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Ductus Arteriosus, Patent

2
Pipeline Programs
4
Companies
4
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 4 programs with unclassified modality

On Market (1)

Approved therapies currently available

Cumberland Pharmaceuticals
CALDOLORApproved
ibuprofen
Cumberland Pharmaceuticals
Nonsteroidal Anti-inflammatory Drug [EPC]intravenous2009

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Cumberland Pharmaceuticals
1 program
1
IbuprofenPhase 4Small Molecule1 trial
Active Trials
NCT00470743Withdrawn0Est. Jun 2009
Abbott
AbbottABBOTT PARK, IL
2 programs
Percutaneous Patent Ductus Arteriosus ClosureN/A1 trial
Transcatheter PDA ClosureN/A1 trial
Active Trials
NCT05547165Recruiting240Est. Feb 2026
NCT04205877Not Yet Recruiting5,000Est. Dec 2031
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
Percutaneous Patent Ductus Arteriosus ClosureN/A
PFM Medical
PFM MedicalCA - Carlsbad
1 program
Transcatheter PDA CoilN/A1 trial
Active Trials
NCT00828334Completed357Est. Oct 2007

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Cumberland PharmaceuticalsIbuprofen
AbbottPercutaneous Patent Ductus Arteriosus Closure
AbbottTranscatheter PDA Closure
PFM MedicalTranscatheter PDA Coil

Clinical Trials (4)

Total enrollment: 5,597 patients across 4 trials

NCT00470743Cumberland PharmaceuticalsIbuprofen

Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies

Start: May 2007Est. completion: Jun 20090
Phase 4Withdrawn
NCT05547165AbbottPercutaneous Patent Ductus Arteriosus Closure

Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants

Start: Feb 2023Est. completion: Feb 2026240 patients
N/ARecruiting
NCT04205877AbbottTranscatheter PDA Closure

The U.S. PDA Registry

Start: Jan 2020Est. completion: Dec 20315,000 patients
N/ANot Yet Recruiting
NCT00828334PFM MedicalTranscatheter PDA Coil

NIT-OCCLUD PDA Phase II Sentinel Trial

Start: Nov 2002Est. completion: Oct 2007357 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 5,597 patients
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.