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Depressive Disorder, Major

72
Pipeline Programs
30
Companies
50
Clinical Trials
6
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
8
0
18
2
25
19
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
1100%
+ 123 programs with unclassified modality

On Market (6)

Approved therapies currently available

Takeda
TRINTELLIXApproved
vortioxetine
Takeda
oral2013
390M Part D
Takeda
ACTOPLUS METApproved
pioglitazone and metformin hydrochloride
Takeda
oral2005
131K Part D
BUPROPION HYDROCHLORIDEApproved
bupropion
Unknown Company
oral2014
Takeda
VORTIOXETINE HYDROBROMIDEApproved
vortioxetine
Takeda
Takeda
VORTIOXETINEApproved
vortioxetine
Takeda
oral
Eli Lilly and Company
CYMBALTAApproved
duloxetine hydrochloride
Eli Lilly and Company
oral2004

Competitive Landscape

33 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
21 programs
2
9
5
2
Bupropion Hydrochloride Extended-releasePhase 4
Bupropion extended releasePhase 4
323U66 SR 150 mg tabletPhase 3
BupropionPhase 3
Paroxetine CRPhase 3
+16 more programs
Prevail Therapeutics
6
1
1
5
2
DuloxetinePhase 4
sertralinePhase 4
BrenipatidePhase 3Peptide
DuloxetinePhase 3
Duloxetine HydrochloridePhase 3
+10 more programs
Pfizer
PfizerNEW YORK, NY
9 programs
3
1
4
Venlafaxine ERPhase 41 trial
Venlafaxine ERPhase 41 trial
sertralinePhase 4
sertralinePhase 41 trial
DVS SRPhase 35 trials
+4 more programs
Active Trials
NCT00406952Completed165Est. Aug 2007
NCT00163059Completed30Est. Dec 2005
NCT00275197Completed262Est. Jul 2007
+9 more trials
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
3 programs
2
EstrogenPhase 4
sertralinePhase 4
Study of Genetic Differences in People With DepressionN/A1 trial
Active Trials
NCT00229463Completed200Est. Jan 2011
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
3 programs
1
LY2216684PHASE_11 trial
LY2216684PHASE_11 trial
duloxetinePHASE_31 trial
Active Trials
NCT01389765Completed24Est. Aug 2011
NCT01389752Completed22Est. Sep 2011
NCT00191685Completed200Est. Sep 2005
Takeda
TakedaTOKYO, Japan
3 programs
1
ACTOPLUS MET(Pioglitazone)PHASE_21 trial
VortioxetinePHASE_21 trial
VortioxetinePHASE_31 trial
Active Trials
NCT00671515Completed23Est. Nov 2011
NCT02919501Completed55Est. Apr 2017
NCT01153009Completed614Est. Mar 2012
Alliance Pharmaceuticals
1 program
1
EstrogenPhase 41 trial
Active Trials
NCT00229450Completed17Est. Aug 2004
Genome & Company
Genome & CompanyKorea - Suwon
1 program
1
GeneSight PsychotropicPhase 41 trial
Active Trials
NCT02466477Completed542Est. Sep 2019
Innovation Pharmaceuticals
1 program
1
GeneSight PsychotropicPhase 4
AbbVie
AbbVieNORTH CHICAGO, IL
12 programs
2
10
RapastinelPhase 31 trial
RapastinelPhase 31 trial
RapastinelPhase 31 trial
RapastinelPhase 31 trial
RapastinelPhase 31 trial
+7 more programs
Active Trials
NCT03352453Terminated138Est. Jun 2019
NCT02116361Completed258Est. Dec 2016
NCT03675776Terminated50Est. Jul 2019
+9 more trials
Lundbeck
LundbeckDenmark - Copenhagen
7 programs
1
4
VortioxetinePhase 31 trial
VortioxetinePhase 31 trial
Vortioxetine 10 mg/dayPhase 3
Vortioxetine 10 mg/dayPhase 3
VortioxetinePhase 2
+2 more programs
Active Trials
NCT02871297Terminated662Est. Apr 2022
NCT03108625Completed94Est. Apr 2020
Sunshine Biopharma
Sunshine BiopharmaQC - Varennes
1 program
1
Mitizodone Phosphate tabletsPhase 2/31 trial
Active Trials
NCT04984512Unknown600Est. May 2024
Syndeio Biosciences
1
AGN-241751Phase 21 trial
Active Trials
NCT03586427Completed251Est. Aug 2019
Syneos Health
Syneos HealthNC - Morrisville
1 program
1
REL-1017Phase 2
GSK
GSKLONDON, United Kingdom
15 programs
