Dental Caries

14
Pipeline Programs
5
Companies
17
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
11
0
2
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

5 companies ranked by most advanced pipeline stage

ADvantage Therapeutics
8 programs
1
4
1
38% diammine silver fluoridePhase 31 trial
38% silver diamine fluoridePhase 21 trial
Anti-caries varnishPhase 21 trial
Silver Diamine FluoridePhase 21 trial
Test varnishPhase 21 trial
+3 more programs
Active Trials
NCT02327507UnknownEst. Jul 2016
NCT02645617CompletedEst. Oct 2016
NCT04184271CompletedEst. Mar 2019
+4 more trials
ADEL
ADELKorea - Seoul
1 program
1
SDFPhase 31 trial
Active Trials
NCT05188846UnknownEst. Mar 2023
Armata Pharmaceuticals
Armata PharmaceuticalsLOS ANGELES, CA
7 programs
7
C16G2Phase 21 trial
C16G2Phase 21 trial
C16G2Phase 21 trial
C16G2 GelPhase 21 trial
C16G2 RinsePhase 21 trial
+2 more programs
Active Trials
NCT02509845CompletedEst. Mar 2016
NCT03196219CompletedEst. Jan 2018
NCT02254993CompletedEst. Jul 2015
+4 more trials
T-Therapeutics
T-TherapeuticsUK - Cambridge
1 program
Daily tooth brushing programmeN/A1 trial
Active Trials
NCT06441500RecruitingEst. Dec 2025
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
Transbond XTN/A1 trial
Active Trials
NCT03753256Recruiting20Est. Dec 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
ADELSDF
ADvantage Therapeutics38% diammine silver fluoride
ADvantage TherapeuticsSilver Diamine Fluoride
ADvantage Therapeutics38% silver diamine fluoride
Armata PharmaceuticalsC16G2
ADvantage TherapeuticsTest varnish
Armata PharmaceuticalsC16G2 Strip
Armata PharmaceuticalsC16G2 Varnish
ADvantage TherapeuticsAnti-caries varnish
Armata PharmaceuticalsC16G2 Gel
Armata PharmaceuticalsC16G2
Armata PharmaceuticalsC16G2
Armata PharmaceuticalsC16G2 Rinse
ADvantage TherapeuticsVarnish
T-TherapeuticsDaily tooth brushing programme

Showing 15 of 17 trials with date data

Clinical Trials (17)

Total enrollment: 20 patients across 17 trials

NCT05188846ADELSDF

Caries Arresting in Primary Molar Teeth Using SDF VS ART

Start: Jan 2022Est. completion: Mar 2023
Phase 3Unknown
NCT02536040ADvantage Therapeutics38% diammine silver fluoride

Stopping Cavities Study: Diammine Silver Fluoride

Start: Jan 2016Est. completion: Jul 2016
Phase 3Completed
NCT04186663ADvantage TherapeuticsSilver Diamine Fluoride

Pharmacokinetics of Advantage Arrest in Children

Start: Aug 2019Est. completion: Mar 2020
Phase 2Completed
NCT04184271ADvantage Therapeutics38% silver diamine fluoride

Pharmacokinetics of Advantage Arrest

Start: Aug 2017Est. completion: Mar 2019
Phase 2Completed
NCT03196219Armata PharmaceuticalsC16G2

A Phase 2 Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Varnish and Strip in Adolescent and Adult Subjects

Start: Jul 2017Est. completion: Jan 2018
Phase 2Completed
NCT03082196ADvantage TherapeuticsTest varnish

Efficacy Of A PVP-I Fluoride Varnish

Start: Mar 2017Est. completion: May 2019
Phase 2Completed
NCT03052842Armata PharmaceuticalsC16G2 Strip

A Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Dental Strip Application

Start: Feb 2017Est. completion: Apr 2017
Phase 2Completed
NCT03004365Armata PharmaceuticalsC16G2 Varnish

A Study to Evaluate the Safety and Microbiology of C16G2 Varnish Administered in Multiple Doses to Dental Subjects

Start: Jan 2017Est. completion: Mar 2017
Phase 2Completed
NCT04183231ADvantage TherapeuticsAnti-caries varnish

Pharmacokinetics of Advantage Anti-Caries Varnish

Start: Nov 2016Est. completion: Apr 2018
Phase 2Completed
NCT02594254Armata PharmaceuticalsC16G2 Gel

Phase 2 Study to Evaluate the Microbiology and Safety of C16G2 Administered to Adult and Adolescent Dental Subjects

Start: Nov 2015Est. completion: Sep 2016
Phase 2Completed
NCT02509845Armata PharmaceuticalsC16G2

Study to Evaluate the Safety and Microbiology of C16G2 in Adolescent and Adult Dental Subjects

Start: Jul 2015Est. completion: Mar 2016
Phase 2Completed
NCT02254993Armata PharmaceuticalsC16G2

Phase 2, Open-Label Study for Safety, Microbiology and PK of Single or Multiple Oral C16G2 Gel Doses

Start: Oct 2014Est. completion: Jul 2015
Phase 2Completed
NCT02044081Armata PharmaceuticalsC16G2 Rinse

Phase 2, Safety & Microbiology Study of C16G2 in Multiple Oral Gel &/or Mouth Rinse Doses to Healthy Adults

Start: Feb 2014Est. completion: Aug 2014
Phase 2Completed
NCT02645617ADvantage TherapeuticsVarnish

Safety Evaluation of Advantage Anti-Caries Varnish

Start: Mar 2016Est. completion: Oct 2016
Phase 1Completed
NCT06441500T-TherapeuticsDaily tooth brushing programme

Oral Health and Dental Caries Prevention Intervention for Children in Romania

Start: Jan 2024Est. completion: Dec 2025
N/ARecruiting
NCT03753256Heidelberg PharmaTransbond XT

Evaluation of Optical Coherence Tomography in Dentistry

Start: Dec 2017Est. completion: Dec 202720 patients
N/ARecruiting
NCT02327507ADvantage TherapeuticsToothpaste & Telephone Support

Everybody Brush: A Community-wide Toothpaste Distribution Campaign

Start: Jun 2014Est. completion: Jul 2016
N/AUnknown

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
2 actively recruiting trials targeting 20 patients
5 companies competing in this space