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Critical Illness

11
Pipeline Programs
28
Companies
50
Clinical Trials
5 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
4
0
3
4
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
1100%
+ 57 programs with unclassified modality

Competitive Landscape

23 companies ranked by most advanced pipeline stage

UNION therapeutics
UNION therapeuticsDenmark - Hellerup
10 programs
4
1
fixed citrate doses protocolPhase 41 trial
Fospropofol disodium for injectionPhase 21 trial
Fospropofol disodium for injectionPhase 21 trial
Nafamostat MesylatePhase 21 trial
Sedation drugsPhase 21 trial
+5 more programs
Active Trials
NCT03523169Completed120Est. Dec 2017
NCT07328724Not Yet Recruiting4,000Est. Dec 2036
NCT02999932Terminated1,706Est. May 2022
+7 more trials
B. Braun
B. BraunGermany - Melsungen
10 programs
1
2
Filter: NOE96E, ELD96E, NLF1E, TNA1EPhase 41 trial
MCT/LCTPhase 42 trials
Nutriflex Omega specialPhase 31 trial
Space GlucoseControlN/A2 trials
Space TGCN/A1 trial
+5 more programs
Active Trials
NCT01886365Completed75Est. Oct 2012
NCT01523665Completed508Est. Jul 2013
NCT01164449Completed20Est. Aug 2011
+9 more trials
Abbott
AbbottABBOTT PARK, IL
3 programs
1
Data CollectionPhase 41 trial
Freestyle NavigatorN/A1 trial
VITAL AFN/A1 trial
Active Trials
NCT00694473Completed76Est. Dec 2017
NCT01448135Completed50Est. Nov 2014
NCT00574431Completed200Est. Mar 2009
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
4 programs
2
Targeting NormoxemiaPhase 31 trial
Targeting NormoxemiaPhase 31 trial
Automated TitrationN/A1 trial
MidazolamN/A1 trial
Active Trials
NCT06374225Completed300Est. Jan 2026
NCT00744380Completed23Est. Oct 2012
NCT04534959Active Not Recruiting6,000Est. Jun 2025
+1 more trials
Fresenius Kabi
Fresenius KabiGermany - Bad Homburg
4 programs
Fresubin OriginalN/A1 trial
GlutamineN/A1 trial
Early Goal-Directed NutritionPHASE_41 trial
SmofKabiven® extra NitrogenPHASE_41 trial
Active Trials
NCT01167075Completed58Est. Feb 2009
NCT00133978Completed1,223Est. May 2012
NCT01372176Completed203Est. Nov 2016
+1 more trials
T-Therapeutics
T-TherapeuticsUK - Cambridge
3 programs
Electronic ICU Medical Transfer ToolN/A1 trial
Fluid management guided by BLSN/A1 trial
Revealed AlertsN/A1 trial
Active Trials
NCT03590002CompletedEst. Sep 2021
NCT03393065UnknownEst. Dec 2019
NCT06996626RecruitingEst. Jun 2027
Innovation Pharmaceuticals
3 programs
Family meetings using time limited trials as default ICU communication and care planning approachN/A
Nurse directedN/A1 trial
Nutritionally complete Tube Feed with standard protein levelsN/A1 trial
Active Trials
NCT01420302Completed300Est. Mar 2012
NCT06714240Recruiting26Est. Sep 2028
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
2 programs
AEGISN/A1 trial
Family meetings using time limited trials as default ICU communication and care planning approachN/A1 trial
Active Trials
NCT02677909Withdrawn0Est. Jul 2021
NCT04181294Completed209Est. Dec 2019
NeurOptics
NeurOpticsCA - Irvine
2 programs
Establishing Normative Data for Pupillometer Assessments in Neuro-Intensive CareN/A1 trial
NPi-200 and NPi-300 pupillometersN/A1 trial
Active Trials
NCT02804438Recruiting1,000Est. Sep 2028
NCT04993833Completed70Est. Aug 2022
Frontera Therapeutics
Frontera TherapeuticsChina - Suzhou
2 programs
Intervention. Early and integral communication strategyN/A1 trial
Patients received the standard physical therapyN/A1 trial
Active Trials
NCT05035563Completed350Est. Jul 2022
NCT05287919Completed54Est. Jan 2020
Philips
PhilipsNetherlands - Amsterdam
2 programs
Philips IntelliVue X3 Patient MonitorN/A1 trial
TraceBookN/A1 trial
Active Trials
NCT05673408Recruiting189Est. Dec 2026
NCT03599856Unknown408Est. Jun 2019
Baxter International
2 programs
OlimelPHASE_31 trial
Withholding PN during the first week of ICU stayPHASE_41 trial
Active Trials
NCT01206166Terminated125Est. Jul 2015
NCT00512122Active Not Recruiting4,640Est. Dec 2026
Medtronic
MedtronicNJ - Phillipsburg
1 program
Bispectral IndexN/A1 trial
Active Trials
NCT00734409Completed300Est. Jul 2011
Edwards Lifesciences
1 program
FloTrac™ and EV1000™N/A1 trial
Active Trials
NCT02742974Unknown196Est. Dec 2019
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
Live musicN/A1 trial
Active Trials
NCT05541029Recruiting171Est. May 2027
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
Multi-component Family Support InterventionN/A1 trial
Active Trials
NCT05019261Active Not Recruiting1,163Est. Apr 2026
iNova Pharmaceuticals
iNova PharmaceuticalsAustralia - Chatswood
1 program
Music TherapyN/A1 trial
Active Trials
NCT03931733Completed118Est. Mar 2020
Orion
OrionUK - Cambridge
1 program
SOCN/A
Orion Pharma
Orion PharmaUK - Reading
1 program
SOCN/A1 trial
Active Trials
NCT01707680Terminated155Est. Nov 2015
Vera Therapeutics
Vera TherapeuticsBRISBANE, CA
1 program
SentecN/A1 trial
Active Trials
NCT03060018CompletedEst. Dec 2018
Takeda
TakedaTOKYO, Japan
1 program
TAK-954PHASE_25 trials
Active Trials
NCT03477903Terminated1Est. Aug 2018
NCT03500224Completed6Est. Jun 2018
NCT03296787Completed32Est. Aug 2019
+2 more trials
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
1 program
intensive insulin therapy to maintain normoglycemiaPHASE_21 trial
Active Trials
NCT00115479Completed1,200Est. Jun 2005
Humanwell Pharmaceutical
1 program
RemifentanilPHASE_41 trial
Active Trials
NCT02635802Unknown1,500Est. Sep 2016

