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Cryopyrin-associated Periodic Syndromes

6
Pipeline Programs
4
Companies
7
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
4
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
2100%
+ 5 programs with unclassified modality

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Sandoz
SandozAustria - Kundl
4 programs
4
ACZ885Phase 31 trial
ACZ885Phase 31 trial
CanakinumabPhase 3Monoclonal Antibody1 trial
canakinumabPhase 3Monoclonal Antibody1 trial
Active Trials
NCT01576367Completed17Est. Oct 2015
NCT01302860Completed17Est. Nov 2014
NCT00685373Completed166Est. Apr 2010
+1 more trials
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
1
TranilastPhase 21 trial
Active Trials
NCT03923140Unknown71Est. Oct 2024
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
1
124I AT-01Phase 11 trial
Active Trials
NCT06974877Recruiting30Est. Jan 2032
Swedish Orphan Biovitrum
1 program
anakinraN/A1 trial
Active Trials
NCT02326376Completed12Est. Sep 2019

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
SandozACZ885
SandozACZ885
Sandozcanakinumab
SandozCanakinumab
UNION therapeuticsTranilast
Allergy Therapeutics124I AT-01
Swedish Orphan Biovitrumanakinra

Clinical Trials (7)

Total enrollment: 332 patients across 7 trials

Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease

Start: Jan 2012Est. completion: Oct 201517 patients
Phase 3Completed

Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease

Start: Nov 2010Est. completion: Nov 201417 patients
Phase 3Completed

Efficacy and Safety Study of Canakinumab Administered for 6 Months (24 Weeks) in Japanese Patients With Cryopyrin-associated Periodic Syndromes Followed by an Extension Phase

Start: Oct 2009Est. completion: Feb 201219 patients
Phase 3Completed

Efficacy and Safety of ACZ885 in Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease

Start: May 2008Est. completion: Apr 2010166 patients
Phase 3Completed

A Clinical Study of Tranilast in the Treatment of Cryopyrin-Associated Periodic Syndrome (CAPS)

Start: May 2019Est. completion: Oct 202471 patients
Phase 2Unknown

Repeat PET/CT Imaging in People With CAPS and Anakinra-Induced Amyloidosis Using an Amyloid-Reactive Peptide to Measure Changes in Organ-Specific Amyloid Load

Start: Sep 2025Est. completion: Jan 203230 patients
Phase 1Recruiting

Kineret CAPS Post Authorisation Study

Start: Apr 2015Est. completion: Sep 201912 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 332 patients
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.