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Constipation

28
Pipeline Programs
28
Companies
50
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
7
1
8
10
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

26 companies ranked by most advanced pipeline stage

Bayer
BayerLEVERKUSEN, Germany
6 programs
2
1
3
MacrogolPhase 41 trial
Polyethylene glycolPhase 41 trial
Polyethylene glycol 3350Phase 41 trial
Polyethylene Glycol 3350 Powder for SolutionPhase 31 trial
PEG 3350 laxative plus electrolytesPhase 21 trial
+1 more programs
Active Trials
NCT01212445Completed154Est. Nov 2011
NCT01885104Completed65Est. Oct 2013
NCT02292459Withdrawn0Est. Dec 2015
+3 more trials
Sandoz
SandozAustria - Kundl
5 programs
1
1
1
Tegaserod and Polyethylene Glycol 3350Phase 41 trial
TegaserodPhase 31 trial
TegaserodPhase 2/31 trial
TegaserodN/A1 trial
tegaserodN/A1 trial
Active Trials
NCT00563615Unknown60Est. Oct 2006
NCT00563758Terminated250Est. Feb 2006
NCT00365820Terminated670Est. Apr 2007
+2 more trials
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
3 programs
1
1
1
MOVANTIK™Phase 41 trial
Polyethylene glycolPhase 31 trial
naloxegolPhase 21 trial
Active Trials
NCT02745353Terminated7Est. Jun 2017
NCT02705378Withdrawn0Est. Dec 2019
NCT02946580Terminated53Est. Feb 2018
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
AlvimopanPhase 4
MSD
MSDIreland - Ballydine
1 program
1
AlvimopanPhase 41 trial
Active Trials
NCT02789111Completed49Est. Dec 2018
Orion Pharma
Orion PharmaUK - Reading
1 program
1
Polyethylene glycol 4000Phase 41 trial
Active Trials
NCT00603681Completed67Est. Jul 2008
Orion
OrionUK - Cambridge
1 program
1
Polyethylene glycol 4000Phase 4
Cumberland Pharmaceuticals
1 program
1
lactulosePhase 41 trial
Active Trials
NCT00712543Completed50Est. Sep 2009
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
5 programs
1
3
1
MethylnaltrexonePhase 31 trial
MOA-728Phase 21 trial
MOA-728Phase 21 trial
SP-333 1 mgPhase 21 trial
MOA-728Phase 11 trial
Active Trials
NCT00444158Completed24Est. Jul 2007
NCT00605644Completed128Est. May 2008
NCT00366431Completed420Est. Mar 2007
+2 more trials
Pfizer
PfizerNEW YORK, NY
2 programs
1
N-methylnaltrexone bromidePhase 3
The Bowel Research Collaborative Data Tracking System Implementation StudyN/A1 trial
Active Trials
NCT00728975Completed533Est. Feb 2010
Norgine
NorgineAustria - Vienna
2 programs
2
MOVICOLPhase 31 trial
PEG 3350 plus electrolytesPhase 31 trial
Active Trials
NCT00796354Completed210Est. Feb 2010
NCT01251822Completed240Est. Dec 2011
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
1
Symbiotic LactofosPhase 31 trial
Active Trials
NCT01286376Unknown60Est. Aug 2011
ViiV Healthcare
ViiV HealthcareNC - Durham
1 program
1
alvimopanPhase 2
Theravance Biopharma
1 program
1
TD-1211 Dose 1Phase 11 trial
Active Trials
NCT01655771Completed47Est. Mar 2013
Medtronic
MedtronicNJ - Phillipsburg
4 programs
3D HRAMN/A1 trial
High-resolution anorectal manometryN/A1 trial
Sacral NeuromodulationN/A1 trial
Sacral NeuromodulationN/A1 trial
Active Trials
NCT06924957Enrolling By Invitation120Est. Dec 2025
NCT02812823Unknown100Est. Mar 2019
NCT02961582Completed67Est. Dec 2021
+1 more trials
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
4 programs
Predictors of Constipation in Healthy ChildrenN/A1 trial
BisacodylPHASE_31 trial
Bisacodyl 10 mgPHASE_31 trial
sodium picosulphatePHASE_31 trial
Active Trials
NCT00398021Completed1,430Est. Mar 2010
NCT02211976Completed30
NCT00526097Completed368
+1 more trials
Ironwood Pharmaceuticals
2 programs
IspaghulaN/A1 trial
MD-1100 AcetatePHASE_21 trial
Active Trials
NCT02144376Completed24Est. Jun 2016
NCT00306748Completed40Est. Aug 2006
Takeda
TakedaTOKYO, Japan
2 programs
lubiprostoneN/A1 trial
LubiprostonePHASE_45 trials
Active Trials
NCT00706004Completed9Est. Dec 2009
NCT03010631Completed49Est. May 2017
NCT02138136Completed419Est. May 2017
+3 more trials
Ferring Pharmaceuticals
Ferring PharmaceuticalsArgentina - Buenos Aires
2 programs
KLYXPHASE_21 trial
GlycerinePHASE_31 trial
Active Trials
NCT01335386Completed60Est. Jul 2010
NCT01474499Completed300Est. May 2012
Biocorp
BiocorpFrance - Issoire
1 program
FeSCN/A1 trial
Active Trials
NCT06285851Completed14Est. Dec 2023
Seed Therapeutics
Seed TherapeuticsNY - New York
1 program
PDS-08N/A1 trial
Active Trials
NCT04534036CompletedEst. Feb 2022
Novartis
NovartisBASEL, Switzerland
1 program
TegaserodPHASE_2_3
Sanofi
SanofiPARIS, France
1 program
SENNA+CASSIAPHASE_31 trial
Active Trials
NCT00931853Completed117Est. Dec 2011
Ipsen
IpsenChina - Tianjin
1 program
PEG 4000PHASE_41 trial
Active Trials
NCT00276354Completed246Est. Nov 2001
Stoke Therapeutics
1 program
Transanal irrigation with Peristeen Anal IrrigationPHASE_41 trial
Active Trials
NCT00286520Completed80Est. Aug 2005
Coloplast
ColoplastAustralia - Mulgrave
1 program
Transanal irrigation with Peristeen Anal IrrigationPHASE_4

