Drug Interaction

8
Pipeline Programs
7
Companies
7
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
8
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
2100%
+ 6 programs with unclassified modality

Competitive Landscape

7 companies ranked by most advanced pipeline stage

HM
Hua MedicineChina - Shanghai
2 programs
2
DorzagliatinPhase 11 trial
DorzagliatinPhase 11 trial
Active Trials
NCT04080596Completed18Est. Dec 2017
NCT04080609Completed15Est. Apr 2018
Biogen
BiogenCAMBRIDGE, MA
1 program
1
BIIB074Phase 11 trial
Active Trials
NCT03385525Completed30Est. Oct 2017
Vicore Pharma
Vicore PharmaSweden - Stockholm
1 program
1
Drug Drug InteractionPhase 11 trial
Active Trials
NCT05830799Completed19Est. May 2023
Cinclus Pharma
Cinclus PharmaSweden - Stockholm
1 program
1
Drug Drug InteractionPhase 11 trial
Active Trials
NCT07308041Completed12Est. Dec 2025
Harmony Biosciences
Harmony BiosciencesPLYMOUTH MEETING, PA
1 program
1
Part 1Phase 11 trial
Active Trials
NCT06930872Completed29Est. Nov 2025
H
HutchmedChina - Hong Kong
1 program
1
fruquintinib with food/fruquintinib without food/fruquintinib with rabeprazolePhase 1Small Molecule1 trial
Active Trials
NCT04645940Completed14Est. Nov 2020
Bristol Myers Squibb
1 program
1
omeprazole and pantoprazolePhase 1Small Molecule

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Cinclus PharmaDrug Drug Interaction
Harmony BiosciencesPart 1
Vicore PharmaDrug Drug Interaction
Hutchmedfruquintinib with food/fruquintinib without food/fruquintinib with rabeprazole
Hua MedicineDorzagliatin
Hua MedicineDorzagliatin
BiogenBIIB074

Clinical Trials (7)

Total enrollment: 137 patients across 7 trials

NCT07308041Cinclus PharmaDrug Drug Interaction

A Study to Investigate the Effect of Linaprazan Glurate on the Pharmacokinetics of Amoxicillin

Start: Nov 2025Est. completion: Dec 202512 patients
Phase 1Completed
NCT06930872Harmony BiosciencesPart 1

Drug Interaction Study of ZYN002 Transdermal Gel and Probe Substrates

Start: Jun 2025Est. completion: Nov 202529 patients
Phase 1Completed
NCT05830799Vicore PharmaDrug Drug Interaction

A Trial to Evaluate the Impact of C21 on the Exposure of 4 Substrates in Healthy Volunteers

Start: Mar 2023Est. completion: May 202319 patients
Phase 1Completed
NCT04645940Hutchmedfruquintinib with food/fruquintinib without food/fruquintinib with rabeprazole

Fruquintinib Food Effect and Proton Pump Inhibitor Study

Start: Sep 2020Est. completion: Nov 202014 patients
Phase 1Completed
NCT04080609Hua MedicineDorzagliatin

DDI Study Between Dorzagliatin and Rifampicin

Start: Mar 2018Est. completion: Apr 201815 patients
Phase 1Completed
NCT04080596Hua MedicineDorzagliatin

DDI Study to Investigate the Impact of Itraconazole on the Pharmacokinetics of Dorzagliatin

Start: Oct 2017Est. completion: Dec 201718 patients
Phase 1Completed
NCT03385525BiogenBIIB074

Study to Evaluate the Effect of UGT Inhibition by Valproic Acid on the Pharmacokinetics of BIIB074

Start: Sep 2017Est. completion: Oct 201730 patients
Phase 1Completed

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

7 companies competing in this space