Dental Caries

Pipeline Programs

Companies

Clinical Trials

3 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

18 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

ViiV HealthcareNC - Durham

7 programs

NaFPhase 4

Sodium fluoride / silica and carbopol, 0.5gPhase 4

FluoridePhase 3

Sodium FluoridePhase 3

0.425 % w/w phytate,1150ppm FN/A

+2 more programs

ADvantage TherapeuticsFL - Miami

6 programs

38% diammine silver fluoridePhase 31 trial

silver diamine fluoridePhase 33 trials

Test varnishPhase 22 trials

anti-caries varnishPhase 22 trials

PREDICTN/A

+1 more programs

Active Trials

NCT02327507Unknown21,731Est. Jul 2016

NCT04947527Completed274Est. Aug 2024

NCT03082196Completed284Est. May 2019

+6 more trials

ADELKorea - Seoul

2 programs

SDFPhase 31 trial

Silver Diamine FluoridePhase 3

Active Trials

NCT05188846Unknown50Est. Mar 2023

Enterprise TherapeuticsUK - Brighton

1 program

Fluoride varnishPhase 31 trial

Active Trials

NCT00067353Completed500Est. Aug 2005

Vantage BiosciencesUK - London

2 programs

C16G2 GelPhase 2

C16G2 StripPhase 2

Armata PharmaceuticalsLOS ANGELES, CA

1 program

C16G2Phase 25 trials

Active Trials

NCT03196219Completed20Est. Jan 2018

NCT03052842Completed30Est. Apr 2017

NCT03004365Completed33Est. Mar 2017

+2 more trials

Coordination PharmaceuticalsIL - Chicago

1 program

calcium glycerophosphatePhase 11 trial

Active Trials

NCT00875212Completed12Est. Jul 2008

Oregon TherapeuticsFrance - Paris

7 programs

DPBRN Development of a Patient Based Provider Intervention for Early Caries ManagementN/A1 trial

DPBRN Longitudinal Study of Dental Restorations Placed on Previously Un-restored SurfacesN/A1 trial

DPBRN Longitudinal Study of Questionable Occlusal Caries LesionsN/A1 trial

DPBRN Longitudinal Study of Repaired or Replaced Dental RestorationsN/A1 trial

DPBRN Prevalence of Questionable Occlusal Caries LesionsN/A1 trial

+2 more programs

Active Trials

NCT01309958Completed334Est. Oct 2010

NCT01201408Completed9,291Est. Sep 2011

NCT01309971Completed2,624Est. Dec 2011

+4 more trials

SolventumMN - St. Paul

6 programs

3M ESPE Adper Scotchbond SEN/A1 trial

Adhesive AN/A1 trial

Adper Easy Bond Self-etch dental adhesiveN/A1 trial

Flowable compositeN/A1 trial

Supreme Universal RestorativeN/A1 trial

+1 more programs

Active Trials

NCT00658138Completed61Est. Dec 2011

NCT00643461Completed46Est. Jun 2012

NCT01369134Completed40Est. Feb 2013

+3 more trials

GSKLONDON, United Kingdom

5 programs

0.425 % w/w phytate,1150ppm FN/A1 trial

Fluoride free toothpasteN/A1 trial

Toothpaste containing 1150ppm FN/A1 trial

NaFPHASE_41 trial

Sodium fluoride / silica and carbopol, 0.5gPHASE_41 trial

Active Trials

NCT02751320Completed58Est. Aug 2016

NCT02399163Completed80Est. Aug 2015

NCT02436473Withdrawn0Est. Nov 2016

+2 more trials

Colorado TherapeuticsCO - Louisville

2 programs

GC Strep Mutans Saliva SamplingN/A1 trial

UDMA-K18 smooth surface sealantN/A1 trial

Active Trials

NCT03389373Withdrawn0Est. Jul 2018

NCT03306433Completed16Est. Dec 2018

MottCT - Farmington

1 program

Chemfil ROCK Glassionomer restorationN/A1 trial

Active Trials

NCT01523613Completed93Est. Oct 2014

Innovation PharmaceuticalsMA - Wakefield

1 program

DIMOH: New Digital Methods for Monitoring Oral Health. An in Vivo AssessmentN/A1 trial