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Fresenius KabiSmofKabiven® extra Nitrogen
Humanwell PharmaceuticalRemifentanil
UNION therapeuticsfixed citrate doses protocol
Fresenius KabiEarly Goal-Directed Nutrition
AbbottData Collection
Baxter InternationalWithholding PN during the first week of ICU stay
B. BraunMCT/LCT
B. BraunFilter: NOE96E, ELD96E, NLF1E, TNA1E
Colorado TherapeuticsTargeting Normoxemia
Colorado TherapeuticsTargeting Normoxemia
B. BraunNutriflex Omega special
Baxter InternationalOlimel
UNION therapeuticsFospropofol disodium for injection
UNION therapeuticsNafamostat Mesylate
UNION therapeuticsFospropofol disodium for injection

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 30,286 patients across 50 trials

NCT03992716Fresenius KabiSmofKabiven® extra Nitrogen

Reaching Protein Target With SmofKabiven® Extra Nitrogen vs Olimel N9E During the Early Phase of Acute Critical Illness

Start: Nov 2019Est. completion: Mar 20207 patients
Phase 4Terminated

the Research of Analgesia and Sedation Effect of Remifentanil on ICU Short Operation

Start: Dec 2015Est. completion: Sep 20161,500 patients
Phase 4Unknown
NCT02663960UNION therapeuticsfixed citrate doses protocol

Compare Efficacy and Simplicity of Regional Citrate Anticoagulation With Fixed Dose Versus Adjusted Citrate Program

Start: Aug 2015Est. completion: May 201670 patients
Phase 4Completed
NCT01372176Fresenius KabiEarly Goal-Directed Nutrition

Early Goal-Directed Nutrition in ICU Patients - EAT-ICU Trial

Start: Jun 2013Est. completion: Nov 2016203 patients
Phase 4Completed
NCT00574431AbbottData Collection

ICU Nutrition Study Bern

Start: Feb 2008Est. completion: Mar 2009200 patients
Phase 4Completed
NCT00512122Baxter InternationalWithholding PN during the first week of ICU stay

Impact of Early Parenteral Nutrition Completing Enteral Nutrition in Adult Critically Ill Patients

Start: Aug 2007Est. completion: Dec 20264,640 patients
Phase 4Active Not Recruiting

ICULIP, Influence of Two Lipid Emulsions in the Nosocomial Infection in Critical Patients

Start: Nov 2006Est. completion: Feb 2011212 patients
Phase 4Terminated
NCT00209768B. BraunFilter: NOE96E, ELD96E, NLF1E, TNA1E

