. completion: Apr 2023190 patients
N/ACompleted
NCT01812447OlympusSpiration Valve System

Evaluation of the Spiration® Valve System for Emphysema to Improve Lung Function

Start: Jun 2013Est. completion: Aug 2022172 patients
N/ACompleted
NCT01719263Uptake MedicalInterVapor® treatment plus Optimal Medical Therapy

Sequential Segmental Treatment of Emphysema With Upper Lobe Predominance (STEP-UP) Study

Start: Jun 2013Est. completion: Oct 201569 patients
N/ACompleted
NCT01806636Boston ScientificPneumRx Coil System

Post Market Observational, Prospective, Multi-center Study

Start: May 2013Est. completion: Jul 20191,275 patients
N/ATerminated
NCT03673176Siemens HealthineersStereotactic Ablative Radiotherapy

Lung Volume Reduction for Severe Emphysema by Stereotactic Ablative Radiation Therapy

Start: Feb 2013Est. completion: Aug 20219 patients
N/ACompleted
NCT01608490Boston ScientificRePneu Lung Volume Reduction Coil System

Lung Volume Reduction Coil Treatment in Patients With Emphysema (RENEW) Study

Start: Oct 2012Est. completion: Jul 2019315 patients
N/ATerminated
NCT01101958PulmonxChartis System

A Study of the Use of Chartis System to Optimize Subject Selection for Endobronchial Lung Volume Reduction (ELVR)

Start: Jan 2012Est. completion: Mar 201396 patients
N/ACompleted
NCT01241942XVIVOSteen Solution™

Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability

Start: Dec 2010Est. completion: Mar 201311 patients
N/ATerminated

Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction

Start: Nov 2009Est. completion: Aug 201134 patients
N/ACompleted
NCT01220908Boston ScientificLung Volume Reduction Coil

Evaluation of the PneumRx Lung Volume Reduction Coil to Treat Emphysema

Start: Jan 2008Est. completion: Mar 201236 patients
N/ACompleted
NCT00475007OlympusIBV® Valve System

Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema

Start: Sep 2007Est. completion: Aug 2017277 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
3 actively recruiting trials targeting 4,372 patients
16 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.