Depressive Disorder, Major
Pipeline by Development Stage
Drug Modality Breakdown
On Market (6)
Approved therapies currently available
Competitive Landscape
33 companies ranked by most advanced pipeline stage
+3 more companies
Trial Timeline
Clinical trial activity over time
Showing 15 of 50 trials with date data
Clinical Trials (50)
Total enrollment: 17,691 patients across 50 trials
Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder
Interventional Study of Wellbutrin XL in Major Depressive Disorder With Atypical Features
Open-Label Drug Interaction Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) 100mg On The Pharmacokinetics Of Tamoxifen When Coadministered To Healthy Post-Menopausal Female Subjects
Open Label Drug Interaction Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) 100mg On The Pharmacokinetics Of Aripiprazole When Coadministered To Healthy Subjects
Study to Assess Clinical Response of Duloxetine in Patients Hospitalized for Severe Depression
Open-Label, Randomized Study Evaluating Treatment With Venlafaxine Extended-Release Plus Dialogues Time to Talk Program
Sexual Functioning Study With Antidepressants
A Comparison of Sertraline Versus Venlafaxine XR in the Treatment of Major Depression
Estrogen and Perimenopausal Depression
Study Evaluating Venlafaxine ER in Recurrent Depression
A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive Disorder
A Study to Evaluate the Efficacy of Sage-217 in the Treatment of Adult Participants With Major Depressive Disorder (MDD)
Study of Rapastinel as Monotherapy in Major Depressive Disorder (MDD)
Study of Rapastinel as Monotherapy in Patients With Major Depressive Disorder (MDD)
Study of Adjunctive or Monotherapy Rapastinel Treatment in Patients With Major Depressive Disorder (MDD)
Study of Monotherapy Rapastinel in the Prevention of Relapse in Patients With Major Depressive Disorder (MDD)
Study of Rapastinel as Monotherapy in Patients With MDD
Continuation With Vortioxetine in Child and Adolescent Patients With Major Depressive Disorder (MDD) From 7 to 17 Years of Age
Long-term Safety Study of Rapastinel as Adjunctive Therapy in Patients With Major Depressive Disorder
A Study of Rapastinel as Adjunctive Therapy in the Prevention of Relapse in Patients With Major Depressive Disorder
A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-03)
A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-02)
A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-01)
Long-term, Open-label, Flexible-dose, Extension Study of Vortioxetine in Child and Adolescent Participants With Major Depressive Disorder (MDD) From 7 to 18 Years of Age
Safety and Efficacy of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder
Paroxetine-referenced Study Evaluating Three Doses of DVS SR in Outpatients With MDD
A Local Register Study For Major Depression Of Paroxetine Controlled Release
Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) vs. Escitalopram in Postmenopausal Women
Study Evaluating the Effects of DVS SR and Duloxetine on the Pharmacokinetics of Desipramine in Healthy Subjects
Study Evaluating the Long-Term Safety of Desvenlafaxine Succinate Sustained-Release (DVS SR) in Subjects With Pain Associated With Diabetic Peripheral Neuropathy
Study of the Safety and Efficacy of Desvenlafaxine Succinate for Vasomotor Symptoms in Postmenopausal Women
Study Evaluating the Effects of DVS SR and Paroxetine on the Pharmacokinetics of Desipramine in Healthy Subjects
A United States Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depression
Study to Evaluate the Efficacy of Duloxetine in Outpatients With Major Depressive Disorder and Pain
A Randomized Double Blind Study Evaluating Duloxetine in Outpatients With MDD and Pain
Duloxetine Versus Placebo in the Prevention of Recurrence of Major Depressive Disorder
Major Depressive Disorder In The Elderly
Duloxetine in the Treatment of Melancholic Depression
Depression Study In Elderly Patients
Study Evaluating DVS SR in Patients With Fibromyalgia Syndrome
The Efficacy And Safety Of Mitizodone Phosphate Tablets In The Treatment of Patient With Major Depressive Disorder
A Study to Test Different Doses of BI 1569912 in People With Depression
A Study to Test Different Doses of BI 1569912 in People With Depression Who Take Anti-depressive Medicine
A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of Suicide
A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression
A Home-based Study Using Mobile Technology to Test Whether BI 1358894 is Effective in People With Depression
Zelquistinel in the Treatment of Major Depressive Disorder
Safety, Tolerability, PK Profile, and Symptom Response of a 7-Day Dosing With 25 mg or 50 mg Daily of REL-1017 in MDD
A Study of Rapastinel for Rapid Treatment of Depression and Suicidality in Major Depressive Disorder
Study of the Efficacy and Safety of Initial Administration of 17 mg Vortioxetine Intravenously With 10 mg/Day Vortioxetine Orally in Patients With Major Depressive Disorder
Phase Legend
Key Insights
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