Degenerative Disc Disease

6
Pipeline Programs
13
Companies
40
Clinical Trials
6 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
2
0
1
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

12 companies ranked by most advanced pipeline stage

DiscGenics
DiscGenicsUT - Salt Lake City
3 programs
2
1
IDCTPhase 31 trial
IDCTPhase 11 trial
IDCTPhase 11 trial
Active Trials
NCT03955315CompletedEst. Nov 2022
NCT03347708CompletedEst. Nov 2022
NCT07254806RecruitingEst. Nov 2028
Vivex Biologics
Vivex BiologicsGA - Atlanta
5 programs
1
VIA Disc NPPhase 21 trial
Active AllograftN/A1 trial
VIA Disc NPN/A1 trial
VIA Disc NPN/A1 trial
VIA Disc Nucleus Pulposus AllograftN/A1 trial
Active Trials
NCT03709901Unknown218Est. Jan 2022
NCT05201287Active Not Recruiting35Est. Dec 2024
NCT06778447Recruiting496Est. May 2028
+2 more trials
KB
Kuros BiosciencesSwitzerland - Schlieren
5 programs
1
TGplPTH1-34 in fibrinPhase 21 trial
MagnetOs Easypack PuttyN/A1 trial
MagnetOs Flex MatrixN/A1 trial
MagnetOs PuttyN/A1 trial
MagnetOs PuttyN/A1 trial
Active Trials
NCT04679844RecruitingEst. Aug 2027
NCT05037968RecruitingEst. Dec 2026
NCT04128852WithdrawnEst. Dec 2023
+2 more trials
BT
1 program
1
SM04690Phase 11 trial
Active Trials
NCT03246399TerminatedEst. Dec 2018
Globus Medical
Globus MedicalAUDUBON, PA
15 programs
ALTERAN/A1 trial
Advanced Materials Science in XLIF StudyN/A1 trial
CALIBERN/A1 trial
Cervical Interbody Implant StudyN/A1 trial
Degenerative Disc DiseaseN/A1 trial
+10 more programs
Active Trials
NCT03162666Withdrawn0Est. Nov 2020
NCT03649490Enrolling By InvitationEst. Dec 2026
NCT02075554Completed58Est. Feb 2017
+12 more trials
Medacta
MedactaSwitzerland - Castel San Pietro
3 programs
MUST MINI systemN/A1 trial
MySpineN/A1 trial
MySpine MCN/A1 trial
Active Trials
NCT05821920UnknownEst. Jun 2025
NCT05846477UnknownEst. Feb 2024
NCT05844358CompletedEst. Sep 2022
Cerapedics
CerapedicsCO - Westminster
2 programs
CT radioraphic assessmentN/A1 trial
P-15L Bone GraftN/A1 trial
Active Trials
NCT05144126Unknown300Est. Sep 2025
NCT03438747Active Not Recruiting290Est. Feb 2028
Induce Biologics
Induce BiologicsCA - Irvine
2 programs
Natural Matrix ProteinN/A1 trial
Natural Matrix ProteinN/A1 trial
Active Trials
NCT06000319Enrolling By Invitation200Est. Aug 2027
NCT05972616Completed53Est. Feb 2024
Providence Therapeutics
1 program
Anterior Cervical Discectomy and FusionN/A1 trial
Active Trials
NCT04229017Active Not RecruitingEst. Dec 2025
Aspen Medical products
1 program
Lumbar back braceN/A1 trial
Active Trials
NCT03484403Completed61Est. Sep 2019
HighRidge Medical
HighRidge MedicalCO - Westminster
1 program
One level Mobi-C and one level fusionN/A1 trial
Active Trials
NCT06485206Recruiting97Est. May 2029
Olympus
OlympusPA - Center Valley
1 program
TLIF with a PEEK Spacer System and XIA Spinal SystemN/A1 trial
Active Trials
NCT00678171Completed30Est. Mar 2010

