Skip to main content

Cervical Degenerative Disc Disease

1
Pipeline Programs
4
Companies
12
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
1
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Medtronic
MedtronicNJ - Phillipsburg
3 programs
1
PRESTIGE® LP Cervical DiscPhase 31 trial
PRESTIGE LP device at two adjacent levelsN/A1 trial
PRESTIGE LP™ Cervical DiscN/A1 trial
Active Trials
NCT00637156Completed397Est. Feb 2018
NCT03062657Terminated25Est. Jan 2023
NCT00667459Completed280Est. Jun 2014
Spine BioPharma
Spine BioPharmaNY - New York
8 programs
Anterior Cervical Discectomy & FusionN/A1 trial
Anterior Cervical Discectomy and FusionN/A1 trial
Cervical TDRN/A1 trial
PureGen Osteoprogenitor Cell AllograftN/A1 trial
Synergy Cervical Disc systemN/A1 trial
+3 more programs
Active Trials
NCT04469231Active Not Recruiting175Est. Jan 2026
NCT05740176Active Not Recruiting200Est. Dec 2026
NCT00432159Completed500Est. May 2016
+5 more trials
Globus Medical
Globus MedicalAUDUBON, PA
1 program
Simplify DiscN/A1 trial
Active Trials
NCT02667067Completed150Est. Jul 2021
NuVasive
NuVasiveCA - San Diego
1 program
Simplify DiscN/A

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
MedtronicPRESTIGE® LP Cervical Disc
Spine BioPharmaSynergy cervical spine disc replacement
Spine BioPharmaSynergy cervical disc system
Spine BioPharmaSynergy Cervical Disc system
Spine BioPharmaSynergy cervical disc system
Spine BioPharmaAnterior Cervical Discectomy and Fusion
Spine BioPharmaAnterior Cervical Discectomy & Fusion
MedtronicPRESTIGE LP™ Cervical Disc
Globus MedicalSimplify Disc
Spine BioPharmaPureGen Osteoprogenitor Cell Allograft
Spine BioPharmaCervical TDR
MedtronicPRESTIGE LP device at two adjacent levels

Clinical Trials (12)

Total enrollment: 1,907 patients across 12 trials

NCT00667459MedtronicPRESTIGE® LP Cervical Disc

Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDD

Start: Jan 2005Est. completion: Jun 2014280 patients
Phase 3Completed
NCT06383962Spine BioPharmaSynergy cervical spine disc replacement

Post-Market Data Collection to Evaluate the Performance of the Synergy Disc®

Start: Mar 2026Est. completion: Dec 203450 patients
N/ARecruiting
NCT06413225Spine BioPharmaSynergy cervical disc system

Multi-Centre Post-Market Data Collection

Start: Sep 2024Est. completion: Sep 20340
N/AWithdrawn
NCT06383949Spine BioPharmaSynergy Cervical Disc system

Real World Data Collection on the Synergy Disc

Start: Aug 2024Est. completion: Feb 203350 patients
N/ARecruiting
NCT05880823Spine BioPharmaSynergy cervical disc system

Post Market Data Collection Protocol to Evaluate the Performance of the Synergy Disc

Start: Jan 2024Est. completion: May 203450 patients
N/ARecruiting
NCT05740176Spine BioPharmaAnterior Cervical Discectomy and Fusion

The Synergy Disc for the Treatment of 2 Level Cervical Degenerative Disc Disease Compared With Cervical Fusion Surgery

Start: Jun 2023Est. completion: Dec 2026200 patients
N/AActive Not Recruiting
NCT04469231Spine BioPharmaAnterior Cervical Discectomy & Fusion

The Synergy Disc To Anterior Cervical Discectomy and Fusion

Start: Oct 2020Est. completion: Jan 2026175 patients
N/AActive Not Recruiting
NCT03062657MedtronicPRESTIGE LP™ Cervical Disc

An Investigation of the Metal Concentration in Patients Implanted With the PRESTIGE LP™ Cervical Disc at Two Contiguous Levels in the Cervical Spine

Start: Jun 2018Est. completion: Jan 202325 patients
N/ATerminated

Investigation of the Simplify® Cervical Artificial Disc

Start: Nov 2015Est. completion: Jul 2021150 patients
N/ACompleted
NCT01291134Spine BioPharmaPureGen Osteoprogenitor Cell Allograft

PureGen: Radiographic Analysis of Fusion for ACDF

Start: Feb 2011Est. completion: Aug 201330 patients
N/ATerminated

Comparison of DISCOVER™ Artificial Cervical Disc and ACDF for Treatment of Cervical DDD (IDE Study)

Start: Jul 2006Est. completion: May 2016500 patients
N/ACompleted
NCT00637156MedtronicPRESTIGE LP device at two adjacent levels

Study of the Safety and Effectiveness of the Artificial Cervical Disc - Low Profile Device at Two Adjacent Levels

Start: Jun 2006Est. completion: Feb 2018397 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
3 actively recruiting trials targeting 1,907 patients
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.