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Chronic Sinusitis

2
Pipeline Programs
13
Companies
10
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1100%
+ 9 programs with unclassified modality

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Integra LifeSciences
Integra LifeSciencesAustralia - Clayton
3 programs
1
SinuplastyPhase 31 trial
FESS instruments with or without balloon treatmentN/A1 trial
Relieva™ Balloon Sinuplasty™ SystemN/A1 trial
Active Trials
NCT00939393Completed72Est. Jul 2010
NCT00939471Completed44Est. May 2010
NCT00231062Completed115Est. Jun 2006
SaNOtize
SaNOtizeBC - Vancouver
1 program
1
Nitric OxidePhase 21 trial
Active Trials
NCT04163978Completed56Est. May 2022
Ondine Biomedical
Ondine BiomedicalBC - Vancouver
1 program
PhotodisinfectionN/A1 trial
Active Trials
NCT01854619Unknown48Est. Mar 2014
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
Porcine Intestinal submucosal xenograftN/A1 trial
Active Trials
NCT02981017Withdrawn0Est. Dec 2019
Sanofi
SanofiPARIS, France
1 program
Seprapack Sinus DressingN/A1 trial
Active Trials
NCT00140608TerminatedEst. May 2005
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
Steroid-releasing sinus implantN/A1 trial
Active Trials
NCT02687438Completed20Est. Feb 2016
Chia Tai TianQing Pharmaceutical Group
1 program
TQC2731 injectionPHASE_21 trial
Active Trials
NCT06036927Completed80Est. Mar 2025
Regeneron
RegeneronTARRYTOWN, NY
1 program
dupilumabPHASE_2Monoclonal Antibody1 trial
Active Trials
NCT04362501Completed33Est. Sep 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Integra LifeSciencesSinuplasty
Chia Tai TianQing Pharmaceutical GroupTQC2731 injection
Regenerondupilumab
SaNOtizeNitric Oxide
Angeles TherapeuticsPorcine Intestinal submucosal xenograft
Allergy TherapeuticsSteroid-releasing sinus implant
Ondine BiomedicalPhotodisinfection
Integra LifeSciencesFESS instruments with or without balloon treatment
Integra LifeSciencesRelieva™ Balloon Sinuplasty™ System
SanofiSeprapack Sinus Dressing

Clinical Trials (10)

Total enrollment: 468 patients across 10 trials

NCT00231062Integra LifeSciencesSinuplasty

Clinical Evaluation to Confirm Safety and Efficacy of Sinuplasty in the Paranasal Sinuses (CLEAR)

Start: Apr 2005Est. completion: Jun 2006115 patients
Phase 3Completed
NCT06036927Chia Tai TianQing Pharmaceutical GroupTQC2731 injection

A Clinical Study of TQC2731 Injection in the Treatment of Chronic Rhinosinusitis With Nasal Polyps

Start: Dec 2023Est. completion: Mar 202580 patients
Phase 2Completed
NCT04362501Regenerondupilumab

Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)

Start: Oct 2020Est. completion: Sep 202533 patients
Phase 2Completed
NCT04163978SaNOtizeNitric Oxide

Nitric Oxide Releasing Sinus Irrigation (NOSi) to Treat Recalcitrant Chronic Rhinosinusitis (RCRS)

Start: Oct 2019Est. completion: May 202256 patients
Phase 2Completed
NCT02981017Angeles TherapeuticsPorcine Intestinal submucosal xenograft

Improvement of Outcomes in Draf III/Endoscopic Modified Lothrop Procedure

Start: Nov 2016Est. completion: Dec 20190
N/AWithdrawn
NCT02687438Allergy TherapeuticsSteroid-releasing sinus implant

The PIO (Propel In Office) III Study of In-office Placement of a Steroid-Eluting Implant Immediately Following Ethmoid Sinus Surgery

Start: Dec 2015Est. completion: Feb 201620 patients
N/ACompleted
NCT01854619Ondine BiomedicalPhotodisinfection

Photodynamic Therapy for the Treatment of Chronic Rhinosinusitis

Start: May 2013Est. completion: Mar 201448 patients
N/AUnknown
NCT00939393Integra LifeSciencesFESS instruments with or without balloon treatment

Balloon Sinus Dilation In Office or OR

Start: Apr 2008Est. completion: Jul 201072 patients
N/ACompleted
NCT00939471Integra LifeSciencesRelieva™ Balloon Sinuplasty™ System

Safety and Efficacy of Balloon Sinuplasty in Pediatric Sinusitis

Start: Apr 2007Est. completion: May 201044 patients
N/ACompleted
NCT00140608SanofiSeprapack Sinus Dressing

Efficacy of Seprapack Sinus Dressing Versus No Dressing in the Prevention of Intranasal Adhesions Following Sinus Surgery

Start: Jun 2003Est. completion: May 2005
N/ATerminated

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
13 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.