Critical Illness

7
Pipeline Programs
9
Companies
19
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
1
4
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Fresenius Kabi
Fresenius KabiGermany - Bad Homburg
4 programs
2
Early Goal-Directed NutritionPhase 41 trial
SmofKabiven® extra NitrogenPhase 41 trial
Fresubin OriginalN/A1 trial
GlutamineN/A1 trial
Active Trials
NCT01167075Completed58Est. Feb 2009
NCT00133978Completed1,223Est. May 2012
NCT01372176Completed203Est. Nov 2016
+1 more trials
Abbott
AbbottABBOTT PARK, IL
3 programs
1
Data CollectionPhase 41 trial
Freestyle NavigatorN/A1 trial
VITAL AFN/A1 trial
Active Trials
NCT00694473Completed76Est. Dec 2017
NCT01448135Completed50Est. Nov 2014
NCT00574431Completed200Est. Mar 2009
Humanwell Pharmaceutical
1 program
1
RemifentanilPhase 41 trial
Active Trials
NCT02635802UnknownEst. Sep 2016
AM-Pharma
AM-PharmaNetherlands - Utrecht
1 program
1
CholecalciferolPhase 31 trial
Active Trials
NCT03188796RecruitingEst. Mar 2027
Takeda
TakedaTOKYO, Japan
1 program
1
TAK-954Phase 25 trials
Active Trials
NCT03477903Terminated1Est. Aug 2018
NCT03500224Completed6Est. Jun 2018
NCT03296787Completed32Est. Aug 2019
+2 more trials
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
1 program
1
intensive insulin therapy to maintain normoglycemiaPhase 21 trial
Active Trials
NCT00115479Completed1,200Est. Jun 2005
T-Therapeutics
T-TherapeuticsUK - Cambridge
3 programs
Electronic ICU Medical Transfer ToolN/A1 trial
Fluid management guided by BLSN/A1 trial
Revealed AlertsN/A1 trial
Active Trials
NCT03590002CompletedEst. Sep 2021
NCT03393065UnknownEst. Dec 2019
NCT06996626RecruitingEst. Jun 2027
Vera Therapeutics
Vera TherapeuticsBRISBANE, CA
1 program
SentecN/A1 trial
Active Trials
NCT03060018CompletedEst. Dec 2018

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Fresenius KabiSmofKabiven® extra Nitrogen
Humanwell PharmaceuticalRemifentanil
Fresenius KabiEarly Goal-Directed Nutrition
AbbottData Collection
AM-PharmaCholecalciferol
TakedaTAK-954
Novo Nordiskintensive insulin therapy to maintain normoglycemia
TakedaTAK-954
TakedaTAK-954
TakedaTAK-954
TakedaTAK-954
T-TherapeuticsRevealed Alerts
T-TherapeuticsElectronic ICU Medical Transfer Tool
T-TherapeuticsFluid management guided by BLS
Vera TherapeuticsSentec

Showing 15 of 19 trials with date data

Clinical Trials (19)

Total enrollment: 3,091 patients across 19 trials

NCT03992716Fresenius KabiSmofKabiven® extra Nitrogen

Reaching Protein Target With SmofKabiven® Extra Nitrogen vs Olimel N9E During the Early Phase of Acute Critical Illness

Start: Nov 2019Est. completion: Mar 20207 patients
Phase 4Terminated

the Research of Analgesia and Sedation Effect of Remifentanil on ICU Short Operation

Start: Dec 2015Est. completion: Sep 2016
Phase 4Unknown
NCT01372176Fresenius KabiEarly Goal-Directed Nutrition

Early Goal-Directed Nutrition in ICU Patients - EAT-ICU Trial

Start: Jun 2013Est. completion: Nov 2016203 patients
Phase 4Completed
NCT00574431AbbottData Collection

ICU Nutrition Study Bern

Start: Feb 2008Est. completion: Mar 2009200 patients
Phase 4Completed
NCT03188796AM-PharmaCholecalciferol

The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients

Start: Oct 2017Est. completion: Mar 2027
Phase 3Recruiting

TAK-954 in Critically Ill Participants With Enteral Feeding Intolerance (EFI)

Start: Aug 2018Est. completion: Aug 20181 patients
Phase 2Terminated
NCT00115479Novo Nordiskintensive insulin therapy to maintain normoglycemia

KULeuven Intensive Insulin Therapy Study in Medical Intensive Care Patients

Start: Mar 2002Est. completion: Jun 20051,200 patients
Phase 2Completed

A Study to Evaluate the Mass Balance, Pharmacokinetics (PK), Metabolism and Excretion of TAK-954 Containing Microtracer ([14C]-TAK-954) in Healthy Male Participants

Start: Apr 2018Est. completion: Jun 20186 patients
Phase 1Completed

A Study to Evaluate the Effect of Renal Impairment and Dialysis Treatment on the Pharmacokinetics (PK) of a Single Intravenous (IV) TAK-954

Start: Nov 2017Est. completion: Aug 201932 patients
Phase 1Completed

A Study to Evaluate the Effect of Hepatic Impairment on the Single Dose Pharmacokinetics (PK) of Intravenous TAK-954

Start: Nov 2017Est. completion: Sep 201825 patients
Phase 1Completed

A Study to Evaluate the Effect of the Potent Cytochrome P-450 3A4 (CYP3A4) Inhibitor Itraconazole on the Pharmacokinetics (PK) of TAK-954 in Healthy Adult Participants

Start: May 2017Est. completion: Jul 201710 patients
Phase 1Completed

Real-time NOMA Evaluation

Start: Jun 2025Est. completion: Jun 2027
N/ARecruiting
NCT03590002T-TherapeuticsElectronic ICU Medical Transfer Tool

Evaluating the Effectiveness of an Electronic Medical Transfer Tool to Improve Communication During Transfers From ICU

Start: Jul 2018Est. completion: Sep 2021
N/ACompleted
NCT03393065T-TherapeuticsFluid management guided by BLS

Lung Ultrasound Guided Protocol for Fluid Management for the Critically Ill Patient: a Randomized Study

Start: Dec 2017Est. completion: Dec 2019
N/AUnknown

Transcutaneous Partial Oxygen and Carbon Dioxide Pressures Compared With Blood Gas Values

Start: Aug 2017Est. completion: Dec 2018
N/ACompleted

Tolerance and Efficacy of a Predigested, High Protein, High Omega 3 Fat Enteral Feeding Formula Versus a Standard Formula In Multiple Intensive Care Unit Settings

Start: Oct 2011Est. completion: Nov 201450 patients
N/ACompleted
NCT00694473AbbottFreestyle Navigator

Continuous Glucose Monitoring With a Subcutaneous Sensor During Critical Illness and Surgery

Start: Jun 2008Est. completion: Dec 201776 patients
N/ACompleted
NCT01167075Fresenius KabiFresubin Original

A Study in Critically Ill Patients Investigating Tolerability and Efficacy of Low-volume Pharmaconutrition (Intestamin)

Start: Feb 2006Est. completion: Feb 200958 patients
N/ACompleted

Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients

Start: Apr 2005Est. completion: May 20121,223 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
2 actively recruiting trials targeting 3,091 patients
9 companies competing in this space