Constipation

31
Pipeline Programs
15
Companies
50
Clinical Trials
1 recruiting
3
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
8
1
10
11
Early DiscoveryClinical DevelopmentMarket

On Market (3)

Approved therapies currently available

U
AMITIZAApproved
lubiprostone
Unknown Company
Chloride Channel Activator [EPC]oral2006
U
LUBIPROSTONEApproved
lubiprostone
Unknown Company
oral2021
U
POLYETHYLENE GLYCOL 3350Approved
polyethylene glycol
Unknown Company
Osmotic Laxative [EPC]oral2009

Competitive Landscape

14 companies ranked by most advanced pipeline stage

Bayer
BayerLEVERKUSEN, Germany
4 programs
1
1
2
MacrogolPhase 41 trial
Polyethylene glycolPhase 41 trial
Polyethylene Glycol 3350 Powder for SolutionPhase 31 trial
PEG 3350 laxative plus electrolytesPhase 21 trial
Active Trials
NCT01212445Completed154Est. Nov 2011
NCT02292459Withdrawn0Est. Dec 2015
NCT01810653Completed97Est. Dec 2008
+1 more trials
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
3 programs
1
1
1
MOVANTIK™Phase 41 trial
Polyethylene glycolPhase 31 trial
naloxegolPhase 21 trial
Active Trials
NCT02745353Terminated7Est. Jun 2017
NCT02705378Withdrawn0Est. Dec 2019
NCT02946580Terminated53Est. Feb 2018
Takeda
TakedaTOKYO, Japan
2 programs
1
LubiprostonePhase 45 trials
lubiprostoneN/A1 trial
Active Trials
NCT00706004Completed9Est. Dec 2009
NCT03010631Completed49Est. May 2017
NCT02138136Completed419Est. May 2017
+3 more trials
Ipsen
IpsenChina - Tianjin
1 program
1
PEG 4000Phase 41 trial
Active Trials
NCT00276354Completed246Est. Nov 2001
Ambrosia Biosciences
1 program
1
Probiotic ArmPhase 41 trial
Active Trials
NCT06959758RecruitingEst. Aug 2027
C
ColoplastAustralia - Mulgrave
1 program
1
Transanal irrigation with Peristeen Anal IrrigationPhase 4
Stoke Therapeutics
1 program
1
Transanal irrigation with Peristeen Anal IrrigationPhase 4
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
8 programs
1
4
3
MethylnaltrexonePhase 31 trial
N-methylnaltrexone bromidePhase 3
N-methylnaltrexone bromidePhase 31 trial
MOA-728Phase 21 trial
MOA-728Phase 21 trial
+3 more programs
Active Trials
NCT00444158CompletedEst. Jul 2007
NCT00366431CompletedEst. Mar 2007
NCT00605644CompletedEst. May 2008
+4 more trials
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
4 programs
3
BisacodylPhase 31 trial
Bisacodyl 10 mgPhase 31 trial
sodium picosulphatePhase 31 trial
Predictors of Constipation in Healthy ChildrenN/A1 trial
Active Trials
NCT00398021Completed1,430Est. Mar 2010
NCT02211976Completed30
NCT00526097Completed368
+1 more trials
Ferring Pharmaceuticals
Ferring PharmaceuticalsArgentina - Buenos Aires
2 programs
1
1
GlycerinePhase 31 trial
KLYXPhase 21 trial
Active Trials
NCT01335386Completed60Est. Jul 2010
NCT01474499Completed300Est. May 2012
Sanofi
SanofiPARIS, France
1 program
1
SENNA+CASSIAPhase 31 trial
Active Trials
NCT00931853Completed117Est. Dec 2011
Novartis
NovartisBASEL, Switzerland
1 program
1
TegaserodPhase 2/35 trials
Active Trials
NCT00277550Withdrawn0
NCT00511771No Longer Available
NCT00414024Terminated11Est. May 2007
+2 more trials
Ironwood Pharmaceuticals
2 programs
1
MD-1100 AcetatePhase 21 trial
IspaghulaN/A1 trial
Active Trials
NCT02144376CompletedEst. Jun 2016
NCT00306748CompletedEst. Aug 2006
Seed Therapeutics
Seed TherapeuticsNY - New York
1 program
PDS-08N/A1 trial
Active Trials
NCT04534036CompletedEst. Feb 2022

