Diphtheria

45
Pipeline Programs
5
Companies
50
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
4
0
31
10
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Vaccine
25100%
+ 27 programs with unclassified modality

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Sanofi
SanofiPARIS, France
27 programs
1
19
6
DTacP-IPV combined vaccinePhase 4Vaccine1 trial
Diphteria, Tetanus, Polio, Acellular Pertussis, Hib vaccinePhase 4Vaccine1 trial
Diphtheria and Tetanus Toxoids and Acellular PertussisPhase 43 trials
Diphtheria, Tetanus, Polio, Acellular Pertussis and Hib VacPhase 41 trial
Diphtheria, tetanus, polio and pertussis vaccinationPhase 41 trial
+22 more programs
Active Trials
NCT00804284Completed62,538Est. Jan 2015
NCT00362427Completed460Est. Mar 2009
NCT02992418Terminated688Est. Dec 2019
+31 more trials
GSK
GSKLONDON, United Kingdom
22 programs
2
11
4
Boostrix TMPhase 41 trial
DTPa-HBV-IPV/HibPhase 41 trial
GSK Biologicals' combined DTPa-IPV/Hib vaccinePhase 4Vaccine1 trial
Infanrix hexaPhase 41 trial
BoostrixPhase 31 trial
+17 more programs
Active Trials
NCT00297856Completed10,000Est. Dec 2006
NCT02757950Completed2,462Est. May 2017
NCT00908115Completed1,258Est. Jun 2008
+19 more trials
Novartis
NovartisBASEL, Switzerland
1 program
1
DTwP-HepB-Hib VaccinePhase 3Vaccine1 trial
Active Trials
NCT01470287Completed175Est. Apr 2012
M&
Merck & Co.RAHWAY, NJ
1 program
1
Hybrid 5 component DTaP, Vero IPV, Hep B and PRP-OMPCPhase 2
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
Pilot Study Freeze and Transport Immune CellsN/A1 trial
Active Trials
NCT00138268CompletedEst. Feb 2005

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GSKDTPa-HBV-IPV/Hib
GSKInfanrix hexa
SanofiDiphtheria, tetanus, polio and pertussis vaccination
GSKBoostrix TM
SanofiDTacP-IPV combined vaccine
SanofiTetanus and Diphtheria Toxoids Adsorbed
SanofiDiphtheria, Tetanus, Polio, Acellular Pertussis and Hib Vac
GSKGSK Biologicals' combined DTPa-IPV/Hib vaccine
SanofiTetanus and Diphtheria Toxoids Adsorbed
SanofiDiphtheria and Tetanus Toxoids and Acellular Pertussis
SanofiDiphteria, Tetanus, Polio, Acellular Pertussis, Hib vaccine
GSKInfanrix-IPV/Hib
SanofiAdacel®
GSKInfanrix-IPV/Hib
SanofiDTaP-IPV-Hep B-PRP~T combined vaccine

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 38,798 patients across 50 trials

NCT04535037GSKDTPa-HBV-IPV/Hib

A Study to Evaluate Immunogenicity and Safety of GlaxoSmithKline (GSK)'s Infanrix Hexa Vaccine (DTPa-HBV-IPV/Hib) Versus MCM Vaccine BV's Vaxelis Vaccine (DTaP5-HBV-IPV-Hib) in Healthy Infants and Toddlers

Start: May 2021Est. completion: Jul 2022500 patients
Phase 4Completed
NCT02853929GSKInfanrix hexa

Evaluation of Immunogenicity and Safety of a Booster Dose of Infanrix Hexa™ in Healthy Infants Born to Mothers Vaccinated With Boostrix™ During Pregnancy or Immediately Post-delivery

Start: Sep 2016Est. completion: Mar 2019551 patients
Phase 4Completed
NCT01546909SanofiDiphtheria, tetanus, polio and pertussis vaccination

Antibody Persistence to REVAXIS or DT Polio and Immune Response to TETRAVAC-ACELLULAIRE

Start: Feb 2012Est. completion: Dec 2012278 patients
Phase 4Completed
NCT01362322GSKBoostrix TM

Immunogenicity and Safety of BoostrixTM Using a New Syringe in 10 to 15-year Old Adolescents

Start: Jul 2011Est. completion: Sep 2012671 patients
Phase 4Completed
NCT01031303SanofiDTacP-IPV combined vaccine

Immunogenicity and Safety of TETRAXIM™ Given as a Booster Dose at 4 to 6 Years of Age

Start: Dec 2009Est. completion: Jan 2011123 patients
Phase 4Completed
NCT00457249SanofiTetanus and Diphtheria Toxoids Adsorbed

