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Candidiasis

16
Pipeline Programs
6
Companies
36
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
7
0
6
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
7100%
+ 13 programs with unclassified modality

On Market (1)

Approved therapies currently available

Pfizer
VFENDApproved
voriconazole
Pfizer
Azole Antifungal [EPC]intravenous2002
10K Part D

Competitive Landscape

6 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
6 programs
2
2
1
VoriconazolePhase 4Small Molecule5 trials
Active anidulafunginPhase 31 trial
voriconazolePhase 3Small Molecule1 trial
Anidulafungin, VER002Phase 21 trial
voriconazolePhase 2Small Molecule1 trial
+1 more programs
Active Trials
NCT01202253Completed50Est. May 2011
NCT00037219Completed120Est. Nov 2002
NCT00739934Completed40Est. Oct 2009
+7 more trials
Astellas
AstellasChina - Shenyang
5 programs
1
3
1
FluconazolePhase 4Small Molecule2 trials
MicafunginPhase 31 trial
MicafunginPhase 31 trial
micafunginPhase 31 trial
FK463Phase 21 trial
Active Trials
NCT00036179Completed75Est. Jan 2002
NCT00105144Completed611Est. Apr 2006
NCT00106288Completed637Est. Dec 2005
+3 more trials
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
1
fluconazolePhase 3Small Molecule1 trial
Active Trials
NCT00734539Completed362Est. Apr 2013
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
2 programs
2
MK0991, caspofungin acetate/Duration of Treatment: variablePhase 2
caspofungin acetatePhase 2
MSD
MSDIreland - Ballydine
2 programs
2
MK0991, caspofungin acetate/Duration of Treatment: variablePhase 21 trial
caspofungin acetatePhase 21 trial
Active Trials
NCT00083343Completed48Est. Feb 2006
NCT00330395Completed16Est. Oct 2006
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
4 programs
FluconazoleN/ASmall Molecule1 trial
Funguria in Hospitalized PatientsN/A1 trial
CaspofunginPHASE_31 trial
FluconazolePHASE_4Small Molecule5 trials
Active Trials
NCT00000744Completed400Est. Dec 1995
NCT00138502Completed926Est. Dec 2008
NCT00095316Terminated1,200Est. Sep 2006
+5 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Allergy TherapeuticsFluconazole
PfizerVoriconazole
AstellasFluconazole
PfizerVoriconazole
PfizerVoriconazole
Astellasmicafungin
PfizerVoriconazole
Pfizervoriconazole
PfizerActive anidulafungin
Human BioSciencesfluconazole
Allergy TherapeuticsCaspofungin
AstellasMicafungin
Allergy TherapeuticsFluconazole
AstellasMicafungin
Allergy TherapeuticsFluconazole

Showing 15 of 34 trials with date data

Clinical Trials (36)

Total enrollment: 7,350 patients across 36 trials

Comparison of Two Treatments to Prevent Invasive Fungal Infections in Patients Who Have Received Liver Transplants

Est. completion: Nov 2005500 patients
Phase 4Completed
NCT00455364PfizerVoriconazole

Voriconazole as Prophylactic Therapy in Lung Transplant Recipients

Start: Apr 2007Est. completion: Apr 200720 patients
Phase 4Terminated

Fluconazole Versus Micafungin for Candida Bloodstream Infection in Non-Neutropenic Patients

Start: Aug 2006Est. completion: Dec 20080
Phase 4Withdrawn
NCT00143312PfizerVoriconazole

Voriconazole for Secondary Prophylaxis of Invasive Fungal Infections in Patients With Allogeneic Stem Cell Transplants

Start: Feb 2005Est. completion: Apr 200845 patients
Phase 4Completed
NCT00647907PfizerVoriconazole

A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections

Start: Apr 2003Est. completion: May 20047 patients
Phase 4Completed

Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDS

330 patients
Phase 3Completed

Study to Compare the Efficacy and Safety of Micafungin Versus Conventional Amphotericin B for the Treatment of Neonatal Candidiasis

Start: Feb 2013Est. completion: Dec 201430 patients
Phase 3Terminated
NCT01188759PfizerVoriconazole

Voriconazole And Anidulafungin Combination For Invasive Aspergillosis In Pediatric Subjects

Start: May 2012Est. completion: Aug 20140
Phase 3Withdrawn
NCT01092832Pfizervoriconazole

A Study Of The Safety, Tolerability And Effective Of Voriconazole For The Treatment Of Serious Candida Infection And Candida Infection Of The Throat In Pediatric Patients

Start: Oct 2010Est. completion: Jun 201323 patients
Phase 3Terminated
NCT00805740PfizerActive anidulafungin

An Evaluation Of The Effectiveness And Safety Of Anidulafungin Compared To Caspofungin For The Treatment Of Deep Tissue Infection Due To Candida

