Skip to main content

Biological Availability

11
Pipeline Programs
5
Companies
24
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
11
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
3100%
+ 8 programs with unclassified modality

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Bayer
BayerLEVERKUSEN, Germany
4 programs
4
BAY1817080 - Formulation APhase 11 trial
BAY1841788Phase 15 trials
SorafenibPhase 1Small Molecule1 trial
levonorgestrel/ MicrolutPhase 11 trial
Active Trials
NCT03773068Completed30Est. Aug 2019
NCT06661122Recruiting100Est. Aug 2031
NCT06334120Recruiting600Est. Jun 2028
+5 more trials
Pfizer
PfizerNEW YORK, NY
4 programs
4
Nirmatrelvir/ ritonavirPhase 1Small Molecule1 trial
Nirmatrelvir/ ritonavirPhase 1Small Molecule1 trial
PaxlovidPhase 11 trial
methylprednisolonePhase 11 trial
Active Trials
NCT05525910Completed15Est. Nov 2022
NCT05544786Completed12Est. Nov 2022
NCT06397144Withdrawn0Est. Dec 2025
+1 more trials
Orion Pharma
Orion PharmaUK - Reading
1 program
1
BAY1841788Phase 11 trial
Active Trials
NCT03048110Completed15Est. Jul 2017
Orion
OrionUK - Cambridge
1 program
1
BAY1841788Phase 1
Xspray Pharma
Xspray PharmaSweden - Solna
1 program
1
Dasatinib ASD 100 mgPhase 11 trial
Active Trials
NCT05439408Completed110Est. Jun 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
BayerBAY1841788
BayerBAY1841788
BayerBAY1841788
BayerBAY1841788
BayerBAY1841788
BayerBAY1841788
PfizerPaxlovid
PfizerNirmatrelvir/ ritonavir
PfizerNirmatrelvir/ ritonavir
Xspray PharmaDasatinib ASD 100 mg
BayerBAY1841788
BayerBAY1817080 - Formulation A
BayerBAY1841788
Bayerlevonorgestrel/ Microlut
Orion PharmaBAY1841788

Showing 15 of 24 trials with date data

Clinical Trials (24)

Total enrollment: 20,171 patients across 24 trials

A Study to Learn More About How Safe Darolutamide is and How Well it Works Under Real World Conditions When Taken in Addition to Standard Androgen Deprivation Therapy (ADT) in Indian Participants With High-risk Non-metastatic Castration-resistant Prostate Cancer (nmCRPC)

Start: Aug 2022Est. completion: Apr 202750 patients
Phase 4Recruiting

A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies

Start: Apr 2023Est. completion: Mar 2030985 patients
Phase 3Active Not Recruiting

Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer

Start: Oct 2020Est. completion: Jun 2028402 patients
Phase 3Active Not Recruiting

A Study Called ARAMON to Learn to What Extent Does Study Treatment With Darolutamide Affects Testosterone Levels in Men With Prostate Cancer That Had Not Been Treated With Hormonal Therapy Compared to Treatment With Enzalutamide

Start: Dec 2022Est. completion: Dec 202428 patients
Phase 2Completed

A Study to Learn How Well Darolutamide Administered Together With Androgen Deprivation Therapy (ADT) Works in Men With Metastatic Hormone-sensitive Prostate Cancer. Results Will be Compared With ADT Alone From a Previously Conducted Study.

Start: Nov 2021Est. completion: Jun 2026223 patients
Phase 2Active Not Recruiting

Study to Compare the Effects of Drug Darolutamide and Drug Enzalutamide on Physical Function, Including Balance and Daily Activity, in Patients With Castration-resistant Prostate Cancer (CRPC)

Start: Dec 2019Est. completion: Jul 202230 patients
Phase 2Terminated

A Study on 2 Different Combination Tablets of Nirmatrelvir Plus Ritonavir to Compare Them With Marketed Paxlovid in Healthy Participants

Start: Aug 2025Est. completion: Dec 20250
Phase 1Withdrawn
NCT05544786PfizerNirmatrelvir/ ritonavir

Relative Bioavailability Study of Nirmatrelvir/Ritonavir Oral Powder Relative to the Commercial Tablets and Estimation of the Effect of Food on Bioavailability of the Nirmatrelvir/Ritonavir Oral Powder in Healthy Participants.