BupropionN/A1 trial
MAN/A1 trial
Ropinirole CRN/A1 trial
Bupropion HCl XL tablet 150mgPHASE_11 trial
GSK163090PHASE_11 trial
+10 more programs
Active Trials
NCT02039960Completed1Est. Jan 2014
NCT02752178Completed393Est. Sep 2018
NCT00285727Completed60Est. Oct 2007
+13 more trials
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
10 programs
BI 1358894PHASE_11 trial
BI 1569912PHASE_11 trial
BI 1358894PHASE_21 trial
BI 1358894PHASE_21 trial
BI 1569912PHASE_21 trial
+5 more programs
Active Trials
NCT03854578Completed73Est. Sep 2019
NCT04937829Completed59Est. Nov 2023
NCT04423757Terminated45Est. May 2022
+7 more trials
Abbott
AbbottABBOTT PARK, IL
2 programs
Deep Brain StimulationN/A1 trial
Deep Brain Stimulation, Libra Deep Brain Stimulation SystemN/A1 trial
Active Trials
NCT01331330Completed9Est. Jan 2015
NCT00617162Terminated125Est. Jun 2015
Otsuka
OtsukaJapan - Tokushima
2 programs
Outcomes in MEasurement-Based TreatmentN/A1 trial
The Effect of Patient Cost-Sharing on Antidepressant and Adjunctive Therapy UseN/A1 trial
Active Trials
NCT01141387Completed914Est. Aug 2010
NCT01141400Completed48,865Est. Oct 2010
Biogen
BiogenCAMBRIDGE, MA
2 programs
SAGE-217PHASE_31 trial
SAGE-217PHASE_31 trial
Active Trials
NCT04476030Completed440Est. Dec 2021
NCT04442490Completed543Est. Apr 2021
Electromedical Products International
Active Alpha-Stim CESN/A1 trial
Active Trials
NCT04963907Unknown230Est. Dec 2022
Neurotech Pharmaceuticals
1 program
Active Cervel Neurotech Multi-Coil Transcranial Magnetic StimulatorN/A1 trial
Active Trials
NCT01909232Completed92Est. Jul 2014
Q Therapeutics
Q TherapeuticsUT - Salt Lake City
1 program
L-dopa/CarbidopaN/A1 trial
Active Trials
NCT05909267RecruitingEst. Oct 2025
Biocorp
BiocorpFrance - Issoire
1 program
LF/Erinacine A-enriched Hericium/Plain chocolate + antidepressantN/A1 trial
Active Trials
NCT04179006Unknown120Est. Dec 2023
Magstim
MagstimUK - Carmarthenshire
1 program
Navigated Transcranial Magnetic StimulationN/A1 trial
Active Trials
NCT03795051Completed30Est. Sep 2019
NeuroQore
NeuroQoreCA - Mountain View
1 program
NeuroQore rTMS DeviceN/A1 trial
Active Trials
NCT02667041Completed20Est. Mar 2018
Verona Pharma
Verona PharmaUK - London
1 program
Psychoeducational Family InterventionN/A1 trial
Active Trials
NCT05988333Recruiting384Est. Sep 2026
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
RESPECT-DN/A1 trial
Active Trials
NCT01583400Completed131Est. Oct 2013
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
SSRIsN/A1 trial
Active Trials
NCT02023567Unknown2,400Est. Dec 2016
Integrated Biosciences
Integrated BiosciencesCA - San Carlos
1 program
Treatment Package for First-Episode DepressionN/A1 trial
Active Trials
NCT05616559Recruiting800Est. Dec 2026
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
Valence-Specific Ecological Momentary InterventionN/A1 trial
Active Trials
NCT06311136Recruiting200Est. Aug 2025

+3 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Genome & CompanyGeneSight Psychotropic
GSKBupropion extended release
PfizerDVS SR
PfizerDVS SR
Boehringer IngelheimDuloxetine
PfizerVenlafaxine ER
GSKBupropion Hydrochloride Extended-release
Pfizersertraline
Alliance PharmaceuticalsEstrogen
PfizerVenlafaxine ER
BiogenSAGE-217
BiogenSAGE-217
AbbVieRapastinel
AbbVieRapastinel
AbbVieRapastinel

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 17,691 patients across 50 trials

NCT02466477Genome & CompanyGeneSight Psychotropic

Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder

Start: Jun 2015Est. completion: Sep 2019542 patients
Phase 4Completed
NCT01477931GSKBupropion extended release

