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Degenerative Disc Disease

18
Pipeline Programs
30
Companies
50
Clinical Trials
10 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
6
1
0
6
3
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

40 companies ranked by most advanced pipeline stage

Zimmer Biomet
Zimmer BiometFL - Jacksonville
7 programs
1
TM-Ardis InterbodyPhase 41 trial
Aspen Spinous Process SystemN/A1 trial
Evaluate Effectiveness of the Biomet Lumbar Spinal Fusion SystemN/A1 trial
Spine Patient Outcomes Registry for Biomet/EBI (Electro-Biology, Inc)N/A1 trial
SpineLink® , SpineLink® IIN/A1 trial
+2 more programs
Active Trials
NCT01016314Withdrawn0Est. Jan 2016
NCT00758719Completed53Est. Aug 2012
NCT00726284Completed651Est. Dec 2007
+4 more trials
NanoFUSE Biologics
1
NanoFUSE® Bioactive MatrixPhase 41 trial
Active Trials
NCT03751943Unknown50Est. Mar 2021
Celling Biosciences
1
Solum IV, Bone Marrow Concentrate with general fluid concentratePhase 41 trial
Active Trials
NCT03223701Withdrawn0Est. Dec 2018
Spine BioPharma
25 programs
1
1
3
CHARITÉ Artificial DiscPhase 31 trial
HEALOS and Leopard CagePhase 31 trial
Lumbar I/F with cage and pedicle screwsPhase 31 trial
Intradiscal rhGDF-5Phase 21 trial
Intradiscal rhGDF-5Phase 1/21 trial
+20 more programs
Active Trials
NCT02108249Completed35Est. Dec 2019
NCT02068768Terminated13Est. Mar 2016
NCT00215332Completed367Est. Jul 2007
+12 more trials
Medtronic
MedtronicNJ - Phillipsburg
16 programs
1
rhBMP-2/CRM/CD HORIZON® Spinal SystemPhase 31 trial
INFUSE® Bone Graft/MASTERGRAFT® Granules/CD HORIZON®N/A1 trial
INFUSE® Bone Graft/PEEK Spacer/Anterior Cervical PlateN/A1 trial
Oblique Lateral Interbody FusionN/A1 trial
TELAMON P™ /INFUSE® Bone Graft/CD HORIZON® Spinal SystemN/A1 trial
+11 more programs
Active Trials
NCT01491542Completed46Est. Mar 2007
NCT00485173Completed224Est. Jun 2012
NCT02657421Terminated168Est. May 2018
+13 more trials
NuVasive
NuVasiveCA - San Diego
12 programs
1
XL TDRPhase 31 trial
Advanced Materials Science in XLIF StudyN/A
Cervical Interbody Implant StudyN/A
ILIFN/A
Lumbar Interbody Implant StudyN/A
+7 more programs
Active Trials
NCT00927238Completed246Est. Jul 2015
Angitia Biopharmaceuticals
Angitia BiopharmaceuticalsCA - Woodland Hills
1 program
1
AGA111Phase 32 trials
Active Trials
NCT06115512Active Not Recruiting412Est. Nov 2026
NCT05574543Completed60Est. Jul 2022
BioSurface Technologies
2 programs
2
PrefixPhase 1/21 trial
PrefixPhase 1/21 trial
Active Trials
NCT00798902Unknown22Est. Oct 2012
NCT00798239Unknown24Est. Jul 2012
Biocorp
1 program
1
LDGraftPhase 1/21 trial
Active Trials
NCT06462729Recruiting40Est. Dec 2027
Locate Bio
1 program
1
LDGraftPhase 1/2
Bioinova
BioinovaCzech Republic - Prague
1 program
1
Suspension of human autologous MSC 3P in 1.5 mlPhase 1/21 trial
Active Trials
NCT03827096Terminated10Est. Dec 2016
AnGes
1 program
1
AMG0103Phase 11 trial
Active Trials
NCT03263611Completed25Est. Feb 2021
Kolon TissueGene
1
TG-C High DosePhase 11 trial
Active Trials
NCT06144970Not Yet Recruiting24Est. Nov 2027
Globus Medical
Globus MedicalAUDUBON, PA
15 programs
ALTERAN/A1 trial
Advanced Materials Science in XLIF StudyN/A1 trial
CALIBERN/A1 trial
Cervical Interbody Implant StudyN/A1 trial
Degenerative Disc DiseaseN/A1 trial
+10 more programs
Active Trials
NCT03162666Withdrawn0Est. Nov 2020
