Colonoscopy

Pipeline Programs

Companies

Clinical Trials

2 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

18 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Oregon TherapeuticsFrance - Paris

1 program

GolytelyPhase 41 trial

Active Trials

NCT00889655Unknown432Est. May 2010

NorgineAustria - Vienna

6 programs

Macrogol 3350 Na sulphate NaCl KCl Ascorbic Acid Na AscorbatePhase 31 trial

Macrogol3350 NA sulphate NACl KCl ascorbic acid NA ascorbatePhase 31 trial

macrogol3350 NA sulphate NACL KCL ascorbic acid NA ascorbatePhase 31 trial

macrogol3350 NA sulphate NACL KCL ascorbic acid NA ascorbatePhase 21 trial

+1 more programs

Active Trials

NCT01715272Completed60Est. Jan 2013

NCT00312481Completed65Est. May 2006

NCT00321230Completed30Est. May 2001

+3 more trials

BiocorpFrance - Issoire

2 programs

fospropofol disodiumPhase 31 trial

fospropofol disodiumPhase 21 trial

Active Trials

NCT00209534Completed200Est. Feb 2004

NCT00209573Completed270Est. Dec 2004

PaionGermany - Aachen

2 programs

RemimazolamPhase 31 trial

Active Trials

NCT02532647Completed79Est. Dec 2016

NCT02290873Completed461Est. Apr 2016

MedtronicNJ - Phillipsburg

2 programs

PillCam® COLON 2 procedure using MgC boostsPhase 2/31 trial

PillCam Colon 2 Capsule Endoscopy (PCCE) After Incomplete ColonoscopyN/A1 trial

Active Trials

NCT01480635Unknown74Est. Oct 2012

NCT01185002Completed80Est. Jun 2011

Cumberland PharmaceuticalsTN - Nashville

1 program

Crystalline LactulosePhase 21 trial

Active Trials

NCT01650870Completed40Est. Sep 2012

Sichuan Haisco PharmaceuticalChina - Chengdu

1 program

HSK3486Phase 21 trial

Active Trials

NCT03773042Completed64Est. Jun 2017

EisaiChina - Liaoning

4 programs

fospropofol disodiumPHASE_2

fospropofol disodiumPHASE_21 trial

AQUAVAN®PHASE_2_31 trial

fospropofol disodiumPHASE_3

Active Trials

NCT00209599Terminated100Est. Mar 2005

NCT00125424Completed125Est. Sep 2005

Angeles TherapeuticsCA - Los Angeles

1 program

CAP-straightN/A1 trial

Active Trials

NCT03566615Unknown1,630Est. Jan 2023

Bausch HealthQUEBEC, Quebec, Canada

1 program

Comparing Two Different Ways to Take MoviPrep® Before ColonoscopyN/A1 trial

Active Trials

NCT00929916Completed125Est. Apr 2009

PENTAX MedicalJapan - Tokyo

1 program

Conventional Pediatric ColonoscopeN/A1 trial

Active Trials

NCT03807089Completed283Est. May 2017

T-TherapeuticsUK - Cambridge

1 program

Diagnostic ColonoscopyN/A1 trial

Active Trials

NCT06935734Not Yet RecruitingEst. Jul 2025

OlympusPA - Center Valley

1 program

Motorized Spiral ColonoscopyN/A1 trial

Active Trials

NCT03000361Completed30Est. Feb 2017

UNION therapeuticsDenmark - Hellerup

1 program

The Correlation Between the Difficulty of Colonoscopy and the Patient's PersonalityN/A1 trial

Active Trials

NCT05584423Recruiting322Est. Nov 2024

Intelligent TherapeuticsCA - La Jolla

1 program

Using an electrical stimulation device to relieve pain during colonoscopyN/A1 trial

