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Chronic Venous Insufficiency

1
Pipeline Programs
5
Companies
8
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Servier
ServierFrance - Suresnes
2 programs
1
DetralexPhase 41 trial
in daily everyday routine practiceN/A1 trial
Active Trials
NCT04757766Completed350Est. May 2022
NCT01654016Completed84Est. Sep 2019
InterVene
InterVeneCA - Redwood City
3 programs
BlueLeaf ProcedureN/A1 trial
BlueLeaf SystemN/A1 trial
ReLeafN/A1 trial
Active Trials
NCT05047302Withdrawn0Est. Nov 2026
NCT03216005Terminated14Est. Oct 2023
NCT02462096Terminated2Est. Jun 2017
Tactile Medical
Tactile MedicalMN - Minneapolis
1 program
Dual Action Pneumatic Compression DeviceN/A1 trial
Active Trials
NCT02015221Completed81Est. Aug 2015
Theraclion
TheraclionFrance - Malakoff
1 program
Sonovein TreatmentN/A1 trial
Active Trials
NCT05926830Completed70Est. Jun 2025
AngioDynamics
AngioDynamicsChina - Hong Kong
1 program
VenaCure EVLT 400 µm fiber Procedure KitN/A1 trial
Active Trials
NCT02215369Completed112Est. Jan 2019

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
ServierDetralex
TheraclionSonovein Treatment
InterVeneBlueLeaf Procedure
Servierin daily everyday routine practice
InterVeneBlueLeaf System
InterVeneReLeaf
AngioDynamicsVenaCure EVLT 400 µm fiber Procedure Kit
Tactile MedicalDual Action Pneumatic Compression Device

Clinical Trials (8)

Total enrollment: 713 patients across 8 trials

NCT01654016ServierDetralex

Study of Antiinflammatory Effects of Detralex (Daflon)

Start: Aug 2012Est. completion: Sep 201984 patients
Phase 4Completed
NCT05926830TheraclionSonovein Treatment

Extracorporeal Flow Abolition in Relation With Primary Insufficiency of Great Saphenous Veins (GSV) Using High Intensity Focused Ultrasound (HIFU) Generated by Sonovein: A Multi Center Prospective Pivotal Study

Start: Oct 2023Est. completion: Jun 202570 patients
N/ACompleted
NCT05047302InterVeneBlueLeaf Procedure

Investigation of Femoropopliteal In Situ Valve Formation With the InterVene System (INFINITE-Canada)

Start: Oct 2022Est. completion: Nov 20260
N/AWithdrawn
NCT04757766Servierin daily everyday routine practice

VAP-PRO-C6. Effectiveness and Tolerability of Venoactive Drugs in Combination Therapy in Patients With CVD (CEAP C6)

Start: Mar 2021Est. completion: May 2022350 patients
N/ACompleted
NCT03216005InterVeneBlueLeaf System

Investigation of Femoropopliteal In Situ Valve Formation With the InterVene System

Start: Nov 2017Est. completion: Oct 202314 patients
N/ATerminated
NCT02462096InterVeneReLeaf

A Feasibility Study of the ReLeaf Catheter System

Start: Sep 2015Est. completion: Jun 20172 patients
N/ATerminated
NCT02215369AngioDynamicsVenaCure EVLT 400 µm fiber Procedure Kit

SeCure Endovenous Laser Treatment Study

Start: Jan 2015Est. completion: Jan 2019112 patients
N/ACompleted
NCT02015221Tactile MedicalDual Action Pneumatic Compression Device

Evaluation of a Dual Action Pneumatic Compression Device: Patient Ease of Use and Comfort

Start: Nov 2013Est. completion: Aug 201581 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.