Cytomegalovirus Retinitis

5
Pipeline Programs
4
Companies
19
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
2
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
375%
Monoclonal Antibody
125%
+ 6 programs with unclassified modality

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Ionis Pharmaceuticals
4 programs
2
Fomivirsen sodiumPhase 21 trial
Fomivirsen sodiumPhase 21 trial
Fomivirsen sodiumN/A1 trial
Fomivirsen sodiumN/A1 trial
Active Trials
NCT00002187Completed
NCT00002355Completed60
NCT00002356Completed
+1 more trials
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
3 programs
2
GanciclovirPhase 1Small Molecule1 trial
GanciclovirPhase 1Small Molecule1 trial
Foscarnet sodiumN/A1 trial
Active Trials
NCT00000665Completed
NCT00000668Completed48Est. Feb 1995
NCT00001062CompletedEst. Jan 1998
Sandoz
SandozAustria - Kundl
1 program
1
SevirumabPhase 1Monoclonal Antibody1 trial
Active Trials
NCT00002016Completed
Roche
RocheSTAVANGER NORWAY, Norway
2 programs
GanciclovirN/ASmall Molecule1 trial
ZidovudineN/A5 trials
Active Trials
NCT00002135Completed
NCT00000969Completed400Est. Sep 1992
NCT00000651Completed750Est. May 1993
+3 more trials

Clinical Trials (19)

Total enrollment: 2,488 patients across 19 trials

A Randomized, Double Blind, Comparative Study of Dideoxycytidine (ddC) Alone or ddC/AZT Combination Versus Zidovudine (ZDV) Alone in Patients With HIV Infection Who Have Received Prior ZDV Therapy

Est. completion: May 1993750 patients
Phase 3Completed

A Randomized Comparison of Intravitreal ISIS 2922 Plus Ganciclovir Versus Ganciclovir as Treatment for Patients With Cytomegalovirus Retinitis ( CMVR )

194 patients
Phase 2Completed

A Randomized Phase II Study of Two Doses of Interferon Alfa-2a (IFN Alfa-2a) in Combination With Zidovudine (AZT) and Dideoxycytidine (ddC) Versus AZT and ddC Only in Patients With HIV Infection and Less Than 400 CD4 Cells/mm3

Est. completion: Feb 199560 patients
Phase 2Completed

(Ro 24-2027) A Randomized, Double-Blind, Comparative Study of Dideoxycytidine (ddC) Versus Zidovudine (AZT) in Patients With AIDS or Advanced ARC

600 patients
Phase 2Completed

The Safety and Effectiveness of ISIS 2922 in Patients With AIDS Who Have Cytomegalovirus (CMV) of the Eyes

Phase 2Completed

A Phase I Pharmacokinetic and Tolerance Study of 28-Day Regimens of Oral Ganciclovir

Est. completion: Feb 199548 patients
Phase 1Completed

A Randomized Study of Activity, Safety, and Tolerance of Oral Ro 24-7429 (Tat Antagonist) in Patients With HIV Infection

96 patients
Phase 1Completed

A Study of Ganciclovir in the Treatment of Cytomegalovirus of the Eyes

Est. completion: Jan 1998
Phase 1Completed

A Study of Dideoxycytidine Plus Zidovudine in the Treatment of AIDS or Advanced AIDS Related Complex (ARC)

68 patients
Phase 1Completed

A Phase I/II Trial to Assess the Safety and Tolerance of Escalating Doses of a Human Anti-Cytomegalovirus Monoclonal Antibody (SDZ MSL-109) in Patients With the Acquired Immunodeficiency Syndrome and CMV Retinitis

Phase 1Completed
NCT00002135RocheGanciclovir

An Open-Label Safety Study of Oral Ganciclovir Maintenance Treatment of CMV Retinitis in People With Limited Venous Access

N/ACompleted

A Study of ISIS 2922 in the Treatment of Advanced Cytomegalovirus Retinitis

N/ACompleted

Studies of the Ocular Complications of AIDS (SOCA) CMV Retinitis Trial: Foscarnet-Ganciclovir Component

N/ACompleted

A Prospective, Randomized, Open-Label, Comparative Trial of Dideoxyinosine (ddI) Versus Dideoxycytidine (ddC) in HIV-Infected Patients Who Are Intolerant of or Who Have Failed Zidovudine (AZT) Therapy

Est. completion: Sep 1992400 patients
N/ACompleted

A Study of the Safety and Tolerance of Long-Term Therapy With Intravenous Cytovene (Ganciclovir Sodium) for Cytomegalovirus Retinitis in Persons With AIDS

100 patients
N/ACompleted

A Study of ddC in Patients With AIDS or Advanced AIDS-Related Complex (ARC) Who Have Not Had Success With Zidovudine (AZT)

N/ACompleted

Dideoxycytidine ( Ro 24-2027 ). A Treatment Protocol for the Use of Dideoxycytidine ( ddC ) in Patients With AIDS or Advanced ARC Who Cannot Be Maintained on Zidovudine ( AZT ) Therapy.

N/ACompleted

A Clinical Trial of Alternating and Intermittent Regimens of 2',3'-Dideoxycytidine and 3'-Azido-3'-Deoxythymidine in the Treatment of Patients With AIDS and Advanced ARC

Est. completion: Sep 1991112 patients
N/ACompleted

A Comparison of ISIS 2922 Used Immediately or Later in Patients With Cytomegalovirus (CMV) of the Eyes

60 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 companies competing in this space