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Diarrhoea

5
Pipeline Programs
9
Companies
11
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
2
0
1
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Vaccine
1100%
+ 14 programs with unclassified modality

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
1 program
1
Idoform PlusPhase 41 trial
Active Trials
NCT01491659Withdrawn0Est. Mar 2013
Ferrosan
FerrosanDenmark - Søborg
1 program
1
probioticsPhase 31 trial
Active Trials
NCT00823056Completed454Est. Dec 2011
ViiV Healthcare
ViiV HealthcareNC - Durham
4 programs
1
2
AltSonflex1-2-3Phase 2
altSonflex1-2-3 Dose APhase 2
altSonflex PlaceboPhase 1
Database analysisN/A
GSK
GSKLONDON, United Kingdom
3 programs
Database analysisN/A1 trial
AltSonflex1-2-3PHASE_21 trial
altSonflex1-2-3 Dose APHASE_21 trial
Active Trials
NCT01175252Completed1Est. Jun 2012
NCT07320716Not Yet Recruiting528Est. Oct 2028
NCT06663436Completed200Est. Oct 2025
Ipsen
IpsenChina - Tianjin
2 programs
SmectaPHASE_31 trial
SmectaPHASE_31 trial
Active Trials
NCT00352989Completed302Est. Mar 2007
NCT00352716Completed300Est. Feb 2007
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
Causes of Rotavirus Vaccine Failure in Zambian ChildrenN/AVaccine1 trial
Active Trials
NCT01886833Completed420Est. Apr 2016
MediaPharma
MediaPharmaItaly - Chieti
1 program
Local radio campaign to reduce under-five child mortalityN/A1 trial
Active Trials
NCT01517230Completed100,000Est. Apr 2015
Impact Therapeutics
Impact TherapeuticsChina - Shanghai
1 program
Provision of household latrinesN/A1 trial
Active Trials
NCT01214785Completed100Est. Jun 2017
Ferring Pharmaceuticals
Ferring PharmaceuticalsArgentina - Buenos Aires
1 program
VSL#3PHASE_2_31 trial
Active Trials
NCT00973908Completed231Est. Dec 2012

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
PfizerIdoform Plus
Ferrosanprobiotics
IpsenSmecta
IpsenSmecta
Ferring PharmaceuticalsVSL#3
GSKAltSonflex1-2-3
GSKaltSonflex1-2-3 Dose A
Allergy TherapeuticsCauses of Rotavirus Vaccine Failure in Zambian Children
MediaPharmaLocal radio campaign to reduce under-five child mortality
Impact TherapeuticsProvision of household latrines
GSKDatabase analysis

Clinical Trials (11)

Total enrollment: 102,536 patients across 11 trials

NCT01491659PfizerIdoform Plus

A Study to Evaluate the Effect and Safety of Idoform Plus on Bowel Side Effects in Healthy Subjects Treated With Amoxicillin/ Clavulanate

Start: Jan 2013Est. completion: Mar 20130
Phase 4Withdrawn
NCT00823056Ferrosanprobiotics

The Effect of Probiotics on Infections in Toddlers

Start: Jan 2009Est. completion: Dec 2011454 patients
Phase 3Completed
NCT00352989IpsenSmecta

Effectiveness of Smecta in Combination With Oral Rehydration in the Treatment of Acute Watery Diarrhoea in Infants and Children

Start: Jul 2006Est. completion: Mar 2007302 patients
Phase 3Completed
NCT00352716IpsenSmecta

Effectiveness of Smecta in the Treatment of Acute Diarrhoea in Children

Start: Jun 2006Est. completion: Feb 2007300 patients
Phase 3Completed
NCT00973908Ferring PharmaceuticalsVSL#3

Probiotics for the Prevention of Antibiotics Associated Diarrhoea and Clostridium Difficile Associated Diarrhoea

Start: Apr 2010Est. completion: Dec 2012231 patients
Phase 2/3Completed
NCT07320716GSKAltSonflex1-2-3

Long-Term Immunogenicity of the altSonflex1-2-3 Shigella Vaccine in African Children

Start: Jan 2026Est. completion: Oct 2028528 patients
Phase 2Not Yet Recruiting
NCT06663436GSKaltSonflex1-2-3 Dose A

A Study on the Immune Response and Safety of a Multicomponent Shigella Vaccine in Preventing Shigellosis in Infants

Start: Nov 2024Est. completion: Oct 2025200 patients
Phase 2Completed
NCT01886833Allergy TherapeuticsCauses of Rotavirus Vaccine Failure in Zambian Children

Causes of Rotavirus Vaccine Failure in Zambian Children

Start: Apr 2012Est. completion: Apr 2016420 patients
N/ACompleted
NCT01517230MediaPharmaLocal radio campaign to reduce under-five child mortality

Can Mass Media Campaigns Reduce Child Mortality

Start: Mar 2012Est. completion: Apr 2015100,000 patients
N/ACompleted
NCT01214785Impact TherapeuticsProvision of household latrines

Cluster Randomised Trial of Improved Sanitation in Rural Orissa, India

Start: Sep 2010Est. completion: Jun 2017100 patients
N/ACompleted
NCT01175252GSKDatabase analysis

Trends Over Time (1990-2010) of Diarrhoea-related Hospitalizations and Deaths in Children < 5 Years of Age in Brazil

Start: Dec 2008Est. completion: Jun 20121 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
9 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.