Cervical Dystonia

Pipeline Programs

Companies

Clinical Trials

1 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

AbbVieNORTH CHICAGO, IL

3 programs

Botulinum toxin APhase 41 trial

botulinum toxin type APhase 21 trial

Telemedicine follow-up visitN/A1 trial

Active Trials

NCT03969537Completed27Est. Jun 2020

NCT00564681Completed242Est. Dec 2009

NCT00773253Completed10Est. Jan 2011

MedtronicNJ - Phillipsburg

2 programs

Deep brain stimulationPhase 31 trial

Deep brain stimulationN/A1 trial

Active Trials

NCT00132990Completed10Est. Sep 2005

NCT00148889Completed63Est. Apr 2008

Syneos HealthNC - Morrisville

2 programs

DaxibotulinumtoxinA for injectionPhase 31 trial

daxibotulinumtoxinA for injectionPhase 31 trial

Active Trials

NCT03608397Completed301Est. Jun 2020

NCT03617367Completed357Est. May 2021

AEON BiopharmaCA - Irvine

2 programs

ABP-450Phase 21 trial

Active Trials

NCT04871451Completed51Est. Jul 2023

NCT04849988Completed61Est. Jul 2022

BiocorpFrance - Issoire

1 program

MTR-601Phase 21 trial

Active Trials

NCT06830642Suspended80Est. Aug 2026

IpsenChina - Tianjin

10 programs

Botulinum toxin type AN/A1 trial

DYSPORT™ Clinical & Health Economics Outcomes Registry in Cervical DystoniaN/A1 trial

IPN10200PHASE_21 trial

Botulinum toxin type APHASE_31 trial

+5 more programs

Active Trials

NCT01753349Completed1,050Est. Sep 2017

NCT01314365Completed350Est. Mar 2014

NCT06937931Recruiting132Est. Nov 2027

+7 more trials

Merz TherapeuticsNC - Raleigh

1 program

CC BoNT/AN/A1 trial

Active Trials

NCT05884528Completed270Est. Jul 2024

EisaiChina - Liaoning

1 program

BOTULINUM TOXIN TYPE BPHASE_21 trial

Active Trials

NCT00165776Completed133Est. Nov 2006

Motric BioCA - Oakland

1 program

MTR-601PHASE_2

US WorldMedsKY - Louisville

1 program

Botulinum Toxin Type BPHASE_41 trial

Active Trials

NCT00702754Completed502Est. Sep 2008

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

IpsenDysport®

AbbVieBotulinum toxin A

US WorldMedsBotulinum Toxin Type B

Syneos HealthdaxibotulinumtoxinA for injection

Syneos HealthDaxibotulinumtoxinA for injection

IpsenBotulinum toxin type A

MedtronicDeep brain stimulation

IpsenBotulinum toxin type A

IpsenIPN10200

BiocorpMTR-601

AEON BiopharmaABP-450

Showing 15 of 23 trials with date data

Clinical Trials (23)

Total enrollment: 5,110 patients across 23 trials

NCT00950664 IpsenDysport®

A Study to Compare Dysport® and Botox® in the Treatment of Cervical Dystonia

Start: Aug 2009Est. completion: Jul 2011103 patients

Phase 4Completed

NCT00773253 AbbVieBotulinum toxin A

Botox for Cervical Dystonia Following EMG Mapping

Start: Apr 2008Est. completion: Jan 201110 patients

Phase 4Completed

NCT00702754 US WorldMedsBotulinum Toxin Type B

An Open Label Safety and Immunogenicity Study of MYOBLOC (Neurobloc; Botulinum Toxin Type B) Injectable Solution in Patients With Cervical Dystonia

Start: Jun 2001Est. completion: Sep 2008502 patients

Phase 4Completed

NCT03617367 Syneos HealthdaxibotulinumtoxinA for injection

Long-Term Safety and Efficacy of Repeat Treatments of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-OLS)

Start: Sep 2018Est. completion: May 2021357 patients

Phase 3Completed

NCT03608397 Syneos HealthDaxibotulinumtoxinA for injection

Single Treatment of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-1)

Start: Jun 2018Est. completion: Jun 2020301 patients

Phase 3Completed

NCT01753336 IpsenBotulinum toxin type A

Long Term Safety And Effectiveness Of Dysport® In Adults With Cervical Dystonia

Start: Mar 2013Est. completion: Oct 2015112 patients

Phase 3Completed

NCT01753310 IpsenBotulinum toxin type A

Efficacy and Safety of DYSPORT® Using 2mL Dilution in Adults With Cervical Dystonia.

