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Caries

5
Pipeline Programs
4
Companies
7
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
4
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
4 programs
1
3
0 ppm FPhase 31 trial
NaFPhase 31 trial
Sodium Fluoride ToothpastePhase 31 trial
Calcium sodium phosphosilicatePhase 21 trial
Active Trials
NCT01657877Completed100Est. Jun 2013
NCT03383783Completed28Est. May 2018
NCT00708097Completed57Est. Jul 2008
+1 more trials
Mott
MottCT - Farmington
1 program
1
Silver Diamine FluoridePhase 31 trial
Active Trials
NCT02601833Completed98Est. Sep 2020
Solventum
SolventumMN - St. Paul
1 program
Clinpro 5000N/A1 trial
Active Trials
NCT01650493Completed29Est. Jul 2013
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
Oral Health Care Early Intervention ProjectN/A1 trial
Active Trials
NCT00793507Completed1,178Est. Apr 2011

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
ViiV Healthcare0 ppm F
MottSilver Diamine Fluoride
ViiV HealthcareSodium Fluoride Toothpaste
ViiV HealthcareNaF
ViiV HealthcareCalcium sodium phosphosilicate
SolventumClinpro 5000
Colorado TherapeuticsOral Health Care Early Intervention Project

Clinical Trials (7)

Total enrollment: 1,555 patients across 7 trials

NCT03383783ViiV Healthcare0 ppm F

Evaluation of the Fluoride Dose Response of a Modified In Situ Caries Model

Start: Dec 2017Est. completion: May 201828 patients
Phase 3Completed
NCT02601833MottSilver Diamine Fluoride

Effectiveness of Silver Diamine Fluoride as a Treatment for Caries in Comparison to Traditional Restorative Techniques

Start: Jan 2016Est. completion: Sep 202098 patients
Phase 3Completed
NCT01005966ViiV HealthcareSodium Fluoride Toothpaste

In Situ Caries Model of Fluoride Toothpastes

Start: Nov 2008Est. completion: Mar 200965 patients
Phase 3Completed
NCT00708097ViiV HealthcareNaF

In Situ Caries Efficacy of Fluoride Toothpastes

Start: Apr 2008Est. completion: Jul 200857 patients
Phase 3Completed
NCT01657877ViiV HealthcareCalcium sodium phosphosilicate

Anti-caries Potential of a Sodium Monofluorophosphate and Calcium Sodium Phosphosilicate Dentifrice

Start: May 2012Est. completion: Jun 2013100 patients
Phase 2Completed
NCT01650493SolventumClinpro 5000

In-situ Evaluation of Anti-caries Technology

Start: Jun 2012Est. completion: Jul 201329 patients
N/ACompleted
NCT00793507Colorado TherapeuticsOral Health Care Early Intervention Project

Oral Health Care Early Intervention Project

Start: Nov 2008Est. completion: Apr 20111,178 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 late-stage (Phase 3) programs, potential near-term approvals
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.