NCT03649490Enrolling By Invitation300Est. Dec 2026
NCT02075554Completed58Est. Feb 2017
+12 more trials
Vivex Biologics
Vivex BiologicsGA - Atlanta
5 programs
Active AllograftN/A1 trial
VIA Disc NPN/A1 trial
VIA Disc NPN/A1 trial
VIA Disc Nucleus Pulposus AllograftN/A1 trial
VIA Disc NPPHASE_21 trial
Active Trials
NCT03709901Unknown218Est. Jan 2022
NCT05201287Unknown35Est. Dec 2024
NCT06778447Recruiting496Est. May 2028
+2 more trials
Kuros Biosciences
Kuros BiosciencesSwitzerland - Schlieren
5 programs
MagnetOs Easypack PuttyN/A1 trial
MagnetOs Flex MatrixN/A1 trial
MagnetOs PuttyN/A1 trial
MagnetOs PuttyN/A1 trial
TGplPTH1-34 in fibrinPHASE_21 trial
Active Trials
NCT04679844Recruiting60Est. Aug 2027
NCT05037968Recruiting100Est. Dec 2026
NCT04128852Withdrawn0Est. Dec 2023
+2 more trials
Stryker
StrykerCA - San Jose
4 programs
AccuLIF expandable TLIF cageN/A1 trial
Spinal FusionN/A1 trial
Structural allograftN/A1 trial
Tritanium Posterior Lumbar CageN/A1 trial
Active Trials
NCT02704689Terminated9Est. Jan 2017
NCT06226272Not Yet Recruiting5,222Est. Jan 2032
NCT04388332Recruiting60Est. Dec 2026
+1 more trials
Baxter
BaxterCosta Rica - Cartago
3 programs
Actifuse ABXN/A
Actifuse ABXN/A
Bone graft substitute, autograft or allograftN/A
Baxter International
3 programs
Actifuse ABXN/A1 trial
Actifuse ABXN/A1 trial
Bone graft substitute, autograft or allograftN/A1 trial
Active Trials
NCT01013389Completed20Est. Dec 2012
NCT01018771Completed100Est. Dec 2012
NCT00974623Terminated329Est. Nov 2013
Medacta
MedactaSwitzerland - Castel San Pietro
3 programs
MUST MINI systemN/A1 trial
MySpineN/A1 trial
MySpine MCN/A1 trial
Active Trials
NCT05821920Unknown44Est. Jun 2025
NCT05846477Unknown44Est. Feb 2024
NCT05844358Completed102Est. Sep 2022
Spinal Stabilization Technologies
3 programs
PerQdiscN/A1 trial
PerQdisc Nucleus Replacement SystemN/A1 trial
PerQdisc® Nucleus Replacement Device.N/A1 trial
Active Trials
NCT05105490Withdrawn0Est. Dec 2021
NCT05508360Recruiting72Est. Aug 2030
NCT04004156Terminated9Est. Jan 2023
DiscGenics
DiscGenicsUT - Salt Lake City
3 programs
IDCTPHASE_11 trial
IDCTPHASE_11 trial
IDCTPHASE_31 trial
Active Trials
NCT03955315Completed38Est. Nov 2022
NCT03347708Completed60Est. Nov 2022
NCT07254806Recruiting162Est. Nov 2028
Cerapedics
CerapedicsCO - Westminster
2 programs
CT radioraphic assessmentN/A1 trial
P-15L Bone GraftN/A1 trial
Active Trials
NCT05144126Unknown300Est. Sep 2025
NCT03438747Active Not Recruiting290Est. Feb 2028
Induce Biologics
Induce BiologicsCA - Irvine
2 programs
Natural Matrix ProteinN/A1 trial
Natural Matrix ProteinN/A1 trial
Active Trials
NCT06000319Enrolling By Invitation200Est. Aug 2027
NCT05972616Completed53Est. Feb 2024
Centinel Spine
Centinel SpinePA - West Chester
2 programs
Prodisc C VivoN/A1 trial
STALIF®N/A1 trial
Active Trials
NCT07370493Enrolling By Invitation200Est. Dec 2030
NCT05610397Unknown200Est. Sep 2024
Camber Spine
1 program
ALIFN/A1 trial
Active Trials
NCT04566874Unknown100Est. Jul 2021
Providence Therapeutics
1 program
Anterior Cervical Discectomy and FusionN/A1 trial
Active Trials
NCT04229017Active Not Recruiting236Est. Dec 2025
Providence Medical Technology
Anterior Cervical Discectomy and FusionN/A
Aclarion
AclarionCO - Broomfield
1 program
Bone Marrow Aspirate ConcentrateN/A1 trial
Active Trials
NCT07386548Not Yet Recruiting90Est. Dec 2030
Medical Metrics
CT radioraphic assessmentN/A

