Skip to main content

Degenerative Disc Disease

18
Pipeline Programs
30
Companies
50
Clinical Trials
8 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
6
1
0
6
3
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

40 companies ranked by most advanced pipeline stage

Zimmer Biomet
Zimmer BiometFL - Jacksonville
7 programs
1
TM-Ardis InterbodyPhase 41 trial
Aspen Spinous Process SystemN/A1 trial
Evaluate Effectiveness of the Biomet Lumbar Spinal Fusion SystemN/A1 trial
Spine Patient Outcomes Registry for Biomet/EBI (Electro-Biology, Inc)N/A1 trial
SpineLink® , SpineLink® IIN/A1 trial
+2 more programs
Active Trials
NCT01016314Withdrawn0Est. Jan 2016
NCT00758719Completed53Est. Aug 2012
NCT00726284Completed651Est. Dec 2007
+4 more trials
NanoFUSE Biologics
1
NanoFUSE® Bioactive MatrixPhase 41 trial
Active Trials
NCT03751943Unknown50Est. Mar 2021
Celling Biosciences
1
Solum IV, Bone Marrow Concentrate with general fluid concentratePhase 41 trial
Active Trials
NCT03223701Withdrawn0Est. Dec 2018
Spine BioPharma
25 programs
1
1
3
CHARITÉ Artificial DiscPhase 31 trial
HEALOS and Leopard CagePhase 31 trial
Lumbar I/F with cage and pedicle screwsPhase 31 trial
Intradiscal rhGDF-5Phase 21 trial
Intradiscal rhGDF-5Phase 1/21 trial
+20 more programs
Active Trials
NCT04566874Unknown100Est. Jul 2021
NCT02108249Completed35Est. Dec 2019
NCT02068768Terminated13Est. Mar 2016
+16 more trials
Medtronic
MedtronicNJ - Phillipsburg
16 programs
1
rhBMP-2/CRM/CD HORIZON® Spinal SystemPhase 31 trial
INFUSE® Bone Graft/MASTERGRAFT® Granules/CD HORIZON®N/A1 trial
INFUSE® Bone Graft/PEEK Spacer/Anterior Cervical PlateN/A1 trial
Oblique Lateral Interbody FusionN/A1 trial
TELAMON P™ /INFUSE® Bone Graft/CD HORIZON® Spinal SystemN/A1 trial
+11 more programs
Active Trials
NCT01491542Completed46Est. Mar 2007
NCT00485173Completed224Est. Jun 2012
NCT02657421Terminated168Est. May 2018
+13 more trials
NuVasive
NuVasiveCA - San Diego
12 programs
1
XL TDRPhase 31 trial
Advanced Materials Science in XLIF StudyN/A
Cervical Interbody Implant StudyN/A
ILIFN/A
Lumbar Interbody Implant StudyN/A
+7 more programs
Active Trials
NCT00927238Completed246Est. Jul 2015
Angitia Biopharmaceuticals
Angitia BiopharmaceuticalsCA - Woodland Hills
1 program
1
AGA111Phase 32 trials
Active Trials
NCT06115512Active Not Recruiting412Est. Nov 2026
NCT05574543Completed60Est. Jul 2022
BioSurface Technologies
2 programs
2
PrefixPhase 1/21 trial
PrefixPhase 1/21 trial
Active Trials
NCT00798902Unknown22Est. Oct 2012
NCT00798239Unknown24Est. Jul 2012
Locate Bio
1 program
1
LDGraftPhase 1/2
Biocorp
1 program
1
LDGraftPhase 1/21 trial
Active Trials
NCT06462729Recruiting40Est. Dec 2027
Bioinova
BioinovaCzech Republic - Prague
1 program
1
Suspension of human autologous MSC 3P in 1.5 mlPhase 1/21 trial
Active Trials
NCT03827096Terminated10Est. Dec 2016
AnGes
1 program
1
AMG0103Phase 11 trial
Active Trials
NCT03263611Completed25Est. Feb 2021
Kolon TissueGene
1
TG-C High DosePhase 11 trial
Active Trials
NCT06144970Not Yet Recruiting24Est. Jul 2029
Globus Medical
Globus MedicalAUDUBON, PA
15 programs
ALTERAN/A1 trial
Advanced Materials Science in XLIF StudyN/A1 trial
CALIBERN/A
Cervical Interbody Implant StudyN/A1 trial
Degenerative Disc DiseaseN/A1 trial
+10 more programs
Active Trials
NCT03162666Withdrawn0Est. Nov 2020
NCT03649490Enrolling By Invitation300Est. Dec 2026