Start: Apr 2009Est. completion: Jun 201241 patients
Phase 3Terminated

Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight

Start: Nov 2008Est. completion: Apr 2013362 patients
Phase 3Completed

Caspofungin Study for Fungal Infections in Adults in Critical Care Settings

Start: Oct 2004Est. completion: Sep 20061,200 patients
Phase 3Terminated

Study of Micafungin in Patients With Invasive Candidiasis or Candidemia

Start: Sep 2004Est. completion: Apr 2006611 patients
Phase 3Completed

Reducing Vaginal Infections in Women

Start: May 2003Est. completion: Dec 2006400 patients
Phase 3Completed

Micafungin Versus AmBisome in Invasive Candidiasis and Candidemia

Start: Jan 2003Est. completion: Dec 2005637 patients
Phase 3Completed

A Study of Amphotericin B in the Treatment of Fungal Infections of the Mouth in HIV-Infected Patients Who Have Not Had Success With Fluconazole

Est. completion: Apr 199870 patients
Phase 2Completed

Dexamethasone in Cryptococcal Meningitis

Est. completion: Sep 199636 patients
Phase 2Completed
NCT00739934Pfizervoriconazole

Study Of The Pharmacokinetics And Safety Of Voriconazole In Children 2 To 11 Years Old Who Are At High Risk For Systemic Fungal Infection

Start: Dec 2008Est. completion: Oct 200940 patients
Phase 2Completed
NCT00330395MSDcaspofungin acetate

Open, Pharmacokinetic Study of Caspofungin in Neonates and Infants (0991-058)

Start: May 2006Est. completion: Oct 200616 patients
Phase 2Completed

Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis

Start: May 2005Est. completion: Apr 2008143 patients
Phase 2Completed
NCT00083343MSDMK0991, caspofungin acetate/Duration of Treatment: variable

Caspofungin for the Treatment of Non-blood Candida Infections (0991-045)

Start: May 2004Est. completion: Feb 200648 patients
Phase 2Completed
NCT00037219PfizerAnidulafungin, VER002

The Safety and Effectiveness of Intravenous Anidulafungin as a Treatment for Patients With Invasive Candidiasis.

Start: Aug 2001Est. completion: Nov 2002120 patients
Phase 2Completed

Study of FK463 in the Treatment of Candidemia or Invasive Candidiasis

Start: Feb 1999Est. completion: Jan 200275 patients
Phase 2Completed

Phase II Study of Fluconazole for Lymphocutaneous and Visceral Sporotrichosis

Start: Aug 1996Est. completion: Aug 199630 patients
Phase 2Completed

Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis

Start: Sep 199178 patients
Phase 2Completed

High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals

Start: Apr 2010Est. completion: Jan 2017168 patients
Phase 1/2Completed

A Study to Assess the Effect of Concomitant Administration of Fluconazole on the Clinical Pharmacokinetics of Methadone

Est. completion: Jun 199424 patients
Phase 1Completed

A Study to Learn How Fluconazole, Carbamazepine and Itraconazole Affect How the Body Processes ASP3082 in Healthy Adults

Start: Feb 2026Est. completion: Jul 202654 patients
Phase 1Recruiting
NCT00136968PfizerVoriconazole

Assessment of Voriconazole Penetration Into the Brain by Fluorine-Magnetic Resonance Spectroscopy

Start: Apr 2005Est. completion: May 200512 patients
Phase 1Completed

A Randomized, Prospective, Double-Blind Study Comparing Fluconazole With Placebo for Primary and Secondary Prophylaxis of Mucosal Candidiasis in HIV-Infected Women

Est. completion: Dec 1995400 patients
N/ACompleted

Pilot Study to Determine the Feasibility of Fluconazole for Induction Treatment and Suppression of Relapse of Histoplasmosis in Patients With the Acquired Immunodeficiency Syndrome

Est. completion: Nov 199490 patients
N/ACompleted

Multi-center Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis

120 patients
N/ACompleted
NCT01480219PfizerVoriconazole

Evaluation Of The Importance Of Risk-Factor Adjustment For Assessing The Relationship Between Voriconazole Utilization And The Development Of Non-Melanoma Skin Cancer Among Lung And Heart/Lung Transplant Patients, 2002-2009g

Start: Aug 2011Est. completion: Mar 2012467 patients
N/ACompleted
NCT01202253Pfizeranidulafungin

Early Clinical Experience With Anidulafungin In Patients With Liver Disease In The United Kingdom

Start: Feb 2011Est. completion: May 201150 patients
N/ACompleted
NCT01137292PfizerVoriconazole

Open, Non Comparative Study Of Voriconazole In Slovak Patients With Very High Risk Of Developing An Invasive Fungal Infection

Start: Apr 2007Est. completion: Nov 2009177 patients
N/ACompleted
NCT00138502Allergy TherapeuticsFunguria in Hospitalized Patients

Funguria in Hospitalized Patients

Start: Sep 2001Est. completion: Dec 2008926 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

6 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 7,350 patients
6 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.