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Bone Marrow / Autologous Transplants

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Pipeline Programs
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41
Clinical Trials
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Pipeline by Development Stage

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Phase 2/3
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Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

1 companies ranked by most advanced pipeline stage

Sanofi
SanofiPARIS, France
1 program
PlerixaforN/A5 trials
Active Trials
NCT00720603No Longer Available
NCT05087212Completed53Est. Dec 2022
NCT04177810Completed25Est. May 2023
+2 more trials

Trial Timeline

Clinical trial activity over time

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Showing 15 of 40 trials with date data

Clinical Trials (41)

Total enrollment: 2,507 patients across 41 trials

Mobilization of Stem Cells With AMD3100 (Plerixafor) in Combination With G-CSF in Multiple Myeloma Patients

Start: Oct 2021Est. completion: Dec 202253 patients
Phase 4Completed

Stem Cell Harvesting Using GCSF Plus Plerxiafor, in First -Line, for Heavily Pre- Treated Pediatric Oncology Patients.

Start: Feb 2014Est. completion: Feb 202030 patients
Phase 4Unknown

Evaluation of Plerixafor Plus G-CSF to Mobilize and Collect 5×10^6CD34+ Cells/kg in Non-Hodgkin's Lymphoma (NHL) Patients for Autologous Transplantation

Start: Apr 2013Est. completion: Nov 2014100 patients
Phase 3Completed

A Multi-centre, Open Label, Single-arm Study Intended to Further Investigate the Safety and Efficacy of Plerixafor as a Front-line Mobilisation Agent in Combination With G-CSF in Patients With Lymphoma or MM (Multiple Myeloma).

Start: Sep 2008Est. completion: Nov 2010118 patients
Phase 3Completed

Mobilization of Stem Cells With AMD3100 (Plerixafor) in Multiple Myeloma Patients

Start: Jan 2005Est. completion: Jan 2008302 patients
Phase 3Completed

Mobilization of Stem Cells With AMD3100 (Plerixafor) in Non-Hodgkin's Lymphoma Patients

Start: Jan 2005Est. completion: Dec 2007298 patients
Phase 3Completed

Plerixafor and Cemiplimab in Metastatic Pancreatic Cancer

Start: Nov 2020Est. completion: May 202325 patients
Phase 2Completed

Whole Brain Radiation Therapy With Standard Temozolomide Chemo-Radiotherapy and Plerixafor in Treating Patients With Glioblastoma

Start: Dec 2018Est. completion: Feb 202421 patients
Phase 2Completed

Study of the Impact of CD34+ Cell Dose on Absolute Lymphocyte Count Following High-Dose Therapy and Autologous Stem Cell Transplantation for Relapsed and Refractory Diffuse Large B-cell Lymphoma (DLBCL)

Start: Oct 2015Est. completion: Oct 202659 patients
Phase 2Active Not Recruiting

Plerixafor Plus Granulocyte Colony-Stimulating Factor For Mobilization And Collection Of Peripheral Hematopoietic Stem Cells In Japanese Participants With Non-Hodgkin Lymphoma

Start: Nov 2014Est. completion: Mar 201632 patients
Phase 2Completed

Plerixafor Plus Granulocyte Colony-stimulating Factor (G-CSF) For Mobilization And Collection Of Peripheral Hematopoietic Stem Cells In Japanese Participants With Multiple Myeloma

Start: Oct 2014Est. completion: Jul 201514 patients
Phase 2Completed

An Exploratory Safety Study to Investigate the Extent of Tumor Cell Mobilization (TCM) After Use of G-CSF Alone or G-CSF Plus Plerixafor in Multiple Myeloma (MM) Patients Who May be Poor Mobilizers of Stem Cells

Start: Jun 2013Est. completion: Sep 201623 patients
Phase 2Completed

A Phase II Study Evaluating the Safety and Efficacy of Subcutaneous Plerixafor

Start: May 2013Est. completion: Aug 2016127 patients
Phase 2Completed

Healthy Donor Study II - Comparing Plerixafor With G-CSF and Plerixafor

Start: Apr 2012Est. completion: Dec 201510 patients
Phase 2Completed

Alteration in Timing of Plerixafor Administration

Start: Jun 201034 patients
Phase 2Completed

Evaluation of the Drug Plerixafor in Combination With Chemotherapy and G-CSF for Stem Cell Collection

Start: Mar 2010Est. completion: Feb 201445 patients
Phase 2Completed

Study of Plerixafor for Rescue of Poor Mobilizers in Autologous Stem Cell Transplant

Start: May 2009Est. completion: May 201321 patients
Phase 2Completed

Evaluation of the Safety and Efficacy of the Addition of AMD3100 to a G-CSF Mobilization Regimen in Patients With Lymphoma (NHL and HD) and Multiple Myeloma (MM).

