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Depressive Disorder, Major

72
Pipeline Programs
30
Companies
50
Clinical Trials
1 recruiting
4
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
8
0
19
2
25
18
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
1100%
+ 125 programs with unclassified modality

On Market (4)

Approved therapies currently available

Takeda
TRINTELLIXApproved
vortioxetine
Takeda
oral2013
390M Part D
Takeda
ACTOPLUS METApproved
pioglitazone and metformin hydrochloride
Takeda
oral2005
131K Part D
Takeda
VORTIOXETINEApproved
vortioxetine
Takeda
oral
Takeda
VORTIOXETINE HYDROBROMIDEApproved
vortioxetine
Takeda

Competitive Landscape

34 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
21 programs
2
9
5
2
Bupropion Hydrochloride Extended-releasePhase 4
Bupropion extended releasePhase 4
323U66 SR 150 mg tabletPhase 3
BupropionPhase 3
Paroxetine CRPhase 3
+16 more programs
Prevail Therapeutics
6
1
1
5
2
DuloxetinePhase 41 trial
sertralinePhase 41 trial
BrenipatidePhase 3Peptide1 trial
DuloxetinePhase 31 trial
Duloxetine HydrochloridePhase 31 trial
+10 more programs
Active Trials
NCT01241435Completed36Est. Apr 2011
NCT01389765Completed24Est. Aug 2011
NCT01389752Completed22Est. Sep 2011
+12 more trials
Pfizer
PfizerNEW YORK, NY
9 programs
3
1
4
Venlafaxine ERPhase 41 trial
Venlafaxine ERPhase 41 trial
sertralinePhase 4
sertralinePhase 4
DVS SRPhase 35 trials
+4 more programs
Active Trials
NCT00406952Completed165Est. Aug 2007
NCT00163059Completed30Est. Dec 2005
NCT00275197Completed262Est. Jul 2007
+7 more trials
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
3 programs
2
EstrogenPhase 41 trial
sertralinePhase 4
Study of Genetic Differences in People With DepressionN/A1 trial
Active Trials
NCT00229463Completed200Est. Jan 2011
NCT00229450Completed17Est. Aug 2004
Takeda
TakedaTOKYO, Japan
3 programs
1
ACTOPLUS MET(Pioglitazone)PHASE_25 trials
VortioxetinePHASE_2
VortioxetinePHASE_31 trial
Active Trials
NCT02098733Completed1,168Est. May 2014
NCT02098746Completed294Est. Jul 2014
NCT02024971Completed1,103Est. Nov 2013
+3 more trials
Viatris
ViatrisCANONSBURG, PA
2 programs
1
1
sertralinePhase 41 trial
sertraline/[S,S]-reboxetinePhase 21 trial
Active Trials
NCT00636246Completed510Est. Aug 2005
NCT00644982Completed163Est. Sep 2003
Alliance Pharmaceuticals
1 program
1
EstrogenPhase 4
Genome & Company
Genome & CompanyKorea - Suwon
1 program
1
GeneSight PsychotropicPhase 41 trial
Active Trials
NCT02466477Completed542Est. Sep 2019
Innovation Pharmaceuticals
1 program
1
GeneSight PsychotropicPhase 4
AbbVie
AbbVieNORTH CHICAGO, IL
12 programs
2
10
RapastinelPhase 31 trial
RapastinelPhase 31 trial
RapastinelPhase 31 trial
RapastinelPhase 31 trial
RapastinelPhase 31 trial
+7 more programs
Active Trials
NCT03352453Terminated138Est. Jun 2019
NCT02116361Completed258Est. Dec 2016
NCT03002077Completed617Est. Dec 2018
+9 more trials
Lundbeck
LundbeckDenmark - Copenhagen
7 programs
1
4
VortioxetinePhase 31 trial
VortioxetinePhase 31 trial
Vortioxetine 10 mg/dayPhase 31 trial
Vortioxetine 10 mg/dayPhase 31 trial
VortioxetinePhase 21 trial
+2 more programs
Active Trials
NCT07775261Recruiting46Est. Nov 2026
NCT02752178Completed393Est. Sep 2018
NCT05616559Recruiting800Est. Dec 2026
+5 more trials
Sunshine Biopharma
Sunshine BiopharmaQC - Varennes
1 program
1
Mitizodone Phosphate tabletsPhase 2/31 trial
Active Trials
NCT04984512Recruiting600Est. Nov 2027
Syndeio Biosciences
1
AGN-241751Phase 21 trial
Active Trials
NCT03586427Completed251Est. Aug 2019
Syneos Health
Syneos HealthNC - Morrisville
1 program
1
REL-1017Phase 21 trial
Active Trials
NCT03051256Completed62Est. Sep 2019
GSK
GSKLONDON, United Kingdom
15 programs
BupropionN/A1 trial
MAN/A
Ropinirole CRN/A1 trial
Bupropion HCl XL tablet 150mgPHASE_11 trial
GSK163090PHASE_11 trial
+10 more programs
Active Trials
NCT02039960Completed1Est. Jan 2014
NCT00285727Completed60Est. Oct 2007
NCT02698553Completed16Est. Jun 2016
+12 more trials
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
10 programs
BI 1358894PHASE_11 trial
BI 1569912PHASE_11 trial
BI 1358894PHASE_21 trial
BI 1358894PHASE_21 trial
BI 1569912PHASE_21 trial
+5 more programs
Active Trials
NCT03854578Completed73Est. Sep 2019
NCT04937829Completed59Est. Nov 2023
NCT04423757Terminated45Est. May 2022
+5 more trials
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
3 programs
LY2216684PHASE_1
LY2216684PHASE_1
duloxetinePHASE_3
Abbott
AbbottABBOTT PARK, IL
2 programs
Deep Brain StimulationN/A1 trial
Deep Brain Stimulation, Libra Deep Brain Stimulation SystemN/A1 trial
Active Trials
NCT01331330Completed9Est. Jan 2015
NCT00617162Terminated125Est. Jun 2015
Otsuka
OtsukaJapan - Tokushima
2 programs
Outcomes in MEasurement-Based TreatmentN/A1 trial
The Effect of Patient Cost-Sharing on Antidepressant and Adjunctive Therapy UseN/A1 trial
Active Trials
NCT01141387Completed914Est. Aug 2010
NCT01141400Completed48,865Est. Oct 2010
Biogen
BiogenCAMBRIDGE, MA
2 programs
SAGE-217PHASE_31 trial
SAGE-217PHASE_31 trial
Active Trials
NCT04442490Completed543Est. Apr 2021
NCT04476030Completed440Est. Dec 2021
Electromedical Products International
Active Alpha-Stim CESN/A1 trial
Active Trials
NCT04963907Unknown230Est. Dec 2022
Neurotech Pharmaceuticals
1 program
Active Cervel Neurotech Multi-Coil Transcranial Magnetic StimulatorN/A1 trial
Active Trials
NCT01909232Completed92Est. Jul 2014
Q Therapeutics
Q TherapeuticsUT - Salt Lake City
1 program
L-dopa/CarbidopaN/A1 trial
Active Trials
NCT05909267RecruitingEst. Oct 2025
Biocorp
BiocorpFrance - Issoire
1 program
LF/Erinacine A-enriched Hericium/Plain chocolate + antidepressantN/A1 trial
Active Trials
NCT04179006Unknown120Est. Dec 2023
Magstim
1 program
Navigated Transcranial Magnetic StimulationN/A1 trial
Active Trials
NCT03795051Completed30Est. Sep 2019
NeuroQore
NeuroQoreCA - Mountain View
1 program
NeuroQore rTMS DeviceN/A1 trial
Active Trials
NCT02667041Completed20Est. Mar 2018
Verona Pharma
Verona PharmaUK - London
1 program
Psychoeducational Family InterventionN/A1 trial
Active Trials
NCT05988333Unknown384Est. Sep 2026
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
RESPECT-DN/A1 trial
Active Trials
NCT01583400Completed131Est. Oct 2013
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
SSRIsN/A1 trial
Active Trials
NCT02023567Unknown2,400Est. Dec 2016
Integrated Biosciences
Integrated BiosciencesCA - San Carlos
1 program
Treatment Package for First-Episode DepressionN/A