Interventional Study of Wellbutrin XL in Major Depressive Disorder With Atypical Features

Start: Nov 2010Est. completion: Sep 201150 patients
Phase 4Completed

Open-Label Drug Interaction Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) 100mg On The Pharmacokinetics Of Tamoxifen When Coadministered To Healthy Post-Menopausal Female Subjects

Start: Aug 2010Est. completion: Oct 201030 patients
Phase 4Completed

Open Label Drug Interaction Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) 100mg On The Pharmacokinetics Of Aripiprazole When Coadministered To Healthy Subjects

Start: Aug 2010Est. completion: Oct 201038 patients
Phase 4Completed

Study to Assess Clinical Response of Duloxetine in Patients Hospitalized for Severe Depression

Start: Feb 2007Est. completion: Aug 2008339 patients
Phase 4Completed
NCT00401726PfizerVenlafaxine ER

Open-Label, Randomized Study Evaluating Treatment With Venlafaxine Extended-Release Plus Dialogues Time to Talk Program

Start: Jun 2006Est. completion: Oct 2007537 patients
Phase 4Completed
NCT00316160GSKBupropion Hydrochloride Extended-release

Sexual Functioning Study With Antidepressants

Start: Sep 2004Est. completion: May 2005347 patients
Phase 4Completed

A Comparison of Sertraline Versus Venlafaxine XR in the Treatment of Major Depression

Start: Oct 2002Est. completion: Sep 2003163 patients
Phase 4Completed

Estrogen and Perimenopausal Depression

Start: Apr 2002Est. completion: Aug 200417 patients
Phase 4Completed
NCT00046020PfizerVenlafaxine ER

Study Evaluating Venlafaxine ER in Recurrent Depression

Start: Aug 2000Est. completion: Oct 20051,096 patients
Phase 4Completed

A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive Disorder

Start: Nov 2020Est. completion: Dec 2021440 patients
Phase 3Completed

A Study to Evaluate the Efficacy of Sage-217 in the Treatment of Adult Participants With Major Depressive Disorder (MDD)

Start: May 2020Est. completion: Apr 2021543 patients
Phase 3Completed

Study of Rapastinel as Monotherapy in Major Depressive Disorder (MDD)

Start: Jul 2019Est. completion: Dec 20200
Phase 3Withdrawn

Study of Rapastinel as Monotherapy in Patients With Major Depressive Disorder (MDD)

Start: Oct 2018Est. completion: Jul 201950 patients
Phase 3Terminated

Study of Adjunctive or Monotherapy Rapastinel Treatment in Patients With Major Depressive Disorder (MDD)

Start: Aug 2018Est. completion: Jul 2019230 patients
Phase 3Terminated

Study of Monotherapy Rapastinel in the Prevention of Relapse in Patients With Major Depressive Disorder (MDD)

Start: Aug 2018Est. completion: Jul 2019363 patients
Phase 3Terminated

Study of Rapastinel as Monotherapy in Patients With MDD

Start: Jun 2018Est. completion: Jul 2019439 patients
Phase 3Terminated

Continuation With Vortioxetine in Child and Adolescent Patients With Major Depressive Disorder (MDD) From 7 to 17 Years of Age

Start: Mar 2017Est. completion: Apr 202094 patients
Phase 3Completed

Long-term Safety Study of Rapastinel as Adjunctive Therapy in Patients With Major Depressive Disorder

Start: Feb 2017Est. completion: Dec 2018617 patients
Phase 3Completed

A Study of Rapastinel as Adjunctive Therapy in the Prevention of Relapse in Patients With Major Depressive Disorder

Start: Nov 2016Est. completion: Feb 20191,304 patients
Phase 3Completed

A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-03)

Start: Nov 2016Est. completion: Nov 2018429 patients
Phase 3Completed

A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-02)

Start: Nov 2016Est. completion: Dec 2018658 patients
Phase 3Completed

A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-01)

Start: Oct 2016Est. completion: Nov 2018465 patients
Phase 3Completed

Long-term, Open-label, Flexible-dose, Extension Study of Vortioxetine in Child and Adolescent Participants With Major Depressive Disorder (MDD) From 7 to 18 Years of Age

Start: Aug 2016Est. completion: Apr 2022662 patients
Phase 3Terminated
NCT01153009TakedaVortioxetine

Safety and Efficacy of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder

Start: Jun 2010Est. completion: Mar 2012614 patients
Phase 3Completed

Paroxetine-referenced Study Evaluating Three Doses of DVS SR in Outpatients With MDD

