Skip to main content

Common Cold

24
Pipeline Programs
14
Companies
21
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
5
0
11
5
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

DELSYMApproved
dextromethorphan
Unknown Company
Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC]oral1982

Competitive Landscape

14 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
8 programs
2
2
2
2
Paracetamol and CaffeinePhase 4
Test tabletPhase 4
AcetylcystinePhase 3
paracetamol + caffeinePhase 3
Carbomer 980Phase 2
+3 more programs
JSC Valenta Pharmaceuticals
4 programs
1
2
1
IngavirinPhase 41 trial
Imidazolyl ethanamide pentandioic acidPhase 31 trial
XC8, film-coated tablets, 10 mgPhase 31 trial
XC8, film-coated tablets, 20 mg/dayPhase 21 trial
Active Trials
NCT05269329Completed160Est. Oct 2021
NCT02644018Completed190Est. May 2016
NCT05273619Completed250Est. Jul 2022
+1 more trials
Sandoz
SandozAustria - Kundl
3 programs
1
1
DextromethorphanPhase 41 trial
XylometazolinePhase 31 trial
AcetylcysteinePHASE_31 trial
Active Trials
NCT05070650Withdrawn0Est. Apr 2025
NCT00452270Completed60Est. Apr 2007
NCT01257542Terminated140Est. Mar 2011
Ache Laboratorios Farmaceuticos
2 programs
2
Brompheniramine + PhenylephrinePhase 31 trial
Bronpheniramine and fenilefrinePhase 31 trial
Active Trials
NCT01393548Completed879Est. Dec 2016
NCT00967759Withdrawn0
EMS
EMSBrazil - Hortolândia
2 programs
2
Irlanda-1-AssociationPhase 31 trial
Irlanda-2-AssociationPhase 31 trial
Active Trials
NCT02656888Withdrawn0Est. Sep 2020
NCT02656914Withdrawn0Est. Sep 2020
Pfizer
PfizerNEW YORK, NY
1 program
1
Advil Congestion ReliefPhase 31 trial
Active Trials
NCT01938144Withdrawn0Est. Nov 2016
Tasly Pharmaceutical
Tasly PharmaceuticalChina - Tianjin
1 program
1
Antiwei GranulesPhase 31 trial
Active Trials
NCT06697886Recruiting480Est. Jul 2025
Dexa Medica
Dexa MedicaIndonesia - Tangerang
1 program
1
SilfaminPhase 2
Medica Corp
Medica CorpMA - Bedford
1 program
1
SilfaminPhase 21 trial
Active Trials
NCT06497439Completed60Est. Sep 2024
Prevail Therapeutics
1 program
1
Nasal GlucagonPhase 11 trial
Active Trials
NCT02778100Completed36Est. Apr 2013
GSK
GSKLONDON, United Kingdom
5 programs
Acetaminophen 650mg+Dextromethorphan 20mg+Phenylephrine 10mgPHASE_11 trial
Paracetamol hot drinkPHASE_21 trial
AcetylcystinePHASE_31 trial
paracetamol + caffeinePHASE_31 trial
Paracetamol and CaffeinePHASE_41 trial
Active Trials
NCT03415243Completed28Est. Mar 2018
NCT01277081Completed200Est. Dec 2010
NCT02822287Completed58Est. Mar 2016
+2 more trials
Marinomed Biotech
Marinomed BiotechAustria - Korneuburg
1 program
Coldamaris lozengesN/A1 trial
Active Trials
NCT04533906Completed29Est. Nov 2020
Novartis
NovartisBASEL, Switzerland
1 program
XylometazolinePHASE_3
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
DextromethorphanPHASE_4

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GSKParacetamol and Caffeine
SandozDextromethorphan
JSC Valenta PharmaceuticalsIngavirin
SandozAcetylcysteine
Tasly PharmaceuticalAntiwei Granules
JSC Valenta PharmaceuticalsXC8, film-coated tablets, 10 mg
EMSIrlanda-1-Association
EMSIrlanda-2-Association
PfizerAdvil Congestion Relief
GSKAcetylcystine
JSC Valenta PharmaceuticalsImidazolyl ethanamide pentandioic acid
Ache Laboratorios FarmaceuticosBrompheniramine + Phenylephrine
GSKparacetamol + caffeine
SandozXylometazoline
Medica CorpSilfamin

Showing 15 of 20 trials with date data

Clinical Trials (21)

Total enrollment: 3,327 patients across 21 trials

NCT01466348GSKParacetamol and Caffeine

Effects of a Common Cold Treatment on Cognitive Function

Start: Feb 2011Est. completion: Apr 201172 patients
Phase 4Completed
NCT01257542SandozDextromethorphan

Acute Cough Study In Children

Start: Dec 2010Est. completion: Mar 2011140 patients
Phase 4Terminated
NCT03154515JSC Valenta PharmaceuticalsIngavirin