+4 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Genome & CompanyGeneSight Psychotropic
GSKBupropion extended release
PfizerDVS SR
PfizerDVS SR
TakedaPioglitazone
TakedaPioglitazone
Prevail TherapeuticsDuloxetine
TakedaPioglitazone
Boehringer IngelheimDuloxetine
TakedaPioglitazone
PfizerVenlafaxine ER
GSKBupropion Hydrochloride Extended-release
Prevail Therapeuticssertraline
TakedaPioglitazone
TakedaPioglitazone

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 20,243 patients across 50 trials

NCT02466477Genome & CompanyGeneSight Psychotropic

Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder

Start: Jun 2015Est. completion: Sep 2019542 patients
Phase 4Completed
NCT01477931GSKBupropion extended release

Interventional Study of Wellbutrin XL in Major Depressive Disorder With Atypical Features

Start: Nov 2010Est. completion: Sep 201150 patients
Phase 4Completed

Open Label Drug Interaction Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) 100mg On The Pharmacokinetics Of Aripiprazole When Coadministered To Healthy Subjects

Start: Aug 2010Est. completion: Oct 201038 patients
Phase 4Completed

Open-Label Drug Interaction Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) 100mg On The Pharmacokinetics Of Tamoxifen When Coadministered To Healthy Post-Menopausal Female Subjects

Start: Aug 2010Est. completion: Oct 201030 patients
Phase 4Completed
NCT00770835TakedaPioglitazone

Efficacy and Safety of Pioglitazone in Treating Subjects With Vascular Complications Associated With Type 2 Diabetes Mellitus.

