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Degenerative Lumbar Spondylolisthesis

1
Pipeline Programs
3
Companies
5
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Novadip Biosciences
Novadip BiosciencesBelgium - Mont-Saint-Guibert
1 program
1
NVDX3Phase 1/21 trial
Active Trials
NCT05961956Active Not Recruiting5Est. Apr 2026
Olympus
OlympusPA - Center Valley
3 programs
Spinal fusionN/A1 trial
Study of OP-1 Putty in Uninstrumented Posterolateral FusionsN/A1 trial
Use of OP-1 Putty in Uninstrumented posterolateral fusionN/A1 trial
Active Trials
NCT00677950Completed336Est. Nov 2005
NCT00678353Completed202Est. Aug 2007
NCT00679107Completed48Est. Jul 2005
Spine BioPharma
Spine BioPharmaNY - New York
1 program
minimally invasive MID-line Lumbar FusionN/A1 trial
Active Trials
NCT02290314Unknown60Est. Dec 2019

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Novadip BiosciencesNVDX3
Spine BioPharmaminimally invasive MID-line Lumbar Fusion
OlympusStudy of OP-1 Putty in Uninstrumented Posterolateral Fusions
OlympusSpinal fusion
OlympusUse of OP-1 Putty in Uninstrumented posterolateral fusion

Clinical Trials (5)

Total enrollment: 651 patients across 5 trials

NCT05961956Novadip BiosciencesNVDX3

Study With NVDX3 for Treatment of Low Grade Degenerative Lumbar Spondylolisthesis

Start: Oct 2023Est. completion: Apr 20265 patients
Phase 1/2Active Not Recruiting
NCT02290314Spine BioPharmaminimally invasive MID-line Lumbar Fusion

Midline Lumbar Fusion Versus Posterior Lumbar Interbody Fusion

Start: Dec 2014Est. completion: Dec 201960 patients
N/AUnknown
NCT00678353OlympusStudy of OP-1 Putty in Uninstrumented Posterolateral Fusions

Study of OP-1 Putty in Uninstrumented Posterolateral Fusions

Start: May 2007Est. completion: Aug 2007202 patients
N/ACompleted
NCT00677950OlympusSpinal fusion

OP-1 Putty for Posterolateral Fusions

Start: Oct 2001Est. completion: Nov 2005336 patients
N/ACompleted
NCT00679107OlympusUse of OP-1 Putty in Uninstrumented posterolateral fusion

A Prospective Pilot Study of the OP-1 Putty in Uninstrumented Posterolateral Fusions

Start: Jun 1999Est. completion: Jul 200548 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.