+10 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
NanoFUSE BiologicsNanoFUSE® Bioactive Matrix
Celling BiosciencesSolum IV, Bone Marrow Concentrate with general fluid concentrate
Zimmer BiometTM-Ardis Interbody
DiscGenicsIDCT
Angitia BiopharmaceuticalsAGA111
NuVasiveXL TDR
Spine BioPharmaHEALOS and Leopard Cage
MedtronicrhBMP-2/CRM/CD HORIZON® Spinal System
Spine BioPharmaLumbar I/F with cage and pedicle screws
Spine BioPharmaCHARITÉ Artificial Disc
Vivex BiologicsVIA Disc NP
Kuros BiosciencesTGplPTH1-34 in fibrin
Spine BioPharmaIntradiscal rhGDF-5
BiocorpLDGraft
Angitia BiopharmaceuticalsAGA111

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 10,219 patients across 50 trials

NCT03751943NanoFUSE BiologicsNanoFUSE® Bioactive Matrix

NanoFUSE® PL Gutter PMCF

Start: Jan 2019Est. completion: Mar 202150 patients
Phase 4Unknown
NCT03223701Celling BiosciencesSolum IV, Bone Marrow Concentrate with general fluid concentrate

Efficacy of Using Solum IV and BMC With GFC in TLIF

Start: Sep 2017Est. completion: Dec 20180
Phase 4Withdrawn
NCT02429908Zimmer BiometTM-Ardis Interbody

Post-Market Surveillance Study of the TM Ardis Interbody Fusion System

Start: Mar 2014Est. completion: Sep 201880 patients
Phase 4Completed

A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease

Start: Dec 2025Est. completion: Nov 2028162 patients
Phase 3Recruiting

A Phase 3 Study of AGA111 in Patients With Degenerative Disc Disease Undergoing Lumbar Interbody Fusion

Start: Dec 2023Est. completion: Nov 2026412 patients
Phase 3Active Not Recruiting

XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD)

Start: Jul 2009Est. completion: Jul 2015246 patients
Phase 3Completed
NCT00316121Spine BioPharmaHEALOS and Leopard Cage

Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease

Start: Apr 2006138 patients
Phase 3Completed
NCT00707265MedtronicrhBMP-2/CRM/CD HORIZON® Spinal System

rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study

Start: Mar 2002Est. completion: Feb 2010463 patients
Phase 3Completed
NCT00215319Spine BioPharmaLumbar I/F with cage and pedicle screws

Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion.