Active Trials

NCT04050306Unknown70Est. Dec 2020

T-TherapeuticsUK - Cambridge

1 program

Daily tooth brushing programmeN/A1 trial

Active Trials

NCT06441500RecruitingEst. Dec 2025

Angeles TherapeuticsCA - Los Angeles

1 program

Extended Contact RMGIN/A1 trial

Active Trials

NCT04528134Completed38Est. Jul 2025

Human BioSciencesWV - Martinsburg

1 program

HydrationN/A1 trial

Active Trials

NCT06714929Recruiting7,200Est. May 2028

UNION therapeuticsDenmark - Hellerup

1 program

Mechanical Caries RemovalN/A1 trial

Active Trials

NCT07493278Completed32Est. Feb 2026

Heidelberg PharmaGermany - Ladenburg

1 program

Transbond XTN/A1 trial

Active Trials

NCT03753256Recruiting20Est. Dec 2027

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

2030

2031

GSKNaF

GSKSodium fluoride / silica and carbopol, 0.5g

ADELSDF

ADvantage Therapeutics38% diammine silver fluoride

Enterprise TherapeuticsFluoride varnish

ADvantage Therapeuticssilver diamine fluoride

ADvantage TherapeuticsTest varnish

ADvantage Therapeuticssilver diamine fluoride

Armata PharmaceuticalsC16G2

ADvantage TherapeuticsTest varnish

Armata PharmaceuticalsC16G2

ADvantage Therapeuticsanti-caries varnish

Armata PharmaceuticalsC16G2

Showing 15 of 46 trials with date data

Clinical Trials (46)

Total enrollment: 68,666 patients across 46 trials

NCT01128946 GSKNaF

Enamel Remineralization Potential of Dentifrices in Situ

Start: Nov 2009Est. completion: Mar 201083 patients

Phase 4Completed

NCT01563172 GSKSodium fluoride / silica and carbopol, 0.5g

Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride

Start: Jan 2009Est. completion: Jun 200965 patients

Phase 4Completed

NCT05188846 ADELSDF

Caries Arresting in Primary Molar Teeth Using SDF VS ART

Start: Jan 2022Est. completion: Mar 202350 patients

Phase 3Unknown

NCT02536040 ADvantage Therapeutics38% diammine silver fluoride

Stopping Cavities Study: Diammine Silver Fluoride

Start: Jan 2016Est. completion: Jul 201666 patients

Phase 3Completed

NCT00067353 Enterprise TherapeuticsFluoride varnish

Yakima Head Start Fluoride Varnish Study

Start: Nov 2003Est. completion: Aug 2005500 patients

Phase 3Completed

NCT05670743 ADvantage Therapeuticssilver diamine fluoride

Pharmacokinetics of Advantage Arrest in Healthy Children 13-Months to 13-Years of Age

Start: Mar 2023Est. completion: Aug 202423 patients

Phase 2Completed

NCT04947527 ADvantage TherapeuticsTest varnish

Efficacy and Safety Evaluation of Anti-Caries Varnish

Start: Jun 2022Est. completion: Aug 2024274 patients

Phase 2Completed

NCT04186663 ADvantage Therapeuticssilver diamine fluoride

Pharmacokinetics of Advantage Arrest in Children

Start: Aug 2019Est. completion: Mar 202059 patients

Phase 2Completed

NCT04184271 ADvantage Therapeuticssilver diamine fluoride

Pharmacokinetics of Advantage Arrest

Start: Aug 2017Est. completion: Mar 201916 patients

Phase 2Completed

NCT03196219 Armata PharmaceuticalsC16G2

A Phase 2 Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Varnish and Strip in Adolescent and Adult Subjects

Start: Jul 2017Est. completion: Jan 201820 patients

Phase 2Completed

NCT03082196 ADvantage TherapeuticsTest varnish

Efficacy Of A PVP-I Fluoride Varnish

Start: Mar 2017Est. completion: May 2019284 patients

Phase 2Completed

NCT03052842 Armata PharmaceuticalsC16G2

A Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Dental Strip Application

Start: Feb 2017Est. completion: Apr 201730 patients

Phase 2Completed

NCT03004365 Armata PharmaceuticalsC16G2

A Study to Evaluate the Safety and Microbiology of C16G2 Varnish Administered in Multiple Doses to Dental Subjects

