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Degenerative Arthritis

11
Pipeline Programs
4
Companies
14
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
2
5
0
3
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

R-Bio
R-BioTX - Houston
6 programs
1
1
1
JOINTSTEMPhase 31 trial
JOINTSTEMPhase 21 trial
Autologous Adipose Tissue derived MSCs TransplantationPhase 1/21 trial
Autologous Adipose Tissue derived MSCs 1x10^8cells/3mlN/A1 trial
JOINTSTEMN/A1 trial
+1 more programs
Active Trials
NCT03000712Completed26Est. May 2020
NCT04825730Not Yet Recruiting14Est. Dec 2029
NCT04821102Unknown21Est. Dec 2024
+3 more trials
Biocorp
BiocorpFrance - Issoire
6 programs
1
1
1
JOINTSTEMPhase 3
JOINTSTEMPhase 2
Autologous Adipose Tissue derived MSCs TransplantationPhase 1/2
Autologous Adipose Tissue derived MSCs 1x10^8cells/3mlN/A
JOINTSTEMN/A
+1 more programs
Kolon Life Science
Kolon Life ScienceKorea - Seoul
5 programs
1
3
1
TissueGene-CPhase 31 trial
TissueGene-CPhase 21 trial
TissueGene-CPhase 21 trial
TissueGene-CPhase 21 trial
TissueGene-CPhase 11 trial
Active Trials
NCT02341391Completed12Est. Sep 2008
NCT01671072Completed54Est. Jan 2013
NCT02341378Completed28Est. Oct 2010
+2 more trials
Zimmer Biomet
Zimmer BiometFL - Jacksonville
3 programs
Duracon®N/A1 trial
I-beam designN/A1 trial
Zimmer Trabecular Metal Total Ankle SystemN/A1 trial
Active Trials
NCT00588887Terminated150Est. Jun 2008
NCT00588783Terminated100Est. Oct 2008
NCT02038140Active Not Recruiting120Est. Mar 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
R-BioJOINTSTEM
Kolon Life ScienceTissueGene-C
R-BioJOINTSTEM
Kolon Life ScienceTissueGene-C
Kolon Life ScienceTissueGene-C
Kolon Life ScienceTissueGene-C
R-BioAutologous Adipose Tissue derived MSCs Transplantation
Kolon Life ScienceTissueGene-C
R-BioJOINTSTEM
R-BioJOINTSTEM
R-BioAutologous Adipose Tissue derived MSCs 1x10^8cells/3ml
Zimmer BiometZimmer Trabecular Metal Total Ankle System
Zimmer BiometI-beam design
Zimmer BiometDuracon®

Clinical Trials (14)

Total enrollment: 1,008 patients across 14 trials

NCT03990805R-BioJOINTSTEM

A Phase 3 Study to Evaluate the Efficacy and Safety of JointStem in Treatment of Osteoarthritis

Start: Jun 2019Est. completion: Dec 2020260 patients
Phase 3Completed
NCT02072070Kolon Life ScienceTissueGene-C

Efficacy and Safety Study of TissueGene-C to Degenerative Arthritis

Start: Nov 2013Est. completion: Aug 2015163 patients
Phase 3Completed
NCT02658344R-BioJOINTSTEM

Clinical Trial to Evaluate Efficacy and Safety of JOINTSTEM in Patients With Degenerative Arthritis

Start: Jul 2015Est. completion: Dec 201624 patients
Phase 2Completed
NCT01825811Kolon Life ScienceTissueGene-C

Efficacy and Safety Study of TissueGene-C Mixed With Fibrin-glue for the Patients With Degenerative Arthritis

Start: Oct 2012Est. completion: Jun 201418 patients
Phase 2Completed
NCT01671072Kolon Life ScienceTissueGene-C

Efficacy and Safety Study of TissueGene-C to Degenerative Arthritis

Start: Jul 2011Est. completion: Jan 201354 patients
Phase 2Completed
NCT02341378Kolon Life ScienceTissueGene-C

Efficacy and Safety Study of TissueGene-C to Degenerative Arthritis

Start: Aug 2009Est. completion: Oct 201028 patients
Phase 2Completed
NCT01300598R-BioAutologous Adipose Tissue derived MSCs Transplantation

Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Degenerative Arthritis

Start: Dec 2008Est. completion: Mar 201218 patients
Phase 1/2Completed
NCT02341391Kolon Life ScienceTissueGene-C

Safety and Biological Efficacy Study of TisssueGene-C to Degenerative Arthritis

Start: Feb 2007Est. completion: Sep 200812 patients
Phase 1Completed
NCT04825730R-BioJOINTSTEM

Follow-up Study for Participants of Jointstem Investigator Initiated Trial by Arthroscopy

Start: Dec 2023Est. completion: Dec 202914 patients
N/ANot Yet Recruiting
NCT04821102R-BioJOINTSTEM

Investigator Initiated Trial to Evaluate Cartilage Regeneration by Arthroscopy After JOINTSTEM Administration

Start: Jul 2023Est. completion: Dec 202421 patients
N/AUnknown
NCT03000712R-BioAutologous Adipose Tissue derived MSCs 1x10^8cells/3ml

Investigator Initiated Trial to Evaluate the Efficacy and Safety of Intra-articular Injection of ADMSC Comared to Negative Control After High Tibial Osteotomy in the Osteoarthritis Patients.

Start: Nov 2016Est. completion: May 202026 patients
N/ACompleted
NCT02038140Zimmer BiometZimmer Trabecular Metal Total Ankle System

Zimmer Trabecular Metal Total Ankle PMCF

Start: Mar 2014Est. completion: Mar 2027120 patients
N/AActive Not Recruiting
NCT00588783Zimmer BiometI-beam design

I-beam and Cruciate Tibial Components Used in Total Knee Replacement

Start: Aug 2006Est. completion: Oct 2008100 patients
N/ATerminated
NCT00588887Zimmer BiometDuracon®

Total Knee Replacement With Duracon® and Vanguard™ Prostheses

Start: Jun 2005Est. completion: Jun 2008150 patients
N/ATerminated

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.