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Drug Interaction

10
Pipeline Programs
14
Companies
15
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
10
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
6100%
+ 12 programs with unclassified modality

Competitive Landscape

14 companies ranked by most advanced pipeline stage

Emalex Biosciences
Emalex BiosciencesIL - Chicago
3 programs
3
EcopipamPhase 11 trial
ItraconazolePhase 1Small Molecule
ecopipam HCLPhase 1
Active Trials
NCT05334108Completed56Est. Aug 2022
Syneos Health
Syneos HealthNC - Morrisville
2 programs
2
ItraconazolePhase 1Small Molecule1 trial
ecopipam HCLPhase 11 trial
Active Trials
NCT06194864Completed45Est. May 2024
NCT04902105Completed38Est. Jul 2021
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
AZD1981Phase 11 trial
Active Trials
NCT01254461Completed30Est. Apr 2011
Syndax Pharmaceuticals
1 program
1
EntinostatPhase 1Small Molecule1 trial
Active Trials
NCT03187015Completed26Est. Aug 2017
Cognition Therapeutics
Cognition TherapeuticsPA - Pittsburgh
1 program
1
ItraconazolePhase 1Small Molecule
Santhera Pharmaceuticals
Santhera PharmaceuticalsSwitzerland - Pratteln
1 program
1
VamorolonePhase 11 trial
Active Trials
NCT06689527Completed18Est. Oct 2024
Zenshine Pharmaceuticals
1 program
1
ZX-7101APhase 11 trial
Active Trials
NCT06057103Completed18Est. Apr 2024
Hua Medicine
Hua MedicineChina - Shanghai
2 programs
DorzagliatinPHASE_11 trial
DorzagliatinPHASE_11 trial
Active Trials
NCT04080596Completed18Est. Dec 2017
NCT04080609Completed15Est. Apr 2018
Biogen
BiogenCAMBRIDGE, MA
1 program
BIIB074PHASE_11 trial
Active Trials
NCT03385525Completed30Est. Oct 2017
Cinclus Pharma
Cinclus PharmaSweden - Stockholm
1 program
Drug Drug InteractionPHASE_11 trial
Active Trials
NCT07308041Completed12Est. Dec 2025
Vicore Pharma
Vicore PharmaSweden - Stockholm
1 program
Drug Drug InteractionPHASE_11 trial
Active Trials
NCT05830799Completed19Est. May 2023
Harmony Biosciences
Harmony BiosciencesPLYMOUTH MEETING, PA
1 program
Part 1PHASE_11 trial
Active Trials
NCT06930872Completed29Est. Nov 2025
Hutchmed
HutchmedChina - Hong Kong
1 program
fruquintinib with food/fruquintinib without food/fruquintinib with rabeprazolePHASE_1Small Molecule1 trial
Active Trials
NCT04645940Completed14Est. Nov 2020
Bristol Myers Squibb
1 program
omeprazole and pantoprazolePHASE_1Small Molecule1 trial
Active Trials
NCT01170533Completed20Est. Aug 2010

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Cinclus PharmaDrug Drug Interaction
Harmony BiosciencesPart 1
Santhera PharmaceuticalsVamorolone
Syneos HealthItraconazole
Zenshine PharmaceuticalsZX-7101A
Vicore PharmaDrug Drug Interaction
Emalex BiosciencesEcopipam
Syneos Healthecopipam HCL
Hutchmedfruquintinib with food/fruquintinib without food/fruquintinib with rabeprazole
Hua MedicineDorzagliatin
Hua MedicineDorzagliatin
BiogenBIIB074
Syndax PharmaceuticalsEntinostat
AstraZenecaAZD1981
Bristol Myers Squibbomeprazole and pantoprazole

Clinical Trials (15)

Total enrollment: 388 patients across 15 trials

NCT07308041Cinclus PharmaDrug Drug Interaction

A Study to Investigate the Effect of Linaprazan Glurate on the Pharmacokinetics of Amoxicillin

Start: Nov 2025Est. completion: Dec 202512 patients
Phase 1Completed
NCT06930872Harmony BiosciencesPart 1

Drug Interaction Study of ZYN002 Transdermal Gel and Probe Substrates

Start: Jun 2025Est. completion: Nov 202529 patients
Phase 1Completed
NCT06689527Santhera PharmaceuticalsVamorolone

Evaluation of Vamorolone CYP3A4 Induction on Midazolam (a Sensitive CYP 3A4 Substrate) Pharmacokinetics

Start: Aug 2024Est. completion: Oct 202418 patients
Phase 1Completed
NCT06194864Syneos HealthItraconazole

Drug Interaction Study

Start: Jan 2024Est. completion: May 202445 patients
Phase 1Completed
NCT06057103Zenshine PharmaceuticalsZX-7101A

A Study to Evaluate Drug-drug Interaction of ZX-7101A Tablets and Oseltamivir Phosphate Capsules in Healthy Adult Subjects

Start: Aug 2023Est. completion: Apr 202418 patients
Phase 1Completed
NCT05830799Vicore PharmaDrug Drug Interaction

A Trial to Evaluate the Impact of C21 on the Exposure of 4 Substrates in Healthy Volunteers

Start: Mar 2023Est. completion: May 202319 patients
Phase 1Completed
NCT05334108Emalex BiosciencesEcopipam

Drug-Drug Interaction Study to Evaluate the Effects of Ecopipam on the Pharmacokinetics of Multiple Substrates for Drug Metabolism and Transport

Start: Apr 2022Est. completion: Aug 202256 patients
Phase 1Completed
NCT04902105Syneos Healthecopipam HCL

Drug-Drug Interaction Study to Evaluate the Effect of Inhibition of UGTs on the PK of Ecopipam and Its Active Metabolite

Start: May 2021Est. completion: Jul 202138 patients
Phase 1Completed
NCT04645940Hutchmedfruquintinib with food/fruquintinib without food/fruquintinib with rabeprazole

Fruquintinib Food Effect and Proton Pump Inhibitor Study

Start: Sep 2020Est. completion: Nov 202014 patients
Phase 1Completed
NCT04080609Hua MedicineDorzagliatin

DDI Study Between Dorzagliatin and Rifampicin

Start: Mar 2018Est. completion: Apr 201815 patients
Phase 1Completed
NCT04080596Hua MedicineDorzagliatin

DDI Study to Investigate the Impact of Itraconazole on the Pharmacokinetics of Dorzagliatin

Start: Oct 2017Est. completion: Dec 201718 patients
Phase 1Completed
NCT03385525BiogenBIIB074

Study to Evaluate the Effect of UGT Inhibition by Valproic Acid on the Pharmacokinetics of BIIB074

Start: Sep 2017Est. completion: Oct 201730 patients
Phase 1Completed
NCT03187015Syndax PharmaceuticalsEntinostat

A Study to Examine the Effects of Entinostat on Midazolam in Healthy Adult Subjects

Start: May 2017Est. completion: Aug 201726 patients
Phase 1Completed
NCT01254461AstraZenecaAZD1981

A Drug-Drug Interaction Study Between AZD1981 and Pravastatin to Study the Effect of AZD1981 on the Kinetics of Pravastatin

Start: Feb 2011Est. completion: Apr 201130 patients
Phase 1Completed
NCT01170533Bristol Myers Squibbomeprazole and pantoprazole

PPI and Clopidogrel Response

Start: Mar 2009Est. completion: Aug 201020 patients
Phase 1Completed

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

14 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.