NCT04689854Enrolling By Invitation150Est. Dec 2025
+11 more trials
Vivex Biologics
Vivex BiologicsGA - Atlanta
5 programs
Active AllograftN/A1 trial
VIA Disc NPN/A1 trial
VIA Disc NPN/A1 trial
VIA Disc Nucleus Pulposus AllograftN/A1 trial
VIA Disc NPPHASE_21 trial
Active Trials
NCT03709901Unknown218Est. Jan 2022
NCT06778447Recruiting496Est. May 2028
NCT05201287Unknown35Est. Dec 2024
+2 more trials
Kuros Biosciences
Kuros BiosciencesSwitzerland - Schlieren
5 programs
MagnetOs Easypack PuttyN/A1 trial
MagnetOs Flex MatrixN/A1 trial
MagnetOs PuttyN/A1 trial
MagnetOs PuttyN/A1 trial
TGplPTH1-34 in fibrinPHASE_21 trial
Active Trials
NCT04679844Recruiting60Est. Aug 2027
NCT05037968Recruiting100Est. Dec 2026
NCT04128852Withdrawn0Est. Dec 2023
+2 more trials
Stryker
StrykerCA - San Jose
4 programs
AccuLIF expandable TLIF cageN/A1 trial
Spinal FusionN/A1 trial
Structural allograftN/A1 trial
Tritanium Posterior Lumbar CageN/A1 trial
Active Trials
NCT02704689Terminated9Est. Jan 2017
NCT06226272Not Yet Recruiting5,222Est. Jan 2032
NCT04388332Recruiting60Est. Dec 2026
+1 more trials
Baxter
BaxterCosta Rica - Cartago
3 programs
Actifuse ABXN/A
Actifuse ABXN/A
Bone graft substitute, autograft or allograftN/A
Baxter International
3 programs
Actifuse ABXN/A1 trial
Actifuse ABXN/A1 trial
Bone graft substitute, autograft or allograftN/A1 trial
Active Trials
NCT01013389Completed20Est. Dec 2012
NCT01018771Completed100Est. Dec 2012
NCT00974623Terminated329Est. Nov 2013
Medacta
MedactaSwitzerland - Castel San Pietro
3 programs
MUST MINI systemN/A1 trial
MySpineN/A1 trial
MySpine MCN/A1 trial
Active Trials
NCT05821920Unknown44Est. Jun 2025
NCT05846477Unknown44Est. Feb 2024
NCT05844358Completed102Est. Sep 2022
Spinal Stabilization Technologies
3 programs
PerQdiscN/A1 trial
PerQdisc Nucleus Replacement SystemN/A1 trial
PerQdisc® Nucleus Replacement Device.N/A1 trial
Active Trials
NCT05105490Withdrawn0Est. Dec 2021
NCT05508360Recruiting72Est. Aug 2030
NCT04004156Terminated9Est. Jan 2023
DiscGenics
DiscGenicsUT - Salt Lake City
3 programs
IDCTPHASE_11 trial
IDCTPHASE_11 trial
IDCTPHASE_31 trial
Active Trials
NCT03347708Completed60Est. Nov 2022
NCT03955315Completed38Est. Nov 2022
NCT07254806Recruiting162Est. Nov 2028
Cerapedics
CerapedicsCO - Westminster
2 programs
CT radioraphic assessmentN/A
P-15L Bone GraftN/A1 trial
Active Trials
NCT03438747Active Not Recruiting290Est. Feb 2028
Induce Biologics
Induce BiologicsCA - Irvine
2 programs
Natural Matrix ProteinN/A1 trial
Natural Matrix ProteinN/A1 trial
Active Trials
NCT06000319Enrolling By Invitation200Est. Aug 2027
NCT05972616Completed53Est. Feb 2024
Centinel Spine
Centinel SpinePA - West Chester
2 programs
Prodisc C VivoN/A1 trial
STALIF®N/A1 trial
Active Trials
NCT07370493Enrolling By Invitation200Est. Dec 2030
NCT05610397Unknown200Est. Sep 2024
Camber Spine
1 program
ALIFN/A
Providence Medical Technology
Anterior Cervical Discectomy and FusionN/A1 trial
Active Trials
NCT04229017Active Not Recruiting236Est. Dec 2025
Providence Therapeutics
1 program
Anterior Cervical Discectomy and FusionN/A
Aclarion
AclarionCO - Broomfield
1 program
Bone Marrow Aspirate ConcentrateN/A1 trial
Active Trials
NCT07386548Not Yet Recruiting90Est. Dec 2030
Medical Metrics
CT radioraphic assessmentN/A1 trial
Active Trials
NCT05144126Unknown300Est. Sep 2025

