Arthroplasty, Replacement, Knee

4
Pipeline Programs
4
Companies
6
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
2
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
3 programs
1
2
Dabigatran Dose 1 - day 2 to completionPhase 31 trial
enoxaparinPhase 31 trial
Dabigatran etexilatePhase 21 trial
Active Trials
NCT00246025Completed512
NCT00152971Completed2,615
NCT00168805Completed2,101
Astellas
AstellasChina - Shenyang
1 program
1
YM150Phase 21 trial
Active Trials
NCT00595426Completed685Est. May 2009
Arthrex
ArthrexCA - Santa Barbara
1 program
NanoScope™ Operative ArthroscopyN/A1 trial
Active Trials
NCT05002387UnknownEst. Jan 2024
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
Total Knee ArthroplastyN/A1 trial
Active Trials
NCT00899041Completed67Est. Oct 2013

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Boehringer Ingelheimenoxaparin
Boehringer IngelheimDabigatran Dose 1 - day 2 to completion
AstellasYM150
Boehringer IngelheimDabigatran etexilate
ArthrexNanoScope™ Operative Arthroscopy
Johnson & JohnsonTotal Knee Arthroplasty

Clinical Trials (6)

Total enrollment: 5,980 patients across 6 trials

NCT00168805Boehringer Ingelheimenoxaparin

RE-MODEL Dabigatran Etexilate 150mg or 220mg Once Daily (o.d.) Versus (v.s.) Enoxaparin 40mg o.d. for Prevention of Thrombosis After Knee Surgery

Start: Nov 20042,101 patients
Phase 3Completed
NCT00152971Boehringer IngelheimDabigatran Dose 1 - day 2 to completion

Dabigatran Etexilate vs Enoxaparin in Prevention of Venous Thromboembolism (VTE) Post Total Knee Replacement

Start: Nov 20042,615 patients
Phase 3Completed
NCT00595426AstellasYM150

A Study to Evaluate the Safety and Efficacy of YM150 in Patients With Knee Replacement Surgery

Start: May 2008Est. completion: May 2009685 patients
Phase 2Completed
NCT00246025Boehringer IngelheimDabigatran etexilate

A Study of BIBR 1048 in Prevention of Venous Thromboembolism in Patients With TKR Surgery.

Start: Oct 2005512 patients
Phase 2Completed
NCT05002387ArthrexNanoScope™ Operative Arthroscopy

Diagnostic Knee Needle Arthroscopy in Predicting Unicompartmental Knee Osteoarthritis

Start: Sep 2021Est. completion: Jan 2024
N/AUnknown
NCT00899041Johnson & JohnsonTotal Knee Arthroplasty

Functional Evaluation of a Standard and a High-flexion Knee Prosthesis Using Thigh-calf Contact Force Measurements

Start: Oct 2008Est. completion: Oct 201367 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
4 companies competing in this space