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Cardiac Arrest

6
Pipeline Programs
24
Companies
35
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
3
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1100%
+ 38 programs with unclassified modality

Competitive Landscape

24 companies ranked by most advanced pipeline stage

Defence Therapeutics
Defence TherapeuticsBC - Vancouver
3 programs
1
1
IntraosseousPhase 41 trial
amiodaronePhase 31 trial
Laryngeal Mask AirwayN/A1 trial
Active Trials
NCT02607644Completed965Est. May 2018
NCT01401647Completed3,024Est. Jan 2016
NCT02088736Completed1,103Est. Jun 2017
Boston Scientific
Boston ScientificCA - Valencia
1 program
1
procedurePhase 41 trial
Active Trials
NCT00180362Completed200Est. Sep 2004
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
2 programs
1
Amiodarone Hydrochloride InjectionPhase 31 trial
EchocardiographyN/A
Active Trials
NCT06680869Recruiting585Est. Jan 2028
Young BioPharma
Young BioPharmaMA - Lowell
1 program
1
Amiodarone InjectionPhase 31 trial
Active Trials
NCT04845607Unknown302Est. Feb 2023
Medtronic
MedtronicNJ - Phillipsburg
2 programs
1
EpinephrinePhase 21 trial
near infrared spectroscopyN/A1 trial
Active Trials
NCT01531426Completed94Est. Jan 2013
NCT00401882Terminated7Est. Mar 2012
Zoll
ZollCA - San Jose
5 programs
AutoPulseN/A1 trial
Low Volume VentilationN/A1 trial
Quality of Pediatric Resuscitation in a Multicenter CollaborativeN/A1 trial
RapidShockN/A1 trial
ZOLL Intravascular Temperature Management SystemN/A1 trial
Active Trials
NCT00597207Completed4,231Est. Dec 2013
NCT07479836Not Yet Recruiting1,656Est. Mar 2028
NCT02708134Recruiting7,000Est. Jan 2030
+2 more trials
Neurescue
NeurescueDenmark - Copenhagen
3 programs
NEURESCUE deviceN/A1 trial
NEURESCUE deviceN/A1 trial
REBOAN/A1 trial
Active Trials
NCT05444049Completed6Est. Sep 2024
NCT05146661Completed10Est. Nov 2023
NCT04491903Withdrawn0Est. Nov 2020
One Biosciences
One BiosciencesFrance - Paris
3 programs
nitritePHASE_11 trial
Up to 2 liter infusion of cold 4 degree C normal salinePHASE_1_21 trial
DefibrillationPHASE_41 trial
Active Trials
NCT01178359CompletedEst. Apr 2016
NCT00329563CompletedEst. Mar 2006
NCT00101881CompletedEst. Jan 2005
Autonomous Therapeutics
2 programs
Baseline Investigation of Patients With Cardiac Arrest in ChinaN/A1 trial
InfliximabN/AMonoclonal Antibody1 trial
Active Trials
NCT03926325Unknown200,000Est. Dec 2023
NCT07176754Not Yet Recruiting208Est. Oct 2028
Eppendorf
EppendorfGermany - Hamburg
2 programs
HemoadsorptionN/A
Mild therapeutic hypothermiaN/A1 trial
Active Trials
NCT00457431Terminated249Est. Mar 2021
Human BioSciences
Human BioSciencesWV - Martinsburg
2 programs
ICU-RESUS CPR Improvement BundleN/A1 trial
Quantitative Measurement of Cardiopulmonary Resuscitation (CPR) During In Hospital Cardiac ArrestN/A1 trial
Active Trials
NCT02837497Completed1,127Est. Mar 2021
NCT00628693Completed89Est. Nov 2015
Berlin Heart
Berlin HeartTX - The Woodlands
1 program
Automated Pupillometry for Coma Prognostication After Cardiac ArrestN/A1 trial
Active Trials
NCT02607878Completed470Est. Jul 2017
Philips
PhilipsNetherlands - Amsterdam
1 program
Automatic RR MeasurementN/A1 trial
Active Trials
NCT02973243Completed446Est. Feb 2017
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
EchocardiographyN/A1 trial
Active Trials
NCT04906252Completed813Est. Jan 2025
Temple Therapeutics
Temple TherapeuticsNetherlands - Geleen
1 program
EchocardiographyN/A
A&D Medical
A&D MedicalMI - Ann Arbor
1 program
Esophageal Cooling DeviceN/A
Getinge
GetingeChina - Suzhou
1 program
Extracorporeal cardiopulmonary resuscitationN/A1 trial
Active Trials
NCT03101787Completed134Est. Feb 2022
Flosonics
FlosonicsON - Sudbury
1 program
FloPatch FP120N/A1 trial
Active Trials
NCT05558228Unknown35Est. Sep 2024
Masimo
MasimoIRVINE, CA
1 program
Frontal 4 channel EEGN/A1 trial
Active Trials
NCT01946802Completed39Est. Oct 2016
CytoSorbents
CytoSorbentsPRINCETON, NJ
1 program
HemoadsorptionN/A1 trial
Active Trials
NCT03632837Unknown40Est. Sep 2019
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
Identification of Ventricular Fibrillation and Optimization of Defibrillation During CPRN/A1 trial
Active Trials
NCT02952105Unknown90Est. May 2018
GE HealthCare
1 program
LUCAS2 ADN/A1 trial
Active Trials
NCT02479152Completed126Est. Apr 2017
Utah Medical
Utah MedicalIreland - Dublin
1 program
REASON 1 Trial: Sonography in Cardiac ArrestN/A1 trial
Active Trials
NCT01446471Completed793Est. Nov 2015
Innovation Pharmaceuticals
1 program
Vascular occlusion testN/A1 trial
Active Trials
NCT01073098Unknown51Est. Mar 2013

