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Dentin Sensitivity

7
Pipeline Programs
4
Companies
18
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
3
0
1
3
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
19 programs
3
1
3
Stannous Fluoride DentifricePhase 4
Stannous fluoridePhase 4
stannous fluoridePhase 4
stannous fluoridePhase 3
Dentifrice containing 5% w/w KNO3 and 0.454% w/w SnF2Phase 2
+14 more programs
GSK
GSKLONDON, United Kingdom
15 programs
0.454% Stannous fluorideN/A1 trial
0.454% w/w stannous fluorideN/A1 trial
Dissolvable polymer strip containing NovaminN/A1 trial
Stannous Fluoride dentificeN/A1 trial
Stannous Fluoride dentificeN/A1 trial
+10 more programs
Active Trials
NCT03310268Completed185Est. Feb 2018
NCT02705716Completed409Est. May 2016
NCT02937623Completed126Est. Dec 2016
+12 more trials
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
2 programs
12027-019N/A1 trial
Experimental Mouth Rinse 12027-033N/A1 trial
Active Trials
NCT01133379Completed174Est. Jul 2010
NCT02113579Completed375Est. May 2014
Coordination Pharmaceuticals
1 program
With sonic activationN/A1 trial
Active Trials
NCT03039270Completed31Est. Apr 2016

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GSKStannous fluoride
GSKstannous fluoride
GSKStannous Fluoride Dentifrice
GSKstannous fluoride
GSKDentifrice containing 5% w/w KNO3 and 0.454% w/w SnF2
GSKPotassium nitrate and sodium fluoride
GSK0.454% Stannous fluoride
GSKDissolvable polymer strip containing Novamin
GSKStannous fluoride
GSKStannous fluoride
GSKStannous fluoride
GSKstannous fluoride
GSK0.454% w/w stannous fluoride
GSKStannous Fluoride dentifice
Coordination PharmaceuticalsWith sonic activation

Showing 15 of 18 trials with date data

Clinical Trials (18)

Total enrollment: 3,494 patients across 18 trials

NCT02923895GSKStannous fluoride

To Investigate the Efficacy of an Occluding Dentifrice in Dentinal Hypersensitivity (DH)

Start: Oct 2016Est. completion: Dec 2016197 patients
Phase 4Completed
NCT02731833GSKstannous fluoride

Short Term Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity

Start: Apr 2016Est. completion: May 2016229 patients
Phase 4Completed
NCT02773758GSKStannous Fluoride Dentifrice

Study to Investigate the Efficacy of an Occluding Dentifrice in Providing Relief From Dentine Hypersensitivity

Start: Jan 2016Est. completion: Mar 2016143 patients
Phase 4Completed
NCT02832375GSKstannous fluoride

Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity

Start: Mar 2016Est. completion: May 2016242 patients
Phase 3Completed
NCT03361774GSKDentifrice containing 5% w/w KNO3 and 0.454% w/w SnF2

A Clinical Method Development Study to Characterise The Efficacy of a Dentifrice For The Relief Of Dentin Hypersensitivity

Start: Oct 2018Est. completion: Dec 20180
Phase 2Withdrawn
NCT02226562GSKPotassium nitrate and sodium fluoride

Clinical Study Investigating the Efficacy of a Mouthwash in Providing Long Term Relief From Dentinal Hypersensitivity

Start: Sep 2014Est. completion: Dec 2014191 patients
Phase 2Completed
NCT03310268GSK0.454% Stannous fluoride

A Clinical Study to Evaluate a Stannous Fluoride Toothpaste for the Relief of Dentinal Hypersensitivity

Start: Nov 2017Est. completion: Feb 2018185 patients
N/ACompleted
NCT02937623GSKDissolvable polymer strip containing Novamin

To Evaluate the Efficacy of an Experimental Dissolvable Strip in Rapidly Relieving Dentinal Hypersensitivity (DH)

Start: Nov 2016Est. completion: Dec 2016126 patients
N/ACompleted
NCT02924350GSKStannous fluoride

The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity (DH)

Start: Nov 2016Est. completion: Mar 2017205 patients
N/ACompleted
NCT02861664GSKStannous fluoride

Assessment of the Efficacy of an Experimental Occlusion Technology Dentifrice in Dentinal Hypersensitivity

Start: Sep 2016Est. completion: Dec 2016135 patients
N/ACompleted
NCT02768194GSKStannous fluoride

Dentine Tubule Occlusion Assessment in a Modified in Situ Model

Start: Jul 2016Est. completion: Sep 201626 patients
N/ACompleted
NCT02752958GSKstannous fluoride

Impact of Long Term Management of Dentine Hypersensitivity (DH) With a Daily Use Anti-sensitivity Toothpaste on the Quality of Life Related to Oral Health

Start: May 2016Est. completion: Feb 201775 patients
N/ACompleted
NCT02705716GSK0.454% w/w stannous fluoride

Study Investigating Efficacy of an Occluding Dentifrice for Dentine Hypersensitivity

Start: Mar 2016Est. completion: May 2016409 patients
N/ACompleted
NCT02751450GSKStannous Fluoride dentifice

The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity(DH)

Start: Feb 2016Est. completion: Jun 2016263 patients
N/ACompleted

Evaluation of Sensitivity With and Without Sonic Activation of a Desensitizing Gel Before in Office Bleaching in Adults

Start: Jan 2016Est. completion: Apr 201631 patients
N/ACompleted
NCT02612064GSKStannous Fluoride dentifice

The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity

Start: Nov 2015Est. completion: Jun 2016488 patients
N/ACompleted
NCT02113579Johnson & JohnsonExperimental Mouth Rinse 12027-033

Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity

Start: Mar 2014Est. completion: May 2014375 patients
N/ACompleted

Tooth Sensitivity Relief by Two Mouthrinses

Start: May 2010Est. completion: Jul 2010174 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.