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Ambrosia BiosciencesProbiotic Arm
AstraZenecaMOVANTIK™
BayerPolyethylene glycol
TakedaLubiprostone
NovartisTegaserod
NovartisTegaserod
BayerMacrogol
NovartisTegaserod
NovartisTegaserod
NovartisTegaserod
IpsenPEG 4000
AstraZenecaPolyethylene glycol
TakedaLubiprostone
BayerPolyethylene Glycol 3350 Powder for Solution
TakedaLubiprostone

Showing 15 of 48 trials with date data

Clinical Trials (50)

Total enrollment: 10,550 patients across 50 trials

The Effects of Tegaserod vs. Placebo on Whole Gut Transit Time in Patients With Chronic Constipation and Dyspepsia

0
Phase 4Withdrawn

Effects of Probiotics (BioKid LR - Contains Nine Different Species of Probiotics Bacteria Including L. Reuteri) in Children With Functional Constipation

Start: Aug 2024Est. completion: Aug 2027
Phase 4Recruiting

Naloxegol for the Prevention of Constipation in Postoperative Spinal Surgery Patients

Start: Jan 2017Est. completion: Feb 201853 patients
Phase 4Terminated
NCT04534465BayerPolyethylene glycol

Study to Gather Information on the Acceptability of a New Flavor System With Increasing Levels of 2, 4, 6 g or Higher of Mannitol for PEG 3350 in Subjects Having Infrequent Bowel Movements.

Start: Feb 2013Est. completion: Mar 201350 patients
Phase 4Completed
NCT00844831TakedaLubiprostone

Effects of Lubiprostone on Small Bowel and Colonic Bacteria: A Correlation Study With Segmental and Whole Gut Transit

Start: May 2009Est. completion: May 201125 patients
Phase 4Completed

Effect of Tegaserod on Gastric Emptying in Patients With Diabetic Gastroparesis

Start: Jan 2007Est. completion: Mar 200740 patients
Phase 4Terminated

Effect of Tegaserod on Orocecal Transit in Elderly Chronic Constipation Patients

Start: Jul 2006Est. completion: Apr 200760 patients
Phase 4Terminated

A Study to Compare the Effect of Transipeg 2.95 g or Forlax Junior 4 g in Children With Constipation

Start: Apr 2006Est. completion: Dec 200897 patients
Phase 4Completed

Preference of Tegaserod vs. PEG 3350 in Patients With Constipation

Start: May 2005Est. completion: Sep 200552 patients
Phase 4Completed

Efficacy, Safety and Tolerability of Tegaserod in Patients With Chronic Constipation

Start: Apr 2004Est. completion: Feb 2006250 patients
Phase 4Completed

Efficacy of Tegaserod in Relieving the Symptoms of Female Patients With Irritable Bowel Syndrome (IBS), Excluding Those With Predominant Diarrhea IBS

Start: Apr 2004Est. completion: Jun 2005664 patients
Phase 4Completed

Study of Long-term Use of Forlax® in Elderly Patients With Chronic Constipation

Start: Dec 1999Est. completion: Nov 2001246 patients
Phase 4Completed
NCT02705378AstraZenecaPolyethylene glycol

The Effect of Naloxegol on Refractory Constipation in the Intensive Care Unit

Start: May 2017Est. completion: Dec 20190
Phase 3Withdrawn
NCT03010631TakedaLubiprostone

Comparative Pharmacokinetics and Food-Effect Bioavailability of Lubiprostone Sprinkle in Healthy Volunteers