Start: Dec 2000Est. completion: Nov 2006139 patients
Phase 3Completed
NCT00215306Spine BioPharmaCHARITÉ Artificial Disc

CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease

Start: Mar 2000Est. completion: Mar 2004304 patients
Phase 3Completed

ASCEND: A Clinical Trial to Evaluate the Safety and Effectiveness of VIA Disc NP, a Supplement for Degenerated Intervertebral Discs

Start: Oct 2024Est. completion: Apr 2026110 patients
Phase 2Recruiting
NCT04294004Kuros BiosciencesTGplPTH1-34 in fibrin

KUR-113 Bone Graft Versus Local Autograft for the Treatment of Single-level Transforaminal Lumbar Interbody Fusion

Start: Aug 2020Est. completion: Jul 202550 patients
Phase 2Unknown
NCT01124006Spine BioPharmaIntradiscal rhGDF-5

A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of 2 Doses of Intradiscal rhGDF-5 (Single Administration) for the Treatment of Early Stage Lumbar Disc Degeneration

Start: Jan 2010Est. completion: Sep 201424 patients
Phase 2Completed

LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)

Start: Nov 2024Est. completion: Dec 202740 patients
Phase 1/2Recruiting

A Phase I/II Study of AGA111 for Lumbar Interbody Fusion in Patients With Degenerative Disc Disease

Start: Dec 2020Est. completion: Jul 202260 patients
Phase 1/2Completed
NCT03827096BioinovaSuspension of human autologous MSC 3P in 1.5 ml

Utilization of Autologous Mesenchymal Cells in Posterolateral Spinal Fusion in Degenerative Spine Disease

Start: Aug 2013Est. completion: Dec 201610 patients
Phase 1/2Terminated

Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery

Start: Nov 2008Est. completion: Jul 201224 patients
Phase 1/2Unknown

Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery

Start: Nov 2008Est. completion: Oct 201222 patients
Phase 1/2Unknown
NCT00813813Spine BioPharmaIntradiscal rhGDF-5

Intradiscal rhGDF-5 Phase I/II Clinical Trial

Start: Jun 2008Est. completion: Jun 201332 patients
Phase 1/2Completed

Study to Determine the Safety and Tolerability of TG-C in Subjects with Back Pain Due to Degenerative Disc Disease

Start: Nov 2025Est. completion: Nov 202724 patients
Phase 1Not Yet Recruiting

Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Disc Degeneration

Start: May 2019Est. completion: Nov 202238 patients
Phase 1Completed

Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Intervertebral Disc Degeneration

Start: Feb 2018Est. completion: Nov 202260 patients
Phase 1Completed

AMG0103 in Subjects With Chronic Discogenic Lumbar Back Pain

Start: Feb 2018Est. completion: Feb 202125 patients
Phase 1Completed

A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease

Start: Jul 2017Est. completion: Dec 20186 patients
Phase 1Terminated
NCT07386548AclarionBone Marrow Aspirate Concentrate

Biologic Injection For Adults With Lumbar Disc Herniation

Start: May 2026Est. completion: Dec 203090 patients
N/ANot Yet Recruiting

Retrospective Analysis of Patients Implanted With 2 Levels of Prodisc® C Vivo Devices

Start: Nov 2025Est. completion: Dec 2030200 patients
N/AEnrolling By Invitation

Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease

Start: Feb 2025Est. completion: May 2028496 patients
N/ARecruiting
NCT04679844Kuros BiosciencesMagnetOs Easypack Putty

Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion

Start: Dec 2024Est. completion: Aug 202760 patients
N/ARecruiting
NCT06485206HighRidge MedicalOne level Mobi-C and one level fusion

Evaluation of Safety and Effectiveness of Primary Hybrid Construct of Mobi-C and ACDF in the Treatment of Two-level Symptomatic Degenerative Disc Disease in the Cervical Spine.