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Defence TherapeuticsIntraosseous
Boston Scientificprocedure
One BiosciencesDefibrillation
Oregon TherapeuticsAmiodarone Hydrochloride Injection
Young BioPharmaAmiodarone Injection
Defence Therapeuticsamiodarone
MedtronicEpinephrine
One BiosciencesUp to 2 liter infusion of cold 4 degree C normal saline
One Biosciencesnitrite
ZollLow Volume Ventilation
Autonomous TherapeuticsInfliximab
NeurescueNEURESCUE device
FlosonicsFloPatch FP120
NeurescueNEURESCUE device
Colorado TherapeuticsEchocardiography

Showing 15 of 35 trials with date data

Clinical Trials (35)

Total enrollment: 226,675 patients across 35 trials

Intraosseous vs Intravenous Access for Cardiac Arrest Treatment

Start: Jun 2014Est. completion: Jun 20171,103 patients
Phase 4Completed

Quick ICD Study: Is Extensive Electrophysiological Testing Before, During and After ICD-Implantation Still Necessary ?

Start: May 2004Est. completion: Sep 2004200 patients
Phase 4Completed

Transthoracic Incremental Monophasic Versus Biphasic by Emergency Responders (TIMBER)

Start: Nov 2002Est. completion: Jan 2005
Phase 4Completed
NCT06680869Oregon TherapeuticsAmiodarone Hydrochloride Injection

Early Amiodarone in Shockable Cardiac Arrest

Start: Jan 2025Est. completion: Jan 2028585 patients
Phase 3Recruiting
NCT04845607Young BioPharmaAmiodarone Injection

Prophylactic Amiodarone for Shockable Cardiac Arrest

Start: Apr 2021Est. completion: Feb 2023302 patients
Phase 3Unknown

Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia

Start: May 2012Est. completion: Jan 20163,024 patients
Phase 3Completed

Treatment of Ventricular Tachyarrhythmias Refractory To Shock With Beta Blockers: The SHOCK and BLOCK Trial

Start: Jan 2007Est. completion: Mar 20127 patients
Phase 2Terminated
NCT00329563One BiosciencesUp to 2 liter infusion of cold 4 degree C normal saline

Pilot Community Clinical Study of Hypothermia in Cardiac Arrest

Start: Nov 2004Est. completion: Mar 2006
Phase 1/2Completed

Pilot Study of Sodium Nitrite in Resuscitated Cardiac Arrest Patients

Start: Jan 2010Est. completion: Apr 2016
Phase 1Completed
NCT07479836ZollLow Volume Ventilation

Optimizing Ventilation to Improve Survival From Out-of-hospital Cardiac Arrest: the OPTIVO Randomized Controlled Trial

Start: Mar 2026Est. completion: Mar 20281,656 patients
N/ANot Yet Recruiting

TNF-α Antagonists Mitigate Systemic Inflammatory Response After Cardiac Arrest.

Start: Oct 2025Est. completion: Oct 2028208 patients
N/ANot Yet Recruiting
NCT05444049NeurescueNEURESCUE device

NEURESCUE Device as an Adjunct to In-Hospital Cardiac Arrest (ARISE)

Start: Dec 2022Est. completion: Sep 20246 patients
N/ACompleted
NCT05558228FlosonicsFloPatch FP120

Accuracy of Doppler Ultrasound Versus Manual Palpation of Pulse in Cardiac Arrest

Start: Sep 2022Est. completion: Sep 202435 patients
N/AUnknown
NCT05146661NeurescueNEURESCUE device