Start: Jul 2007Est. completion: Feb 2009807 patients
Phase 3Completed
NCT00368303GSKParoxetine CR

A Local Register Study For Major Depression Of Paroxetine Controlled Release

Start: Dec 2006362 patients
Phase 3Completed

Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) vs. Escitalopram in Postmenopausal Women

Start: Dec 2006Est. completion: Oct 2008595 patients
Phase 3Completed

Study Evaluating the Effects of DVS SR and Duloxetine on the Pharmacokinetics of Desipramine in Healthy Subjects

Start: Sep 2006Est. completion: Sep 200620 patients
Phase 3Completed

Study Evaluating the Long-Term Safety of Desvenlafaxine Succinate Sustained-Release (DVS SR) in Subjects With Pain Associated With Diabetic Peripheral Neuropathy

Start: Jul 2006Est. completion: Jan 2009237 patients
Phase 3Terminated

Study of the Safety and Efficacy of Desvenlafaxine Succinate for Vasomotor Symptoms in Postmenopausal Women

Start: Jun 2006Est. completion: Feb 2007450 patients
Phase 3Completed

Study Evaluating the Effects of DVS SR and Paroxetine on the Pharmacokinetics of Desipramine in Healthy Subjects

Start: May 2006Est. completion: Jun 200620 patients
Phase 3Completed

A United States Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depression

Start: May 2005Est. completion: Nov 200687 patients
Phase 3Completed

Study to Evaluate the Efficacy of Duloxetine in Outpatients With Major Depressive Disorder and Pain

Start: May 2005327 patients
Phase 3Completed
NCT00191919Boehringer IngelheimDuloxetine Hydrochloride

A Randomized Double Blind Study Evaluating Duloxetine in Outpatients With MDD and Pain

Start: May 2005Est. completion: May 2006310 patients
Phase 3Completed

Duloxetine Versus Placebo in the Prevention of Recurrence of Major Depressive Disorder

Start: Mar 2005Est. completion: Jan 2008514 patients
Phase 3Completed
NCT00093288GSKbupropion XL

Major Depressive Disorder In The Elderly

Start: Jun 2004Est. completion: Oct 2005364 patients
Phase 3Completed

Duloxetine in the Treatment of Melancholic Depression

Start: May 2004Est. completion: Sep 2005200 patients
Phase 3Completed
NCT00067444GSKParoxetine CR

Depression Study In Elderly Patients

Start: Jun 2003Est. completion: Jan 2005560 patients
Phase 3Completed

Study Evaluating DVS SR in Patients With Fibromyalgia Syndrome

Est. completion: Jun 2007600 patients
Phase 2/3Completed
NCT04984512Sunshine BiopharmaMitizodone Phosphate tablets

The Efficacy And Safety Of Mitizodone Phosphate Tablets In The Treatment of Patient With Major Depressive Disorder

Start: Nov 2021Est. completion: May 2024600 patients
Phase 2/3Unknown

A Study to Test Different Doses of BI 1569912 in People With Depression

Start: Oct 2024Est. completion: May 2025224 patients
Phase 2Completed

A Study to Test Different Doses of BI 1569912 in People With Depression Who Take Anti-depressive Medicine

Start: Mar 2024Est. completion: Mar 2025243 patients
Phase 2Completed

A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of Suicide

Start: Dec 2020Est. completion: Jul 2023164 patients
Phase 2Completed

A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression

Start: Nov 2020Est. completion: Feb 2024389 patients
Phase 2Completed

A Home-based Study Using Mobile Technology to Test Whether BI 1358894 is Effective in People With Depression

Start: Jun 2020Est. completion: May 202245 patients
Phase 2Terminated

Zelquistinel in the Treatment of Major Depressive Disorder

Start: Jun 2018Est. completion: Aug 2019251 patients
Phase 2Completed

Safety, Tolerability, PK Profile, and Symptom Response of a 7-Day Dosing With 25 mg or 50 mg Daily of REL-1017 in MDD

Start: May 2018Est. completion: Sep 201962 patients
Phase 2Completed

A Study of Rapastinel for Rapid Treatment of Depression and Suicidality in Major Depressive Disorder

Start: Dec 2017Est. completion: Jun 2019138 patients
Phase 2Terminated
NCT02919501TakedaVortioxetine

Study of the Efficacy and Safety of Initial Administration of 17 mg Vortioxetine Intravenously With 10 mg/Day Vortioxetine Orally in Patients With Major Depressive Disorder

Start: Sep 2016Est. completion: Apr 201755 patients
Phase 2Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

25 late-stage (Phase 3) programs, potential near-term approvals
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.