Active Trials

NCT06813703Recruiting60Est. Feb 2026

Knight TherapeuticsQC - Montréal

1 program

Warm vs Cool waterN/A1 trial

Active Trials

NCT01322724Completed175Est. Apr 2012

Colorado TherapeuticsCO - Louisville

1 program

Woman endoscopistN/A1 trial

Active Trials

NCT00883545Completed625Est. Jun 2009

Ferring PharmaceuticalsArgentina - Buenos Aires

1 program

PICOPREPPHASE_31 trial

Active Trials

NCT01356407Completed300Est. Jul 2011

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

Oregon TherapeuticsGolytely

PaionRemimazolam

Ferring PharmaceuticalsPICOPREP

Biocorpfospropofol disodium

NorgineMacrogol 3350 Na sulphate NaCl KCl Ascorbic Acid Na Ascorbate

NorgineMacrogol3350 NA sulphate NACl KCl ascorbic acid NA ascorbate

Norginemacrogol3350 NA sulphate NACL KCL ascorbic acid NA ascorbate

MedtronicPillCam® COLON 2 procedure using MgC boosts

EisaiAQUAVAN®

Sichuan Haisco PharmaceuticalHSK3486

Cumberland PharmaceuticalsCrystalline Lactulose

Norginemacrogol3350 NA sulphate NACL KCL ascorbic acid NA ascorbate

Eisaifospropofol disodium

Biocorpfospropofol disodium

Showing 15 of 27 trials with date data

Clinical Trials (27)

Total enrollment: 6,690 patients across 27 trials

NCT00889655 Oregon TherapeuticsGolytely

A Trial Comparing Bowel Preparation and Patient Tolerability of Miralax Versus Golytely

Start: May 2009Est. completion: May 2010432 patients

Phase 4Unknown

NCT02532647 PaionRemimazolam

Safety and Efficacy of Remimazolam in ASA III and IV Patients Undergoing Colonoscopy

Start: Nov 2015Est. completion: Dec 201679 patients

Phase 3Completed

NCT02290873 PaionRemimazolam

A Phase III Study of the Efficacy and Safety of Remimazolam Compared to Placebo and Midazolam in Colonoscopy Patients

Start: Mar 2015Est. completion: Apr 2016461 patients

Phase 3Completed

NCT01356407 Ferring PharmaceuticalsPICOPREP

Investigation of PICOPREP and PEG-ELS for Bowel Preparation for Colonoscopy

Start: Jan 2011Est. completion: Jul 2011300 patients

Phase 3Completed

NCT00209573 Biocorpfospropofol disodium

A Study of AQUAVAN® Injection Versus Midazolam HCl for Sedation in Patients Undergoing Elective Colonoscopy

Start: Sep 2004Est. completion: Dec 2004270 patients

Phase 3Completed

NCT00427089 NorgineMacrogol 3350 Na sulphate NaCl KCl Ascorbic Acid Na Ascorbate

Comparison of 2L NRL994 With NaP Preparation in Colon Cleansing Prior to Colonoscopies for Colon Tumor Screening

Start: Sep 2004Est. completion: May 2005360 patients

Phase 3Completed

NCT00389233 NorgineMacrogol3350 NA sulphate NACl KCl ascorbic acid NA ascorbate

A Phase III Trial to Assess the Efficacy, Acceptability and Safety of Moviprep® Versus a 4L PEG+E Standard Solution

Start: Jun 2002Est. completion: Dec 2002360 patients

Phase 3Completed

NCT00322062 Norginemacrogol3350 NA sulphate NACL KCL ascorbic acid NA ascorbate

MOVIPREP® Versus NaP Pivotal Phase III Study

Start: Apr 2002Est. completion: Mar 2003340 patients

Phase 3Completed

NCT01185002 MedtronicPillCam® COLON 2 procedure using MgC boosts

Evaluation of PillCam® Colon 2 Capsule Endoscopy Regimen

Start: Jul 2010Est. completion: Jun 201180 patients

Phase 2/3Completed

NCT00125424 EisaiAQUAVAN®

Study of AQUAVAN® Injection (AQUAVAN; Fospropofol Disodium) for Sedation During Colonoscopy

Start: Jul 2005Est. completion: Sep 2005125 patients

Phase 2/3Completed

NCT03773042 Sichuan Haisco PharmaceuticalHSK3486

A Study Evaluating Tolerability, Efficacy, and Safety of HSK3486 Injectable Emulsion in Patients

Start: Dec 2016Est. completion: Jun 201764 patients

Phase 2Completed

NCT01650870 Cumberland PharmaceuticalsCrystalline Lactulose

Safety, Efficacy, and Patient Preference of Split-Dose Crystalline Lactulose as a Preparation for Colonoscopy in Adults