A Trial to Evaluate the Safety and Immunogenicity of ADACEL® Vaccine in Persons 65 Years of Age and Older

Start: Mar 2007Est. completion: Nov 20081,564 patients
Phase 4Completed
NCT00255021SanofiDiphtheria, Tetanus, Polio, Acellular Pertussis and Hib Vac

Immunogenicity and Safety of Sanofi Pasteur Pentaxim Combined Vaccine in Infants in Thailand

Start: Dec 2005Est. completion: Jan 2009186 patients
Phase 4Completed
NCT00325156GSKGSK Biologicals' combined DTPa-IPV/Hib vaccine

Assess the Safety & Reactogenicity of DTPa-IPV/Hib Vaccine Administered at 3, 4, 5 & 18 Mths of Age, in Healthy Infants

Start: Nov 2004Est. completion: Aug 20072,590 patients
Phase 4Completed
NCT00601835SanofiTetanus and Diphtheria Toxoids Adsorbed

Canadian Manufactured Tetanus and Diphtheria Toxoids Adsorbed (Td) Vaccine Compared With U.S. Manufactured Td

Start: May 2004Est. completion: Jul 20053,651 patients
Phase 4Completed
NCT00802867SanofiDiphtheria and Tetanus Toxoids and Acellular Pertussis

Study of DAPTACEL® Administered as a 5th Dose in 4 to 6-Year-Old Children Previously Immunized With PENTACEL™

Start: Feb 2004Est. completion: Sep 2005989 patients
Phase 4Completed
NCT00254917SanofiDiphteria, Tetanus, Polio, Acellular Pertussis, Hib vaccine

Assessment of the Immunogenicity and Safety of PENTAXIM™ in Philippines

Start: Oct 2003Est. completion: Feb 2006387 patients
Phase 4Completed
NCT03128489GSKInfanrix-IPV/Hib

Evaluation of Immunogenicity and Safety of DTPa-IPV/Hib Conjugate Vaccine (Infanrix™-IPV/Hib) Administered at 6, 10 and 14 Weeks in Healthy Indian Infants

Start: Dec 2017Est. completion: Aug 20180
Phase 3Withdrawn

Study of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Adacel® in Healthy Subjects

Start: Dec 2016Est. completion: Dec 2019688 patients
Phase 3Terminated
NCT02858440GSKInfanrix-IPV/Hib

A Study to Assess the Immunogenicity and Safety of GSK Biologicals' Infanrix-IPV/Hib Vaccine Administered as a Three-dose Vaccination Course at 3, 4.5 and 6 Months of Age and a Booster Dose at 18 Months of Age in Healthy Infants in Russia

Start: Sep 2016Est. completion: Nov 2018235 patients
Phase 3Completed
NCT02094833SanofiDTaP-IPV-Hep B-PRP~T combined vaccine

DTaP-IPV-Hep B-PRP~T Combined Vaccine Versus DTaP-IPV//PRP~T Combined Vaccine + Hep B Vaccine in Hep B Primed Infants

Start: Mar 2014Est. completion: Nov 2016310 patients
Phase 3Completed
NCT01988857GSKBoostrix™

Safety of a Booster Dose of GlaxoSmithKline (GSK) Biologicals' Boostrix™ Vaccine in Healthy Vietnamese Children

Start: Feb 2014Est. completion: May 2014302 patients
Phase 3Completed
NCT01948193SanofiHexaxim™: DTaP-IPV-Hep B-PRP~T combined vaccine

Study of DTaP-IPV-Hep B-PRP~T Combined Vaccine in Indian Infants Previously Given a Dose of Hepatitis B Vaccine at Birth

Start: Feb 2014Est. completion: Jun 2015177 patients
Phase 3Completed
NCT01983540SanofiDTaP-IPV-Hep B- PRP~T + Prevenar + Rotarix vaccine

Antibody Persistence at Age 3.5 and 4.5 Years After Primary and Booster DTaP-IPV-Hep B-PRP~T or Infanrix Hexa Vaccination

Start: Oct 2013Est. completion: Dec 2015558 patients
Phase 3Completed

Safety and Immunogenicity Study for Use of Menactra® Versus Adacel® in Subjects 11 to 55 Years of Age in South Korea

Start: Jul 2012Est. completion: Jun 2013300 patients
Phase 3Completed
NCT01470287NovartisDTwP-HepB-Hib Vaccine

Immunogenicity, Safety and Tolerability of a Fully Liquid Pentavalent (DTwP-Hib-Hep B) Vaccine in Infants 6-8 Weeks of Age