Start: Jan 2013Est. completion: Jan 2015134 patients

Phase 3Completed

NCT01261611 IpsenBotulinum toxin type A

Study Comparing Short Term Efficacy of Dysport and Dysport NG to Placebo, and to Assess Efficacy and Safety of Dysport NG of Subjects With Cervical Dystonia

Start: Apr 2011Est. completion: Jun 2013382 patients

Phase 3Completed

NCT00288509 IpsenBotulinum toxin type A

Open-label Extension Study of AbobotulinumtoxinA (Dysport®) for the Treatment of Cervical Dystonia

Start: Feb 2006Est. completion: Jan 2008108 patients

Phase 3Completed

NCT00257660 IpsenBotulinum toxin type A

Randomized, Placebo-Controlled Study of AbobotulinumtoxinA (Dysport®) for the Treatment of Cervical Dystonia

Start: Oct 2005Est. completion: Sep 2006116 patients

Phase 3Completed

NCT00148889 MedtronicDeep brain stimulation

Double-blind, Multicenter Study to Assess the Efficacy of Bilateral Pallidal Stimulation in Patients With Medically Refractory Primary Cervical Dystonia

Start: Jul 2005Est. completion: Apr 200863 patients

Phase 3Completed

NCT00447772 IpsenBotulinum toxin type A

Study to Assess the Efficacy and Safety of Dysport® in Cervical Dystonia

Start: Oct 2004Est. completion: Apr 2008516 patients

Phase 3Completed

NCT06937931 IpsenIPN10200

A Study of IPN10200 for the Treatment of Cervical Dystonia in Adults

Start: Jun 2025Est. completion: Nov 2027132 patients

Phase 2Recruiting

NCT06830642 BiocorpMTR-601

Study of the Oral Treatment MTR-601 in Cervical Dystonia

Start: Feb 2025Est. completion: Aug 202680 patients

Phase 2Suspended

NCT04871451 AEON BiopharmaABP-450

Extension Study of ABP-19000 to Evaluate Safety and Efficacy of Repeat Treatments of ABP-450 in Cervical Dystonia

Start: Jul 2021Est. completion: Jul 202351 patients

Phase 2Completed

NCT04849988 AEON BiopharmaABP-450

A Phase 2 Study to Evaluate the Safety and Efficacy of ABP-450 in the Treatment of Cervical Dystonia

Start: Mar 2021Est. completion: Jul 202261 patients

Phase 2Completed

NCT00564681 AbbViebotulinum toxin type A

Study to Evaluate Safety, Efficacy of Botulinum Toxin Type A in Patients With Cervical Dystonia

Start: Dec 2007Est. completion: Dec 2009242 patients

Phase 2Completed

NCT00165776 EisaiBOTULINUM TOXIN TYPE B

Randomized, Double-Blind, Placebo-Controlled, Parallel, Group Dose-Response, Study of E2014 in Patients WIth Spasmodic Torticollis

Start: Jun 2004Est. completion: Nov 2006133 patients

Phase 2Completed

NCT05884528 Merz TherapeuticsCC BoNT/A

Assessment of Long-term Clinical Response to BoNT in Cervical Dystonia

Start: Jul 2023Est. completion: Jul 2024270 patients

N/ACompleted

NCT03969537 AbbVieTelemedicine follow-up visit

Telemedicine Follow-up for Patients With Cervical Dystonia Treated With Neurotoxin Injections

Start: Apr 2019Est. completion: Jun 202027 patients

N/ACompleted

NCT01753349 IpsenBotulinum toxin type A

Phase IV-Cervical Dystonia-INTEREST IN CD2

Start: Dec 2012Est. completion: Sep 20171,050 patients

N/ACompleted

NCT01314365 IpsenDYSPORT™ Clinical & Health Economics Outcomes Registry in Cervical Dystonia

DYSPORT™ Clinical & Health Economics Outcomes Registry in Cervical Dystonia

Start: Apr 2011Est. completion: Mar 2014350 patients

N/ACompleted

NCT00132990 MedtronicDeep brain stimulation

A Multicenter Pilot Study of Pallidal Deep Brain Stimulation for Cervical Dystonia

Start: Feb 2003Est. completion: Sep 200510 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals

1 actively recruiting trials targeting 5,110 patients

10 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.