Start: Sep 2022Est. completion: Nov 202212 patients
Phase 1Completed
NCT05525910PfizerNirmatrelvir/ ritonavir

Relative Bioavailability Study of Nirmatrelvir/Ritonavir 4 Different Fixed Dose Combination Tablets Relative to the Commercial Tablets in Healthy Participants

Start: Aug 2022Est. completion: Nov 202215 patients
Phase 1Completed
NCT05439408Xspray PharmaDasatinib ASD 100 mg

Comparative Bioavailability of XS004 (Dasatinib) Formulation G and SPRYCEL® (Dasatinib) in Healthy, Adult Subjects Under Fasting Conditions

Start: Jun 2021Est. completion: Jun 2021110 patients
Phase 1Completed

Study to Evaluate the Safety, Tolerability,Pharmacokinetics, and Antitumor Activity of a Thorium-227 Labeled Antibody-chelator Conjugate Alone and in Combination With Darolutamide, in Patients With Metastatic Castration Resistant Prostate Cancer

Start: Dec 2018Est. completion: Oct 202463 patients
Phase 1Completed
NCT03773068BayerBAY1817080 - Formulation A

A Study in Healthy Volunteers Investigating How Quickly and to What Extent BAY1817080 is Taken up, Distributed, Broken Down and Eliminated From the Body, as Well as the Difference Between 2 Different Types of Tablets of BAY1817080 and the Difference Between Oral Dose and Dose in the Vein

Start: Dec 2018Est. completion: Aug 201930 patients
Phase 1Completed

Imaging Study to Compare Effects of Darolutamide and Enzalutamide With Respect to Placebo on the Blood Flow in the Brain in Healthy Male Volunteers.

Start: Oct 2018Est. completion: Nov 201926 patients
Phase 1Completed
NCT03353857Bayerlevonorgestrel/ Microlut

Drug-drug Interaction Between Rifampicin and Progestins/Ethinylestradiol and Midazolam

Start: Nov 2017Est. completion: Feb 201968 patients
Phase 1Completed

Drug-drug Interaction (DDI) Study to Assess ODM-201 as a Victim of CYP3A4 Inhibition or Induction

Start: Feb 2017Est. completion: Jul 201715 patients
Phase 1Completed

Relative Bioavailability of Sorafenib Tablet for Oral Suspension

Start: Nov 2015Est. completion: Jun 201630 patients
Phase 1Completed
NCT01267201Pfizermethylprednisolone

A Study Comparing Drug Availability Of Methylprednisolone In Liquid Form Versus Methylprednisolone In Tablet Form

Start: Nov 2010Est. completion: Dec 201024 patients
Phase 1Completed

A Study to Learn About How Safe Darolutamide is and How Well it Works in Combination With Androgen Deprivation Therapy and Docetaxel in Routine Medical Care for Japanese Men With Low Volume Metastatic Hormone-Sensitive Prostate Cancer

Start: Nov 2024Est. completion: Aug 2031100 patients
N/ARecruiting

An Observational Study to Learn More About the Safety of Darolutamide in Men With Prostate Cancer in Korea

Start: Sep 2024Est. completion: Jun 2028600 patients
N/ARecruiting

An Observational Study to Learn More About the Use of Darolutamide as a Part of a Combination Therapy in Belgian Men With Metastatic Hormone-Sensitive Prostate Cancer in Routine Medical Care

Start: Jul 2024Est. completion: Sep 2024106 patients
N/ACompleted

An Observational Study to Learn More About the Use of Androgen Receptor Inhibitors and How They Affect Men With Nonmetastatic Prostate Cancer in Routine Medical Care in the United States

Start: Jan 2024Est. completion: Apr 20241,800 patients
N/ACompleted

An Observational Study, Called DEAR, to Learn More About Treatment With Darolutamide, Enzalutamide and Apalutamide in Men With Non-metastatic Castration-resistant Prostate Cancer in Real World Settings

Start: Apr 2022Est. completion: Jun 2023870 patients
N/ACompleted

A Study Using Available Data to Learn to What Extent Patients With Prostate Cancer Who Received Second Generation Androgen Receptor Inhibitors Took Their Medication as Prescribed or Stopped Taking Their Medication Completely

Start: Jan 2022Est. completion: Jul 202513,779 patients
N/ACompleted

A Study in Which Non-metastatic Castration-resistant Prostate Cancer (nmCRPC) Patients for Whom a Decision to Treat With Darolutamide Has Been Made Before Enrollment Are Observed and Certain Outcomes Are Described

Start: Jan 2020Est. completion: Dec 2026805 patients
N/AActive Not Recruiting

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 actively recruiting trials targeting 20,171 patients
5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.