Use of In-Line Filtration in Critically Ill Children

Start: Feb 2005Est. completion: Sep 2008821 patients
Phase 4Completed

Strategy to Avoid Excessive Oxygen in Major Burn Patients

Start: Apr 2021Est. completion: Dec 20252,000 patients
Phase 3Active Not Recruiting

Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients

Start: Oct 2020Est. completion: Jun 20256,000 patients
Phase 3Active Not Recruiting
NCT01162928B. BraunNutriflex Omega special

Parenteral Nutrition With Intravenous and Oral Fish Oil for Intensive Care Patients

Start: May 2013Est. completion: Nov 2017100 patients
Phase 3Completed

Trial of Supplemental Parenteral Nutrition in Under and Over Weight Critically Ill Patients (TOP-UP)

Start: Jun 2011Est. completion: Jul 2015125 patients
Phase 3Terminated
NCT05870514UNION therapeuticsFospropofol disodium for injection

Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients

Start: Jun 2023Est. completion: Jun 202460 patients
Phase 2Unknown

Efficacy and Safety of Nafamostat Mesylate for VV-ECMO Anticoagulation

Start: Dec 2022Est. completion: Oct 202440 patients
Phase 2Unknown
NCT05491278UNION therapeuticsFospropofol disodium for injection

Efficacy and Safety of Fospropofol Disodium Versus Propofol for Sedation in Mechanically Ventilated ICU Patients

Start: Aug 2022Est. completion: Sep 202360 patients
Phase 2Completed

Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Mechanically Ventilated ICU Patients

Start: May 2021Est. completion: May 202260 patients
Phase 2Completed

TAK-954 in Critically Ill Participants With Enteral Feeding Intolerance (EFI)

Start: Aug 2018Est. completion: Aug 20181 patients
Phase 2Terminated

Comparison of Two Different Lipid Emulsions for Parenteral Nutrition in Preterm Infants

Start: Jan 2006Est. completion: Feb 200848 patients
Phase 2Completed
NCT00115479Novo Nordiskintensive insulin therapy to maintain normoglycemia

KULeuven Intensive Insulin Therapy Study in Medical Intensive Care Patients

Start: Mar 2002Est. completion: Jun 20051,200 patients
Phase 2Completed

A Study to Evaluate the Mass Balance, Pharmacokinetics (PK), Metabolism and Excretion of TAK-954 Containing Microtracer ([14C]-TAK-954) in Healthy Male Participants

Start: Apr 2018Est. completion: Jun 20186 patients
Phase 1Completed

A Study to Evaluate the Effect of Renal Impairment and Dialysis Treatment on the Pharmacokinetics (PK) of a Single Intravenous (IV) TAK-954

Start: Nov 2017Est. completion: Aug 201932 patients
Phase 1Completed

A Study to Evaluate the Effect of Hepatic Impairment on the Single Dose Pharmacokinetics (PK) of Intravenous TAK-954

Start: Nov 2017Est. completion: Sep 201825 patients
Phase 1Completed

A Study to Evaluate the Effect of the Potent Cytochrome P-450 3A4 (CYP3A4) Inhibitor Itraconazole on the Pharmacokinetics (PK) of TAK-954 in Healthy Adult Participants

Start: May 2017Est. completion: Jul 201710 patients
Phase 1Completed
NCT07328724UNION therapeuticsCritical Illness After Hematopoietic Cell Transplantation

Critical Illness After Hematopoietic Cell Transplantation

Start: Jan 2026Est. completion: Dec 20364,000 patients
N/ANot Yet Recruiting
NCT06714240Innovation PharmaceuticalsNutritionally complete Tube Feed with standard protein levels

Enhanced Protein Intake to Support Muscle Protein Synthesis in ICU

Start: Sep 2025Est. completion: Sep 202826 patients
N/ARecruiting

Real-time NOMA Evaluation

Start: Jun 2025Est. completion: Jun 2027
N/ARecruiting

Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention

Start: Apr 2024Est. completion: Jan 2026300 patients
N/ACompleted
NCT05673408PhilipsPhilips IntelliVue X3 Patient Monitor

NIBP Validation Study

Start: Jun 2023Est. completion: Dec 2026189 patients
N/ARecruiting

Music Listening: A Mechanistic Trial

Start: Mar 2023Est. completion: May 2027171 patients
N/ARecruiting
NCT05019261Oregon TherapeuticsMulti-component Family Support Intervention

Multi-component Family Support Tool Intervention (FST)

Start: Nov 2021Est. completion: Apr 20261,163 patients
N/AActive Not Recruiting
NCT04993833NeurOpticsNPi-200 and NPi-300 pupillometers

