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Chronic Low Back Pain

16
Pipeline Programs
26
Companies
33
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
5
0
9
2
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

25 companies ranked by most advanced pipeline stage

Spine BioPharma
Spine BioPharmaNY - New York
2 programs
2
BiofreezePhase 41 trial
Platelet Rich Plasma Joint InjectionPhase 41 trial
Active Trials
NCT03888820Active Not Recruiting20Est. Apr 2019
NCT03122119Completed51Est. Sep 2022
Abbott
AbbottABBOTT PARK, IL
4 programs
1
3
ABT-712Phase 31 trial
ABT-712Phase 31 trial
Extended release hydrocodone and acetaminophenPhase 31 trial
hydrocodone/acetaminophen extended releasePhase 21 trial
Active Trials
NCT01364922Completed168Est. Oct 2011
NCT00761150Completed308Est. Mar 2009
NCT00763321Completed287Est. Apr 2009
+1 more trials
AbbVie
AbbVieNORTH CHICAGO, IL
3 programs
1
2
ABT-712Phase 3
ABT-712Phase 3
hydrocodone/acetaminophen extended releasePhase 2
Purdue Pharma
Purdue PharmaCT - Stamford
2 programs
2
Buprenorphine transdermal delivery systemPhase 31 trial
Hydrocodone bitartrate q24h film-coated tabletsPhase 31 trial
Active Trials
NCT00315887Completed250Est. Oct 1999
NCT01452529Completed905Est. Oct 2013
BioWave
BioWaveCT - Norwalk
1 program
1
Biowave Targeted Non-Invasive Electronic Pain Control DevicePhase 31 trial
Active Trials
NCT00277797Completed50Est. Oct 2008
Prevail Therapeutics
1 program
1
DuloxetinePhase 3
Pfizer
PfizerNEW YORK, NY
2 programs
2
Bupivacaine TTSPhase 21 trial
PF-06372865Phase 21 trial
Active Trials
NCT01096966Completed263Est. Feb 2011
NCT02262754Completed302Est. Aug 2015
Allodynic Therapeutics
Allodynic TherapeuticsFL - North Miami
1 program
1
Low-dose naltrexone and acetaminophen combinationPhase 21 trial
Active Trials
NCT03201393Completed12Est. Jul 2018
Mainstay Medical
Mainstay MedicalIreland - Dublin
3 programs
ReActiv8 Implantable Stimulation SystemN/A1 trial
ReActiv8 Implantable Stimulation SystemN/A1 trial
ReActiv8 Implantable Stimulation System implanted and activated.N/A1 trial
Active Trials
NCT02577354Completed204Est. Jan 2024
NCT03255200Completed87Est. Dec 2023
NCT01985230Completed96Est. Mar 2024
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
2 programs
Epidural electrical spinal cord stimulatorN/A1 trial
RAND Center of Excellence for the Study of Appropriateness of Care in CAMN/A1 trial
Active Trials
NCT06310226Recruiting20Est. May 2027
NCT03162952Completed2,025Est. Dec 2018
Human BioSciences
Human BioSciencesWV - Martinsburg
2 programs
Experimental Group 1N/A1 trial
Physioterapy interventionN/A1 trial
Active Trials
NCT03463824Completed154Est. Oct 2023
NCT03309540Unknown50Est. Dec 2018
MTI
MTIUT - Salt Lake City
1 program
Cognitive Behavioural TherapyN/A1 trial
Active Trials
NCT03863808Completed30Est. Oct 2019
Axiom
AxiomCA - San Francisco
1 program
DRX9000N/A1 trial
Active Trials
NCT00828880Completed
Orion Pharma
Orion PharmaUK - Reading
1 program
DTx for pain softwareN/A
Orion
OrionUK - Cambridge
1 program
DTx for pain softwareN/A1 trial
Active Trials
NCT04225884Completed34Est. Oct 2023
Curonix
CuronixFL - Pompano Beach
1 program
Freedom Spinal Cord Stimulator SystemN/A1 trial
Active Trials
NCT02403518Terminated45Est. Sep 2020
Omron Healthcare
Omron HealthcareJapan - Kyoto
1 program
HeatTensN/A1 trial
Active Trials
NCT03643731Completed50Est. Aug 2019
Boston Scientific
Boston ScientificCA - Valencia
1 program
Intracept ProcedureN/A1 trial
Active Trials
NCT05207813Completed42Est. Feb 2024
Innovation Pharmaceuticals
1 program
Personalized and automated digital coaching using a mobile applicationN/A1 trial
Active Trials
NCT06498271Not Yet Recruiting330Est. Mar 2026
Providence Therapeutics
1 program
Sham transcranial direct current stimulationN/A1 trial
Active Trials
NCT02771990Completed30Est. Apr 2018
Medtronic
MedtronicNJ - Phillipsburg
1 program
Spinal Cord StimulationN/A2 trials
Active Trials
NCT07507422Not Yet Recruiting970Est. Jan 2034
NCT03586882Unknown100Est. Jun 2020
Nevro
NevroCA - Redwood City
1 program
Spinal Cord StimulatorN/A1 trial
Active Trials
NCT01609972Unknown356Est. Jun 2015
Zimmer Biomet
Zimmer BiometFL - Jacksonville
1 program
The Atavi SystemN/A1 trial
Active Trials
NCT00792129Completed113Est. Jun 2009
Biotronik
BiotronikGermany - Berlin
1 program
Therapy A spinal cord stimulation parameter set using BIO-RNA system and associated componentsN/A1 trial
Active Trials
NCT03594266Completed136Est. Mar 2020
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
DuloxetinePHASE_31 trial
Active Trials
NCT00767806Completed401Est. Jul 2009

