Binge Eating Disorder

12
Pipeline Programs
5
Companies
32
Clinical Trials
5
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
1
1
3
6
Early DiscoveryClinical DevelopmentMarket

On Market (5)

Approved therapies currently available

U
LISDEXAMFETAMINE DIMESYLATEApproved
lisdexamfetamine dimesylate
Unknown Company
oral2023
U
LUMRYZApproved
sodium oxybate
Unknown Company
oral2023
U
SOLRIAMFETOLApproved
solriamfetol
Unknown Company
Takeda
VYVANSEApproved
lisdexamfetamine dimesylate
Takeda
oral2007
Jazz Pharmaceuticals
XYREMApproved
sodium oxybate
Jazz Pharmaceuticals
oral2002

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
2 programs
1
1
SolriamfetolPhase 41 trial
Sodium OxybatePhase 2/31 trial
Active Trials
NCT00514995Completed15Est. Apr 2011
NCT04602936Unknown64Est. Dec 2024
Takeda
TakedaTOKYO, Japan
2 programs
2
1
VYVANSE(Lisdexamfetamine dimesylate)Phase 35 trials
VYVANSE(Lisdexamfetamine dimesylate)Phase 31 trial
Active Trials
NCT02009163Completed418Est. Apr 2015
NCT01890785Completed30Est. Aug 2013
NCT01718509Completed390Est. Sep 2013
+3 more trials
Abbott
AbbottABBOTT PARK, IL
1 program
1
sibutraminePhase 33 trials
Active Trials
NCT00234988Completed93
NCT00402584Completed304
NCT00261911Completed498Est. Feb 2002
Alkermes
AlkermesDUBLIN 4, Ireland
1 program
1
RDC-0313Phase 21 trial
Active Trials
NCT01098435CompletedEst. Jun 2011
Alliance Pharmaceuticals
1 program
1
Sugar PillPhase 1/21 trial
Active Trials
NCT00904306Completed26Est. Jul 2011

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Jazz PharmaceuticalsSolriamfetol
TakedaLisdexamfetamine dimesylate
TakedaLisdexamfetamine dimesylate
TakedaLisdexamfetamine dimesylate
TakedaLisdexamfetamine dimesylate
Abbottsibutramine
TakedaLisdexamfetamine dimesylate
TakedaLisdexamfetamine dimesylate
TakedaLisdexamfetamine dimesylate
TakedaLisdexamfetamine dimesylate
TakedaLisdexamfetamine dimesylate
TakedaLisdexamfetamine dimesylate
TakedaLisdexamfetamine dimesylate
TakedaLisdexamfetamine dimesylate
TakedaLisdexamfetamine dimesylate

Showing 15 of 32 trials with date data

Clinical Trials (32)

Total enrollment: 9,675 patients across 32 trials

Solriamfetol in Binge Eating Disorder

Start: Jun 2021Est. completion: Dec 202464 patients
Phase 4Unknown
NCT01552915TakedaLisdexamfetamine dimesylate

Effectiveness of Vyvanse Compared to Concerta in Adolescents With Attention-deficit/Hyperactivity Disorder

Start: Apr 2012Est. completion: Jan 2014464 patients
Phase 4Completed
NCT01552902TakedaLisdexamfetamine dimesylate

Effectiveness of Vyvanse Compared to Concerta in Adolescents With Attention-deficit/Hyperactivity Disorder

Start: Apr 2012Est. completion: May 2014549 patients
Phase 4Completed
NCT01328756TakedaLisdexamfetamine dimesylate

Lisdexamfetamine Dimesylate 2-year Safety Study in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD)

Start: Jul 2011Est. completion: Sep 2014314 patients
Phase 4Completed
NCT00500071TakedaLisdexamfetamine dimesylate

Dose-Optimization Study Evaluating the Efficacy, Safety and Tolerability of Vyvanse (Lisdexamfetamine Dimesylate) in Children Aged 6-12 Diagnosed With ADHD

Start: Jun 2007Est. completion: Jan 2008318 patients
Phase 4Completed

A Phase IV, Multi-Center, Open-Label Trial of Sibutramine in Combination With a Hypocaloric Diet in Obese and Overweight Thai Subjects.

Start: Jun 200493 patients
Phase 4Completed
NCT02009163TakedaLisdexamfetamine dimesylate

Evaluate the Maintenance of Efficacy of SPD489 in Adults Aged 18-55 Years With Moderate to Severe Binge Eating Disorder

Start: Jan 2014Est. completion: Apr 2015418 patients
Phase 3Completed
NCT01718509TakedaLisdexamfetamine dimesylate

SPD489 in Adults Aged 18-55 Years With Moderate to Severe Binge Eating Disorder

Start: Nov 2012Est. completion: Sep 2013390 patients
Phase 3Completed
NCT01718483TakedaLisdexamfetamine dimesylate

SPD489 in Adults Aged 18-55 Years With Moderate to Severe Binge Eating Disorder

Start: Nov 2012Est. completion: Sep 2013383 patients
Phase 3Completed
NCT01657019TakedaLisdexamfetamine dimesylate

Open Label Extension in Adults With Binge Eating Disorder (BED)

Start: Aug 2012Est. completion: Oct 2014604 patients
Phase 3Completed
NCT01436175TakedaLisdexamfetamine dimesylate

SPD489 Adult Major Depressive Disorder (MDD) Open-label Safety and Tolerability Rollover Extension Study