+10 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
NanoFUSE BiologicsNanoFUSE® Bioactive Matrix
Celling BiosciencesSolum IV, Bone Marrow Concentrate with general fluid concentrate
Zimmer BiometTM-Ardis Interbody
DiscGenicsIDCT
Angitia BiopharmaceuticalsAGA111
NuVasiveXL TDR
Spine BioPharmaHEALOS and Leopard Cage
MedtronicrhBMP-2/CRM/CD HORIZON® Spinal System
Spine BioPharmaLumbar I/F with cage and pedicle screws
Spine BioPharmaCHARITÉ Artificial Disc
Vivex BiologicsVIA Disc NP
Kuros BiosciencesTGplPTH1-34 in fibrin
Spine BioPharmaIntradiscal rhGDF-5
BiocorpLDGraft
Angitia BiopharmaceuticalsAGA111

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 10,230 patients across 50 trials

NCT03751943NanoFUSE BiologicsNanoFUSE® Bioactive Matrix

NanoFUSE® PL Gutter PMCF

Start: Jan 2019Est. completion: Mar 202150 patients
Phase 4Unknown
NCT03223701Celling BiosciencesSolum IV, Bone Marrow Concentrate with general fluid concentrate

Efficacy of Using Solum IV and BMC With GFC in TLIF

Start: Sep 2017Est. completion: Dec 20180
Phase 4Withdrawn
NCT02429908Zimmer BiometTM-Ardis Interbody

Post-Market Surveillance Study of the TM Ardis Interbody Fusion System

Start: Mar 2014Est. completion: Sep 201880 patients
Phase 4Completed

A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease

Start: Dec 2025Est. completion: Nov 2028162 patients
Phase 3Recruiting

A Phase 3 Study of AGA111 in Patients With Degenerative Disc Disease Undergoing Lumbar Interbody Fusion

Start: Dec 2023Est. completion: Nov 2026412 patients
Phase 3Active Not Recruiting

XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD)

Start: Jul 2009Est. completion: Jul 2015246 patients
Phase 3Completed
NCT00316121Spine BioPharmaHEALOS and Leopard Cage

Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease

Start: Apr 2006138 patients
Phase 3Completed
NCT00707265MedtronicrhBMP-2/CRM/CD HORIZON® Spinal System

rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study

Start: Mar 2002Est. completion: Feb 2010463 patients
Phase 3Completed
NCT00215319Spine BioPharmaLumbar I/F with cage and pedicle screws

Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion.

