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Cytomegalovirus Retinitis

9
Pipeline Programs
7
Companies
17
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
3
0
3
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1785%
Monoclonal Antibody
315%
+ 10 programs with unclassified modality

On Market (1)

Approved therapies currently available

Roche
CYTOVENEApproved
ganciclovir
Roche
oral1994

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Roche
RocheSTAVANGER NORWAY, Norway
2 programs
1
GanciclovirN/ASmall Molecule1 trial
ZidovudineN/A4 trials
Active Trials
NCT00002135Completed
NCT00002034Completed100
NCT00000755Completed168Est. Mar 1993
+2 more trials
Genentech
GenentechCA - Oceanside
13 programs
2
1
3
GanciclovirPhase 3Small Molecule
ValganciclovirPhase 3Small Molecule
ValganciclovirPhase 3Small Molecule
GanciclovirPhase 2Small Molecule
Foscarnet sodiumPhase 1
+8 more programs
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
5 programs
1
SevirumabPhase 2Monoclonal Antibody1 trial
CidofovirN/ASmall Molecule
Foscarnet sodiumN/A4 trials
GanciclovirPHASE_1Small Molecule1 trial
GanciclovirPHASE_1Small Molecule
Active Trials
NCT00000964Completed6Est. Oct 1990
NCT00000726Completed53Est. Feb 1992
NCT00000729Completed10Est. Jun 1992
+3 more trials
Kite Pharma
Kite PharmaCA - El Segundo
4 programs
1
CidofovirPhase 2Small Molecule
CidofovirN/ASmall Molecule
CidofovirN/ASmall Molecule
CidofovirN/ASmall Molecule
Ionis Pharmaceuticals
4 programs
Fomivirsen sodiumN/A1 trial
Fomivirsen sodiumN/A1 trial
Fomivirsen sodiumPHASE_21 trial
Fomivirsen sodiumPHASE_21 trial
Active Trials
NCT00002355Completed60
NCT00002187Completed
NCT00002356Completed
+1 more trials
Sandoz
SandozAustria - Kundl
1 program
SevirumabPHASE_1Monoclonal Antibody
Novartis
NovartisBASEL, Switzerland
1 program
SevirumabPHASE_1Monoclonal Antibody2 trials
Active Trials
NCT00002268Completed
NCT00002016Completed

Clinical Trials (17)

Total enrollment: 1,292 patients across 17 trials

A Phase II/III Trial of Human Anti-CMV Monoclonal Antibody MSL 109 (MACRT)

Est. completion: Aug 1998300 patients
Phase 2Completed

A Randomized Comparison of Intravitreal ISIS 2922 Plus Ganciclovir Versus Ganciclovir as Treatment for Patients With Cytomegalovirus Retinitis ( CMVR )

194 patients
Phase 2Completed

The Safety and Effectiveness of ISIS 2922 in Patients With AIDS Who Have Cytomegalovirus (CMV) of the Eyes

Phase 2Completed

The Effect of Stomach Acid on Foscarnet

Est. completion: Oct 19906 patients
Phase 1Completed

Foscarnet Treatment of Serious CMV Retinitis Infection in Patients With Acquired Immunodeficiency Syndrome

Est. completion: Feb 199253 patients
Phase 1Completed

A Multicenter Study To Determine Foscarnet Dose Response in HIV Infected Patients With PGL and/or Constitutional Disease

Est. completion: Jun 199210 patients
Phase 1Completed

A Study of Ganciclovir in the Treatment of Cytomegalovirus of the Eyes

Est. completion: Jan 199825 patients
Phase 1Completed

A Randomized Study of Activity, Safety, and Tolerance of Oral Ro 24-7429 (Tat Antagonist) in Patients With HIV Infection

96 patients
Phase 1Completed

A Phase I/II Trial of Vaccine Therapy of HIV-1 Infected Individuals With 50-500 CD4 Cells/mm3

Est. completion: Mar 1993168 patients
Phase 1Completed

A Phase I Study of the Safety and Pharmacokinetics of Recombinant Human CD4-Immunoglobulin G (rCD4-IgG) Administered by Intravenous Bolus Injection in Combination With Oral Zidovudine in Patients With AIDS and AIDS-Related Complex

40 patients
Phase 1Completed

A Randomized, Phase I/II Trial to Assess the Safety and Antiviral Effects of Escalating Doses of A Human Anti-Cytomegalovirus Monoclonal Antibody (SDZ MSL-109) in Patients With the Acquired Immunodeficiency Syndrome and CMV Viremia and/or Viruria

Phase 1Completed

A Phase I/II Trial to Assess the Safety and Tolerance of Escalating Doses of a Human Anti-Cytomegalovirus Monoclonal Antibody (SDZ MSL-109) in Patients With the Acquired Immunodeficiency Syndrome and CMV Retinitis

Phase 1Completed

A Comparison of ISIS 2922 Used Immediately or Later in Patients With Cytomegalovirus (CMV) of the Eyes

60 patients
N/ACompleted

A Study of ISIS 2922 in the Treatment of Advanced Cytomegalovirus Retinitis

N/ACompleted
NCT00002135RocheGanciclovir

An Open-Label Safety Study of Oral Ganciclovir Maintenance Treatment of CMV Retinitis in People With Limited Venous Access

N/ACompleted

Studies of the Ocular Complications of AIDS (SOCA) CMV Retinitis Trial: Foscarnet-Ganciclovir Component

240 patients
N/ACompleted

A Study of the Safety and Tolerance of Long-Term Therapy With Intravenous Cytovene (Ganciclovir Sodium) for Cytomegalovirus Retinitis in Persons With AIDS

100 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
Small Molecule is the dominant modality (85% of programs)
7 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.