Start: Mar 2009Est. completion: May 201139 patients
Phase 4Completed
NCT00835120TakedaPioglitazone

Pioglitazone for the Treatment of Bipolar Disorder and Comorbid Metabolic Syndrome or Insulin Resistance

Start: Mar 2009Est. completion: Apr 201334 patients
Phase 4Completed

Switching to Duloxetine in Patients With Depression

Start: Jun 2008Est. completion: Jul 2009242 patients
Phase 4Completed
NCT00770445TakedaPioglitazone

Efficacy of Pioglitazone and Metformin on Cardiovascular Risk in Subjects With Insulin-Treated Type 2 Diabetes Mellitus.

Start: May 2008Est. completion: Jul 2010121 patients
Phase 4Completed

Study to Assess Clinical Response of Duloxetine in Patients Hospitalized for Severe Depression

Start: Feb 2007Est. completion: Aug 2008339 patients
Phase 4Completed
NCT01588470TakedaPioglitazone

Myocardial Dysfunction in Type 2 Diabetes Mellitus (T2DM)

Start: Jun 2006Est. completion: Dec 2011130 patients
Phase 4Completed
NCT00401726PfizerVenlafaxine ER

Open-Label, Randomized Study Evaluating Treatment With Venlafaxine Extended-Release Plus Dialogues Time to Talk Program

Start: Jun 2006Est. completion: Oct 2007537 patients
Phase 4Completed
NCT00316160GSKBupropion Hydrochloride Extended-release

Sexual Functioning Study With Antidepressants

Start: Sep 2004Est. completion: May 2005347 patients
Phase 4Completed

Study of Medication and Placebo Response in Major Depression

Start: Dec 200360 patients
Phase 4Completed
NCT00672919TakedaPioglitazone

Pioglitazone Study of Triglyceride Changes in Subjects With Type 2 Diabetes After Conversion From Rosiglitazone.

Start: Nov 2003Est. completion: Aug 2004305 patients
Phase 4Completed
NCT00816218TakedaPioglitazone

Molecular Mechanisms of Type 2 Diabetes Mellitus

Start: Mar 2003Est. completion: Nov 200839 patients
Phase 4Completed

A Comparison of Sertraline Versus Venlafaxine XR in the Treatment of Major Depression

Start: Oct 2002Est. completion: Sep 2003163 patients
Phase 4Completed

Estrogen and Perimenopausal Depression

Start: Apr 2002Est. completion: Aug 200417 patients
Phase 4Completed
NCT00494312TakedaPioglitazone

Safety Study of Pioglitazone Compared To Glyburide on Liver Function

Start: Oct 2000Est. completion: Jun 20052,120 patients
Phase 4Completed
NCT00046020PfizerVenlafaxine ER

Study Evaluating Venlafaxine ER in Recurrent Depression

Start: Aug 2000Est. completion: Oct 20051,096 patients
Phase 4Completed

A Study of Brenipatide in Adult Participants With Major Depressive Disorder

Start: Feb 2026Est. completion: Feb 20281,000 patients
Phase 3Recruiting

A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive Disorder

Start: Nov 2020Est. completion: Dec 2021440 patients
Phase 3Completed

A Study to Evaluate the Efficacy of Sage-217 in the Treatment of Adult Participants With Major Depressive Disorder (MDD)

Start: May 2020Est. completion: Apr 2021543 patients
Phase 3Completed

Study of Rapastinel as Monotherapy in Major Depressive Disorder (MDD)

Start: Jul 2019Est. completion: Dec 20200
Phase 3Withdrawn

Study of Rapastinel as Monotherapy in Patients With Major Depressive Disorder (MDD)

Start: Oct 2018Est. completion: Jul 201950 patients
Phase 3Terminated

Study of Adjunctive or Monotherapy Rapastinel Treatment in Patients With Major Depressive Disorder (MDD)

Start: Aug 2018Est. completion: Jul 2019230 patients
Phase 3Terminated

Study of Monotherapy Rapastinel in the Prevention of Relapse in Patients With Major Depressive Disorder (MDD)

Start: Aug 2018Est. completion: Jul 2019363 patients
Phase 3Terminated

Study of Rapastinel as Monotherapy in Patients With MDD

Start: Jun 2018Est. completion: Jul 2019439 patients
Phase 3Terminated

Continuation With Vortioxetine in Child and Adolescent Patients With Major Depressive Disorder (MDD) From 7 to 17 Years of Age

