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Common Cold

24
Pipeline Programs
14
Companies
22
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
5
0
11
5
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

DELSYMApproved
dextromethorphan
Unknown Company
Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC]oral1982

Competitive Landscape

14 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
8 programs
2
2
2
2
Paracetamol and CaffeinePhase 41 trial
Test tabletPhase 41 trial
AcetylcystinePhase 31 trial
paracetamol + caffeinePhase 31 trial
Carbomer 980Phase 21 trial
+3 more programs
Active Trials
NCT03415243Completed28Est. Mar 2018
NCT02832362Completed30Est. Jul 2016
NCT03005067Completed171Est. Jun 2017
+5 more trials
JSC Valenta Pharmaceuticals
4 programs
1
2
1
IngavirinPhase 41 trial
Imidazolyl ethanamide pentandioic acidPhase 31 trial
XC8, film-coated tablets, 10 mgPhase 31 trial
XC8, film-coated tablets, 20 mg/dayPhase 21 trial
Active Trials
NCT05269329Completed160Est. Oct 2021
NCT02644018Completed190Est. May 2016
NCT05273619Completed250Est. Jul 2022
+1 more trials
Sandoz
SandozAustria - Kundl
3 programs
1
1
DextromethorphanPhase 4
XylometazolinePhase 31 trial
AcetylcysteinePHASE_31 trial
Active Trials
NCT05070650Withdrawn0Est. Apr 2025
NCT00452270Completed60Est. Apr 2007
Ache Laboratorios Farmaceuticos
2 programs
2
Brompheniramine + PhenylephrinePhase 31 trial
Bronpheniramine and fenilefrinePhase 31 trial
Active Trials
NCT01393548Completed879Est. Dec 2016
NCT00967759Withdrawn0
EMS
EMSBrazil - Hortolândia
2 programs
2
Irlanda-1-AssociationPhase 31 trial
Irlanda-2-AssociationPhase 31 trial
Active Trials
NCT02656888Withdrawn0Est. Sep 2020
NCT02656914Withdrawn0Est. Sep 2020
Pfizer
PfizerNEW YORK, NY
1 program
1
Advil Congestion ReliefPhase 31 trial
Active Trials
NCT01938144Withdrawn0Est. Nov 2016
Tasly Pharmaceutical
Tasly PharmaceuticalChina - Tianjin
1 program
1
Antiwei GranulesPhase 31 trial
Active Trials
NCT06697886Recruiting480Est. Jul 2025
Dexa Medica
Dexa MedicaIndonesia - Tangerang
1 program
1
SilfaminPhase 21 trial
Active Trials
NCT06497439Completed60Est. Sep 2024
Medica Corp
Medica CorpMA - Bedford
1 program
1
SilfaminPhase 2
Prevail Therapeutics
1 program
1
Nasal GlucagonPhase 1
GSK
GSKLONDON, United Kingdom
5 programs
Acetaminophen 650mg+Dextromethorphan 20mg+Phenylephrine 10mgPHASE_1
Paracetamol hot drinkPHASE_2
AcetylcystinePHASE_3
paracetamol + caffeinePHASE_3
Paracetamol and CaffeinePHASE_4
Marinomed Biotech
Marinomed BiotechAustria - Korneuburg
1 program
Coldamaris lozengesN/A1 trial
Active Trials
NCT04533906Completed29Est. Nov 2020
Novartis
NovartisBASEL, Switzerland
1 program
XylometazolinePHASE_3
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
DextromethorphanPHASE_4

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
ViiV HealthcareTest tablet
ViiV HealthcareParacetamol and Caffeine
JSC Valenta PharmaceuticalsIngavirin
SandozAcetylcysteine
Tasly PharmaceuticalAntiwei Granules
JSC Valenta PharmaceuticalsXC8, film-coated tablets, 10 mg
EMSIrlanda-2-Association
EMSIrlanda-1-Association
PfizerAdvil Congestion Relief
ViiV HealthcareAcetylcystine
JSC Valenta PharmaceuticalsImidazolyl ethanamide pentandioic acid
Ache Laboratorios FarmaceuticosBrompheniramine + Phenylephrine
ViiV Healthcareparacetamol + caffeine
SandozXylometazoline
Dexa MedicaSilfamin

Showing 15 of 21 trials with date data

Clinical Trials (22)

Total enrollment: 3,405 patients across 22 trials

NCT02246166ViiV HealthcareTest tablet

The Effect of Paracetamol, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide and Chlorpheniramine Maleate Tablets Compared to Placebo in Subjects Suffering From the Common Cold or Influenza.

