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B-cell Malignancy

2
Pipeline Programs
4
Companies
8
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
1
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Cell Therapy
1100%
+ 4 programs with unclassified modality

Competitive Landscape

4 companies ranked by most advanced pipeline stage

BeiGene
BeiGeneChina - Beijing
1 program
1
BGB-16673Phase 1/24 trials
Active Trials
NCT07005713Active Not Recruiting34Est. Apr 2026
NCT06906809Completed37Est. Oct 2025
NCT06776679Completed8Est. Mar 2025
+1 more trials
Avalon GloboCare
Avalon GloboCareFREEHOLD, NJ
1 program
1
CD19-CAR-TPhase 1Cell Therapy1 trial
Active Trials
NCT03952923Completed11Est. Mar 2021
BeOne Medicines
BeOne MedicinesCA - San Carlos
2 programs
BGB-16673PHASE_1_21 trial
BGB-16673PHASE_1_21 trial
Active Trials
NCT06634589Recruiting80Est. Dec 2029
NCT05006716Recruiting614Est. Nov 2029
CRISPR Therapeutics
1 program
CTX110PHASE_1_21 trial
Active Trials
NCT04035434Terminated93Est. Oct 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
BeOne MedicinesBGB-16673
BeiGeneBGB-16673
BeOne MedicinesBGB-16673
CRISPR TherapeuticsCTX110
BeiGeneBGB-16673
BeiGeneBGB-16673
BeiGeneBGB-16673
Avalon GloboCareCD19-CAR-T

Clinical Trials (8)

Total enrollment: 1,023 patients across 8 trials

A Study to Investigate Safety and Effectiveness of BGB-16673 in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies

Start: Nov 2024Est. completion: Dec 202980 patients
Phase 1/2Recruiting

Treatment of Chinese Participants With B-Cell Malignancies With BGB-16673, a Bruton Tyrosine Kinase-Targeted Protein-Degrader

Start: May 2022Est. completion: Jan 2029146 patients
Phase 1/2Recruiting

A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies

Start: Sep 2021Est. completion: Nov 2029614 patients
Phase 1/2Recruiting

A Safety and Efficacy Study Evaluating CTX110 in Subjects With Relapsed or Refractory B-Cell Malignancies (CARBON)

Start: Jul 2019Est. completion: Oct 202493 patients
Phase 1/2Terminated

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple-Ascending Doses of BGB-16673 in Adults With Chronic Spontaneous Urticaria

Start: Jul 2025Est. completion: Apr 202634 patients
Phase 1Active Not Recruiting

Effect of Phenytoin or Itraconazole on How BGB-16673 is Absorbed and Removed From the Body in Healthy Participants

Start: Apr 2025Est. completion: Oct 202537 patients
Phase 1Completed

A Study of How [14C]-BGB-16673 is Absorbed, Broken Down, and Removed From the Body After a Single Oral Dose in Healthy Participants

Start: Jan 2025Est. completion: Mar 20258 patients
Phase 1Completed

CD19-CAR-T in B-cell Malignancies Patients

Start: Aug 2019Est. completion: Mar 202111 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 actively recruiting trials targeting 1,023 patients
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.