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Cardiac Arrest, Out-Of-Hospital

3
Pipeline Programs
4
Companies
4
Clinical Trials
1 recruiting
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
3
Early DiscoveryClinical DevelopmentMarket

On Market (2)

Approved therapies currently available

Pfizer
ADRENALINApproved
epinephrine
Pfizer
alpha-Adrenergic Agonist [EPC]intramuscular, intravenous, subcutaneous2012
51K Part D
Pfizer
PRIMATENE MISTApproved
epinephrine
Pfizer
inhalation1967

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
1 program
1
EpinephrinePhase 41 trial
Active Trials
NCT03826524Recruiting3,790Est. Dec 2028
Zoll
ZollCA - San Jose
1 program
AED 3 with Uni-padzN/A1 trial
Active Trials
NCT05013333Active Not Recruiting38Est. Feb 2029
Ambu
AmbuDenmark - Ballerup
1 program
Fixed PEEP ValveN/A1 trial
Active Trials
NCT07905482Active Not Recruiting3,200Est. Sep 2029
Stryker
StrykerCA - San Jose
1 program
LUCAS 2 Active Decompression 2N/A1 trial
Active Trials
NCT04891380Completed183Est. Jan 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
PfizerEpinephrine
AmbuFixed PEEP Valve
StrykerLUCAS 2 Active Decompression 2
ZollAED 3 with Uni-padz

Clinical Trials (4)

Total enrollment: 7,211 patients across 4 trials

Epinephrine Dose: Optimal Versus Standard Evaluation Trial

Start: May 2023Est. completion: Dec 20283,790 patients
Phase 4Recruiting
NCT07905482AmbuFixed PEEP Valve

The REVIVE-PEEP Trial: Positive End-expiratory Pressure Versus Sham Valve/Zero End-expiratory Pressure in Cardiopulmonary Resuscitation During Manual Ventilation to Improve Neurological Outcomes at Discharge in Adult Patients Suffering an Out-of-hospital Cardiac Arrest

Start: Oct 2026Est. completion: Sep 20293,200 patients
N/AActive Not Recruiting
NCT04891380StrykerLUCAS 2 Active Decompression 2

BCG Biosensor and Non- and Invasive Monitoring During Emergency Medicine Cases, a Prospective Feasibility Study

Start: May 2021Est. completion: Jan 2024183 patients
N/ACompleted
NCT05013333ZollAED 3 with Uni-padz

AED 3 Post-Approval Study

Start: Mar 2021Est. completion: Feb 202938 patients
N/AActive Not Recruiting

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 7,211 patients
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.