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
AstraZenecaMOVANTIK™
MSDAlvimopan
BayerPolyethylene glycol
Cumberland Pharmaceuticalslactulose
TakedaLubiprostone
Orion PharmaPolyethylene glycol 4000
BayerPolyethylene glycol 3350
BayerMacrogol
SandozTegaserod and Polyethylene Glycol 3350
Stoke TherapeuticsTransanal irrigation with Peristeen Anal Irrigation
IpsenPEG 4000
AstraZenecaPolyethylene glycol
TakedaLubiprostone
BayerPolyethylene Glycol 3350 Powder for Solution
TakedaLubiprostone

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 8,155 patients across 50 trials

Naloxegol for the Prevention of Constipation in Postoperative Spinal Surgery Patients

Start: Jan 2017Est. completion: Feb 201853 patients
Phase 4Terminated

Trial of Alvimopan in Major Spine Surgery

Start: Jun 2016Est. completion: Dec 201849 patients
Phase 4Completed
NCT04534465BayerPolyethylene glycol

Study to Gather Information on the Acceptability of a New Flavor System With Increasing Levels of 2, 4, 6 g or Higher of Mannitol for PEG 3350 in Subjects Having Infrequent Bowel Movements.

Start: Feb 2013Est. completion: Mar 201350 patients
Phase 4Completed

A Preference Study Comparing Kristalose® and Liquid Lactulose

Start: Jun 2009Est. completion: Sep 200950 patients
Phase 4Completed
NCT00844831TakedaLubiprostone

Effects of Lubiprostone on Small Bowel and Colonic Bacteria: A Correlation Study With Segmental and Whole Gut Transit

Start: May 2009Est. completion: May 201125 patients
Phase 4Completed
NCT00603681Orion PharmaPolyethylene glycol 4000

Comparison of PEG Solutions With and Without Electrolytes in the Treatment of Constipation

Start: Jan 2008Est. completion: Jul 200867 patients
Phase 4Completed
NCT00770432BayerPolyethylene glycol 3350

Study Comparing PEG 3350 Laxative to Placebo in the Treatment of Occasional Constipation (Study CL2007-12)(P08216)

Start: Nov 2007Est. completion: Jan 2008203 patients
Phase 4Completed

A Study to Compare the Effect of Transipeg 2.95 g or Forlax Junior 4 g in Children With Constipation

Start: Apr 2006Est. completion: Dec 200897 patients
Phase 4Completed
NCT00171522SandozTegaserod and Polyethylene Glycol 3350