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Spine BioPharmaBiofreeze
Spine BioPharmaPlatelet Rich Plasma Joint Injection
Purdue PharmaHydrocodone bitartrate q24h film-coated tablets
AbbottABT-712
AbbottABT-712
Eli Lilly and CompanyDuloxetine
AbbottExtended release hydrocodone and acetaminophen
BioWaveBiowave Targeted Non-Invasive Electronic Pain Control Device
Purdue PharmaBuprenorphine transdermal delivery system
Allodynic TherapeuticsLow-dose naltrexone and acetaminophen combination
PfizerPF-06372865
Abbotthydrocodone/acetaminophen extended release
PfizerBupivacaine TTS
MedtronicSpinal Cord Stimulation
Innovation PharmaceuticalsPersonalized and automated digital coaching using a mobile application

Showing 15 of 32 trials with date data

Clinical Trials (33)

Total enrollment: 8,659 patients across 33 trials

NCT03888820Spine BioPharmaBiofreeze

Biofreeze® vs. a Placebo on Chronic Low Back Pain Walking Gait Characteristics and Pain

Start: Mar 2018Est. completion: Apr 201920 patients
Phase 4Active Not Recruiting
NCT03122119Spine BioPharmaPlatelet Rich Plasma Joint Injection

Effectiveness of Ultrasound Guided Platelet Rich Plasma Injections in the Sacroiliac Joint

Start: May 2017Est. completion: Sep 202251 patients
Phase 4Completed
NCT01452529Purdue PharmaHydrocodone bitartrate q24h film-coated tablets

Efficacy and Safety of Hydrocodone Bitartrate (HYD) in Subjects With Moderate to Severe Chronic Low Back Pain

Start: Oct 2011Est. completion: Oct 2013905 patients
Phase 3Completed
NCT00763321AbbottABT-712

Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP)

Start: Sep 2008Est. completion: Apr 2009287 patients
Phase 3Completed
NCT00761150AbbottABT-712

Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP)

Start: Sep 2008Est. completion: Mar 2009308 patients
Phase 3Completed
NCT00767806Eli Lilly and CompanyDuloxetine

A Study for Patient With Chronic Low Back Pain

Start: Sep 2008Est. completion: Jul 2009401 patients
Phase 3Completed
NCT00325949AbbottExtended release hydrocodone and acetaminophen

A Study of Pain Relief in Low Back Pain

Start: May 2006Est. completion: Jun 2007770 patients
Phase 3Completed
NCT00277797BioWaveBiowave Targeted Non-Invasive Electronic Pain Control Device

Non-Invasive Targeted Electronic Pain Control Device ("Biowave System") Versus Transcutaneous Electrical Nerve Stimulation (TENS) for the Symptomatic Treatment of Chronic Low Back Pain

Start: Feb 2001Est. completion: Oct 200850 patients
Phase 3Completed
NCT00315887Purdue PharmaBuprenorphine transdermal delivery system

The Safety and Efficacy of the Buprenorphine Transdermal Delivery System in Subjects With Chronic Back Pain.

Start: Apr 1999Est. completion: Oct 1999250 patients
Phase 3Completed
NCT03201393Allodynic TherapeuticsLow-dose naltrexone and acetaminophen combination

Low-Dose Naltrexone and Acetaminophen Combination in the Treatment of Chronic Low Back Pain (ANODYNE-4)

Start: Aug 2017Est. completion: Jul 201812 patients
Phase 2Completed
NCT02262754PfizerPF-06372865

PF-06372865 In Subjects With Chronic Low Back Pain

Start: Oct 2014Est. completion: Aug 2015302 patients
Phase 2Completed
NCT01364922Abbotthydrocodone/acetaminophen extended release

Phase 2 Chronic Low Back Pain Study

Start: Jun 2011Est. completion: Oct 2011168 patients
Phase 2Completed
NCT01096966PfizerBupivacaine TTS

Study of the Efficacy and Safety of Bupivacaine TTS Patch in Patients With Chronic Low Back Pain

