Cognitive Dysfunction

3
Pipeline Programs
4
Companies
4
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
1
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

HM
Huadong MedicineChina - Hangzhou
1 program
1
Gulingji capsulesPhase 21 trial
Active Trials
NCT03647384UnknownEst. Dec 2019
Kynexis
KynexisNetherlands - Naarden
1 program
1
KYN-5356Phase 11 trial
Active Trials
NCT06225115CompletedEst. Oct 2024
Alliance Pharmaceuticals
1 program
1
iomazenilPhase 11 trial
Active Trials
NCT00611572Completed23Est. Oct 2018
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
Retinal scanN/A1 trial
Active Trials
NCT07254234Not Yet Recruiting200Est. Aug 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Huadong MedicineGulingji capsules
KynexisKYN-5356
Alliance Pharmaceuticalsiomazenil
Eli Lilly and CompanyRetinal scan

Clinical Trials (4)

Total enrollment: 223 patients across 4 trials

Guilingji Capsule for Mild-to-moderate Cognitive Impairment

Start: Aug 2018Est. completion: Dec 2019
Phase 2Unknown

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of KYN-5356 in Healthy Subjects Aged 18 to 55 Years

Start: Dec 2023Est. completion: Oct 2024
Phase 1Completed

GABA-glutamate Interactions and Psychosis

Start: Jan 2007Est. completion: Oct 201823 patients
Phase 1Completed

A Study of Retinal Imaging to Detect Abnormal Protein Deposits Associated With Alzheimer's Disease

Start: Dec 2025Est. completion: Aug 2026200 patients
N/ANot Yet Recruiting

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 companies competing in this space