Start: Dec 2000Est. completion: Nov 2006139 patients
Phase 3Completed
NCT00215306Spine BioPharmaCHARITÉ Artificial Disc

CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease

Start: Mar 2000Est. completion: Mar 2004304 patients
Phase 3Completed

ASCEND: A Clinical Trial to Evaluate the Safety and Effectiveness of VIA Disc NP, a Supplement for Degenerated Intervertebral Discs

Start: Oct 2024Est. completion: Nov 2027121 patients
Phase 2Active Not Recruiting
NCT04294004Kuros BiosciencesTGplPTH1-34 in fibrin

KUR-113 Bone Graft Versus Local Autograft for the Treatment of Single-level Transforaminal Lumbar Interbody Fusion

Start: Aug 2020Est. completion: Jul 202550 patients
Phase 2Unknown
NCT01124006Spine BioPharmaIntradiscal rhGDF-5

A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of 2 Doses of Intradiscal rhGDF-5 (Single Administration) for the Treatment of Early Stage Lumbar Disc Degeneration

Start: Jan 2010Est. completion: Sep 201424 patients
Phase 2Completed

LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)

Start: Nov 2024Est. completion: Dec 202740 patients
Phase 1/2Recruiting

A Phase I/II Study of AGA111 for Lumbar Interbody Fusion in Patients With Degenerative Disc Disease

Start: Dec 2020Est. completion: Jul 202260 patients
Phase 1/2Completed
NCT03827096BioinovaSuspension of human autologous MSC 3P in 1.5 ml

Utilization of Autologous Mesenchymal Cells in Posterolateral Spinal Fusion in Degenerative Spine Disease

Start: Aug 2013Est. completion: Dec 201610 patients
Phase 1/2Terminated

Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery

Start: Nov 2008Est. completion: Jul 201224 patients
Phase 1/2Unknown

Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery

Start: Nov 2008Est. completion: Oct 201222 patients
Phase 1/2Unknown
NCT00813813Spine BioPharmaIntradiscal rhGDF-5

Intradiscal rhGDF-5 Phase I/II Clinical Trial

Start: Jun 2008Est. completion: Jun 201332 patients
Phase 1/2Completed

Study to Determine the Safety and Tolerability of TG-C in Subjects With Back Pain Due to Degenerative Disc Disease

Start: Jan 2027Est. completion: Jul 202924 patients
Phase 1Not Yet Recruiting

Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Disc Degeneration

Start: May 2019Est. completion: Nov 202238 patients
Phase 1Completed

AMG0103 in Subjects With Chronic Discogenic Lumbar Back Pain

Start: Feb 2018Est. completion: Feb 202125 patients
Phase 1Completed

Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Intervertebral Disc Degeneration

Start: Feb 2018Est. completion: Nov 202260 patients
Phase 1Completed

A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease

Start: Jul 2017Est. completion: Dec 20186 patients
Phase 1Terminated
NCT07386548AclarionBone Marrow Aspirate Concentrate

Biologic Injection For Adults With Lumbar Disc Herniation

Start: May 2026Est. completion: Dec 203090 patients
N/ANot Yet Recruiting

Retrospective Analysis of Patients Implanted With 2 Levels of Prodisc® C Vivo Devices

Start: Nov 2025Est. completion: Dec 2030200 patients
N/AEnrolling By Invitation

Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease

Start: Feb 2025Est. completion: May 2028496 patients
N/ARecruiting
NCT04679844Kuros BiosciencesMagnetOs Easypack Putty

Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion

Start: Dec 2024Est. completion: Aug 202760 patients
N/ARecruiting
NCT06485206HighRidge MedicalOne level Mobi-C and one level fusion

Evaluation of Safety and Effectiveness of Primary Hybrid Construct of Mobi-C and ACDF in the Treatment of Two-level Symptomatic Degenerative Disc Disease in the Cervical Spine.