Efficacy and Safety Study of Ingavirin® 90 mg Once Daily to Treat Influenza and Other Acute Viral Infections in Adults

Start: Jan 2010Est. completion: Oct 2014445 patients
Phase 4Completed
NCT00967759Ache Laboratorios FarmaceuticosBronpheniramine and fenilefrine

Study Comparing 3 Formulations to Evaluate the Efficacy and Safety of the Inflammatory Symptoms of the Upper Respiratory Tract, in Children Between 2 and 6 Years Old

0
Phase 3Withdrawn
NCT05070650SandozAcetylcysteine

Efficacy and Safety of the Combination of Acetylcysteine, Paracetamol and Phenylephrine for the Treatment of Common Cold

Start: Sep 2024Est. completion: Apr 20250
Phase 3Withdrawn
NCT06697886Tasly PharmaceuticalAntiwei Granules

A Study of the Efficacy and Safety of Antiwei Granules in the Treatment of Common Cold

Start: Nov 2023Est. completion: Jul 2025480 patients
Phase 3Recruiting
NCT05273619JSC Valenta PharmaceuticalsXC8, film-coated tablets, 10 mg

Efficacy and Safety of XC8, Film-coated Tablets, 40 mg in Patients With Dry Non-productive Cough Against Acute Respiratory Viral Infection

Start: May 2022Est. completion: Jul 2022250 patients
Phase 3Completed
NCT02656888EMSIrlanda-1-Association

Efficacy and Safety of Irlanda-1-Association on the Treatment of Common Cold in Children

Start: Jun 2019Est. completion: Sep 20200
Phase 3Withdrawn
NCT02656914EMSIrlanda-2-Association

Efficacy and Safety of Irlanda-2 Association on the Treatment of Common Cold

Start: Jun 2019Est. completion: Sep 20200
Phase 3Withdrawn
NCT01938144PfizerAdvil Congestion Relief

Evaluation of the Efficacy and Safety of Two Ibuprofen Combination Products for the Treatment of the Common Cold and Flu in Latin America

Start: Apr 2016Est. completion: Nov 20160
Phase 3Withdrawn
NCT02822287GSKAcetylcystine

Warming Sensation and Tolerability Study of Acetylcysteine 2% Oral Solution for Productive Cough

Start: Feb 2016Est. completion: Mar 201658 patients
Phase 3Completed
NCT02644018JSC Valenta PharmaceuticalsImidazolyl ethanamide pentandioic acid

Efficacy and Safety Study of Ingavirin® to Treat Influenza and Other Acute Respiratory Viral Infections in Patients 3-6 y.o.

Start: Jan 2016Est. completion: May 2016190 patients
Phase 3Completed
NCT01393548Ache Laboratorios FarmaceuticosBrompheniramine + Phenylephrine

Efficacy and Safety of Combination of Brompheniramine and Phenylephrine for the Symptoms Relief of Rhinitis

Start: Aug 2014Est. completion: Dec 2016879 patients
Phase 3Completed
NCT01686646GSKparacetamol + caffeine

Effects of Two Doses of a Common Cold Treatment on Alertness

Start: Nov 2011Est. completion: Nov 2012240 patients
Phase 3Completed
NCT00452270SandozXylometazoline

Decongestant Effect, Timing of Effect and Impact on Sleep and General Well-Being of Xylometazoline in Subjects With a Common Cold

Start: Mar 2007Est. completion: Apr 200760 patients
Phase 3Completed
NCT06497439Medica CorpSilfamin

Efficacy and Safety of Silfamin for Common Cold

Start: Jul 2024Est. completion: Sep 202460 patients
Phase 2Completed
NCT05269329JSC Valenta PharmaceuticalsXC8, film-coated tablets, 20 mg/day

Efficacy and Safety of XC8, Film-coated Tablets, 10 mg in Patients With Dry Non-productive Cough Against Acute Respiratory Viral Infection

Start: Apr 2021Est. completion: Oct 2021160 patients
Phase 2Completed
NCT01277081GSKParacetamol hot drink

Effect of Paracetamol on the Common Cold

Start: Oct 2010Est. completion: Dec 2010200 patients
Phase 2Completed
NCT03415243GSKAcetaminophen 650mg+Dextromethorphan 20mg+Phenylephrine 10mg

To Investigate the Gastrointestinal Behaviour of Two Triple Combination Products in Healthy Male Volunteers

Start: Mar 2018Est. completion: Mar 201828 patients
Phase 1Completed
NCT02778100Prevail TherapeuticsNasal Glucagon

A Study of Nasal Glucagon in Participants With a Common Cold

Start: Mar 2013Est. completion: Apr 201336 patients
Phase 1Completed
NCT04533906Marinomed BiotechColdamaris lozenges

Study to Investigate if Sucking a Coldamaris Lozenge Elutes Sufficient Iota-carrageenan to Inactivate Usual Common Cold Viruses

Start: Aug 2020Est. completion: Nov 202029 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

11 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 3,327 patients
14 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.