CLL

4
Pipeline Programs
3
Companies
4
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
2
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 3 programs with unclassified modality

Competitive Landscape

3 companies ranked by most advanced pipeline stage

BeOne Medicines
BeOne MedicinesCA - San Carlos
2 programs
2
BGB-16673Phase 31 trial
SonrotoclaxPhase 31 trial
Active Trials
NCT06846671Recruiting250Est. Feb 2030
NCT06073821Active Not Recruiting652Est. Dec 2032
Kyowa Hakko Kirin
Kyowa Hakko KirinCA - La Jolla
1 program
1
ZandelisibPhase 2Small Molecule1 trial
Active Trials
NCT05209308Withdrawn0Est. Mar 2023
TG Therapeutics
TG TherapeuticsNEW YORK, NY
1 program
1
TG-1801Phase 11 trial
Active Trials
NCT04806035Terminated21Est. Jun 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
BeOne MedicinesBGB-16673
BeOne MedicinesSonrotoclax
Kyowa Hakko KirinZandelisib
TG TherapeuticsTG-1801

Clinical Trials (4)

Total enrollment: 923 patients across 4 trials

A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors

Start: Apr 2025Est. completion: Feb 2030250 patients
Phase 3Recruiting

Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)

Start: Nov 2023Est. completion: Dec 2032652 patients
Phase 3Active Not Recruiting

Rituximab Plus Venetoclax in Combination With Zandelisib in Subjects With CLL

Start: Nov 2022Est. completion: Mar 20230
Phase 2Withdrawn

Study of TG-1801 Alone or in Combination With Ublituximab in Subjects With B-Cell Lymphoma or Chronic Lymphocytic Leukemia

Start: Apr 2021Est. completion: Jun 202421 patients
Phase 1Terminated

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 923 patients
3 companies competing in this space