Preference of Tegaserod vs. PEG 3350 in Patients With Constipation

Start: May 2005Est. completion: Sep 200552 patients
Phase 4Completed
NCT00286520Stoke TherapeuticsTransanal irrigation with Peristeen Anal Irrigation

Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury

Start: Dec 2003Est. completion: Aug 200580 patients
Phase 4Completed

Study of Long-term Use of Forlax® in Elderly Patients With Chronic Constipation

Start: Dec 1999Est. completion: Nov 2001246 patients
Phase 4Completed
NCT02705378AstraZenecaPolyethylene glycol

The Effect of Naloxegol on Refractory Constipation in the Intensive Care Unit

Start: May 2017Est. completion: Dec 20190
Phase 3Withdrawn
NCT03010631TakedaLubiprostone

Comparative Pharmacokinetics and Food-Effect Bioavailability of Lubiprostone Sprinkle in Healthy Volunteers

Start: Nov 2016Est. completion: May 201749 patients
Phase 3Completed
NCT02292459BayerPolyethylene Glycol 3350 Powder for Solution

Efficacy and Safety of Polyethylene Glycol 3350 (PEG 3350) for Relief of Constipation (MK-8114-005)

Start: Dec 2015Est. completion: Dec 20150
Phase 3Withdrawn
NCT02138136TakedaLubiprostone

Lubiprostone for Children With Constipation

Start: Feb 2014Est. completion: May 2017419 patients
Phase 3Completed

A Trial of Docusate Sodium and Sorbitol Rectal Solution for the in Patients With Constipation

Start: Sep 2011Est. completion: May 2012300 patients
Phase 3Completed
NCT01251822NorginePEG 3350 plus electrolytes

Comparator Study of PEG 3350 Versus Prucalopride in Females With Chronic Constipation

Start: Nov 2010Est. completion: Dec 2011240 patients
Phase 3Completed
NCT00931853SanofiSENNA+CASSIA

Efficacy and Tolerability of Cassia Fistula Plus Senna Alexandrina Miller (Sugar Free) in the Chronic Functional Constipation (CFC).

Start: Sep 2010Est. completion: Dec 2011117 patients
Phase 3Completed

Evaluating the Effectiveness of LACTOFOS in Constipated Patients

Start: Aug 2010Est. completion: Aug 201160 patients
Phase 3Unknown
NCT00936884Bausch HealthMethylnaltrexone

Study Evaluating the Efficacy and Safety of Subcutaneous Methylnaltrexone (MOA-728) for the Treatment of Opioid-Induced-Constipation

Start: Jul 2009Est. completion: Nov 201350 patients
Phase 3Completed

Constipation Associated With Irritable Bowel Syndrome (IBS-C)

Start: Nov 2008Est. completion: Feb 2010210 patients
Phase 3Completed

Sodium Picosulphate vs. Placebo in Functional Constipation

Start: Oct 2007367 patients
Phase 3Completed

Dulcolax vs Placebo in Functional Constipation

Start: Sep 2007368 patients
Phase 3Completed

An Evaluation of the Efficacy and Safety of Tegaserod 6 mg Bid Given Orally to Chinese Patients With Chronic Constipation

Start: Feb 2005Est. completion: Oct 2005600 patients
Phase 3Completed

Efficacy and Tolerability of Bisacodyl Sugar Coated Tablets, Simeticone Chewing Tablets and Their Combination in Constipation and Bloatedness

Start: Oct 200330 patients
Phase 3Completed

Efficacy and Safety of Tegaserod in Opioid-induced Constipation in Patients With Non-cancer Pain

Start: Jul 2006Est. completion: Apr 2007670 patients
Phase 2/3Terminated

Naloxegol in Cancer Opioid-Induced Constipation

Start: May 2016Est. completion: Jun 20177 patients
Phase 2Terminated

Dose-ranging Study to Assess Safety and Efficacy of SP-333 for the Treatment of Opioid-induced Constipation (OIC)

Start: Nov 2013Est. completion: Apr 2015292 patients
Phase 2Completed
NCT01885104BayerPolyethylene Glycol

Safety and Tolerability of Oral Polyethylene Glycol (PEG 3350) Solution in Participants With Constipation (MK-8114-003)

Start: Apr 2013Est. completion: Oct 201365 patients
Phase 2Completed
NCT01212445BayerPEG 3350 laxative plus electrolytes