Start: Nov 2016Est. completion: May 201749 patients
Phase 3Completed
NCT02292459BayerPolyethylene Glycol 3350 Powder for Solution

Efficacy and Safety of Polyethylene Glycol 3350 (PEG 3350) for Relief of Constipation (MK-8114-005)

Start: Dec 2015Est. completion: Dec 20150
Phase 3Withdrawn
NCT02138136TakedaLubiprostone

Lubiprostone for Children With Constipation

Start: Feb 2014Est. completion: May 2017419 patients
Phase 3Completed

A Trial of Docusate Sodium and Sorbitol Rectal Solution for the in Patients With Constipation

Start: Sep 2011Est. completion: May 2012300 patients
Phase 3Completed
NCT00931853SanofiSENNA+CASSIA

Efficacy and Tolerability of Cassia Fistula Plus Senna Alexandrina Miller (Sugar Free) in the Chronic Functional Constipation (CFC).

Start: Sep 2010Est. completion: Dec 2011117 patients
Phase 3Completed
NCT00936884Bausch HealthMethylnaltrexone

Study Evaluating the Efficacy and Safety of Subcutaneous Methylnaltrexone (MOA-728) for the Treatment of Opioid-Induced-Constipation

Start: Jul 2009Est. completion: Nov 2013
Phase 3Completed

Sodium Picosulphate vs. Placebo in Functional Constipation

Start: Oct 2007367 patients
Phase 3Completed

Dulcolax vs Placebo in Functional Constipation

Start: Sep 2007368 patients
Phase 3Completed
NCT00529087Bausch HealthN-methylnaltrexone bromide

Study Evaluating Subcutaneous MOA-728 for the Treatment of Opioid-Induced Constipation (OIC) in Subjects With Chronic Non-Malignant Pain

Start: Aug 2007Est. completion: Dec 2008
Phase 3Completed

Safety and Efficacy of Tegaserod in Opioid-induced Constipation in Patients With Non-cancer Pain.

Start: Feb 2007Est. completion: May 200711 patients
Phase 3Terminated

Safety and Efficacy of Tegaserod in Opioid-induced Constipation in Patients With Non-cancer Pain.

Start: Nov 2006Est. completion: Apr 2007360 patients
Phase 3Terminated

The Effects of Tegaserod on Mechanical Sensitivity of the Esophagus and Stomach in Patients With Heartburn and Dyspepsia.

Start: Apr 2005Est. completion: Sep 200624 patients
Phase 3Completed

An Evaluation of the Efficacy and Safety of Tegaserod 6 mg Bid Given Orally to Chinese Patients With Chronic Constipation

Start: Feb 2005Est. completion: Oct 2005600 patients
Phase 3Completed

The Effect of Tegaserod on Patterns of Flow in the Small Bowel of Patients With Irritable Bowel Syndrome (IBS)

Start: Nov 2004Est. completion: May 200620 patients
Phase 3Terminated

Extension Study to Assess the Long-Term Safety of Tegaserod in Women With Symptoms of Dyspepsia

Start: Sep 2004Est. completion: Aug 2006423 patients
Phase 3Completed

Extension Study to Assess the Long-Term Safety of Tegaserod in Women With Symptoms of Dyspepsia

Start: Sep 2004Est. completion: Aug 2006359 patients
Phase 3Completed

Assessment of Efficacy and Safety of Tegaserod Treatment and Placebo in Women With Dyspepsia

Start: May 2004Est. completion: Jun 20061,296 patients
Phase 3Completed

Assessment of Efficacy and Safety of Tegaserod in Male Patients With Chronic Constipation.

Start: Mar 2004Est. completion: Feb 20051,026 patients
Phase 3Completed

Assessment of Efficacy and Safety of Tegaserod Treatment and Placebo in Women With Dyspepsia

Start: Jan 2004Est. completion: May 20061,296 patients
Phase 3Completed

Assessment of the Role of Tegaserod Therapy in the Management of Gastroesophageal Reflux Disease (GERD) Symptoms in Patients With Incomplete Response to Proton Pump Inhibitors (PPIs).