Start: Mar 2010Est. completion: Feb 2011263 patients
Phase 2Completed
NCT00828880AxiomDRX9000

Restoration of Disc Height Reduces Chronic Low Back Pain

N/ACompleted
NCT07507422MedtronicSpinal Cord Stimulation

Post Market Evaluation of Real World Outcomes and Durability to Support Implantable Inceptiv™ Spinal Cord Stimulation Therapy

Start: Apr 2026Est. completion: Jan 2034970 patients
N/ANot Yet Recruiting
NCT06498271Innovation PharmaceuticalsPersonalized and automated digital coaching using a mobile application

Personalized and Automated Digital Coaching in People With Non-specific Chronic Low Back Pain

Start: Sep 2024Est. completion: Mar 2026330 patients
N/ANot Yet Recruiting
NCT06310226Angeles TherapeuticsEpidural electrical spinal cord stimulator

Phenotyping Response to Spinal Cord Stimulation in Chronic Low Back Pain

Start: Apr 2024Est. completion: May 202720 patients
N/ARecruiting
NCT05207813Boston ScientificIntracept Procedure

CLBP Single-Arm Long-Term Follow-up Study

Start: Feb 2022Est. completion: Feb 202442 patients
N/ACompleted
NCT04225884OrionDTx for pain software

Digital Therapeutics (DTx) for Pain: Pilot Study of a Virtual Reality Software for Chronic Pain

Start: Feb 2020Est. completion: Oct 202334 patients
N/ACompleted
NCT03463824Human BioSciencesExperimental Group 1

The VIGOR Study - Virtual Immersive Gaming to Optimize Recovery in Low Back Pain

Start: Jan 2019Est. completion: Oct 2023154 patients
N/ACompleted
NCT03643731Omron HealthcareHeatTens

Pain Relief in Patients With Chronic Low Back Pain Using HeatTens vs. Standard Care.

Start: Aug 2018Est. completion: Aug 201950 patients
N/ACompleted
NCT03594266BiotronikTherapy A spinal cord stimulation parameter set using BIO-RNA system and associated components

Comparison of the Effects of Two Spinal Cord Stimulation (SCS) Therapies on Subject Reported Pain (BENEFIT-02)

Start: Aug 2018Est. completion: Mar 2020136 patients
N/ACompleted
NCT03586882MedtronicSpinal Cord Stimulation

Effect of Spinal Cord Stimulation on Gait and Balance in Chronic Low Back Pain Patients

Start: Jun 2018Est. completion: Jun 2020100 patients
N/AUnknown
NCT03863808MTICognitive Behavioural Therapy

Effect of Cognitive Behavioral Therapy on Chronic Low Back Pain With Sensitization

Start: Nov 2017Est. completion: Oct 201930 patients
N/ACompleted
NCT03309540Human BioSciencesPhysioterapy intervention

Effect of Physiotherapeutic Interventions on Quality of Life in Patients With Chronic Low Back Pain. (Study 2)

Start: Oct 2017Est. completion: Dec 201850 patients
N/AUnknown
NCT03255200Mainstay MedicalReActiv8 Implantable Stimulation System

ReActiv8 Post Market Surveillance Registry

Start: Oct 2017Est. completion: Dec 202387 patients
N/ACompleted
NCT02403518CuronixFreedom Spinal Cord Stimulator System

Clinical Outcomes of the Freedom Spinal Cord Stimulation (SCS) System for the Management of Chronic Back and Leg Pain

Start: Oct 2016Est. completion: Sep 202045 patients
N/ATerminated
NCT02577354Mainstay MedicalReActiv8 Implantable Stimulation System

ReActiv8 Implantable Neurostimulation System for Chronic Low Back Pain

Start: Aug 2016Est. completion: Jan 2024204 patients
N/ACompleted
NCT01985230Mainstay MedicalReActiv8 Implantable Stimulation System implanted and activated.

ReActiv8 for Chronic Low Back Pain (PMCF)

Start: Feb 2014Est. completion: Mar 202496 patients
N/ACompleted
NCT02771990Providence TherapeuticsSham transcranial direct current stimulation

tDCS for Chronic Low Back Pain

Start: Oct 2013Est. completion: Apr 201830 patients
N/ACompleted
NCT01609972NevroSpinal Cord Stimulator

Comparison of Senza to Commercial Spinal Cord Stimulation for the Treatment of Chronic Pain

Start: Jun 2012Est. completion: Jun 2015356 patients
N/AUnknown
NCT03162952Angeles TherapeuticsRAND Center of Excellence for the Study of Appropriateness of Care in CAM

RAND Center of Excellence for the Study of Appropriateness of Care in CAM

Start: Sep 2011Est. completion: Dec 20182,025 patients
N/ACompleted
NCT00792129Zimmer BiometThe Atavi System

MIS MiLIF Versus Open

Start: Apr 2004Est. completion: Jun 2009113 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

9 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 8,659 patients
26 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.