Start: Feb 2012Est. completion: Mar 20141,570 patients
Phase 3Terminated
NCT01436162TakedaLisdexamfetamine dimesylate

Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder

Start: Oct 2011Est. completion: Dec 20131,105 patients
Phase 3Completed
NCT01106430TakedaLisdexamfetamine dimesylate

Comparison of Lisdexamfetamine Dimesylate With Atomoxetine HCl in Attention-Deficit/Hyperactivity Disorder (ADHD) Subjects With an Inadequate Response to Methylphenidate

Start: Jun 2010Est. completion: Jul 2012267 patients
Phase 3Completed
NCT00784654TakedaLisdexamfetamine dimesylate

Double-blind, Placebo-controlled, Randomised Withdrawal, Extension, Safety and Efficacy Study of LDX in Children and Adolescents Aged 6-17

Start: Jan 2009Est. completion: Oct 2011276 patients
Phase 3Completed
NCT00763971TakedaLisdexamfetamine dimesylate

Randomized, Double-blind Safety and Efficacy Study of Lisdexamfetamine Dimesylate (LDX) in Children and Adolescents Aged 6-17

Start: Nov 2008Est. completion: Mar 2011336 patients
Phase 3Completed
NCT00764868TakedaLisdexamfetamine dimesylate

Vyvanse Adolescent Open-Label Safety and Efficacy Extension Study

Start: Nov 2008Est. completion: Apr 2010269 patients
Phase 3Completed
NCT00735371TakedaLisdexamfetamine dimesylate

Efficacy and Safety of Lisdexamfetamine Dimesylate (LDX) in Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD)

Start: Oct 2008Est. completion: Apr 2009314 patients
Phase 3Completed
NCT00697515TakedaLisdexamfetamine dimesylate

Safety and Efficacy Workplace Environment Study of Lisdexamfetamine Dimesylate (LDX) in Adults With Attention-Deficit Hyperactivity Disorder (ADHD)

Start: Jul 2008Est. completion: Dec 2008142 patients
Phase 3Completed
NCT00500149TakedaLisdexamfetamine dimesylate

A Classroom Study to Assess the Time of Onset of Vyvanse (Lisdexamfetamine Dimesylate) in Pediatric Subjects Aged 6-12 With Attention Deficit/Hyperactivity Disorder (ADHD)

Start: Jun 2007Est. completion: Dec 2007129 patients
Phase 3Completed

A Study to Examine the Efficacy and Safety of Meridia® (Sibutramine Hydrochloride) in Binge-Eating Disorder

Start: Aug 2000304 patients
Phase 3Completed

A Study of Sibutramine in Overweight Adolescents to Assess Weight Loss and Safety.

Start: Jul 2000Est. completion: Feb 2002498 patients
Phase 3Completed

Sodium Oxybate in the Treatment of Binge Eating Disorder

Start: Aug 2007Est. completion: Apr 201115 patients
Phase 2/3Completed
NCT01291173TakedaLisdexamfetamine dimesylate

Forced-dose Titration of SPD489 in Adults With Binge Eating Disorder

Start: May 2011Est. completion: Jan 2012271 patients
Phase 2Completed

ALK33-101: A Study of RDC-0313 (ALKS 33) in Adults With Binge Eating Disorder

Start: May 2010Est. completion: Jun 2011
Phase 2Completed
NCT00985725TakedaLisdexamfetamine dimesylate

SPD489 in Adults With Persistent Executive Function Impairments (EFI) and Partial or Full Remission of Recurrent Major Depressive Disorder

Start: Oct 2009Est. completion: Apr 2011143 patients
Phase 2Completed
NCT00922272TakedaLisdexamfetamine dimesylate

Efficacy, Safety, and Tolerability of SPD489 in Adults With Schizophrenia and Predominant Negative Symptoms

Start: Sep 2009Est. completion: Jan 201192 patients
Phase 2Completed
NCT00905424TakedaLisdexamfetamine dimesylate

Exploratory Study of SPD489 in Adults With Major Depressive Disorder (MDD) as Augmentation Therapy to an Antidepressant

Start: Jul 2009Est. completion: Aug 2010246 patients
Phase 2Completed

Binge Eating and Chromium Study

Start: Jul 2008Est. completion: Jul 201126 patients
Phase 1/2Completed
NCT01890785TakedaLisdexamfetamine dimesylate

Bioavailability Study of SPD489 Administered With Two Different Means of Administration in Healthy Adult Volunteers

Start: Jul 2013Est. completion: Aug 201330 patients
Phase 1Completed
NCT01010750TakedaLisdexamfetamine dimesylate

Lisdexamfetamine Dimesylate (LDX) Pilot Cognition Study to Evaluate the Utility of a Standardized Battery of Tests in Adults With Attention-Deficit Hyperactivity Disorder (ADHD)

Start: Jan 2010Est. completion: Mar 201018 patients
Phase 1Completed
NCT00776555TakedaLisdexamfetamine dimesylate

Compare Subjective Drug Liking & Pharmacokinetics of Vyvanse™ and ADDERALL XR® When Administered as an Oral Solution

Start: Nov 2008Est. completion: Mar 20093 patients
Phase 1Terminated
NCT00746733TakedaLisdexamfetamine dimesylate

Vyvanse and Adderall XR Given Alone and in Combination With Prilosec OTC

Start: Sep 2008Est. completion: Oct 200824 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs — potential near-term approvals
5 companies competing in this space