Inter-Device Reliability of the NPi-300 Pupillometer

Start: Aug 2021Est. completion: Aug 202270 patients
N/ACompleted
NCT05035563Frontera TherapeuticsIntervention. Early and integral communication strategy

Impact of a Communication Strategy in the Prevention of Depressive Symptoms in Patients with Covid-19

Start: Jun 2021Est. completion: Jul 2022350 patients
N/ACompleted
NCT04177446UNION therapeuticsa production consist of various oligopeptides and the whey protein

A Study About Nutritional Support of Enhanced Protein in Critical Patients

Start: Dec 2019Est. completion: May 2020180 patients
N/AUnknown
NCT05287919Frontera TherapeuticsPatients received the standard physical therapy

Neuromuscular Electrical Stimulation (NMES) Preserves Muscle Mass in Intensive Care Unit (ICU)

Start: Aug 2019Est. completion: Jan 202054 patients
N/ACompleted
NCT02999932UNION therapeuticsSpO2 directed oxygen therapy

Peripheral Oxygen Saturation (SpO2) Directed Oxygen Therapy

Start: May 2019Est. completion: May 20221,706 patients
N/ATerminated

The Impact of Receptive Music Therapy in the ICU

Start: Nov 2018Est. completion: Mar 2020118 patients
N/ACompleted
NCT03590002T-TherapeuticsElectronic ICU Medical Transfer Tool

Evaluating the Effectiveness of an Electronic Medical Transfer Tool to Improve Communication During Transfers From ICU

Start: Jul 2018Est. completion: Sep 2021
N/ACompleted

TraceBook: the Clinical Proof of Concept on the Intensive Care.

Start: Jun 2018Est. completion: Jun 2019408 patients
N/AUnknown

Computer-Aided, Non-Invasive, Acoustic Gastrointestinal Surveillance (AGIS) in ICU Patients

Start: Jan 2018Est. completion: Jul 20210
N/AWithdrawn
NCT03393065T-TherapeuticsFluid management guided by BLS

Lung Ultrasound Guided Protocol for Fluid Management for the Critically Ill Patient: a Randomized Study

Start: Dec 2017Est. completion: Dec 2019
N/AUnknown

Transcutaneous Partial Oxygen and Carbon Dioxide Pressures Compared With Blood Gas Values

Start: Aug 2017Est. completion: Dec 2018
N/ACompleted
NCT04181294Angeles TherapeuticsFamily meetings using time limited trials as default ICU communication and care planning approach

Time Limited Trials to Reduce Non-Beneficial Intensive Care Unit Treatments

Start: Aug 2017Est. completion: Dec 2019209 patients
N/ACompleted
NCT03523169UNION therapeuticsCerebral Oxygen Challenge of Passive Leg Raising Test in Sepsis

Cerebral Oxygen Challenge of Passive Leg Raising Test in Sepsis

Start: Dec 2016Est. completion: Dec 2017120 patients
N/ACompleted

The Effects of Anti-infective Central Venous Catheter on Catheter-related Infection in Critically Patients

Start: Mar 2016Est. completion: Dec 20181,818 patients
N/AUnknown
NCT02742974Edwards LifesciencesFloTrac™ and EV1000™

Fluid Resuscitation Optimization in Surgical Trauma Patients (FROST)

Start: Dec 2015Est. completion: Dec 2019196 patients
N/AUnknown
NCT02804438NeurOpticsEstablishing Normative Data for Pupillometer Assessments in Neuro-Intensive Care

Establishing Normative Data for Pupillometer Assessments in Neuro-Intensive Care

Start: Jul 2015Est. completion: Sep 20281,000 patients
N/ARecruiting

Non-interventional Comparison of Sedatives on Weaning From Mechanical Ventilation in Intensive Care Patients

Start: Jun 2012Est. completion: Nov 2015155 patients
N/ATerminated
NCT01523665B. BraunSpace GlucoseControl

Blood Glucose Control in Intensive Care Patients Using the Space GlucoseControl System

Start: Oct 2011Est. completion: Jul 2013508 patients
N/ACompleted

Tolerance and Efficacy of a Predigested, High Protein, High Omega 3 Fat Enteral Feeding Formula Versus a Standard Formula In Multiple Intensive Care Unit Settings

Start: Oct 2011Est. completion: Nov 201450 patients
N/ACompleted
NCT01886365B. BraunSpace GlucoseControl

Computerized Tight Glycemic Control in Cardiac Surgery

Start: Oct 2011Est. completion: Oct 201275 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
5 actively recruiting trials targeting 30,286 patients
28 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.