Arthroplasty, Replacement, Knee

Pipeline Programs

Companies

Clinical Trials

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

AstellasChina - Shenyang

1 program

YM150Phase 21 trial

Active Trials

NCT00595426Completed685Est. May 2009

Syneos HealthNC - Morrisville

1 program

EP=7041Phase 11 trial

Active Trials

NCT02914353Completed80Est. May 2017

StrykerCA - San Jose

14 programs

Cemented Triathlon total knee systemN/A1 trial

Primary total knee replacementN/A1 trial

Scorpio PSN/A1 trial

Triathlon CRN/A1 trial

Triathlon CS fixed bearing total knee prosthesisN/A1 trial

+9 more programs

Active Trials

NCT00436982Completed60Est. Jan 2017

NCT02524730Completed205Est. Feb 2020

NCT02520531Completed84Est. Jun 2018

+11 more trials

Zimmer BiometFL - Jacksonville

5 programs

Cementless Oxford Partial KneeN/A1 trial

HealthLoop mobile applicationN/A1 trial

Vanguard Knee System with Signature Knee GuideN/A1 trial

Zimmer-Biomet Posterior Cruciate Retaining total knee arthroplastyN/A1 trial

knee arthroplasty, standard polyethyleneN/A1 trial

Active Trials

NCT00760188Withdrawn0Est. Dec 2011

NCT03481595Completed294Est. Jun 2020

NCT01092312Terminated325Est. Sep 2016

+2 more trials

Colorado TherapeuticsCO - Louisville

3 programs

Early Clinical Results of Mobile-Bearing Revision Total Knee ArthroplastyN/A1 trial

Multimodal Physical TherapyN/A1 trial

Pre Operative Oral FluidsN/A1 trial

Active Trials

NCT01398800Completed340Est. Jul 2019

NCT04837872Completed10Est. Feb 2019

NCT03719378Completed150Est. Sep 2018

Boehringer IngelheimINGELHEIM, Germany

3 programs

Dabigatran etexilatePHASE_21 trial

Dabigatran Dose 1 - day 2 to completionPHASE_31 trial

enoxaparinPHASE_31 trial

Active Trials

NCT00246025Completed512

NCT00152971Completed2,615

NCT00168805Completed2,101

BiocorpFrance - Issoire

1 program

Gait training with real time biofeedbackN/A1 trial

Active Trials

NCT03849638Unknown50Est. Dec 2024

Spine BioPharmaNY - New York

1 program

Multimodal Physical TherapyN/A

ArthrexCA - Santa Barbara

1 program

NanoScope™ Operative ArthroscopyN/A1 trial

Active Trials

NCT05002387Unknown110Est. Jan 2024

Johnson & JohnsonNEW BRUNSWICK, NJ

1 program

Total Knee ArthroplastyN/A1 trial

Active Trials

NCT00899041Completed67Est. Oct 2013

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

Boehringer IngelheimDabigatran Dose 1 - day 2 to completion

Boehringer Ingelheimenoxaparin

AstellasYM150

Boehringer IngelheimDabigatran etexilate

Syneos HealthEP=7041

ArthrexNanoScope™ Operative Arthroscopy

Zimmer BiometZimmer-Biomet Posterior Cruciate Retaining total knee arthroplasty

BiocorpGait training with real time biofeedback

Zimmer BiometHealthLoop mobile application

Colorado TherapeuticsMultimodal Physical Therapy

Colorado TherapeuticsPre Operative Oral Fluids

StrykerTriathlon Tritanium Knee

StrykerTriathlon Total Knee System with X3 insert

StrykerTriathlon® CR/Kinematic Alignment

Zimmer BiometCementless Oxford Partial Knee

Showing 15 of 30 trials with date data

Clinical Trials (30)

Total enrollment: 11,054 patients across 30 trials

NCT00152971 Boehringer IngelheimDabigatran Dose 1 - day 2 to completion

Dabigatran Etexilate vs Enoxaparin in Prevention of Venous Thromboembolism (VTE) Post Total Knee Replacement

Start: Nov 20042,615 patients

Phase 3Completed

NCT00168805 Boehringer Ingelheimenoxaparin

RE-MODEL Dabigatran Etexilate 150mg or 220mg Once Daily (o.d.) Versus (v.s.) Enoxaparin 40mg o.d. for Prevention of Thrombosis After Knee Surgery

Start: Nov 20042,101 patients

Phase 3Completed

NCT00595426 AstellasYM150

A Study to Evaluate the Safety and Efficacy of YM150 in Patients With Knee Replacement Surgery

Start: May 2008Est. completion: May 2009685 patients

Phase 2Completed

NCT00246025 Boehringer IngelheimDabigatran etexilate

A Study of BIBR 1048 in Prevention of Venous Thromboembolism in Patients With TKR Surgery.

Start: Oct 2005512 patients

Phase 2Completed

NCT02914353 Syneos HealthEP=7041

Study to Evaluate Safety, PK and PD of Single and Multiple Ascending Doses of EP-7041 in Healthy Subjects

Start: Jul 2016Est. completion: May 201780 patients

Phase 1Completed

NCT05002387 ArthrexNanoScope™ Operative Arthroscopy

Diagnostic Knee Needle Arthroscopy in Predicting Unicompartmental Knee Osteoarthritis

Start: Sep 2021Est. completion: Jan 2024110 patients

N/AUnknown

NCT04103515 Zimmer BiometZimmer-Biomet Posterior Cruciate Retaining total knee arthroplasty

Knee Kinematics for Subjects With Zimmer-Biomet Posterior Cruciate Retaining or Posterior Stabilizing Total Knee Arthroplasty

