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Cognitive Dysfunction

2
Pipeline Programs
12
Companies
10
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

11 companies ranked by most advanced pipeline stage

Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
2 programs
1
FluoxetinePhase 11 trial
Active Theta Burst StimulationN/A1 trial
Active Trials
NCT04558164Recruiting70Est. Jun 2026
NCT01615055Withdrawn0Est. Oct 2020
Alliance Pharmaceuticals
1 program
1
iomazenilPhase 11 trial
Active Trials
NCT00611572Completed23Est. Oct 2018
Menarini
MenariniGermany - Dresden
1 program
A mix of bioactive natural compoundsN/A1 trial
Active Trials
NCT03825042Completed80Est. Oct 2018
Medtronic
MedtronicNJ - Phillipsburg
1 program
Dual-monitoringN/A1 trial
Active Trials
NCT03036345Unknown200Est. Jun 2020
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
Retinal scanN/A
Prevail Therapeutics
1 program
Retinal scanN/A1 trial
Active Trials
NCT07254234Not Yet Recruiting200Est. Aug 2026
Masimo
MasimoIRVINE, CA
1 program
SedlineN/A1 trial
Active Trials
NCT04214496Completed106Est. Aug 2022
Medica Corp
Medica CorpMA - Bedford
1 program
Tele-rehabilitationN/A1 trial
Active Trials
NCT03383549Completed60Est. Jun 2019
Kynexis
KynexisNetherlands - Naarden
1 program
KYN-5356PHASE_1
Parexel
ParexelMA - Boston
1 program
KYN-5356PHASE_11 trial
Active Trials
NCT06225115Completed72Est. Oct 2024
Huadong Medicine
Huadong MedicineChina - Hangzhou
1 program
Gulingji capsulesPHASE_21 trial
Active Trials
NCT03647384Unknown348Est. Dec 2019

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Huadong MedicineGulingji capsules
ParexelKYN-5356
Angeles TherapeuticsFluoxetine
Alliance Pharmaceuticalsiomazenil
Prevail TherapeuticsRetinal scan
Angeles TherapeuticsActive Theta Burst Stimulation
MasimoSedline
MenariniA mix of bioactive natural compounds
Medica CorpTele-rehabilitation
MedtronicDual-monitoring

Clinical Trials (10)

Total enrollment: 1,159 patients across 10 trials

Guilingji Capsule for Mild-to-moderate Cognitive Impairment

Start: Aug 2018Est. completion: Dec 2019348 patients
Phase 2Unknown

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of KYN-5356 in Healthy Subjects Aged 18 to 55 Years

Start: Dec 2023Est. completion: Oct 202472 patients
Phase 1Completed

Fluoxetine Prevention Trial

Start: Jun 2018Est. completion: Oct 20200
Phase 1Withdrawn

GABA-glutamate Interactions and Psychosis

Start: Jan 2007Est. completion: Oct 201823 patients
Phase 1Completed

A Study of Retinal Imaging to Detect Abnormal Protein Deposits Associated With Alzheimer's Disease

Start: Dec 2025Est. completion: Aug 2026200 patients
N/ANot Yet Recruiting
NCT04558164Angeles TherapeuticsActive Theta Burst Stimulation

Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment

Start: Jan 2021Est. completion: Jun 202670 patients
N/ARecruiting

Electroencephalographic Biomarker to Predict Acute Post-operatory Cognitive Dysfunction

Start: Jan 2021Est. completion: Aug 2022106 patients
N/ACompleted
NCT03825042MenariniA mix of bioactive natural compounds

Effect of an Antioxidants Mix on Cognitive Performance and Well Being: The Bacopa, Licopene, Astaxantina, Vitamin B12

Start: Jan 2018Est. completion: Oct 201880 patients
N/ACompleted
NCT03383549Medica CorpTele-rehabilitation

Cognitive and Physical Home-rehabilitation by Information and Communications Technology. Games for Older Adults Active Life (GOAL)

Start: Jan 2018Est. completion: Jun 201960 patients
N/ACompleted
NCT03036345MedtronicDual-monitoring

Cerebral Perfusion in the Beach Chair Position

Start: May 2017Est. completion: Jun 2020200 patients
N/AUnknown

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 actively recruiting trials targeting 1,159 patients
12 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.