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Barrett's Esophagus

7
Pipeline Programs
13
Companies
17
Clinical Trials
2 recruiting
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
0
0
0
6
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
2100%
+ 16 programs with unclassified modality

On Market (2)

Approved therapies currently available

AstraZeneca
NEXIUMApproved
esomeprazole magnesium
AstraZeneca
oral2008
74M Part D
AstraZeneca
NEXIUM 24HRApproved
esomeprazole magnesium
AstraZeneca
oral2015

Competitive Landscape

10 companies ranked by most advanced pipeline stage

AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
4 programs
1
3
EsomeprazolePhase 4Small Molecule1 trial
EsomeprazolePhase 4Small Molecule1 trial
Esomeprazole MagnesiumPhase 41 trial
Endoscopy and pH studyPhase 11 trial
Active Trials
NCT00573911Completed16Est. Jan 2011
NCT00352261Completed80Est. Apr 2007
NCT00637988Completed32Est. Jun 2003
+1 more trials
CSA Medical
CSA MedicalMA - Lexington
3 programs
1
Endoscopic spray cryotherapyPhase 41 trial
Prevalence of Dysplasia of the Gastric CardiaN/A1 trial
trūFreeze™ Spray CryotherapyN/A1 trial
Active Trials
NCT01787864Completed170Est. May 2017
NCT01845454Terminated36Est. Jan 2015
NCT00628784Unknown100Est. Mar 2012
Medtronic
MedtronicNJ - Phillipsburg
3 programs
CytospongeN/A1 trial
Cytosponge™ Cell Collection DeviceN/A1 trial
PillCam® ESO 2 in Esophageal PathologiesN/A1 trial
Active Trials
NCT02106910Completed138Est. Aug 2018
NCT02395471Completed191Est. Jun 2018
NCT00885469Completed101Est. Apr 2009
Trio Medicines
Trio MedicinesUK - London
2 programs
YF476PHASE_21 trial
YF476PHASE_21 trial
Active Trials
NCT02597712Completed27Est. Dec 2017
NCT01298999Completed27Est. Dec 2017
Sound Pharmaceuticals
1 program
Balloon Capsule DeviceN/A1 trial
Active Trials
NCT00288119Recruiting2,000Est. Jul 2028
Boston Scientific
Boston ScientificCA - Valencia
1 program
Captivator™ EMRN/A1 trial
Active Trials
NCT02482701Completed291Est. Jun 2017
PENTAX Medical
PENTAX MedicalJapan - Tokyo
1 program
CryoBalloonN/A1 trial
Active Trials
NCT02534233Completed58Est. Feb 2025
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
Endoscopic eradication therapiesN/A
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
Endoscopic eradication therapiesN/A1 trial
Active Trials
NCT02634645Recruiting5,000Est. Jan 2027
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
Study of Endoscopic Barrett's Esophagus DiagnosisN/A1 trial
Active Trials
NCT00591461Terminated13Est. Mar 2010

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
CSA MedicalEndoscopic spray cryotherapy
AstraZenecaEsomeprazole
AstraZenecaEsomeprazole
AstraZenecaEsomeprazole Magnesium
Trio MedicinesYF476
Trio MedicinesYF476
AstraZenecaEndoscopy and pH study
Boston ScientificCaptivator™ EMR
MedtronicCytosponge™ Cell Collection Device
PENTAX MedicalCryoBalloon
Angeles TherapeuticsEndoscopic eradication therapies
MedtronicCytosponge
CSA MedicaltrūFreeze™ Spray Cryotherapy
CSA MedicalPrevalence of Dysplasia of the Gastric Cardia
MedtronicPillCam® ESO 2 in Esophageal Pathologies

Showing 15 of 17 trials with date data

Clinical Trials (17)

Total enrollment: 8,330 patients across 17 trials

NCT00628784CSA MedicalEndoscopic spray cryotherapy

Endoesophageal Cryotherapy For Ablating Barrett's Esophagus and Early Stage Esophageal Cancer

Start: Mar 2007Est. completion: Mar 2012100 patients
Phase 4Unknown

An Open Label pH Comparison of Esomeprazole and Lansoprazole in Barrett's Esophagus Patients

Start: Jan 2006Est. completion: Apr 200780 patients
Phase 4Completed

Barrett's Esophagus - 315 - 3 Way Cross Over

Start: Apr 2002Est. completion: Jun 200332 patients
Phase 4Completed
NCT00637559AstraZenecaEsomeprazole Magnesium

Barrett's Esophagus - 315 - 3 Way Cross-Over

Start: Mar 2002Est. completion: Apr 200350 patients
Phase 4Completed

YF476 in Barrett's Esophagus

Start: May 2013Est. completion: Dec 201727 patients
Phase 2Completed

Trial of a Gastrin Receptor Antagonist in Barrett's Esophagus

Start: Jun 2010Est. completion: Dec 201727 patients
Phase 2Completed
NCT00573911AstraZenecaEndoscopy and pH study

Acid Reflux and Stromal Fibroblasts in Barrett's Esophagus

Start: Aug 2007Est. completion: Jan 201116 patients
Phase 1Completed

The Captivator EMR Registry

Start: Aug 2015Est. completion: Jun 2017291 patients
N/ACompleted
NCT02395471MedtronicCytosponge™ Cell Collection Device

Cytosponge Adequacy Study Evaluation II

Start: Aug 2015Est. completion: Jun 2018191 patients
N/ACompleted

Evaluation of Effect of CryoBalloon Focal Ablation System on Human Esophageal Epithelium

Start: Apr 2015Est. completion: Feb 202558 patients
N/ACompleted
NCT02634645Angeles TherapeuticsEndoscopic eradication therapies

TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus)

Start: Jan 2015Est. completion: Jan 20275,000 patients
N/ARecruiting

Non-Endoscopic Surveillance for Barrett's Esophagus Following Ablative Therapy

Start: Oct 2014Est. completion: Aug 2018138 patients
N/ACompleted
NCT01845454CSA MedicaltrūFreeze™ Spray Cryotherapy

A Dose-Optimization Study for the Initial Treatment of Dysplastic Barrett's Esophagus With trūFreeze™ Spray Cryotherapy

Start: Apr 2013Est. completion: Jan 201536 patients
N/ATerminated
NCT01787864CSA MedicalPrevalence of Dysplasia of the Gastric Cardia

Prevalence of Dysplasia of the Gastric Cardia

Start: Feb 2013Est. completion: May 2017170 patients
N/ACompleted
NCT00885469MedtronicPillCam® ESO 2 in Esophageal Pathologies

PillCam® ESO 2 in Esophageal Pathologies

Start: Dec 2007Est. completion: Apr 2009101 patients
N/ACompleted
NCT00591461Oregon TherapeuticsStudy of Endoscopic Barrett's Esophagus Diagnosis

Study of Endoscopic Barrett's Esophagus Diagnosis

Start: Dec 2007Est. completion: Mar 201013 patients
N/ATerminated
NCT00288119Sound PharmaceuticalsBalloon Capsule Device

Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

Start: Oct 2005Est. completion: Jul 20282,000 patients
N/ARecruiting

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 actively recruiting trials targeting 8,330 patients
13 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.