Start: Jan 2019Est. completion: Nov 202050 patients

N/ACompleted

NCT03849638 BiocorpGait training with real time biofeedback

Gait Analysis and Gait Training in Patient With Total Hip or Total Knee Replacement

Start: Dec 2018Est. completion: Dec 202450 patients

N/AUnknown

NCT03481595 Zimmer BiometHealthLoop mobile application

Improvement of Patient Satisfaction and Overall Outcomes Using HealthLoop

Start: Apr 2018Est. completion: Jun 2020294 patients

N/ACompleted

NCT04837872 Colorado TherapeuticsMultimodal Physical Therapy

Static Progressive Splinting in the Management of Knee Stiffness Following Total Knee Arthroplasty

Start: May 2017Est. completion: Feb 201910 patients

N/ACompleted

NCT03719378 Colorado TherapeuticsPre Operative Oral Fluids

Traditional vs Oral Fluid Management in Total Knee Arthroplasty

Start: Oct 2015Est. completion: Sep 2018150 patients

N/ACompleted

NCT02155712 StrykerTriathlon Tritanium Knee

Triathlon Tritanium Knee Outcomes Study

Start: Oct 2014Est. completion: Mar 2023680 patients

N/ATerminated

NCT02525562 StrykerTriathlon Total Knee System with X3 insert

Stryker NTX Registry Scorpio NRG (Re-"Energize"), Triathlon Total Knee, Triathlon Partial Knee Resurfacing (PKR) With X3 Polyethylene Insert

Start: Jun 2012Est. completion: May 2020237 patients

N/ATerminated

NCT02539992 StrykerTriathlon® CR/Kinematic Alignment

ShapeMatch Cutting Guide Functional Outcomes Study

Start: May 2012Est. completion: May 201544 patients

N/ATerminated

NCT00760188 Zimmer BiometCementless Oxford Partial Knee

Prospective Data Collection on Cementless Oxford Partial Knee

Start: Dec 2011Est. completion: Dec 20110

N/AWithdrawn

NCT02525588 StrykerTriathlon CS fixed bearing total knee prosthesis

Polyethylene Wear Study on the Triathlon Total Knee Prosthesis

Start: Sep 2011Est. completion: Mar 2019100 patients

N/ACompleted

NCT01398800 Colorado TherapeuticsEarly Clinical Results of Mobile-Bearing Revision Total Knee Arthroplasty

Early Clinical Results of Mobile-Bearing Revision Total Knee Arthroplasty

Start: Jul 2011Est. completion: Jul 2019340 patients

N/ACompleted

NCT02520531 StrykerScorpio PS

Scorpio Posterior Stabilised (PS) vs Scorpio NRG ("Energize") PS - Total Knee Arthroplasty

Start: Sep 2010Est. completion: Jun 201884 patients

N/ACompleted

NCT01092312 Zimmer BiometVanguard Knee System with Signature Knee Guide

Signature Personalised Patient Care System With the Vanguard Knee System Study

Start: Mar 2010Est. completion: Sep 2016325 patients

N/ATerminated

NCT00966979 StrykerTriathlon PKR

Triathlon® Partial Knee Replacement (PKR) Outcomes Study

Start: Jan 2010Est. completion: May 2023111 patients

N/ATerminated

NCT02178020 Zimmer Biometknee arthroplasty, standard polyethylene

Outcome Study of Highly-cross Linked Polyethylene vs. Standard Polyethylene for Primary Posterior Stabilized (PS) Total Knee

Start: Jul 2009Est. completion: Jul 2019500 patients

N/AUnknown

NCT00958789 StrykerTriathlon TS Knee System

Triathlon Total Stabilizer (TS) Outcomes Study

Start: Jul 2009Est. completion: Mar 2019180 patients

N/ACompleted

NCT02524730 StrykerPrimary total knee replacement

Scorpio NRG (eNeRGize) Cruciate Retaining (CR) Post-market International Outcome Study

Start: May 2009Est. completion: Feb 2020205 patients

N/ACompleted

NCT00899041 Johnson & JohnsonTotal Knee Arthroplasty

Functional Evaluation of a Standard and a High-flexion Knee Prosthesis Using Thigh-calf Contact Force Measurements

Start: Oct 2008Est. completion: Oct 201367 patients

N/ACompleted

NCT03198533 StrykerTriathlon PA

Evaluation of Triathlon - A New Total Knee Prosthesis System - Triathlon PA vs. Triathlon Pressfit

Start: Jul 2007Est. completion: Nov 201760 patients

N/ACompleted

NCT00493792 StrykerX3 Polyethylene

X-3 Polyethylene Survival Outcomes Study

Start: Feb 2007Est. completion: Nov 2023518 patients

N/ACompleted

NCT02522728 StrykerTriathlon CR

Evaluation of Triathlon - A New Total Knee Prosthesis System - Roentgen Stereophotogrammetric Analysis (RSA) Triathlon CR vs. PS

Start: Jan 2007Est. completion: Sep 201758 patients

N/ACompleted

NCT00436982 StrykerCemented Triathlon total knee system

Evaluation of Triathlon - a New Total Knee Prosthesis System - Triathlon vs. Duracon

Start: Feb 2006Est. completion: Jan 201760 patients

N/ACompleted

NCT00957021 StrykerTriathlon® PS Total Knee System

Triathlon® Posteriorly Stabilized (PS) Total Knee System - Outcomes Study

Start: Dec 2005Est. completion: Jan 2014409 patients

N/ACompleted

NCT00957723 StrykerTriathlon® CR Total Knee System

Triathlon® Cruciate Retaining (CR) Total Knee System Outcomes Study

Start: Feb 2005Est. completion: Sep 2017419 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

10 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.