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Chondral Defect

1
Pipeline Programs
3
Companies
4
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

3 companies ranked by most advanced pipeline stage

EpiBone
EpiBoneNY - Brooklyn
1 program
1
EB-OC Graft ImplantationPhase 1/21 trial
Active Trials
NCT06895889Not Yet Recruiting36Est. Dec 2028
Vericel
VericelCAMBRIDGE, MA
2 programs
MACIPHASE_31 trial
autologous cultured chondrocytes on porcine collagen membranePHASE_31 trial
Active Trials
NCT03588975Recruiting45Est. Jun 2027
NCT06915233Recruiting309Est. Jul 2030
Mobius Therapeutics
Mobius TherapeuticsMO - St. Louis
1 program
JointRep®N/A1 trial
Active Trials
NCT04840147Unknown185Est. Dec 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Vericelautologous cultured chondrocytes on porcine collagen membrane
VericelMACI
EpiBoneEB-OC Graft Implantation
Mobius TherapeuticsJointRep®

Clinical Trials (4)

Total enrollment: 575 patients across 4 trials

NCT06915233Vericelautologous cultured chondrocytes on porcine collagen membrane

A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the Ankle

Start: Mar 2026Est. completion: Jul 2030309 patients
Phase 3Recruiting
NCT03588975VericelMACI

A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee

Start: Oct 2018Est. completion: Jun 202745 patients
Phase 3Recruiting
NCT06895889EpiBoneEB-OC Graft Implantation

EB-OC for the Treatment of Focal Chondral/Osteochondral Defects in the Knee

Start: Jan 2026Est. completion: Dec 202836 patients
Phase 1/2Not Yet Recruiting
NCT04840147Mobius TherapeuticsJointRep®

A Comparison of JointRep® and Microfracture in Repair of Cartilage Lesions on the Femoral Condyle or Trochlea,

Start: Sep 2021Est. completion: Dec 2025185 patients
N/AUnknown

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 actively recruiting trials targeting 575 patients
3 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.