Start: Jan 2017Est. completion: Mar 201733 patients

Phase 2Completed

NCT04183231 ADvantage Therapeuticsanti-caries varnish

Pharmacokinetics of Advantage Anti-Caries Varnish

Start: Nov 2016Est. completion: Apr 201816 patients

Phase 2Completed

NCT02594254 Armata PharmaceuticalsC16G2

Phase 2 Study to Evaluate the Microbiology and Safety of C16G2 Administered to Adult and Adolescent Dental Subjects

Start: Nov 2015Est. completion: Sep 2016135 patients

Phase 2Completed

NCT02509845 Armata PharmaceuticalsC16G2

Study to Evaluate the Safety and Microbiology of C16G2 in Adolescent and Adult Dental Subjects

Start: Jul 2015Est. completion: Mar 201664 patients

Phase 2Completed

NCT02254993 Armata PharmaceuticalsC16G2

Phase 2, Open-Label Study for Safety, Microbiology and PK of Single or Multiple Oral C16G2 Gel Doses

Start: Oct 2014Est. completion: Jul 201552 patients

Phase 2Completed

NCT02044081 Armata PharmaceuticalsC16G2

Phase 2, Safety & Microbiology Study of C16G2 in Multiple Oral Gel &/or Mouth Rinse Doses to Healthy Adults

Start: Feb 2014Est. completion: Aug 201460 patients

Phase 2Completed

NCT02645617 ADvantage Therapeuticsanti-caries varnish

Safety Evaluation of Advantage Anti-Caries Varnish

Start: Mar 2016Est. completion: Oct 201612 patients

Phase 1Completed

NCT00875212 Coordination Pharmaceuticalscalcium glycerophosphate

Effect of Calcium Glycerophosphate (CaGP) - Fluoride Dentifrice on Dental Biofilm pH

Start: Jan 2006Est. completion: Jul 200812 patients

Phase 1Completed

NCT07231237 SolventumVitrebond™ Pulp Protect Liner/Base

Clinical Study Evaluating Solventum™ Vitrebond™ Pulp Protect Liner/Base for Direct Capping of Pulpal Exposure

Start: Jan 2026Est. completion: Feb 2032350 patients

N/ANot Yet Recruiting

NCT07493278 UNION therapeuticsMechanical Caries Removal

Er,Cr:YSGG Laser Versus Conventional Preparation for Minimally Invasive Caries Removal

Start: Oct 2025Est. completion: Feb 202632 patients

N/ACompleted

NCT06714929 Human BioSciencesHydration

Advancing Water Security: A Community Participatory School-Based Hydration Intervention

Start: Aug 2024Est. completion: May 20287,200 patients

N/ARecruiting

NCT06441500 T-TherapeuticsDaily tooth brushing programme

Oral Health and Dental Caries Prevention Intervention for Children in Romania

Start: Jan 2024Est. completion: Dec 2025

N/ARecruiting

NCT04528134 Angeles TherapeuticsExtended Contact RMGI

Orthodontic Varnish Microbiology Study

Start: Feb 2022Est. completion: Jul 202538 patients

N/ACompleted

NCT04050306 Innovation PharmaceuticalsDIMOH: New Digital Methods for Monitoring Oral Health. An in Vivo Assessment

DIMOH: New Digital Methods for Monitoring Oral Health. An in Vivo Assessment

Start: Mar 2019Est. completion: Dec 202070 patients

N/AUnknown

NCT03389373 Colorado TherapeuticsGC Strep Mutans Saliva Sampling

Microbial Testing for Caries Risk Assessment

Start: Feb 2018Est. completion: Jul 20180

N/AWithdrawn

NCT03306433 Colorado TherapeuticsUDMA-K18 smooth surface sealant

Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant

Start: Jan 2018Est. completion: Dec 201816 patients

N/ACompleted

NCT03753256 Heidelberg PharmaTransbond XT

Evaluation of Optical Coherence Tomography in Dentistry

Start: Dec 2017Est. completion: Dec 202720 patients

N/ARecruiting

NCT02889835 SolventumSupreme Universal Restorative

Clinical Performance of Incremental and Bulk Fill Composites in Class II Restorations