Start: Dec 2011Est. completion: Apr 2012175 patients
Phase 3Completed
NCT01249183SanofiConcomitant administration

Safety and Immunogenicity Study of Concomitant Versus Non Concomitant Administration of a Diphtheria, Tetanus, Pertussis and Poliomyelitis Vaccine (REPEVAX) and Influenza Vaccine (VAXIGRIP) in Subjects Aged From 60 Years Old

Start: Oct 2010Est. completion: Sep 2011954 patients
Phase 3Completed
NCT01214889SanofiPENTAXIM™: DTacP IPV//PRP~T combined vaccine

Study of PENTAXIM™ Vaccine Versus TETRAXIM™ Vaccine Given With ACTHIB™ Vaccine in South Korean Infants.

Start: Sep 2010Est. completion: Dec 2011370 patients
Phase 3Completed
NCT01177722SanofiDTaP-IPV-Hep B-PRP-T Vaccine

A Study of DTaP-IPV-Hep B-PRP-T Vaccine Given With Prevenar™ and Rotarix™ in Healthy Latin American Infants

Start: Aug 2010Est. completion: Dec 20111,375 patients
Phase 3Completed
NCT01062477SanofiDTaP//PRP-T Combined Vaccine

A Study of DTaP//PRP-T Combined Vaccine (ACTACEL) Versus Local DTaP and Act-HIB Monovalent Vaccine in Healthy Infants

Start: Jan 2010Est. completion: Dec 20111,056 patients
Phase 3Completed

A Study to Assess the Safety of Adacel® Vaccine

Start: Dec 2009Est. completion: Apr 201030 patients
Phase 3Completed
NCT00797511SanofiTdcP-IPV vaccine

Immunogenicity and Safety of Adacel Polio Vaccine

Start: Nov 2008Est. completion: Jul 2009132 patients
Phase 3Completed
NCT00831753SanofiDTaP IPV HB PRP~T vaccine

Study of DTaP-IPV-Hep B-PRP~T Combined Vaccine Compared to Infanrix®Hexa in Healthy Peruvian Infants

Start: May 2008Est. completion: Nov 2009263 patients
Phase 3Completed
NCT00654901SanofiDTaP-IPV-Hep B-PRP~T vaccine

Study of the DTaP-IPV-Hep B-PRP~T Combined Vaccine Following a Primary Series of DTacP IPV-HepB-PRP-T or Infanrix Hexa™

Start: Mar 2008Est. completion: Jul 2009881 patients
Phase 3Completed

Study to Assess Safety & Immunogenicity of GSK Biologicals' Boostrix (dTpa) Vaccine vs. Chinese DT Vaccine

Start: Mar 2007Est. completion: May 2007660 patients
Phase 3Completed
NCT00343889SanofiDTaP-HB-PRP~T vaccine + OPV

Comparison of DTaP-HB-PRP~T Combined Vaccine to Tritanrix-HepB/Hib™, Both Given Concomitantly With Oral Polio Vaccine

Start: Aug 2006Est. completion: Apr 2008379 patients
Phase 3Completed
NCT00343421SanofiPEDIACEL® and Prevenar®

Study to Compare Pediacel® to Infanrix®-IPV+Hib When Both Are Co-Administered With Prevenar® in Infants and Toddlers

Start: Jul 2006Est. completion: Jun 2009588 patients
Phase 3Completed
NCT00348881SanofiDTaP-HB-PRP~T combined vaccine

Study Comparing a DTaP-HB-PRP~T Combined Vaccine With Tritanrix HepB/Hib™, Concomitantly With OPV in Healthy Infants

Start: Jun 2006Est. completion: Jun 20082,133 patients
Phase 3Completed
NCT00320463GSKDTPa-HBV-IPV/Hib vaccine

Compare Immunogenicity & Safety of 2 Formulations of GSK Biologicals' DTPa-HBV-IPV/Hib Vaccine Given in Healthy Infants

Start: Apr 2006Est. completion: Jan 2007415 patients
Phase 3Completed
NCT00259337SanofiDiphteria/Tetanus/Polio/Acellular Pertussis/Hib vaccine

Immunogenicity and Safety of Pentaxim™ in an Indian Population

Start: Feb 2006Est. completion: Dec 2008226 patients
Phase 3Completed
NCT00316147GSKDTPa-HBV-IPV/Hib vaccine

Immunogenicity & Safety of GSK's Combined DTPa-HBV-IPV/Hib Vaccine in Indian Infants at 2 Diff Vaccination Schedules

Start: Dec 2005Est. completion: Aug 2006224 patients
Phase 3Completed

Safety and Immune Response of Different Pediatric Combination Vaccines.