Start: Mar 2017Est. completion: Apr 202094 patients
Phase 3Completed

Long-term Safety Study of Rapastinel as Adjunctive Therapy in Patients With Major Depressive Disorder

Start: Feb 2017Est. completion: Dec 2018617 patients
Phase 3Completed

A Study of Rapastinel as Adjunctive Therapy in the Prevention of Relapse in Patients With Major Depressive Disorder

Start: Nov 2016Est. completion: Feb 20191,304 patients
Phase 3Completed

A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-03)

Start: Nov 2016Est. completion: Nov 2018429 patients
Phase 3Completed

A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-02)

Start: Nov 2016Est. completion: Dec 2018658 patients
Phase 3Completed

A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-01)

Start: Oct 2016Est. completion: Nov 2018465 patients
Phase 3Completed

Long-term, Open-label, Flexible-dose, Extension Study of Vortioxetine in Child and Adolescent Participants With Major Depressive Disorder (MDD) From 7 to 18 Years of Age

Start: Aug 2016Est. completion: Apr 2022662 patients
Phase 3Terminated
NCT02709655LundbeckVortioxetine 10 mg/day

Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Participants Aged 7 to 11 Years With Major Depressive Disorder (MDD)

Start: May 2016Est. completion: Jan 2022683 patients
Phase 3Completed
NCT02709746LundbeckVortioxetine 10 mg/day

Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Patients Aged 12 to 17 Years With Major Depressive Disorder (MDD)

Start: May 2016Est. completion: Jul 2019784 patients
Phase 3Completed

A Safety Study in Participants With Major Depressive Disorder

Start: Oct 2010Est. completion: Dec 2012608 patients
Phase 3Completed
NCT01153009TakedaVortioxetine

Safety and Efficacy of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder

Start: Jun 2010Est. completion: Mar 2012614 patients
Phase 3Completed
NCT01156597TakedaPioglitazone

Effects of Pioglitazone on High-density Lipoprotein (HDL) Function in Persons With Diabetes

Start: Apr 2008Est. completion: Sep 201030 patients
Phase 3Completed

Paroxetine-referenced Study Evaluating Three Doses of DVS SR in Outpatients With MDD

Start: Jul 2007Est. completion: Feb 2009807 patients
Phase 3Completed
NCT00727857TakedaPioglitazone

Efficacy and Safety of Pioglitazone and Metformin Combination Therapy in Treating Type 2 Diabetes Mellitus.

Start: Jun 2007Est. completion: Aug 2008600 patients
Phase 3Completed
NCT00770653TakedaPioglitazone

Efficacy of Pioglitazone/Metformin Combination Therapy in Subjects With Type 2 Diabetes Mellitus and Dyslipidemia.

Start: Apr 2007Est. completion: May 2009305 patients
Phase 3Completed
NCT00772174TakedaPioglitazone

Efficacy and Safety Study of Pioglitazone Combined With Metformin on Metabolic Syndrome in Subjects With Type 2 Diabetes

Start: Jan 2007Est. completion: Feb 2008418 patients
Phase 3Completed
NCT00770952TakedaPioglitazone

Efficacy of Pioglitazone and Glimepiride Combination Therapy in Treating Subjects With Type 2 Diabetes Mellitus.

Start: Dec 2006Est. completion: Dec 200891 patients
Phase 3Completed
NCT00368303GSKParoxetine CR

A Local Register Study For Major Depression Of Paroxetine Controlled Release

Start: Dec 2006362 patients
Phase 3Completed

Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) vs. Escitalopram in Postmenopausal Women

Start: Dec 2006Est. completion: Oct 2008595 patients
Phase 3Completed

Study Evaluating the Effects of DVS SR and Duloxetine on the Pharmacokinetics of Desipramine in Healthy Subjects

Start: Sep 2006Est. completion: Sep 200620 patients
Phase 3Completed

Study Evaluating the Long-Term Safety of Desvenlafaxine Succinate Sustained-Release (DVS SR) in Subjects With Pain Associated With Diabetic Peripheral Neuropathy

Start: Jul 2006Est. completion: Jan 2009237 patients
Phase 3Terminated

Study of the Safety and Efficacy of Desvenlafaxine Succinate for Vasomotor Symptoms in Postmenopausal Women

Start: Jun 2006Est. completion: Feb 2007450 patients
Phase 3Completed
NCT00376181TakedaPioglitazone

Efficacy, Safety and Tolerability of Pioglitazone-Azilsartan in Subjects With Type 2 Diabetes Mellitus

Start: Jun 2006Est. completion: May 200796 patients
Phase 3Terminated

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

25 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 20,243 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.