Start: Sep 2024Est. completion: May 202997 patients
N/ARecruiting
NCT05037968Kuros BiosciencesMagnetOs Flex Matrix

MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion

Start: Jun 2024Est. completion: Dec 2026100 patients
N/ARecruiting
NCT06226272StrykerSpinal Fusion

Clinical Outcome Measure at Stryker Spine

Start: May 2024Est. completion: Jan 20325,222 patients
N/ANot Yet Recruiting

Evaluation of NB1 Bone Graft Following Lumbar Interbody Arthrodesis

Start: Mar 2024Est. completion: Jun 202630 patients
N/AUnknown
NCT06000319Induce BiologicsNatural Matrix Protein

Natural Matrix Protein™ (NMP™) Fibers in Cervical and Lumbar Interbody Fusion

Start: Jan 2024Est. completion: Aug 2027200 patients
N/AEnrolling By Invitation

Discure Technologies Feasibility Study for DDD

Start: Jan 2024Est. completion: Dec 202420 patients
N/AUnknown
NCT05972616Induce BiologicsNatural Matrix Protein

Natural Matrix Protein™ (NMP™) in Interbody Lumbar Fusion

Start: Aug 2023Est. completion: Feb 202453 patients
N/ACompleted

Retrospective Study With Patients Treated With STALIF® C or M and Ti or FLX Implants for 1 and 2 Levels

Start: Apr 2023Est. completion: Sep 2024200 patients
N/AUnknown
NCT05883436Spine BioPharmaDEXA-C Cervical Interbody System

Investigation of DEXA-C Anterior Cervical Interbody System

Start: Feb 2023Est. completion: Feb 202780 patients
N/ARecruiting
NCT05412277Vivex BiologicsVIA Disc Nucleus Pulposus Allograft

VIA Disc Nucleus Pulposus Older Patients Pilot

Start: Oct 2022Est. completion: Dec 202421 patients
N/AUnknown
NCT05508360Spinal Stabilization TechnologiesPerQdisc Nucleus Replacement System

"Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2)

Start: Aug 2022Est. completion: Aug 203072 patients
N/ARecruiting
NCT05566704Globus MedicalModulus ALIF System

Retrospective Modulus ALIF Study

Start: Aug 2022Est. completion: May 2024123 patients
N/ACompleted

Study of the ReGelTec HYDRAFIL System

Start: Jan 2022Est. completion: Oct 202535 patients
N/ACompleted
NCT05144126Medical MetricsCT radioraphic assessment

Safety, Radiological and Patient Reported Outcomes of i-FACTOR+ Matrix Bone Graft Device - A Canadian, Multicenter, Post-Market Clinical Investigation

Start: Jan 2022Est. completion: Sep 2025300 patients
N/AUnknown

Post Market Observational Trial for the PerQdisc Nucleus Replacement Device

Start: Dec 2021Est. completion: Dec 20210
N/AWithdrawn

VIA Disc NP Pilot for Patients With Symptomatic Degenerated Discs

Start: Dec 2021Est. completion: Dec 202435 patients
N/AUnknown
NCT05114356restor3dTIDAL Cervical Interbody Fusion implant

Cervical Interbody Fusion Device Patient Registry

Start: Nov 2021Est. completion: May 202473 patients
N/ATerminated

Post Marketing Study of MagnetOs Putty Compared to Local Autograft in Patients Undergoing Posterolateral Lumbar Fusion

Start: Aug 2021Est. completion: Dec 202330 patients
N/ACompleted
NCT05821920MedactaMUST MINI system

A Safety Study on Posterior Pedicle Screw System

Start: Jun 2021Est. completion: Jun 202544 patients
N/AUnknown
NCT04689880Globus MedicalXLIF Decade Plate System Study

XLIF Decade Plate System Study

Start: Apr 2021Est. completion: Apr 202375 patients
N/ACompleted

MySpine MC Versus MySpine Standard

Start: Feb 2021Est. completion: Feb 202444 patients
N/AUnknown

Post Marketing Clinical Follow up Study for MagnetOs Putty in Patients With Degenerative Disc Disease

Start: Nov 2020Est. completion: Dec 20230
N/AWithdrawn

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

6 late-stage (Phase 3) programs, potential near-term approvals
8 actively recruiting trials targeting 10,230 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.