Start: Nov 2005Est. completion: Feb 20092,167 patients
Phase 3Completed
NCT00254969SanofiDiphtheria, Tetanus, Polio, Acellular Pertussis and Hib

Immunogenicity and Safety of Pentaxim in South African Infants

Start: Oct 2005Est. completion: Jan 2010212 patients
Phase 3Completed
NCT00258895SanofiDAPTACEL®: DTaP

Safety and Immunogenicity of DAPTACEL® as 5th Dose in Children 4 to 6 Years Old After 4 Doses of Pentacel™ or DAPTACEL®

Start: Mar 2005Est. completion: Apr 2007649 patients
Phase 3Completed
NCT00317161GSKDTPw-HBV/Hib-MenAC conjugate vaccine

Immunogenicity & Safety Study of a Vaccine Against Meningitis in Infants (2,4,6 Months) After a Hepatitis B Birth Dose.

Start: Aug 2004Est. completion: Apr 20051,000 patients
Phase 3Completed
NCT00317135GSKTritanrix-HepB/Meningitec conjugate vaccine

Safety Study of a Vaccine Against Meningitis in Infants ( 2,4 & 6 Months Age) After a Birth Dose of Hepatitis B.

Start: Dec 2003Est. completion: Oct 2004500 patients
Phase 3Completed
NCT00772928SanofiPentacel™: HCPDT-IPV//PRP-T Vaccine and Prevnar®

Study of the Effect of Pneumococcal Conjugate Vaccine (PCV) on Immunogenicity of Pentacel™

Start: Oct 2003Est. completion: Nov 20061,167 patients
Phase 3Completed
NCT00109330GSKCombined diphtheria, tetanus, acellular pertussis vaccine

A Combined Tdap Vaccine Used As A Booster Compared To Licensed Td Vaccine

Start: Nov 2002Est. completion: Apr 20044,116 patients
Phase 3Completed
NCT00662870SanofiDiphtheria and Tetanus Toxoids and Acellular Pertussis

Study of the Safety, Immunogenicity and Lot Comparability of DAPTACEL When Administered With Other Recommended Vaccine

Start: May 2001Est. completion: Jan 20041,941 patients
Phase 3Completed
NCT00879827GSKPediarix TM, Infanrix penta TM

Immunogenicity and Reactogenicity of GSK Bio DTPa-HBV-IPV and Hib Vaccines When Coadministered to Healthy Infants

Start: Sep 2000Est. completion: May 200160 patients
Phase 3Completed
NCT01267058GSKGSK Biologicals' combined diphtheria, tetanus, acellular pertussis vaccine

Booster Study of Combined Diphtheria-tetanus-acellular Pertussis Vaccine in Healthy Adults

Start: Sep 1997Est. completion: Feb 1998550 patients
Phase 3Completed
NCT04398706SanofiDiphtheria and Tetanus Toxoids and Acellular Pertussis

Study of a Pneumococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Toddlers and Infants

Start: May 2020Est. completion: Aug 2023852 patients
Phase 2Completed
NCT00362427SanofiHybrid 5 component DTaP, Vero IPV, Hep B and PRP-OMPC

Study of PR5I, a Pediatric Combination Vaccine With Enhanced Hepatitis B Component Given Concomitantly With Prevnar®

Start: Aug 2006Est. completion: Mar 2009460 patients
Phase 2Completed
NCT00263692GSKProphylaxis: Diphtheria, tetanus, pertussis, poliovirus type 1, type 2 and type 3

Comparison of GSK Biologicals' DTaP-IPV Candidate Vaccine to DTaP and IPV Separately Administered Vaccines in Terms of Immune Response and Safety

Start: Nov 2002Est. completion: Sep 2004401 patients
Phase 2Completed
NCT00291967GSKDTPw-HBV/Hib-MenAC conjugate vaccine

Assess Immune Response Following Primary Vaccination With Tritanrix™-HepB Vaccine Mixed With 3 Formulations of Hib-MenAC Vaccine to Infants

Start: Nov 2002525 patients
Phase 2Completed
NCT02040636SanofiTetanus and Diphtheria Toxoids Adsorbed

Study of Tetanus and Diphtheria Toxoids Adsorbed Combined With Component Pertussis Vaccine and Inactivated Poliomyelitis

Start: Jan 1999Est. completion: May 2000277 patients
Phase 2Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

31 late-stage (Phase 3) programs — potential near-term approvals
5 companies competing in this space