NEURESCUE Device as an Adjunct to Cardiac Arrest

Start: Aug 2022Est. completion: Nov 202310 patients
N/ACompleted

Vfib by ECG or Echo During Cardiac Arrest

Start: Sep 2021Est. completion: Jan 2025813 patients
N/ACompleted

REBOA for Out-of-hospital Cardiac Arrest

Start: Nov 2020Est. completion: Nov 20200
N/AWithdrawn
NCT03926325Autonomous TherapeuticsBaseline Investigation of Patients With Cardiac Arrest in China

Baseline Investigation of Patients With Cardiac Arrest in China

Start: Jul 2019Est. completion: Dec 2023200,000 patients
N/AUnknown
NCT04014842ZollRapidShock

RapidShock Post-Approval Study

Start: Feb 2019Est. completion: Dec 20232,756 patients
N/ACompleted

HaemoAdsorption Nach Reanimation An ECMO

Start: Oct 2018Est. completion: Sep 201940 patients
N/AUnknown
NCT03101787GetingeExtracorporeal cardiopulmonary resuscitation

Early Initiation of Extracorporeal Life Support in Refractory OHCA

Start: May 2017Est. completion: Feb 2022134 patients
N/ACompleted
NCT02973243PhilipsAutomatic RR Measurement

The Vital Signs to Identify, Target, and Assess Level (VITAL) Care Study III

Start: Oct 2016Est. completion: Feb 2017446 patients
N/ACompleted
NCT02837497Human BioSciencesICU-RESUS CPR Improvement Bundle

The ICU-Resuscitation Project (ICU-RESUS)

Start: Oct 2016Est. completion: Mar 20211,127 patients
N/ACompleted
NCT02708134ZollQuality of Pediatric Resuscitation in a Multicenter Collaborative

Quality of Pediatric Resuscitation in a Multicenter Collaborative

Start: May 2016Est. completion: Jan 20307,000 patients
N/ARecruiting
NCT02952105UNION therapeuticsIdentification of Ventricular Fibrillation and Optimization of Defibrillation During CPR

Identification of Ventricular Fibrillation and Optimization of Defibrillation During CPR

Start: Apr 2016Est. completion: May 201890 patients
N/AUnknown
NCT02607644Defence TherapeuticsLaryngeal Mask Airway

Laryngeal Tube vs Laryngeal Mask Airway

Start: Mar 2016Est. completion: May 2018965 patients
N/ACompleted

The Haemodynamic Effects of Mechanical Standard and Active Chest Compression-decompression During Out-of-hospital CPR

Start: Apr 2015Est. completion: Apr 2017126 patients
N/ACompleted
NCT02607878Berlin HeartAutomated Pupillometry for Coma Prognostication After Cardiac Arrest

Automated Pupillometry for Coma Prognostication After Cardiac Arrest

Start: Jan 2015Est. completion: Jul 2017470 patients
N/ACompleted
NCT01946802MasimoFrontal 4 channel EEG

Seizure Detection Using SEDline During Therapeutic Hypothermia in Cardiac Arrest Victims

Start: Dec 2014Est. completion: Oct 201639 patients
N/ACompleted
NCT01847482ZollZOLL Intravascular Temperature Management System

Therapeutic Hypothermia With IntraVascular Temperature Management (IVTM) in Post-Cardiogenic Cardiac Arrest and Post-Return of Spontaneous Circulation Patients in Japan

Start: Mar 2013Est. completion: Jan 201626 patients
N/ACompleted
NCT01531426Medtronicnear infrared spectroscopy

Cerebral Oxygenation in Cardiac Arrest and Hypothermia

Start: Jan 2012Est. completion: Jan 201394 patients
N/ACompleted

Evaluation of Muscle StO2 as a Prognostic Factor After Out of Hospital Cardiac Arrest

Start: Mar 2010Est. completion: Mar 201351 patients
N/AUnknown
NCT01446471Utah MedicalREASON 1 Trial: Sonography in Cardiac Arrest

REASON 1 Trial: Sonography in Cardiac Arrest

Start: Jan 2010Est. completion: Nov 2015793 patients
N/ACompleted

Circulation Improving Resuscitation Care (CIRC)

Start: Jan 2008Est. completion: Dec 20134,231 patients
N/ACompleted
NCT00457431EppendorfMild therapeutic hypothermia

Hypothermia After In-hospital Cardiac Arrest

Start: Apr 2007Est. completion: Mar 2021249 patients
N/ATerminated
NCT00628693Human BioSciencesQuantitative Measurement of Cardiopulmonary Resuscitation (CPR) During In Hospital Cardiac Arrest

Quantitative Measurement of Cardiopulmonary Resuscitation (CPR) During In Hospital Cardiac Arrest

Start: Jun 2006Est. completion: Nov 201589 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 226,675 patients
24 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.