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Brain Injury

2
Pipeline Programs
7
Companies
11
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
0
0
0
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Medtronic
MedtronicNJ - Phillipsburg
1 program
1
Ramsay ScalePhase 41 trial
Active Trials
NCT00538369Terminated67Est. Sep 2007
Pfizer
PfizerNEW YORK, NY
1 program
1
DexmedetomidinePhase 1/25 trials
Active Trials
NCT04801589Recruiting372Est. Sep 2026
NCT01519167Completed91Est. Jan 2014
NCT00464451Withdrawn0Est. May 2011
+2 more trials
Abbott
AbbottABBOTT PARK, IL
1 program
MIND (Management of Traumatic Brain Injury Diagnosis)N/A1 trial
Active Trials
NCT02262286Completed239Est. Sep 2016
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
MethylphenidateN/A1 trial
Active Trials
NCT00453921Completed76Est. May 2013
Moleac
MoleacSingapore - Singapore
1 program
NeuroAiDN/A1 trial
Active Trials
NCT02536079Unknown2,000Est. Dec 2025
Otsuka
OtsukaJapan - Tokushima
1 program
TolvaptanN/A1 trial
Active Trials
NCT02215148Terminated1Est. Aug 2016
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
Vestibular Rehabilitation + audio biofeedbackN/A1 trial
Active Trials
NCT02748109Completed132Est. Jun 2019

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
PfizerDexmedetomidine
MedtronicRamsay Scale
PfizerDexmedetomidine
PfizerDexmedetomidine
PfizerDexmedetomidine
PfizerDexmedetomidine
Oregon TherapeuticsVestibular Rehabilitation + audio biofeedback
OtsukaTolvaptan
AbbottMIND (Management of Traumatic Brain Injury Diagnosis)
MoleacNeuroAiD
Human BioSciencesMethylphenidate

Clinical Trials (11)

Total enrollment: 3,016 patients across 11 trials

NCT01519167PfizerDexmedetomidine

Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Subjects Undergoing Procedure-Type Sedation

Start: Oct 2012Est. completion: Jan 201491 patients
Phase 4Completed
NCT00538369MedtronicRamsay Scale

Combining Observational and Physiologic Sedation Assessment Tools

Start: Nov 2006Est. completion: Sep 200767 patients
Phase 4Terminated
NCT00349245PfizerDexmedetomidine

Dexmedetomidine vs. Remifentanil for Sedation During AFI

Start: Jun 2006Est. completion: Aug 200730 patients
Phase 4Completed
NCT04801589PfizerDexmedetomidine

Goal-Directed Sedation in Mechanically Ventilated Infants and Children

Start: May 2021Est. completion: Sep 2026372 patients
Phase 3Recruiting
NCT00464451PfizerDexmedetomidine

Dexmedetomidine Versus Chloral Hydrate for Pediatric Sedation During EEG

Start: Aug 2009Est. completion: May 20110
Phase 2Withdrawn
NCT00538616PfizerDexmedetomidine

Precedex Versus Propofol-Awakening for Reducing Brain Injury Expansion

Start: Jan 2008Est. completion: Apr 20108 patients
Phase 1/2Completed
NCT02748109Oregon TherapeuticsVestibular Rehabilitation + audio biofeedback

Assessment and Rehabilitation of Central Sensory Impairments for Balance in mTBI

Start: May 2016Est. completion: Jun 2019132 patients
N/ACompleted
NCT02215148OtsukaTolvaptan

Pharmacokinetics and Clinical Response of Tolvaptan in Neurocritical Care Patients

Start: Nov 2014Est. completion: Aug 20161 patients
N/ATerminated
NCT02262286AbbottMIND (Management of Traumatic Brain Injury Diagnosis)

MIND (Management of Traumatic Brain Injury Diagnosis)

Start: Sep 2014Est. completion: Sep 2016239 patients
N/ACompleted
NCT02536079MoleacNeuroAiD

NeuroAiD Safe Treatment Registry

Start: Jun 2014Est. completion: Dec 20252,000 patients
N/AUnknown
NCT00453921Human BioSciencesMethylphenidate

Methylphenidate (Ritalin) and Memory/Attention in Traumatic Brain Injury (TBI)

Start: Feb 2007Est. completion: May 201376 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 3,016 patients
7 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.