Dose-Finding Trial of Polyethylene Glycol 3350 Laxative Plus Electrolytes for the Treatment of Constipation (Protocol P07515)

Start: Oct 2010Est. completion: Nov 2011154 patients
Phase 2Completed

Investigation of KLYX in Patients With Constipation

Start: Apr 2010Est. completion: Jul 201060 patients
Phase 2Completed

Study Evaluating MOA-728 Oral for the Treatment of OIBD in Subjects With Chronic Non-Malignant Pain

Start: Jan 2008Est. completion: May 2008128 patients
Phase 2Completed

Study Evaluating Oral MOA-728 for the Treatment of Opioid-Induced Bowel Dysfunction (OIBD) in Subjects With Chronic Non-Malignant Pain

Start: Aug 2006Est. completion: Mar 2007420 patients
Phase 2Completed

Phase 2 Study of MD-1100 Acetate Administered for 14 Days to Patients Meeting Criteria for Chronic Constipation

Start: Mar 2006Est. completion: Aug 200640 patients
Phase 2Completed

TD-1211 Single-Dose Study in Elderly and Young Healthy Subjects

Start: Aug 2012Est. completion: Mar 201347 patients
Phase 1Completed
NCT00934479TakedaLubiprostone

Intestinal Microecology in Chronic Constipation

Start: Apr 2010Est. completion: Feb 201221 patients
Phase 1Completed

Double-Blind, Double-Dummy, 2-Period Crossover of a 20-Minute Versus a 4-hour IV of MOA-728 in Stable Methadone Subjects

Start: Mar 2007Est. completion: Jul 200724 patients
Phase 1Completed

A Novel Iron Supplement for Athletes: Phase I

Start: Nov 2023Est. completion: Dec 202314 patients
N/ACompleted

Tolerability and Functional Assessment of a Novel Children's Synbiotic

Start: Aug 2020Est. completion: Feb 2022
N/ACompleted

Influence of Body Position on the Defecation Model During Anorectal Manometry.

Start: Jan 2020Est. completion: Dec 2025120 patients
N/AEnrolling By Invitation
NCT02812823MedtronicHigh-resolution anorectal manometry

Comparison of Anorectal Manometry and 3D Manometry in Diagnosis of Functional Disorders in Children

Start: Mar 2018Est. completion: Mar 2019100 patients
N/AUnknown
NCT02961465MedtronicSacral Neuromodulation

Effectiveness and Safety of Sacral Neuromodulation in Patients With Idiopathic Slow-transit Constipation

Start: Feb 2018Est. completion: Dec 202123 patients
N/ACompleted
NCT02961582MedtronicSacral Neuromodulation

Effectiveness and Cost-effectiveness of Sacral Neuromodulation in Patients With Idiopathic Slow-transit Constipation

Start: Feb 2017Est. completion: Dec 202167 patients
N/ACompleted

MRI and Microbiota Analysis in Constipation

Start: Mar 2014Est. completion: Jun 201624 patients
N/ACompleted
NCT00669461TakedaLubiprostone

Lubiprostone as a Treatment for Constipation in Parkinson's Disease

Start: Jun 2009Est. completion: Sep 20101 patients
N/ATerminated
NCT00706004Takedalubiprostone

Short Term Safety and Efficacy of Lubiprostone in Adults With Cystic Fibrosis

Start: Jul 2008Est. completion: Dec 20099 patients
N/ACompleted
NCT00728975PfizerThe Bowel Research Collaborative Data Tracking System Implementation Study

The Bowel Research Collaborative Data Tracking System Implementation Study

Start: Jun 2008Est. completion: Feb 2010533 patients
N/ACompleted
NCT00689026TakedaLubiprostone

Efficacy of Lubiprostone in Combination With Standard PEG Preparation

Start: May 2008Est. completion: Mar 201060 patients
N/ATerminated
NCT00662363TakedaLubiprostone

Lubiprostone (Amitiza®) Vs. Standard Care in Opioid-induced Constipation After Surgery in Inpatient Rehabilitation

Start: Apr 2008Est. completion: Oct 201164 patients
N/ACompleted
NCT00398021Boehringer IngelheimPredictors of Constipation in Healthy Children

Predictors of Constipation in Healthy Children

Start: Jun 2006Est. completion: Mar 20101,430 patients
N/ACompleted

Related Jobs

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

8 late-stage (Phase 3) programs, potential near-term approvals
28 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.