Start: Nov 2007Est. completion: Jun 20095 patients
Phase 2Completed

The Effect of Rituximab on Mobilization With AMD3100 (Plerixafor) Plus G-CSF in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) or Hodgkin Disease (HD)

Start: Feb 2006Est. completion: Jun 200930 patients
Phase 2Completed

AMD3100 (Plerixafor) in Multiple Myeloma (MM) or Non-Hodgkin's Lymphoma (NHL) Patients Predicted to be Unable to Mobilize With G-CSF Alone

Start: Apr 2005Est. completion: Aug 20065 patients
Phase 2Terminated

AMD3100 (Plerixafor) Given to NHL and MM Patients to Increase the Number of PBSCs When Given a Mobilizing Regimen of G-CSF

Start: Jan 2005Est. completion: Dec 200722 patients
Phase 2Completed

AMD3100 (Plerixafor) Added to a Mobilizing Regimen of Granulocyte-colony Stimulating Factor (G-CSF) to Increase the Number of Peripheral Blood Stem Cells (PBSCs) in Patients With Hodgkin's Disease

Start: Nov 2004Est. completion: Jan 200822 patients
Phase 2Completed

Treatment With AMD3100 (Plerixafor) in Non-Hodgkin's Lymphoma and Multiple Myeloma Patients

Start: Sep 2004Est. completion: Feb 200735 patients
Phase 2Completed

Mobilization of Stem Cells With Plerixafor, Chemotherapy and G-CSF in Multiple Myeloma or Non-Hodgkin's Lymphoma Patients

Start: Apr 2004Est. completion: Jul 200640 patients
Phase 2Completed

Quantitating the Impact of Plerixafor

Start: Aug 2015Est. completion: Oct 202012 patients
Phase 1/2Unknown

A Combined Study in Pediatric Cancer Patients for Dose Ranging and Efficacy/Safety of Plerixafor Plus Standard Regimens for Mobilization Versus Standard Regimens Alone

Start: Mar 2014Est. completion: May 201746 patients
Phase 1/2Completed

Donor Enhancement With Plerixafor Post Myeloablative Allogeneic Transplant

Start: Dec 2011Est. completion: May 201541 patients
Phase 1/2Completed

Combination Plerixafor (AMD3100)and Bortezomib in Relapsed or Relapsed/Refractory Multiple Myeloma

Start: Jun 2009Est. completion: Oct 201658 patients
Phase 1/2Completed

To Assess the Safety of Continuous IV Administration of Plerixafor in Patients With Advanced Pancreatic, Ovarian and Colorectal Cancers

Start: Jun 2015Est. completion: Dec 201826 patients
Phase 1Completed

Escalation of Plerixafor for Mobilization of CD34+ Hematopoietic Progenitor Cells and Evaluation of Globin Gene Transfer in Patients With Sickle Cell Disease

Start: Sep 2014Est. completion: Mar 202525 patients
Phase 1Completed

Study in Plerixafor and Granulocyte-colony Stimulating Factor Patients With Relapse Acute Myeloid Leukemia

Start: Jan 2012Est. completion: Aug 201511 patients
Phase 1Terminated

Decitabine and Plerixafor in Elderly Acute Myeloid Leukemia (AML)

Start: Jun 2011Est. completion: Dec 201671 patients
Phase 1Completed

A Pediatric Study of a Plerixafor Containing Regimen In Second Allogeneic Stem Cell Transplantation

Start: May 2010Est. completion: Oct 201312 patients
Phase 1Completed

Study of Plerixafor Combined With Cytarabine and Daunorubicin in Patients With Newly Diagnosed Acute Myeloid Leukemia

Start: Dec 2009Est. completion: Mar 201236 patients
Phase 1Completed

Study of AMD3100 (Plerixafor) and Rituximab in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Start: Jun 2008Est. completion: Sep 201124 patients
Phase 1Completed

This is a Multi-center, Single Arm, Open Label Study Intended to Provide Expanded Access to Plerixafor for Patients With Non-Hodgkin's Lymphoma (NHL), Hodgkin's Disease (HD) or Multiple Myeloma (MM) Who Are to Receive Treatment With an Autologous Peripheral Stem Cell Transplant.

N/ANo Longer Available

Registry of Patients Treated With Plerixafor (Mozobil®) for Haematopoietic Stem Cell Mobilization Before Autologous Transplantation

Start: Dec 2011Est. completion: Nov 2012262 patients
N/ACompleted

Plerixafor Harvesting And No Chemotherapy for Transplantation of Autologous STem Cells In Cancer (PHANTASTIC)

Start: May 2010Est. completion: Jun 201560 patients
N/ACompleted

Study of the Best Timing for Plerixafor in Autologous Hematopoietic Stem Cell Collection

Start: Feb 2010Est. completion: Dec 201110 patients
N/AUnknown

Long-Term Follow-up Study for Non-Hodgkin's Lymphoma Patients Who Received Study Treatment (Plerixafor or Placebo) in the AMD3100-3101 Study (NCT00103610).

Start: Jun 2006Est. completion: Nov 2011178 patients
N/ACompleted

Long-Term Follow-up Study for Multiple Myeloma Patients Who Received Study Treatment (Plerixafor or Placebo) in the AMD3100-3102 Study (NCT00103662).

Start: Jun 2006Est. completion: Jul 2011164 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

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The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.