Start: Sep 2024Est. completion: May 202997 patients
N/ARecruiting
NCT05037968Kuros BiosciencesMagnetOs Flex Matrix

MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion

Start: Jun 2024Est. completion: Dec 2026100 patients
N/ARecruiting
NCT06226272StrykerSpinal Fusion

Clinical Outcome Measure at Stryker Spine

Start: May 2024Est. completion: Jan 20325,222 patients
N/ANot Yet Recruiting

Evaluation of NB1 Bone Graft Following Lumbar Interbody Arthrodesis

Start: Mar 2024Est. completion: Jun 202630 patients
N/ARecruiting
NCT06000319Induce BiologicsNatural Matrix Protein

Natural Matrix Protein™ (NMP™) Fibers in Cervical and Lumbar Interbody Fusion

Start: Jan 2024Est. completion: Aug 2027200 patients
N/AEnrolling By Invitation

Discure Technologies Feasibility Study for DDD

Start: Jan 2024Est. completion: Dec 202420 patients
N/AUnknown
NCT05972616Induce BiologicsNatural Matrix Protein

Natural Matrix Protein™ (NMP™) in Interbody Lumbar Fusion

Start: Aug 2023Est. completion: Feb 202453 patients
N/ACompleted

Retrospective Study With Patients Treated With STALIF® C or M and Ti or FLX Implants for 1 and 2 Levels

Start: Apr 2023Est. completion: Sep 2024200 patients
N/AUnknown
NCT05883436Aurora SpineDEXA-C Cervical Interbody System

Investigation of DEXA-C Anterior Cervical Interbody System

Start: Feb 2023Est. completion: Feb 202780 patients
N/ARecruiting
NCT05412277Vivex BiologicsVIA Disc Nucleus Pulposus Allograft

VIA Disc Nucleus Pulposus Older Patients Pilot

Start: Oct 2022Est. completion: Dec 202421 patients
N/AUnknown
NCT05508360Spinal Stabilization TechnologiesPerQdisc Nucleus Replacement System

"Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2)

Start: Aug 2022Est. completion: Aug 203072 patients
N/ARecruiting
NCT05566704Globus MedicalModulus ALIF System

Retrospective Modulus ALIF Study

Start: Aug 2022Est. completion: May 2024123 patients
N/ACompleted

Study of the ReGelTec HYDRAFIL System

Start: Jan 2022Est. completion: Oct 202535 patients
N/ACompleted
NCT05144126CerapedicsCT radioraphic assessment

Safety, Radiological and Patient Reported Outcomes of i-FACTOR+ Matrix Bone Graft Device - A Canadian, Multicenter, Post-Market Clinical Investigation

Start: Jan 2022Est. completion: Sep 2025300 patients
N/AUnknown

Post Market Observational Trial for the PerQdisc Nucleus Replacement Device

Start: Dec 2021Est. completion: Dec 20210
N/AWithdrawn

VIA Disc NP Pilot for Patients With Symptomatic Degenerated Discs

Start: Dec 2021Est. completion: Dec 202435 patients
N/AUnknown
NCT05114356restor3dTIDAL Cervical Interbody Fusion implant

Cervical Interbody Fusion Device Patient Registry

Start: Nov 2021Est. completion: May 202473 patients
N/ATerminated

Post Marketing Study of MagnetOs Putty Compared to Local Autograft in Patients Undergoing Posterolateral Lumbar Fusion

Start: Aug 2021Est. completion: Dec 202330 patients
N/ACompleted
NCT05821920MedactaMUST MINI system

A Safety Study on Posterior Pedicle Screw System

Start: Jun 2021Est. completion: Jun 202544 patients
N/AUnknown
NCT04689880Globus MedicalXLIF Decade Plate System Study

XLIF Decade Plate System Study

Start: Apr 2021Est. completion: Apr 202375 patients
N/ACompleted

MySpine MC Versus MySpine Standard

Start: Feb 2021Est. completion: Feb 202444 patients
N/AUnknown

Post Marketing Clinical Follow up Study for MagnetOs Putty in Patients With Degenerative Disc Disease

Start: Nov 2020Est. completion: Dec 20230
N/AWithdrawn

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

6 late-stage (Phase 3) programs, potential near-term approvals
10 actively recruiting trials targeting 10,219 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.