Start: Jul 2012Est. completion: Sep 201240 patients

Phase 2Completed

NCT00312481 Norginemacrogol3350 NA sulphate NACL KCL ascorbic acid NA ascorbate

MOVIPREP® Versus PICOLAX® Pilot Study

Start: Jul 2005Est. completion: May 200665 patients

Phase 2Completed

NCT00209599 Eisaifospropofol disodium

A Study of AQUAVAN® Injection Versus Midazolam HCl for Sedation in Elderly Patients Undergoing Elective Colonoscopy

Start: Feb 2005Est. completion: Mar 2005100 patients

Phase 2Terminated

NCT00209534 Biocorpfospropofol disodium

A Study of AQUAVAN® Injection in the Presence of Pre-Medication in Patients Undergoing Elective Colonoscopy

Start: Jan 2003Est. completion: Feb 2004200 patients

Phase 2Completed

NCT00321230 Norginemacrogol3350 NA sulphate NACL KCL ascorbic acid NA ascorbate

Clinical Evaluation of a New Reduced Volume Bowel Preparation

Start: Jan 2001Est. completion: May 200130 patients

Phase 2Completed

NCT01715272 NorgineTF037

A Clinical Investigation to Demonstrate the Performance of a New Enema (TF037) in Distal Bowel Cleansing Compared With Fleet Enema

Start: Oct 2012Est. completion: Jan 201360 patients

Phase 1Completed

NCT06935734 T-TherapeuticsDiagnostic Colonoscopy

Robotic Colonoscopy Using the Triton 4.0 System in Adults for Screening, Surveillance, and Diagnosis of Lower Gastrointestinal Conditions

Start: Apr 2025Est. completion: Jul 2025

N/ANot Yet Recruiting

NCT06813703 Intelligent TherapeuticsUsing an electrical stimulation device to relieve pain during colonoscopy

Analysis of the Analgesic Mechanism of TENS-WAA During Non-anesthetized Colonoscopy Using EEG-fNIRS System

Start: Feb 2025Est. completion: Feb 202660 patients

N/ARecruiting

NCT05584423 UNION therapeuticsThe Correlation Between the Difficulty of Colonoscopy and the Patient's Personality

The Correlation Between the Difficulty of Colonoscopy and the Patient's Personality

Start: Aug 2023Est. completion: Nov 2024322 patients

N/ARecruiting

NCT03566615 Angeles TherapeuticsCAP-straight

Does the Cap Increase the Finding of Polyps When Water Exchange Colonoscopy is Used

Start: Jul 2018Est. completion: Jan 20231,630 patients

N/AUnknown

NCT03000361 OlympusMotorized Spiral Colonoscopy

Motorized Spiral Colonoscopy Trial: A First Feasibility Trial

Start: Dec 2016Est. completion: Feb 201730 patients

N/ACompleted

NCT03807089 PENTAX MedicalConventional Pediatric Colonoscope

Adenoma Detection Rate With a New Pediatric Colonoscope With a Short Turn Radius (Pentax Retroview) Compared With a Standard Pentax Pediatric Colonoscope

Start: Jul 2014Est. completion: May 2017283 patients

N/ACompleted

NCT01322724 Knight TherapeuticsWarm vs Cool water

Comparing Warm Versus Cool Temperature Water During Colonoscopy

Start: Jun 2011Est. completion: Apr 2012175 patients

N/ACompleted

NCT01480635 MedtronicPillCam Colon 2 Capsule Endoscopy (PCCE) After Incomplete Colonoscopy

PillCam Colon 2 Capsule Endoscopy (PCCE) After Incomplete Colonoscopy

Start: Jun 2010Est. completion: Oct 201274 patients

N/AUnknown

NCT00929916 Bausch HealthComparing Two Different Ways to Take MoviPrep® Before Colonoscopy

Comparing Two Different Ways to Take MoviPrep® Before Colonoscopy

Start: Dec 2008Est. completion: Apr 2009125 patients

N/ACompleted

NCT00883545 Colorado TherapeuticsWoman endoscopist

Study of Adherence to Colonoscopy in Women

Start: Oct 2008Est. completion: Jun 2009625 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

6 late-stage (Phase 3) programs, potential near-term approvals

2 actively recruiting trials targeting 6,690 patients

18 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.