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Degenerative Spondylolisthesis

2
Pipeline Programs
5
Companies
4
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
0
0
0
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Spine BioPharma
Spine BioPharmaNY - New York
2 programs
1
Interbody FusionPhase 41 trial
LimiFlexN/A
Active Trials
NCT01921530Unknown178Est. Dec 2019
Ankasa Regenerative Therapeutics
1 program
1
ART352-LPhase 1/21 trial
Active Trials
NCT04378543Unknown12Est. Oct 2023
Zimmer Biomet
Zimmer BiometFL - Jacksonville
1 program
Dynesys Spinal SystemN/A1 trial
Active Trials
NCT01528072Terminated153Est. Apr 2017
Medical Metrics
Medical MetricsTX - Houston
1 program
LimiFlexN/A
Empirical Spine
Empirical SpineCA - San Carlos
1 program
LimiFlexN/A1 trial
Active Trials
NCT03115983Active Not Recruiting299Est. Jan 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Spine BioPharmaInterbody Fusion
Ankasa Regenerative TherapeuticsART352-L
Empirical SpineLimiFlex
Zimmer BiometDynesys Spinal System

Clinical Trials (4)

Total enrollment: 642 patients across 4 trials

NCT01921530Spine BioPharmaInterbody Fusion

Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis

Start: Dec 2013Est. completion: Dec 2019178 patients
Phase 4Unknown
NCT04378543Ankasa Regenerative TherapeuticsART352-L

Safety Evaluation of ART352-L in Subjects Undergoing Posterolateral Spinal Fusion

Start: Sep 2020Est. completion: Oct 202312 patients
Phase 1/2Unknown
NCT03115983Empirical SpineLimiFlex

LimiFlex Clinical Trial for the Treatment of Degenerative Spondylolisthesis With Spinal Stenosis

Start: Jul 2017Est. completion: Jan 2026299 patients
N/AActive Not Recruiting
NCT01528072Zimmer BiometDynesys Spinal System

Dynesys Spinal System Post Market 522 Study

Start: Mar 2012Est. completion: Apr 2017153 patients
N/ATerminated

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.