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
DiscGenicsIDCT
Vivex BiologicsVIA Disc NP
Kuros BiosciencesTGplPTH1-34 in fibrin
DiscGenicsIDCT
DiscGenicsIDCT
Biosplice TherapeuticsSM04690
Vivex BiologicsVIA Disc NP
Kuros BiosciencesMagnetOs Easypack Putty
HighRidge MedicalOne level Mobi-C and one level fusion
Kuros BiosciencesMagnetOs Flex Matrix
Induce BiologicsNatural Matrix Protein
Induce BiologicsNatural Matrix Protein
Vivex BiologicsVIA Disc Nucleus Pulposus Allograft
Globus MedicalModulus ALIF System
CerapedicsCT radioraphic assessment

Showing 15 of 40 trials with date data

Clinical Trials (40)

Total enrollment: 2,199 patients across 40 trials

A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease

Start: Dec 2025Est. completion: Nov 2028
Phase 3Recruiting

ASCEND: A Clinical Trial to Evaluate the Safety and Effectiveness of VIA Disc NP, a Supplement for Degenerated Intervertebral Discs

Start: Oct 2024Est. completion: Apr 2026110 patients
Phase 2Recruiting
NCT04294004Kuros BiosciencesTGplPTH1-34 in fibrin

KUR-113 Bone Graft Versus Local Autograft for the Treatment of Single-level Transforaminal Lumbar Interbody Fusion

Start: Aug 2020Est. completion: Jul 2025
Phase 2Unknown

Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Disc Degeneration

Start: May 2019Est. completion: Nov 2022
Phase 1Completed

Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Intervertebral Disc Degeneration

Start: Feb 2018Est. completion: Nov 2022
Phase 1Completed

A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease

Start: Jul 2017Est. completion: Dec 2018
Phase 1Terminated

Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease

Start: Feb 2025Est. completion: May 2028496 patients
N/ARecruiting
NCT04679844Kuros BiosciencesMagnetOs Easypack Putty

Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion

Start: Dec 2024Est. completion: Aug 2027
N/ARecruiting
NCT06485206HighRidge MedicalOne level Mobi-C and one level fusion

Evaluation of Safety and Effectiveness of Primary Hybrid Construct of Mobi-C and ACDF in the Treatment of Two-level Symptomatic Degenerative Disc Disease in the Cervical Spine.

Start: Sep 2024Est. completion: May 202997 patients
N/ARecruiting
NCT05037968Kuros BiosciencesMagnetOs Flex Matrix

MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion

Start: Jun 2024Est. completion: Dec 2026
N/ARecruiting
NCT06000319Induce BiologicsNatural Matrix Protein

Natural Matrix Protein™ (NMP™) Fibers in Cervical and Lumbar Interbody Fusion

Start: Jan 2024Est. completion: Aug 2027200 patients
N/AEnrolling By Invitation
NCT05972616Induce BiologicsNatural Matrix Protein

Natural Matrix Protein™ (NMP™) in Interbody Lumbar Fusion

Start: Aug 2023Est. completion: Feb 202453 patients
N/ACompleted
NCT05412277Vivex BiologicsVIA Disc Nucleus Pulposus Allograft

VIA Disc Nucleus Pulposus Older Patients Pilot

Start: Oct 2022Est. completion: Dec 202421 patients
N/AActive Not Recruiting
NCT05566704Globus MedicalModulus ALIF System

Retrospective Modulus ALIF Study

Start: Aug 2022Est. completion: May 2024
N/ACompleted
NCT05144126CerapedicsCT radioraphic assessment

Safety, Radiological and Patient Reported Outcomes of i-FACTOR+ Matrix Bone Graft Device - A Canadian, Multicenter, Post-Market Clinical Investigation

Start: Jan 2022Est. completion: Sep 2025300 patients
N/AUnknown

VIA Disc NP Pilot for Patients With Symptomatic Degenerated Discs

Start: Dec 2021Est. completion: Dec 202435 patients
N/AActive Not Recruiting

Post Marketing Study of MagnetOs Putty Compared to Local Autograft in Patients Undergoing Posterolateral Lumbar Fusion

Start: Aug 2021Est. completion: Dec 2023
N/ACompleted
NCT05821920MedactaMUST MINI system

A Safety Study on Posterior Pedicle Screw System

Start: Jun 2021Est. completion: Jun 2025
N/AUnknown
NCT04689880Globus MedicalXLIF Decade Plate System Study