Start: Jan 2015Est. completion: Feb 201553 patients
Phase 4Completed
NCT01466348ViiV HealthcareParacetamol and Caffeine

Effects of a Common Cold Treatment on Cognitive Function

Start: Feb 2011Est. completion: Apr 201172 patients
Phase 4Completed
NCT03154515JSC Valenta PharmaceuticalsIngavirin

Efficacy and Safety Study of Ingavirin® 90 mg Once Daily to Treat Influenza and Other Acute Viral Infections in Adults

Start: Jan 2010Est. completion: Oct 2014445 patients
Phase 4Completed
NCT00967759Ache Laboratorios FarmaceuticosBronpheniramine and fenilefrine

Study Comparing 3 Formulations to Evaluate the Efficacy and Safety of the Inflammatory Symptoms of the Upper Respiratory Tract, in Children Between 2 and 6 Years Old

0
Phase 3Withdrawn
NCT05070650SandozAcetylcysteine

Efficacy and Safety of the Combination of Acetylcysteine, Paracetamol and Phenylephrine for the Treatment of Common Cold

Start: Sep 2024Est. completion: Apr 20250
Phase 3Withdrawn
NCT06697886Tasly PharmaceuticalAntiwei Granules

A Study of the Efficacy and Safety of Antiwei Granules in the Treatment of Common Cold

Start: Nov 2023Est. completion: Jul 2025480 patients
Phase 3Recruiting
NCT05273619JSC Valenta PharmaceuticalsXC8, film-coated tablets, 10 mg

Efficacy and Safety of XC8, Film-coated Tablets, 40 mg in Patients With Dry Non-productive Cough Against Acute Respiratory Viral Infection

Start: May 2022Est. completion: Jul 2022250 patients
Phase 3Completed
NCT02656914EMSIrlanda-2-Association

Efficacy and Safety of Irlanda-2 Association on the Treatment of Common Cold

Start: Jun 2019Est. completion: Sep 20200
Phase 3Withdrawn
NCT02656888EMSIrlanda-1-Association

Efficacy and Safety of Irlanda-1-Association on the Treatment of Common Cold in Children

Start: Jun 2019Est. completion: Sep 20200
Phase 3Withdrawn
NCT01938144PfizerAdvil Congestion Relief

Evaluation of the Efficacy and Safety of Two Ibuprofen Combination Products for the Treatment of the Common Cold and Flu in Latin America

Start: Apr 2016Est. completion: Nov 20160
Phase 3Withdrawn
NCT02822287ViiV HealthcareAcetylcystine

Warming Sensation and Tolerability Study of Acetylcysteine 2% Oral Solution for Productive Cough

Start: Feb 2016Est. completion: Mar 201658 patients
Phase 3Completed
NCT02644018JSC Valenta PharmaceuticalsImidazolyl ethanamide pentandioic acid

Efficacy and Safety Study of Ingavirin® to Treat Influenza and Other Acute Respiratory Viral Infections in Patients 3-6 y.o.

Start: Jan 2016Est. completion: May 2016190 patients
Phase 3Completed
NCT01393548Ache Laboratorios FarmaceuticosBrompheniramine + Phenylephrine

Efficacy and Safety of Combination of Brompheniramine and Phenylephrine for the Symptoms Relief of Rhinitis

Start: Aug 2014Est. completion: Dec 2016879 patients
Phase 3Completed
NCT01686646ViiV Healthcareparacetamol + caffeine

Effects of Two Doses of a Common Cold Treatment on Alertness

Start: Nov 2011Est. completion: Nov 2012240 patients
Phase 3Completed
NCT00452270SandozXylometazoline

Decongestant Effect, Timing of Effect and Impact on Sleep and General Well-Being of Xylometazoline in Subjects With a Common Cold

Start: Mar 2007Est. completion: Apr 200760 patients
Phase 3Completed
NCT06497439Dexa MedicaSilfamin

Efficacy and Safety of Silfamin for Common Cold

Start: Jul 2024Est. completion: Sep 202460 patients
Phase 2Completed
NCT05269329JSC Valenta PharmaceuticalsXC8, film-coated tablets, 20 mg/day

Efficacy and Safety of XC8, Film-coated Tablets, 10 mg in Patients With Dry Non-productive Cough Against Acute Respiratory Viral Infection

Start: Apr 2021Est. completion: Oct 2021160 patients
Phase 2Completed
NCT03005067ViiV HealthcareCarbomer 980

To Evaluate the Efficacy and Safety of 1146A Nasal Spray in Adult Participants With Symptoms of Common Cold

Start: Dec 2016Est. completion: Jun 2017171 patients
Phase 2Completed
NCT01277081ViiV HealthcareParacetamol hot drink

Effect of Paracetamol on the Common Cold

Start: Oct 2010Est. completion: Dec 2010200 patients
Phase 2Completed
NCT03415243ViiV HealthcareAcetaminophen 650mg+Dextromethorphan 20mg+Phenylephrine 10mg

To Investigate the Gastrointestinal Behaviour of Two Triple Combination Products in Healthy Male Volunteers

Start: Mar 2018Est. completion: Mar 201828 patients
Phase 1Completed
NCT02832362ViiV HealthcareCarbomer 980

Local Nasal Tolerability and Safety Study of 1146A in Healthy Adult Participants

Start: Jun 2016Est. completion: Jul 201630 patients
Phase 1Completed
NCT04533906Marinomed BiotechColdamaris lozenges

Study to Investigate if Sucking a Coldamaris Lozenge Elutes Sufficient Iota-carrageenan to Inactivate Usual Common Cold Viruses

Start: Aug 2020Est. completion: Nov 202029 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

11 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 3,405 patients
14 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.