Astigmatism

Pipeline Programs

Companies

Clinical Trials

1 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

AlconFORT WORTH, TX

7 programs

Clareon VivityPhase 41 trial

daily disposable contact lensesPhase 4

weekly replacement soft contact lensPhase 4

Corneal Astigmatism Measurement StudyN/A1 trial

Verion-LenSxN/A

+2 more programs

Active Trials

NCT00818532Completed50Est. Apr 2009

NCT05483127Completed153Est. Oct 2022

NCT04464044Completed40Est. Aug 2020

+1 more trials

LENSARFL - Orlando

1 program

Femto arcsPhase 41 trial

Active Trials

NCT07140653Recruiting60Est. Sep 2026

Bausch HealthQUEBEC, Quebec, Canada

7 programs

ControlN/A5 trials

Evaluation of the Bausch & Lomb PureVision Under Nighttime Driving ConditionsN/A1 trial

Kalifilcon Toric LensN/A1 trial

REVIVE samfilcon B custom toric contact lensesN/A1 trial

enVista® One-Piece Hydrophobic Acrylic Toric IOLN/A1 trial

+2 more programs

Active Trials

NCT03681808Completed242Est. Dec 2019

NCT03653403Completed61Est. Jun 2019

NCT03170388Completed741Est. Apr 2019

+8 more trials

Johnson & JohnsonNEW BRUNSWICK, NJ

6 programs

Etafilcon A toric contact lensN/A1 trial

Investigational daily disposable, soft, toric lenses manufactured on 4th Generation TechnologyN/A1 trial

senofilcon AN/A1 trial

senofilcon A toricN/A1 trial

+1 more programs

Active Trials

NCT01055132Completed70Est. Feb 2010

NCT06967129Completed281Est. Jul 2025

NCT00584831Completed40Est. Feb 2008

+3 more trials

Bausch + LombNJ - Bridgewater

5 programs

Evaluation of the Bausch & Lomb PureVision Under Nighttime Driving ConditionsN/A

REVIVE samfilcon B custom toric contact lensesN/A

enVista® One-Piece Hydrophobic Acrylic Toric IOLN/A

MX60ETPhase N/A

samfilcon APhase N/A

Carl Zeiss MeditecCA - Dublin

1 program

Implant of the AT-TORBI 709 lensN/A1 trial

Active Trials

NCT05058274Completed60Est. Feb 2024

AbbottABBOTT PARK, IL

1 program

LASIKN/A1 trial

Active Trials

NCT01675492Completed126Est. Nov 2016

Rayner Intraocular LensesUK - West Sussex

1 program

Limbal Relaxing IncisionsN/A1 trial

Active Trials

NCT02067429Unknown80

NovartisBASEL, Switzerland

1 program

Verion-LenSxN/A

SandozAustria - Kundl

1 program

Verion-LenSxN/A1 trial

Active Trials

NCT02763124Completed18Est. Oct 2016

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

LENSARFemto arcs

Bausch HealthControl

Bausch HealthREVIVE samfilcon B custom toric contact lenses

Johnson & JohnsonInvestigational daily disposable, soft, toric lenses manufactured on 4th Generation Technology

AlconClareon Vivity

Bausch HealthKalifilcon Toric Lens

Bausch Healthkalifilcon A Daily Disposable Toric

AlconVerofilcon A toric soft contact lenses

Bausch Healthkalifilcon A Daily Disposable Toric LD213001 Contact Lenses

Carl Zeiss MeditecImplant of the AT-TORBI 709 lens

Alconverofilcon A toric contact lenses

Bausch HealthControl

Showing 15 of 26 trials with date data

Clinical Trials (26)

Total enrollment: 4,259 patients across 26 trials

NCT07140653 LENSARFemto arcs

Arcuate Incisions With Light Adjustable Lens for Astigmatism Correction in Lens Surgery

Start: Sep 2025Est. completion: Sep 202660 patients

Phase 4Recruiting

NCT03168334 Bausch HealthControl

A Phase 3, Vehicle-controlled Efficacy and Safety Study of IDP-123 Lotion in the Treatment of Acne Vulgaris (302)

Start: Jul 2017Est. completion: Jul 2018801 patients

Phase 3Completed

NCT03168321 Bausch HealthControl

A Phase 3, Vehicle-controlled Efficacy and Safety Study of IDP-123 Lotion in the Treatment of Acne Vulgaris (301)

Start: Jun 2017Est. completion: Jun 2018813 patients

Phase 3Completed

NCT03170388 Bausch HealthControl

A Phase 2, Multicenter, Randomized, Double-Blind, Vehicle Controlled, Parallel-Group, Clinical Study in the Treatment of Acne Vulgaris

Start: Oct 2017Est. completion: Apr 2019741 patients

Phase 2Completed

NCT03653403 Bausch HealthControl

Open-Label, Randomized Study Evaluating the Absorption and Systemic Pharmacokinetics of Topically Applied IDP-126 Gel in Comparison With Control Gel