XLIF Decade Plate System Study

Start: Apr 2021Est. completion: Apr 2023
N/ACompleted

MySpine MC Versus MySpine Standard

Start: Feb 2021Est. completion: Feb 2024
N/AUnknown

Post Marketing Clinical Follow up Study for MagnetOs Putty in Patients With Degenerative Disc Disease

Start: Nov 2020Est. completion: Dec 2023
N/AWithdrawn
NCT04418830Globus MedicalLumbar Interbody Implant Study

Lumbar Interbody Implant Study

Start: Oct 2020Est. completion: Jul 2026
N/AEnrolling By Invitation
NCT04689854Globus MedicalCervical Interbody Implant Study

Cervical Interbody Implant Study

Start: Jul 2020Est. completion: Dec 2025
N/AEnrolling By Invitation
NCT04418817Globus MedicalModulus in XLIF Study

Modulus in XLIF Study

Start: Mar 2020Est. completion: Jan 2024
N/ACompleted
NCT04229017Providence TherapeuticsAnterior Cervical Discectomy and Fusion

Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD

Start: Mar 2020Est. completion: Dec 2025
N/AActive Not Recruiting
NCT04420143Globus MedicalMLX/XLX ACR Expandable Lumbar Interbody Implants

MLX/XLX ACR Expandable Lumbar Interbody Implants

Start: Jan 2020Est. completion: Oct 2020
N/ACompleted

Cortical Bone Trajectory With Patient Guide

Start: Jun 2019Est. completion: Sep 2022
N/ACompleted
NCT03649490Globus MedicalAdvanced Materials Science in XLIF Study

Advanced Materials Science in XLIF Study

Start: Aug 2018Est. completion: Dec 2026
N/AEnrolling By Invitation
NCT03438747CerapedicsP-15L Bone Graft

P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation

Start: Apr 2018Est. completion: Feb 2028290 patients
N/AActive Not Recruiting

Viable Allograft Supplemented Disc Regeneration in the Treatment of Patients With Low Back Pain

Start: Aug 2017Est. completion: Jan 2022218 patients
N/AUnknown

Patient Outcomes Using an Expandable Spacer

Start: Feb 2017Est. completion: Nov 20200
N/AWithdrawn

Benefit of Lumbar Bracing for Chronic Low Back Pain Due to Degenerative Disc Disease

Start: Dec 2015Est. completion: Sep 201961 patients
N/ACompleted
NCT02388022Globus MedicalDegenerative Disc Disease

A Retrospective Study Using CALIBER® TLIF Expandable Spacer in the Treatment of DDD: 2 Year Follow-up.

Start: Jan 2014Est. completion: Mar 2016200 patients
N/ACompleted

Study of an Expandable Interbody Device for the Lumbar Spine

Start: Jul 2012Est. completion: Feb 201758 patients
N/ACompleted

INDEPENDENCE Spacer for Lumbar Fusion

Start: Jan 2012Est. completion: Aug 201630 patients
N/ACompleted

An Evaluation of Interlaminar Lumbar Instrumented (ILIF™)

Start: Nov 2009Est. completion: Jun 2014
N/ACompleted

Osteocel® Plus in Posterior Lumbar Interbody Fusion (PLIF)

Start: Jun 2009Est. completion: Oct 2012
N/ACompleted

Osteocel® Plus in Transforaminal Lumbar Interbody Fusion (TLIF)

Start: May 2009Est. completion: Oct 2012
N/ACompleted
NCT00948532Globus Medicalbiologic, Osteocel Plus

Osteocel® Plus in eXtreme Lateral Interbody Fusion (XLIF®)

Start: Mar 2009Est. completion: Oct 2012
N/ACompleted
NCT00678171OlympusTLIF with a PEEK Spacer System and XIA Spinal System

A Pilot Study to Evaluate an Osteogenic Protein 1 (OP-1) Putty Spinal System and an Autograft Spinal System

Start: Feb 2007Est. completion: Mar 201030 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
6 actively recruiting trials targeting 2,199 patients
13 companies competing in this space