Start: Mar 2016Est. completion: Jul 202153 patients

N/ACompleted

NCT02751320 GSK0.425 % w/w phytate,1150ppm F

Efficacy of Three Toothpastes Using an in Situ Caries Model

Start: Feb 2016Est. completion: Aug 201658 patients

N/ACompleted

NCT02436473 GSKToothpaste containing 1150ppm F

Clinical Efficacy of Fluoride Toothpastes Using an In Situ Caries Model

Start: Dec 2015Est. completion: Nov 20160

N/AWithdrawn

NCT02399163 GSKFluoride free toothpaste

Evaluation of Oral Hygiene Products in an In Situ Caries Model

Start: Apr 2015Est. completion: Aug 201580 patients

N/ACompleted

NCT02327507 ADvantage TherapeuticsToothpaste & Telephone Support

Everybody Brush: A Community-wide Toothpaste Distribution Campaign

Start: Jun 2014Est. completion: Jul 201621,731 patients

N/AUnknown

NCT01523613 MottChemfil ROCK Glassionomer restoration

High-strength Glass-ionomer Dental Restorations

Start: Nov 2011Est. completion: Oct 201493 patients

N/ACompleted

NCT01369108 SolventumFlowable composite

Clinical Study on a New Flowable Composite as a Restorative in Adult Teeth

Start: Jan 2011Est. completion: Dec 201360 patients

N/ACompleted

NCT01369134 SolventumAdper Easy Bond Self-etch dental adhesive

Clinical Evaluation of a Self-etch Adhesive Using a Selective Etch Technique

Start: Jan 2011Est. completion: Feb 201340 patients

N/ACompleted

NCT01201395 Oregon TherapeuticsDPBRN Longitudinal Study of Repaired or Replaced Dental Restorations

DPBRN Longitudinal Study of Repaired or Replaced Dental Restorations

Start: Sep 2009Est. completion: Sep 20119,813 patients

N/ACompleted

NCT00658138 Solventum3M ESPE Adper Scotchbond SE

Clinical Evaluation of 3M™ ESPE™ Adper™ Scotchbond™ SE Self-Etch Adhesive in Class I and Class II Restorations in Adults

Start: Dec 2008Est. completion: Dec 201161 patients

N/ACompleted

NCT01201876 Oregon TherapeuticsDPBRN Reasons for Replacement or Repair of Dental Restorations

DPBRN Reasons for Replacement or Repair of Dental Restorations

Start: Nov 2008Est. completion: Mar 20106,368 patients

N/ACompleted

NCT01201447 Oregon TherapeuticsDPBRN Prevalence of Questionable Occlusal Caries Lesions

DPBRN Prevalence of Questionable Occlusal Caries Lesions

Start: Aug 2008Est. completion: Mar 20102,624 patients

N/ACompleted

NCT01309971 Oregon TherapeuticsDPBRN Longitudinal Study of Questionable Occlusal Caries Lesions

DPBRN Longitudinal Study of Questionable Occlusal Caries Lesions

Start: Aug 2008Est. completion: Dec 20112,624 patients

N/ACompleted

NCT01309958 Oregon TherapeuticsDPBRN Development of a Patient Based Provider Intervention for Early Caries Management

DPBRN Development of a Patient Based Provider Intervention for Early Caries Management

Start: Jun 2008Est. completion: Oct 2010334 patients

N/ACompleted

NCT00643461 SolventumAdhesive A

Clinical Evaluation of Three Dental Adhesive Systems in Class V Restorations

Start: Apr 2008Est. completion: Jun 201246 patients

N/ACompleted

NCT01201408 Oregon TherapeuticsDPBRN Longitudinal Study of Dental Restorations Placed on Previously Un-restored Surfaces

DPBRN Longitudinal Study of Dental Restorations Placed on Previously Un-restored Surfaces

Start: Nov 2007Est. completion: Sep 20119,291 patients

N/ACompleted

NCT00847470 Oregon TherapeuticsDPBRN Reasons for Placing the First Restoration on Permanent Tooth Surfaces

DPBRN Reasons for Placing the First Restoration on Permanent Tooth Surfaces

Start: Jun 2006Est. completion: Dec 20085,810 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

7 late-stage (Phase 3) programs, potential near-term approvals

3 actively recruiting trials targeting 68,666 patients

20 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.