Start: Aug 2018Est. completion: Jun 201961 patients

Phase 1Completed

NCT06785194 Bausch HealthREVIVE samfilcon B custom toric contact lenses

Revive Toric RWE Study

Start: May 2026Est. completion: Jul 202630 patients

N/ANot Yet Recruiting

NCT06967129 Johnson & JohnsonInvestigational daily disposable, soft, toric lenses manufactured on 4th Generation Technology

Evaluation of Daily Disposable Toric Soft Lenses Manufactured With an Alternative Hydration Process

Start: Apr 2025Est. completion: Jul 2025281 patients

N/ACompleted

NCT06784063 AlconClareon Vivity

Visual Performance With Clareon® Vivity® Intraocular Lenses (IOLs)

Start: Apr 2025Est. completion: Jun 202540 patients

N/ACompleted

NCT06098937 Bausch HealthKalifilcon Toric Lens

Kalifilcon A Toric Compared to Commercially Available Lenses

Start: Sep 2023Est. completion: Sep 202330 patients

N/ACompleted

NCT06069609 Bausch Healthkalifilcon A Daily Disposable Toric

Orientation Characteristics of Daily Disposable Toric Contact Lenses

Start: Aug 2023Est. completion: Aug 202330 patients

N/ACompleted

NCT05483127 AlconVerofilcon A toric soft contact lenses

Clinical Comparison of Two Daily Disposable Toric Soft Contact Lenses

Start: Sep 2022Est. completion: Oct 2022153 patients

N/ACompleted

NCT05129124 Bausch Healthkalifilcon A Daily Disposable Toric LD213001 Contact Lenses

Insertion Clinical Study to Evaluate the Orientation Characteristics of Multiple Kalifilcon A Daily Disposable Toric LD213001 Contact Lenses

Start: Nov 2021Est. completion: Jan 202230 patients

N/ACompleted

NCT05058274 Carl Zeiss MeditecImplant of the AT-TORBI 709 lens

Clinical Results of a Monofocal Aspheric Bitoric Intraocular Lens With Plate Haptics in Hyperopic Eyes (HIPER-AT-TORBI)

Start: Nov 2021Est. completion: Feb 202460 patients

N/ACompleted

NCT04464044 Alconverofilcon A toric contact lenses

Clinical Performance of a Daily Disposable Toric Silicone Hydrogel Contact Lens

Start: Jul 2020Est. completion: Aug 202040 patients

N/ACompleted

NCT03681808 Bausch HealthControl

Evaluate the Safety and Effectiveness of the Biotrue ONEday for Astigmatism

Start: Oct 2018Est. completion: Dec 2019242 patients

N/ACompleted

NCT02763124 SandozVerion-LenSx

Pseudophakic Astigmatic Reduction With Verion-LenSx Arcuate Incisions

Start: May 2016Est. completion: Oct 201618 patients

N/ACompleted

NCT02067429 Rayner Intraocular LensesLimbal Relaxing Incisions

Limbal Relaxing Incision Versus Toric Intraocular Lens for Corneal Astigmatism During Cataract Surgery.

Start: Jun 201480 patients

N/AUnknown

NCT01852084 Bausch HealthenVista® One-Piece Hydrophobic Acrylic Toric IOL

Hydrophobic Acrylic Toric IOL Designed to Reduce the Effects of Preoperative Corneal Astigmatism

Start: Mar 2013Est. completion: Dec 2016191 patients

N/ACompleted

NCT01675492 AbbottLASIK

Safety and Effectiveness of Wavefront-guided LASIK for the Correction of Mixed Astigmatism

Start: Dec 2012Est. completion: Nov 2016126 patients

N/ACompleted

NCT01579045 Johnson & Johnsonsenofilcon A

Effect of Head and Gaze Position on Soft Toric Contact Lens Performance

Start: Aug 2012Est. completion: Mar 201324 patients

N/ACompleted

NCT01055132 Johnson & JohnsonEtafilcon A toric contact lens

Dispensing Evaluation of New Daily Disposable Toric Soft Contact Lens.

Start: Jan 2010Est. completion: Feb 201070 patients

N/ACompleted

NCT00818532 AlconCorneal Astigmatism Measurement Study

Corneal Astigmatism Measurement Study

Start: Dec 2008Est. completion: Apr 200950 patients

N/ACompleted

NCT00581659 Bausch HealthEvaluation of the Bausch & Lomb PureVision Under Nighttime Driving Conditions

Evaluation of the Bausch & Lomb PureVision Under Nighttime Driving Conditions

Start: Nov 2007Est. completion: Oct 200840 patients

N/ACompleted

NCT00584831 Johnson & Johnsonsenofilcon A

Effect of Eye Movement on Toric Lens Orientation and Visual Acuity

Start: Oct 2007Est. completion: Feb 200840 patients

N/ACompleted

NCT00584220 Johnson & Johnsonsenofilcon A toric

Evaluation of Two Toric Soft Contact Lenses After Two Weeks of Wear

Start: Sep 2007Est. completion: Dec 200796 patients

N/ACompleted

NCT00762502 Johnson & Johnsonsenofilcon A toric contact lens

Comparison of Senofilcon A Toric Lenses to Balafilcon A Toric Lenses Over Extended Wear Period

Start: Jun 2007Est. completion: Jan 2008112 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 4,259 patients

10 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.