Start: Jan 2004Est. completion: Apr 200530 patients
Phase 3Completed

Efficacy and Tolerability of Bisacodyl Sugar Coated Tablets, Simeticone Chewing Tablets and Their Combination in Constipation and Bloatedness

Start: Oct 200330 patients
Phase 3Completed

Assessment of the Effects of Tegaserod in the Management of Gastroesophageal Reflux Disease (GERD) in Patients With Incomplete Response to Proton Pump Inhibitors (PPIs).

Start: Jun 2003Est. completion: Feb 200554 patients
Phase 3Completed

Efficacy and Safety of Tegaserod in Opioid-induced Constipation in Patients With Non-cancer Pain

Start: Jul 2006Est. completion: Apr 2007670 patients
Phase 2/3Terminated

Naloxegol in Cancer Opioid-Induced Constipation

Start: May 2016Est. completion: Jun 20177 patients
Phase 2Terminated

Dose-ranging Study to Assess Safety and Efficacy of SP-333 for the Treatment of Opioid-induced Constipation (OIC)

Start: Nov 2013Est. completion: Apr 2015
Phase 2Completed
NCT01212445BayerPEG 3350 laxative plus electrolytes

Dose-Finding Trial of Polyethylene Glycol 3350 Laxative Plus Electrolytes for the Treatment of Constipation (Protocol P07515)

Start: Oct 2010Est. completion: Nov 2011154 patients
Phase 2Completed

Investigation of KLYX in Patients With Constipation

Start: Apr 2010Est. completion: Jul 201060 patients
Phase 2Completed

Study Evaluating MOA-728 Oral for the Treatment of OIBD in Subjects With Chronic Non-Malignant Pain

Start: Jan 2008Est. completion: May 2008
Phase 2Completed
NCT00547586Bausch HealthN-methylnaltrexone bromide

Study Evaluating Oral MOA-728 For The Treatment Of OIBD In Subjects With Chronic Non-Malignant Pain

Start: Oct 2007Est. completion: Feb 2008
Phase 2Completed

Study Evaluating Oral MOA-728 for the Treatment of Opioid-Induced Bowel Dysfunction (OIBD) in Subjects With Chronic Non-Malignant Pain

Start: Aug 2006Est. completion: Mar 2007
Phase 2Completed

Phase 2 Study of MD-1100 Acetate Administered for 14 Days to Patients Meeting Criteria for Chronic Constipation

Start: Mar 2006Est. completion: Aug 2006
Phase 2Completed

Assessment of the Effect of Tegaserod (2 mg Tid and 6 mg Tid) on Dyspeptic Symptoms in Diabetic Patients With Symptoms of Diabetic Gastropathy

Start: May 2004Est. completion: Apr 2005120 patients
Phase 2Terminated

A Study to Assess the Efficacy, Safety and Tolerability of Tegaserod Alone and in Combination With Omeprazole Given Orally in Patients With Symptoms of Symptomatic Gastroesophageal Reflux Disease (sGERD)

Start: Jan 2004Est. completion: Jun 2005832 patients
Phase 2Completed
NCT00934479TakedaLubiprostone

Intestinal Microecology in Chronic Constipation

Start: Apr 2010Est. completion: Feb 201221 patients
Phase 1Completed

Double-Blind, Double-Dummy, 2-Period Crossover of a 20-Minute Versus a 4-hour IV of MOA-728 in Stable Methadone Subjects

Start: Mar 2007Est. completion: Jul 2007
Phase 1Completed

A Treatment Investigational New Drug (tIND) Program of Tegaserod in Women With Irritable Bowel Syndrome With Constipation or With Chronic Idiopathic Constipation

N/ANo Longer Available

Tolerability and Functional Assessment of a Novel Children's Synbiotic

Start: Aug 2020Est. completion: Feb 2022
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

10 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 10,550 patients
15 companies competing in this space